A review on enteric coated tablet
Journal name: World Journal of Pharmaceutical Research
Original article title: A review on enteric coated tablet
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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R. A. Dhawale, K. J. Kore, R. V. Shete
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: A review on enteric coated tablet
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20191-13879
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
The review provides an in-depth exploration of enteric-coated tablets, solid dosage forms designed to release medication specifically in the small intestine, bypassing the harsh acidic environment of the stomach. Enteric coatings serve to protect drugs from gastric conditions and enhance the therapeutic efficacy of medications, particularly those intended for intestinal absorption. The work outlines the materials commonly used for enteric coatings, their ideal properties, advantages, disadvantages, and the manufacturing processes involved in producing these specialized tablets.
Mechanism of Action of Enteric Coatings
Enteric coatings function as barriers that prevent drug release in the acidic environment of the stomach (pH 1.5-3) but allow dissolution in the more alkaline conditions of the small intestine (pH 7-9). This pH-sensitive mechanism is crucial for drugs that could be inactivated or cause irritation if exposed to gastric fluids. Several polymers, such as Cellulose Acetate Phthalate (CAP) and Polyvinyl Acetate Phthalate (PVAP), are used in enteric coatings due to their ability to remain insoluble in acidic conditions while becoming soluble in the intestinal milieu. These coatings help ensure that active ingredients are delivered directly to their intended site of action, enhancing therapeutic outcomes, particularly for conditions affecting the intestines.
Advantages and Disadvantages of Enteric Coating
The enterprise of enteric coating brings multiple advantages; primarily, it protects drugs from gastric acid, thus enhancing stability and preventing gastrointestinal irritation. This is particularly important for acid-labile drugs or drugs that may cause gastric distress, such as certain non-steroidal anti-inflammatory drugs (NSAIDs). The coatings can also mask unpleasant tastes and improve tablet aesthetics, facilitating swallowing. However, the enteric coating process can be tedious, requiring a high level of technical skill and appropriate equipment, which can deter small-scale manufacturers. The complexities involved in the formulation and application of these coatings can lead to variability in drug release profiles, requiring careful design and quality control measures.
Manufacturing Process of Enteric Coated Tablets
The manufacturing of enteric-coated tablets typically involves a multi-step process that begins with the preparation of core tablets through methods like wet granulation. These tablets are then coated using specialized techniques, such as spray coating within a controlled atmosphere to ensure even application of the enteric coating solution. Key factors during the coating process include temperature management, spray rate control, and proper drying to achieve a consistent coating layer that meets predetermined specifications. Commonly, a functional enteric coating composition includes polymers, plasticizers, and other agents that enhance the properties of the final product while maintaining compatibility with the active ingredients.
Conclusion
In conclusion, enteric-coated tablets offer significant benefits in delivering medication directly to the intestines, improving drug stability and minimizing adverse effects related to gastric acid. The choice of polymers and the method of coating application are critical for the successful development of enteric-coated formulations. While the process poses certain challenges, it remains a prominent choice for pharmaceutical formulations due to its effectiveness in providing therapeutic solutions and its user-friendly nature in terms of formulation. Continuous advancements in coating technology and research into new materials will further enhance the viability of enteric-coated tablets in the pharmaceutical industry.
FAQ section (important questions/answers):
What are enteric coated tablets designed for?
Enteric coated tablets are designed to bypass the stomach and release medication in the small intestine, enhancing drug absorption and reducing gastric irritation.
What materials are commonly used for enteric coatings?
Common materials include cellulose acetate phthalate (CAP), polyvinyl acetate phthalate (PVAP), shellac, and plant fibers. These materials dissolve in alkaline conditions found in the small intestine.
What advantages do enteric coated tablets offer?
Advantages include protecting drugs from gastric fluids, preventing nausea during intake, masking unpleasant tastes, and allowing for targeted release in the intestines.
What are the ideal properties of enteric coatings?
Ideal properties include resistance to gastric fluids, susceptibility to intestinal fluids, compatibility with components, nontoxicity, cost-effectiveness, and ease of application.
What is the main disadvantage of enteric coating processes?
The main disadvantage is that the coating process is tedious and time-consuming, requiring skilled technicians to ensure quality production.
How are enteric coated tablets manufactured?
They are manufactured through a spray coating technique, applying enteric coating solutions to pre-formed core tablets within a controlled environment to ensure even coating and drying.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “A review on enteric coated tablet”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
'Drugs' refers to various chemical compounds used to diagnose or treat conditions. The formulation of drugs into enteric-coated tablets allows for controlled release and targeted action, particularly valuable for drugs that are sensitive to stomach acidity or are intended to act in the intestines.
2) Surface:
The word 'surface' pertains to the outer layer of an object. For enteric-coated tablets, the surface plays a vital role in shielding the drug from the gastric environment until it reaches the small intestine, where the coating dissolves, permitting the release of the active ingredients.
3) Reason:
'Reason' refers to the explanation for why something occurs. In pharmaceutical contexts, understanding the reason for a drug’s formulation decisions, such as enteric coating, is crucial for ensuring that medications are effective and safe for patients by minimizing adverse reactions, like gastric irritation.
4) Substance:
'Substances' are materials with distinct physical and chemical properties. In the context of enteric-coated tablets, various substances, including polymers and plasticizers, are utilized to create the coating that protects the drug during its passage through the stomach until it reaches the intestine.
5) Disease:
'Disease' refers to a pathological condition that results in dysfunction or distress in the body, often necessitating treatment. Many drugs are specifically formulated as enteric-coated tablets to target diseases effectively, especially those affecting the intestines, where the tablets can release their active ingredients.
6) Irritation:
'Irritation' is the response of bodily tissues to harmful stimuli, often resulting in discomfort or inflammation. Enteric-coated tablets are designed to prevent this, especially in cases where medications could cause gastric irritation, thus ensuring patient compliance and therapeutic efficacy.
7) Water:
'Water' is a universal solvent and a key component in creating pharmaceutical formulations. It acts as a medium in which many excipients, such as gels and polymers for enteric coatings, are dissolved and processed, contributing to the desired tablet consistency and performance.
8) Maharashtra (Maharastra, Maha-rashtra):
Maharashtra is a western state in India known for its pharmaceutical industry. The reference to Maharashtra highlights the region's significant role in pharmaceutical research and education, exemplified by institutions like Rajgad Dnyanpeeth’s College of Pharmacy that focus on developing advanced drug delivery systems.
9) Powder:
'Powder' refers to finely ground solid particles. In the pharmaceutical context, active ingredients and excipients often start in powdered form before being compressed into tablets or formulated into coatings. This form is essential for achieving the desired bioavailability and dosage consistency.
10) India:
'India' is a country known for its rapidly growing pharmaceutical sector. The mention of India underscores its importance in global medicine production and research, particularly in the development of innovative drug delivery systems like enteric-coated tablets to improve patient health outcomes.
11) Pune:
'Pune' is a city in Maharashtra renowned for its educational institutions and pharmaceutical companies. The reference to Pune emphasizes its role as a hub for pharmaceutical research and development, particularly in formulating effective drug delivery mechanisms such as enteric coatings.
12) Surrounding:
'Surrounding' relates to what is adjacent or near. In pharmaceutical contexts, surrounding conditions, like pH and temperature, are pivotal in determining how and when an enteric-coated tablet will dissolve and release its active drug, impacting the overall effectiveness of treatment.
13) Measurement:
'Measurement' refers to the process of quantifying certain properties. In the field of pharmaceuticals, precise measurement of drug dosages and coating thickness is essential to ensure consistency, effectiveness, and safety of enteric-coated tablets and other formulations.
14) Agriculture:
'Agriculture' encompasses the cultivation of crops and rearing of animals for food, fiber, and other products. The link to agriculture signifies the potential use of enteric coatings not only in pharmaceuticals but also in agrochemical formulations that protect nutrients from degradation.
15) Antibiotic (Antibacterial):
'Antibiotic' refers to a type of medication used to treat bacterial infections. Enteric coating may be particularly beneficial for certain antibiotics that can be deactivated by stomach acid, ensuring that they are released at the right site to maximize their effectiveness.
16) Dividing:
'Dividing' indicates splitting something into parts. In the context of pharmaceutical tablets, careful dividing of layers or components during formulation ensures that each has specific properties, such as controlled release or targeted action within the digestive system.
17) Relative:
'Relative' pertains to how something relates to another. In pharmacology, determining the relative effectiveness or bioavailability of a drug formulation, such as an enteric-coated tablet versus a traditional tablet, is crucial for optimizing therapeutic outcomes.
18) Entering:
'Entering' refers to the act of going into or joining. In the realm of enteric-coated tablets, understanding how and when a drug enters the intestine is critical for designing coatings that ensure timely release and absorption of the active ingredient at the target site.
19) Falling:
'Falling' typically denotes descending motion. In the coating process of enteric tablets, the falling motion of tablets in a coating pan allows for even distribution of the coating material, ensuring uniform coverage and effective performance of the enteric coating.
20) Nausea:
'Nausea' is an unpleasant sensation often associated with the urge to vomit. Enteric-coated tablets may be specifically designed to minimize nausea caused by certain medications, improving patient comfort and adherence to treatment regimens.
21) Filling (Filled):
'Filled' refers to occupying a volume or space with a substance. In pharmaceuticals, core tablets can be filled with active ingredients and excipients, which are then coated to create enteric-coated tablets, enhancing delivery and effectiveness of the drug.
22) Sugar:
'Sugar' refers to sweet-tasting soluble carbohydrates used in many formulations for flavoring. In enteric-coated tablets, sugar may be used as a sweetener or to mask undesirable tastes, improving patient compliance with medication regimens.
23) Honey:
'Honey' is a natural sweetener made by bees. It is mentioned as a potential flavoring agent in formulations, possibly enhancing the taste of enteric-coated tablets and thus resulting in higher patient acceptability and adherence.
24) Table:
'Table' refers to a tabular format used to organize data or information. In pharmaceutical literature, tables are often utilized to present data regarding the properties of substances, dosage forms, and formulations, aiding in the assessment and comparison of various formulations.
25) Wall:
'Wall' refers to the boundary of a structure. In pharmaceuticals, the term often pertains to tablet walls that contain active ingredients, ensuring they are protected during the digestion process until released at the appropriate site in the gastrointestinal tract.
26) Line:
'Line' signifies a boundary or direction. In pharmaceutical contexts, lines may represent processes, pathways, or divisions within a formulation. Understanding the line of release for active ingredients in enteric-coated tablets is vital for drug efficacy and patient outcomes.
Other Science Concepts:
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