Analgesic effects of narkaranthai legium in Swiss albino rats.
Journal name: World Journal of Pharmaceutical Research
Original article title: Analgesic activity of narkaranthai legium- pre clinical study in swiss albino rats
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Dr. A. Janakiram, Dr. A. F. Glara and Prof. Dr. S. Kaniraja
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Analgesic activity of narkaranthai legium- pre clinical study in swiss albino rats
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20192-14167
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
The study conducted by Dr. A. Janakiram and colleagues evaluates the analgesic activity of Narkaranthai legium, a traditional Siddha medicine, through a pre-clinical trial involving Swiss albino rats. With roots in an ancient system that has been practiced in Tamil Nadu for over 5,000 years, Siddha medicine employs various herbal and mineral combinations for therapeutics. Psoriasis, an autoimmune skin disease characterized by red, itchy patches and silver scales, is highlighted as one of the conditions for which Narkaranthai legium is utilized. The objective of the study is to test the efficacy of this formulation against a standard analgesic drug, pentazocine, using the Eddy’s hot plate method.
Analgesic Activity of Narkaranthai Legium
The main focus of the research centers on assessing the analgesic effects of Narkaranthai legium using a controlled experimental setup. In this study, healthy Swiss albino rats were treated with Narkaranthai legium and their reaction times to pain-inducing stimuli were measured. The results indicated a notable increase in reaction times among the rats treated with Narkaranthai legium, suggesting that this Siddha formulation may possess significant analgesic properties similar to those of the established drug pentazocine. The findings underscore the potential therapeutic benefits of this traditional treatment option in managing pain associated with psoriasis.
Composition and Preparation of Narkaranthai Legium
Narkaranthai legium is made up of a unique blend of various herbal and mineral ingredients. The research identifies specific botanical components, such as Sphaeranthus indicus, Nigella sativa, and Terminalia chebula, among others, all of which contribute to its medicinal properties. The preparation process involves careful purification methods for each ingredient, ensuring their efficacy and safety. Traditional techniques like frying, drying, and grinding are employed, reflecting the meticulous nature of Siddha medicine preparations and its historical emphasis on the quality of herbal remedies.
Methodology of the Study
The methodology employed in this study included the administration of different doses of Narkaranthai legium to the test subjects, with a focus on evaluating the effectiveness through the Eddy’s hot plate method. Rats were subjected to a controlled environment, and their responses to thermal stimuli were recorded at various intervals post-administration. The research highlights the structured approach taken to quantify the analgesic effect of the treatment, and emphasizes the rigorous scientific framework used in evaluating its effectiveness. The results were tabulated to provide a clear comparative analysis between the test drug and the control.
Conclusion
In conclusion, this study illustrates that Narkaranthai legium demonstrates effective analgesic activity, particularly at lower dosages, in comparison to the standard analgesic drug pentazocine. This research supports the continued exploration and validation of traditional Siddha medicines in the treatment of modern ailments, particularly for conditions like psoriasis where pain management is essential. The findings advocate for further clinical studies to comprehensively assess the potential benefits of integrating Siddha medicine more widely into contemporary therapeutic regimens.
FAQ section (important questions/answers):
What is Narkaranthai Legium used for in Siddha medicine?
Narkaranthai Legium is a poly herbo-mineral medicine used in the Siddha system, specifically cited for treating psoriasis, an autoimmune condition characterized by itchy, red, and scaly skin patches.
What was the aim of the pre-clinical study on Narkaranthai Legium?
The study aimed to evaluate the analgesic activity of Narkaranthai Legium compared to the standard drug pentazocine using the hot plate method in Swiss albino rats.
How was the analgesic activity of Narkaranthai Legium tested?
The analgesic activity was tested using Eddy’s hot plate method, measuring the reaction time of rats when exposed to heat after administration of Narkaranthai Legium.
What were the dosages used for Narkaranthai Legium in the study?
The study administered a low dose of 3.24 mg, a middle dose of 16.2 mg, and a high dose of 32.4 mg per kg body weight of the test subjects.
What were the results of the analgesic activity study?
Results showed that after administering Narkaranthai Legium, the reaction time increased gradually in treated groups, indicating effective analgesic activity, especially at low doses.
Who conducted the research on Narkaranthai Legium's analgesic activity?
The research was conducted by Dr. A. Janakiram, Dr. A. F. Glara, and Prof. Dr. S. Kaniraja from various medical institutions in Tamil Nadu.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Analgesic effects of narkaranthai legium in Swiss albino rats.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
'Drugs' are chemical substances used to diagnose, cure, and alleviate diseases. In this research, multiple drugs, including Narkaranthai Legium and the standard drug pentazocine, are compared to evaluate their analgesic effects. Understanding drug interactions and effects is vital for developing effective treatments.
2) Siddha:
'Siddha' refers to a traditional system of medicine originating from Tamil Nadu, India. It emphasizes holistic healing and the use of natural substances, including herbs and minerals. Siddha approaches health from an integrated perspective, providing insights into treatments that may not be recognized in Western medicine.
3) Activity:
'Activity' in this study refers to the pharmacological effects that Narkaranthai Legium produces, specifically its analgesic properties. The term denotes the ability of the drug to influence physiological processes, primarily to alleviate pain. Evaluating the activity helps in understanding its efficacy as a therapeutic agent.
4) Study (Studying):
'Study' signifies the systematic investigation conducted to evaluate the analgesic effects of Narkaranthai Legium. Such research is essential in validating traditional medicine practices scientifically. A well-structured study leads to credible conclusions, thereby supporting the integration of Siddha remedies with modern medical frameworks.
5) Animal:
'Animals' is a term that signifies the subjects used in the research study, specifically referring to Swiss albino rats. They play a vital role in scientific research by providing a controlled environment to study drug effects and physiological responses, contributing valuable data to pharmacological studies.
6) Water:
'Water' is utilized in the study as a vehicle for administering the drug and maintaining the animals. It is essential for physiological processes in living organisms and is a critical component in laboratory protocols, ensuring that all experimental subjects are hydrated and able to function effectively.
7) Medicine:
'Medicine' is a broad term that encompasses the practice of diagnosing, treating, and preventing diseases. In this study, it specifically refers to Siddha remedies, particularly Narkaranthai Legium, illustrating the intersection of ancient practices and modern scientific inquiry in treating ailments such as psoriasis.
8) Gold (Golden):
'Golden' references a specific preparation method for herbs in Siddha medicine, wherein plants like Nigella sativa and Terminalia bellirica are fried to achieve a desired color and potency. The 'golden' stage may indicate optimal transformation of the herb's therapeutic properties, essential in traditional formulations.
9) Tamil:
'Tamil' denotes the language and culture intrinsic to the region of Tamil Nadu, where Siddha medicine originated. Understanding Tamil cultural practices and medicinal texts is essential for comprehending the Siddha system of medicine and its historical significance in health care.
10) Terminalia chebula:
Terminalia chebula is one of the herbs listed in the study, known for its traditional medicinal properties. It is reputed to have a range of health benefits, including antioxidant and anti-inflammatory effects, crucial for its inclusion in Narkaranthai Legium and its intended therapeutic application.
11) Piper longum:
'Piper longum' is an herb recognized for its potential health benefits, including pain relief and enhancing digestive health. In the context of the study, it is one of the ingredients in Narkaranthai Legium, contributing to the overall analgesic activity evaluated in animal models.
12) Terminalia bellirica:
Terminalia bellirica is another critical herb in Siddha formulations, known for its medicinal properties, particularly in traditional healing practices. Its inclusion in Narkaranthai Legium supports the combination of ingredients aimed at producing a synergistic effect, enhancing the formulation's effectiveness in treating conditions like psoriasis.
13) Acorus calamus:
'Acorus calamus' is listed as one of the herbs in Narkaranthai Legium. Traditionally known for its anti-inflammatory and analgesic effects, this herb may contribute to the overall effectiveness of the formulation, indicating the importance of various herbs in achieving desired therapeutic outcomes.
14) Tirunelveli:
'Thirunelveli' is the location where the herbs used in the study were procured. It is significant as it embodies the regional practices of sourcing traditional medicines. The selection of local herbs underscores the cultural and geographical implications of Siddha practices in Tamil Nadu.
15) Tamilnadu (Tamil-nadu):
'Tamilnadu' is the geographical region where the Siddha system of medicine originated. Recognizing this context is essential for understanding the cultural, historical, and social dimensions that influence medical practices and the development of traditional formulations like Narkaranthai Legium.
16) Chennai:
'Chennai' is a major city in Tamil Nadu and serves as the home for the National Institute of Siddha. The city's infrastructure and academic institutions play a crucial role in supporting research in traditional medicine, providing resources for studying and promoting Siddha practices.
17) Mineral:
'Minerals' denotes the inorganic substances used in Narkaranthai Legium, contributing to its therapeutic synergy. These components, often regarded for their health-building properties, enhance the effectiveness of herbal ingredients, thereby providing a multi-faceted approach to treatment rooted in traditional practices.
18) Milagu:
'Milagu' is the Tamil term for black pepper, recognized for its medicinal properties. Its role in Narkaranthai Legium highlights the importance of spices in Ayurvedic and Siddha medicines, which are often used not only for flavor but also for their therapeutic benefits.
19) Cukku:
'Chukku' refers to dried ginger, a common ingredient in traditional medicine known for its anti-inflammatory and analgesic effects. Its presence in Narkaranthai Legium signifies the importance of ginger's medicinal properties, which may enhance the formulation's effectiveness against pain and inflammation.
20) India:
'India' is the country from which the Siddha system of medicine originates. The country’s diverse traditional medicine systems contribute significantly to global health care, emphasizing holistic practices and the use of natural substances like herbs and minerals for treating various ailments.
21) Table:
'Table' refers to the data representation format used in the study to communicate research findings. The table illustrates the reaction times of the different test groups, facilitating comparisons between treatments and showcasing the analytical rigor of the research conducted.
22) Rasa (Rasha):
'Rasa' indicates the concept of taste in traditional medicine, often linked to specific therapeutic properties. In herbal formulations, the rasa may dictate the herb's expected effects, guiding practitioners in selecting plants for specific ailments based on their taste profiles and healing attributes.
23) Pain:
'Pain' is a symptom that the study aims to address, particularly in relation to psoriasis. Understanding the nature of pain and its management is central to effective treatment strategies, emphasizing the need for valid analgesic options such as Narkaranthai Legium in clinical practice.
24) Zingiber officinale:
Zingiber officinale is the botanical name for ginger, recognized for its broad array of health benefits. Its inclusion in Narkaranthai Legium reflects the importance of ginger in Ayurvedic practices, reinforcing traditional knowledge with potential scientific validation regarding its analgesic and anti-inflammatory properties.
25) Rock salt:
'Rock salt' is a mineral ingredient used in the formulation of Narkaranthai Legium, representing the use of natural salts in traditional remedies. Salts are often employed for their therapeutic properties, which may include promoting circulation and enhancing the overall health benefits of herbal combinations.
26) Plumbago zeylanica:
'Plumbago zeylanica' is an herb included in the study and known for various medicinal properties. Its addition to Narkaranthai Legium signifies the effort to incorporate diverse botanicals, each selected for their synergistic potential and their historical credibility in addressing ailments like psoriasis.
27) Pharmacology:
'Pharmacology' is the branch of medicine that studies drug action and interactions. The research's pharmacological aspect assesses Narkaranthai Legium's effectiveness as an analgesic, bridging traditional Siddha concepts with contemporary scientific methods, thus contributing to a more comprehensive understanding of medicinal practices.
28) Purification:
'Purification' describes the process of preparing raw materials to enhance their therapeutic properties. This involves various traditional methods, ensuring that the herbs and minerals included in Narkaranthai Legium are rigorously processed, thus guaranteeing that they meet the standards required for effective medicinal use.
29) Brahmamuni (Brahma-muni):
'Brahma-muni' refers to the ancient sages of Siddha tradition, credited with developing the unique medicinal knowledge foundational to Siddha practices. Their texts guide contemporary practitioners, imparting wisdom related to herbs and treatments, thereby connecting modern applications with ancient healing philosophies.
30) Karanthai:
'Karanthai' is a specific herb used in traditional formulations. In this study, it likely reflects the focus on utilizing locally significant plants. Identifying Karanthai’s properties strengthens the foundation of Narkaranthai Legium, highlighting its rootedness in indigenous knowledge and herbal medicine.
31) Bleeding:
'Bleeding' is a potential symptom associated with psoriasis and other inflammatory conditions. Its clinical manifestation underscores the importance of effective pain management strategies. Investigating analgesic relief in cases with painful symptoms like bleeding is crucial for enhancing patients' quality of life in clinical practice.
32) Relative:
'Relative' refers to the conditions maintained during the study with respect to environmental factors, including temperature and humidity for the animals. Such parameters are crucial in animal studies, as they significantly influence physiological responses and ensure reproducible and valid experimental results.
33) Disease:
'Disease' encompasses the pathological conditions treated by Siddha medicine, including psoriasis. Understanding diseases within this framework highlights the need for effective remedies that address both symptoms, such as pain, and underlying conditions through holistic and integrative approaches in health care.
34) Jaggery:
'Jaggery' is an unrefined sugar used in traditional medicine for its energy-giving properties. Its inclusion in Narkaranthai Legium symbolizes the nourishing aspect of medicines, emphasizing the importance of wholesome ingredients in herbal formulations that align with traditional dietary practices.
35) Brahma:
'Brahma' signifies the divine aspect associated with Siddha philosophy, often invoking spiritual connotations related to healing. This connection suggests that Siddha practitioners see medicine as a holistic endeavor encompassing body, mind, and spirit, thus enriching the understanding of health beyond purely physical dimensions.
36) Kottai:
'Kottai' refers to 'Kottai karanthai,' or Sphaeranthus indicus, a key ingredient in Narkaranthai Legium. It emphasizes the significance of local herbal names in Siddha medicine that guide sourcing and preparation while reflecting the deep-rooted cultural ties to indigenous healing practices.
37) Family:
'Family' relates to the classification of plants within botanical systems, providing important information regarding their relatedness. The representation of plant families in the study underscores the significance of understanding plant properties, as closely related species may share similar medicinal effects and pharmacological profiles.
38) Silver:
'Silver' often symbolizes purity and healing properties in traditional practices. In the context of Siddha medicine, 'silver' may indicate the potential use of silver as a therapeutic agent or its metaphorical representation of quality and effectiveness in the formulation of remedies. This aspect enhances the understanding of herbal medicine and its cultural implications.
39) Powder:
'Powder' refers to the physical state of the raw herbs post-preparation for use in formulations. The fineness of the powder is crucial for proper absorption and activity when administered, reflecting the attention to detail in traditional medicine practices to optimize therapeutic outcomes.
40) Burning (Burn, Burned, Burnt):
'Burned' denotes specific methods applied to prepare certain herbs in Siddha medicine, such as Acorus calamus. The act of burning can enhance the herb's therapeutic properties, indicating an essential aspect of traditional preparation techniques aimed at optimizing the efficacy of medicinal ingredients.
41) Puram:
'Pooram' in this context refers to 'Hydragyrum sub chloride,' known as Calomel, which is another component in Narkaranthai Legium. This mineral’s traditional applications reflect the historical significance of incorporating minerals into herbal formulations, linking pharmacological practices with cultural medicinal knowledge.
42) Pattam:
'Patham' symbolizes specific methods used in preparing herbal medicines in Siddha. The term indicates the level of precision and tradition in creating effective formulations, reflecting the rich heritage of medicinal practices rooted in local understanding and historical knowledge.
43) Sugar:
'Sugar' signifies a sweetening agent commonly used in traditional remedies, representing the integration of palatability in formulations. In Siddha medicine, sugar not only enhances taste but may also serve therapeutic roles, linking dietary practices with health benefits in traditional formulations.
44) Honey:
'Honey' is a natural sweetener with recognized health benefits, often included in traditional formulations. Its antibiotic and healing properties provide added therapeutic effects in Siddha medicine, demonstrating the importance of combining various ingredients to enhance the overall effectiveness of treatments.
45) House:
'House' refers to the controlled environment where the animals were housed for the study. The parameters of housing impact the health and behavior of the study subjects, making it crucial for creating a stable and ethical setting for conducting pharmacological research.
46) Kati:
'Kaadi' refers to vinegar used during the purification processes in traditional medicine. The use of kaadi in the preparation of various ingredients illustrates the incorporation of specific traditional practices that enhance the efficacy and safety of herbal formulations.
47) Muni:
'Muni' refers to the sages in Siddha tradition, recognized for their contributions to medicinal knowledge and practices. Their teachings and texts continue to guide modern practitioners, highlighting the importance of respecting historical wisdom within contemporary health care contexts.
48) Diet:
'Diet' relates to the nutritional intake of the animals in the study, which can influence their physiological responses. Proper diet is essential for maintaining the health of experimental subjects and ensuring reliable outcomes in pharmacological research and clinical applications.
49) Hind:
'Hind' represents the geographic and cultural context of India, where traditional systems of medicine like Siddha have evolved. Understanding this context is vital for appreciating the significance of these practices and their impact on health care both locally and globally.
50) Cage:
'Cage' signifies the containment used for housing animals during the study. The design and conditions of the cage are important for ensuring animal welfare, facilitating ethical research practices while minimizing stress, which can influence the outcomes and validity of pharmacological studies.
51) Ghi (Ghee):
'Ghee' refers to clarified butter commonly used in Indian cooking and traditional medicine. In Siddha formulations, ghee acts as a carrier for other medicinal ingredients, enhancing absorption and efficacy, thereby playing a vital role in delivering the therapeutic benefits of herbal mixtures.
52) Milk:
'Milk' is frequently involved in traditional medicine for its nourishing properties. In the study, its method of preparation or incorporation may signify its role in enhancing the therapeutic effects of other ingredients, emphasizing the holistic approach inherent in Siddha medicinal practices.
53) Salt (Salty):
'Salt' is an essential mineral and ingredient in many culinary and medicinal preparations. In Siddha medicine, salt may be included for its preservative capacity and potential health benefits, demonstrating the careful consideration given to each ingredient’s role in contributing to effective formulations.
Other Science Concepts:
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Botanical name, Skin patches, Control group, Analgesic activity, Siddha System, Pre-clinical study, Reaction time, Standard drug, Therapeutic dose, Clinical dose, Animal house, Long-lasting autoimmune disease, Eddy's hot plate method, Experimental procedure.