Antidiabetic activity of cissus routndifolia leaves supplement

| Posted in: Science

Journal name: World Journal of Pharmaceutical Research
Original article title: Antidiabetic activity of cissus routndifolia leaves supplement
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
This page presents a generated summary with additional references; See source (below) for actual content.

Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

Wael Mustafa Ali Mohammed, Abdulaziz A. Y. Abbas, Hatem Mohmmed


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Antidiabetic activity of cissus routndifolia leaves supplement

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20192-14005


Download the PDF file of the original publication


Summary of article contents:

Introduction

The research article discusses the antidiabetic effects of Cissus rotundifolia (CR), a plant belonging to the Vitaceae family, traditionally used in Yemen and various regions of Africa. The study focuses on assessing the efficacy and safety of supplementing diabetic patients with fresh boiled leaves of Cissus rotundifolia. The plant is believed to contain various bioactive components, including flavonoids, hydrolysable tannins, antioxidants, and vitamin C, which collectively contribute to its anti-diabetic properties. The study involved eighteen diabetic patients who were administered different doses of CR leaves alongside glibenclamide, a common diabetes medication.

Hypoglycemic Effects of Cissus rotundifolia

The treatment with Cissus rotundifolia demonstrated significant hypoglycemic activity among the diabetic patients involved in the study. Administered in daily doses of 100g and 50g combined with glibenclamide, the results indicated a marked decrease in blood glucose levels over ten days. Measurements taken before and after the supplementation showed a consistent reduction in blood glucose concentration, signifying the potential of CR as an effective dietary aid in managing diabetes.

Impact on Liver and Kidney Function

In addition to its hypoglycemic effects, the study also evaluated the impact of Cissus rotundifolia on liver and kidney functions by measuring serum levels of urea, alanine aminotransferase (ALT), and aspartate aminotransferase (AST). Initial observations indicated elevated enzyme levels in diabetic patients prior to the CR intervention. After supplementation, there was a significant decrease in these enzyme levels, suggesting that CR supplementation might improve liver and kidney function in addition to its blood glucose-lowering effects.

Nutritional Benefits and Phytochemical Composition

Cissus rotundifolia leaves are rich in essential nutrients, including proteins, fats, crude fiber, and vital macro- and microelements. The presence of phytochemicals like β-sitosterol and quercetin, known for their beneficial properties in diabetes management, was also noted. The nutritional evaluation revealed that the leaves contain high levels of essential amino acids and unsaturated fatty acids, contributing to their overall health benefits and supporting the idea that dietary intake of such plants could be an effective strategy for diabetes prevention and management.

Conclusion

The findings of the study suggest that supplementing diabetic patients with Cissus rotundifolia leaves is safe and effective in lowering blood glucose levels. The plant's phytochemical compounds likely work synergistically to exhibit anti-diabetic properties without causing clinical abnormalities. The study highlights Cissus rotundifolia as a promising supplementary treatment for managing type 2 diabetes, reinforcing the potential of traditional medicinal plants in modern therapeutic applications. Further research is encouraged to explore the mechanisms of action and long-term effects of this botanical supplement.

FAQ section (important questions/answers):

What is the purpose of the study on Cissus rotundifolia?

The study aims to assess the efficacy and safety of Cissus rotundifolia leaves in controlling blood glucose levels in diabetic patients, comparing its effects to the standard drug glibenclamide.

How was the experiment designed for diabetic patients?

Eighteen diabetic patients were divided into three groups. They received varying doses of fresh boiled Cissus rotundifolia leaves or glibenclamide for 10 days, all under physician supervision.

What were the main findings regarding blood glucose levels?

The study found that supplementation with Cissus rotundifolia led to a significant decrease in blood glucose levels in diabetic patients after 10 days compared to initial levels.

What other health markers were measured during the study?

In addition to blood glucose levels, the study measured serum urea, ALT, and AST levels, showing significant decreases after Cissus rotundifolia supplementation.

What phytochemicals are believed to contribute to its antidiabetic effect?

The phytochemicals in Cissus rotundifolia, such as flavonoids, β-sitosterol, and quercetin, may enhance insulin activity and have potential antidiabetic effects.

Were there any reported side effects from using Cissus rotundifolia?

The supplementation with Cissus rotundifolia leaves showed no signs of clinical abnormalities, indicating that it is safe for controlling blood glucose levels in diabetic patients.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Antidiabetic activity of cissus routndifolia leaves supplement”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Activity:
Activity refers to the effectiveness of a substance, in this context, the antidiabetic effects of Cissus rotundifolia (CR). It signifies the capacity of CR to reduce blood glucose levels and improve health metrics in diabetic patients, suggesting the potential utility of CR as a health supplement.

2) Blood:
Blood is a vital fluid in the body that transports oxygen and nutrients, and regulates physiological processes. In this study, monitoring blood glucose levels is critical to assess the effectiveness of Cissus rotundifolia in managing diabetes, as elevated glucose levels indicate a need for intervention.

3) Phytochemical:
Phytochemicals are bioactive compounds found in plants that may have health benefits, including anti-diabetic properties. In this study, the phytochemicals in Cissus rotundifolia, such as flavonoids and other antioxidants, are posited to contribute to lowering blood glucose levels in diabetic patients.

4) Table:
A table is a systematic arrangement of data, often used to convey research findings clearly. In this paper, tables are employed to display the effects of different treatments on blood glucose and biochemical parameters, facilitating comparison and analysis of results among the experimental groups.

5) Drug:
Drugs are substances used to modify physiological processes for therapeutic purposes. The exploration of Cissus rotundifolia alongside conventional drugs emphasizes the potential integration of herbal remedies into modern pharmacotherapy.

6) Disease:
Diseases are conditions that impair normal bodily functions. The research specifically addresses diabetes, a chronic disease, emphasizing the need for effective treatments. Understanding diverse approaches, including herbal remedies, adds depth to the management of chronic diseases.

7) Science (Scientific):
Scientific refers to a systematic method of obtaining knowledge through observation and experimentation. The research exemplifies scientific inquiry, demonstrating how empirical methods can lead to insights into natural remedies and their role in disease management.

8) Mineral:
Minerals, as referenced here, are vital nutrients required by the body for various functions. The diverse minerals present in Cissus rotundifolia enhance its role in nutrition and potential therapeutic benefits, including supporting metabolic processes related to diabetes management.

9) Flavonoid:
Flavonoids are a class of phytochemicals with known antioxidant properties. The study mentions flavonoids in Cissus rotundifolia as contributing to its hypoglycemic effects, supporting the notion that dietary intake of flavonoids can offer protective effects against diabetes.

10) Medicine:
Medicine is the science or practice of diagnosing, treating, and preventing disease. The research situates Cissus rotundifolia within traditional medicine frameworks, exploring how botanical studies can enhance modern medical understanding and treatment approaches for diabetes.

11) Study (Studying):
A study denotes a detailed investigation or examination of a subject. This research investigates the antidiabetic properties of Cissus rotundifolia, contributing to the ongoing discourse on herbal supplements' role in managing diabetes and encouraging further research in this domain.

12) Food:
Food provides the necessary nutrients for growth and energy. In this context, Cissus rotundifolia is discussed as a dietary component in traditional medicine, showcasing how commonly consumed plants can aid in managing health conditions like diabetes.

13) Pain:
Pain is an unpleasant sensory or emotional experience typically associated with tissue damage. The traditional uses of Cissus rotundifolia in treating various pains highlight the broader potential benefits of the plant beyond its hypoglycemic properties.

14) Veterinary medicine:
Veterinary medicine is the branch of medicine concerned with the health of animals. Mentioning this field in the context of Cissus rotundifolia suggests potential applications of its medicinal properties for animals as well, showcasing its versatile use in healthcare.

15) Pharmacological:
Pharmacological refers to the study of drug action and interaction in biological systems. The study suggests that Cissus rotundifolia may possess pharmacological properties that impact glucose metabolism, advocating for its inclusion in further pharmacological research.

16) Agriculture:
Agriculture is the practice of cultivating soil, growing crops, and raising animals to provide food and other products. The cultivation of Cissus rotundifolia within agricultural practices underscores the potential economic benefits of integrating medicinal plants into modern farming.

17) Discussion:
Discussion refers to the part of research where findings are analyzed and contextualized. In this paper, the discussion section evaluates the implications of the results, comparing the efficacy of Cissus rotundifolia with established therapies and exploring future research directions.

18) Account:
An account provides a narrative or explanation. The article gives accounts of Cissus rotundifolia's traditional usage and studies, which highlight the significance of historical knowledge in validating its potential health benefits.

19) Village:
A village is a small settlement, often rural, where local knowledge and traditional practices are prevalent. The context of the village signifies the grassroots origins of Cissus rotundifolia use, emphasizing the importance of local culture in the understanding of herbal remedies.

20) Family:
In this context, family refers to a taxonomic classification group in biological classification. Cissus rotundifolia belongs to the Vitaceae family, underscoring its botanical lineage and potential related benefits that may be shared among similar plant species.

21) Botany:
Botany is the scientific study of plants. The study intersects with botany by exploring the botanical characteristics and health benefits of Cissus rotundifolia, emphasizing how botanical knowledge can inform health and nutrition.

22) Egypt:
Egypt is mentioned as part of the geographical distribution of Cissus rotundifolia, highlighting the plant's regional significance. This geo-botanical perspective reinforces the concept of traditional medicine being deeply rooted in the local flora of distinct regions.

23) Water:
Water is essential for life and serves as a solvent for many chemical processes. In this study, the preparation method involving water to boil Cissus rotundifolia leaves indicates the plant's extraction process, vital in accessing its beneficial compounds.

24) Fever:
Fever is a common symptom indicating infection or illness. The references to Cissus rotundifolia’s traditional use in treating fever suggest its broader application in alleviating various ailments, enhancing the understanding of its potential medicinal roles.

25) Fainting (Fainted):
Faint refers to a temporary loss of consciousness, often due to insufficient blood flow to the brain. The traditional uses of Cissus rotundifolia in treating such conditions indicate its diverse applications in folk medicine.

26) Genu:
Genu seems to refer to a lesser-known term in this context; however, if it relates to genu in medical terminology, it could imply a reference to a specific anatomical structure. Contextual interpretation is needed for precise meaning.

27) Accu (Accukuta):
Accu likely refers to medical devices or brands that measure blood glucose levels. The use of such devices in the study underscores the necessity of precise measurement in clinical research to evaluate the effectiveness of treatments.

28) Diet:
Diet comprises the kinds of food consumed regularly. The study reinforces the concept of dietary interventions using Cissus rotundifolia leaves to complement diabetes treatment, suggesting broader strategies for managing glucose levels.

29) Sign:
Sign refers to evidence indicating a particular condition or finding. In the context of this research, significant reductions in blood glucose levels after Cissus rotundifolia supplementation highlight its potential efficacy as an antidiabetic agent.

30) Rich (Rch):
Rich denotes an abundance of certain qualities or nutrients. Cissus rotundifolia is described as rich in phytochemicals and essential nutrients, pointing to its potential health benefits in managing diabetes and overall nutrition.

31) Male:
Male refers to the gender of the subjects in the study. It specifies that the subjects for the experiment were male diabetic patients, which is relevant for understanding the demographic focus and results of the study.

32) Life:
Life refers to the existence of living organisms. The study explores how Cissus rotundifolia can contribute to improving the quality of life for diabetic patients by potentially managing their condition and enhancing overall well-being.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Antidiabetic activity of cissus routndifolia leaves supplement’. Further sources in the context of Science might help you critically compare this page with similair documents:

Phytochemical, Further studies, Dietary management, Traditional medicine, Statistical analysis, Antioxidant activity, Hypoglycemic activity, Significant decrease, Blood glucose level, Herbal product, Nutritional evaluation, Essential amino acid, Diabetic patient, Antihyperglycaemic activity.

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