Effects of Garcinia kola bark extract on diabetic rat renal tissues
Journal name: World Journal of Pharmaceutical Research
Original article title: The medicinal effects of garcinia kola stem bark extract on renal tissues in alloxan induced diabetic rats (aidrs)
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Josiah S. Hart and John Nwolim Paul
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: The medicinal effects of garcinia kola stem bark extract on renal tissues in alloxan induced diabetic rats (aidrs)
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20192-14080
Download the PDF file of the original publication
Summary of article contents:
Introduction
The study conducted by Josiah S. Hart and John Nwolim Paul focuses on the potential medicinal effects of Garcinia kola stem bark extract on renal tissues in Alloxan-induced diabetic rats. With the rising prevalence of diabetes mellitus, which is particularly concerning due to dietary habits that favor carbohydrate-heavy meals, researchers are exploring alternative therapies. Given the alarming global statistics regarding diabetes, the study aims to investigate the histological impact of the extract on kidney health, an area not extensively studied despite traditional uses of Garcinia kola for medicinal purposes.
Impact of Alloxan on Renal Structures
One significant finding from the research is the severe histological damage inflicted on renal tissues upon the administration of Alloxan, a compound recognized for its toxic effects on pancreatic cells. Initial observations indicated obliteration of the Bowman’s capsular space, leading to generalized tubulonephropathies evident within the first week. As the experiment progressed, the damage escalated, characterized by severe hyalinization, nodular necrosis, and complete tubulonephritis by the third week. These pathological changes underscore the adverse effects of diabetes on kidney structures, emphasizing the need for effective therapeutic interventions.
Healing Potential of Garcinia Kola Extract
A key aspect of the study lies in the positive effects observed from Garcinia kola stem bark extract on damaged renal tissues. By the third week of treatment, rats receiving the extract exhibited restored renal histology, with intact glomeruli and renal tubules. This suggests a potential curative role of the extract, highlighting its active ingredients that may mitigate the damage induced by diabetes. The restoration of kidney structure signifies the extract's potential as an alternative therapy for diabetic conditions, positioning it as a substance of interest for managing diabetes-related kidney issues.
Comparison with Standard Treatments
The research also evaluated the efficacy of glibenclamide, a standard anti-diabetic drug, in restoring kidney structure in diabetic rats. Findings indicated that glibenclamide-treated specimens showed significant improvements in histological parameters, akin to those observed with Garcinia kola extract treatment. Both treatments appeared to reduce oxidative stress attributed to Alloxan-induced damage, demonstrating the therapeutic potential of natural extracts alongside conventional medications. This comparison provides evidence supporting the use of Garcinia kola as a viable alternative or complementary therapy in managing diabetes.
Conclusion
In conclusion, the study indicates that Garcinia kola stem bark extract possesses medicinal properties that may be beneficial in the management of diabetic conditions, particularly concerning renal health. The documented improvements in kidney structure following treatment with the extract emphasize its potential as a therapeutic agent. As diabetes continues to pose significant public health challenges, integrating traditional knowledge and modern scientific research could pave the way for innovative treatment approaches, ensuring better management of diabetes and its complications.
FAQ section (important questions/answers):
What was the main aim of the study on Garcinia kola?
The study aimed to investigate the effects of Garcinia kola stem bark extract on the histology of the kidneys in Alloxan-induced diabetic rats, focusing on its potential medicinal properties for diabetes management.
What method was used to induce diabetes in rats?
Diabetes was induced in the rats using a single intraperitoneal injection of Alloxan monohydrate at a dosage of 150mg/kg body weight, which damages insulin-producing pancreatic cells.
How many groups were the rats divided into for the study?
The 72 male Wistar rats were divided into six groups, with each group consisting of 12 animals, further subdivided for various treatments and controls during the experiment.
What significant findings were observed regarding kidney tissues?
The study revealed that Garcinia kola stem bark extract showed curative effects on kidney tissues, demonstrating intact glomeruli and renal tubules after three weeks of administration, implying restoration from diabetic damage.
What role does Garcinia kola play in managing diabetes?
Garcinia kola stem bark extract has active ingredients that could counteract oxidative stress caused by diabetes, indicating its potential as an alternative therapy in managing diabetic renal complications.
Was any ethical clearance obtained for this study?
Yes, ethical clearance was obtained from the Research Ethics Committee of the University of Port Harcourt, ensuring that the study adhered to ethical standards in animal research.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Effects of Garcinia kola bark extract on diabetic rat renal tissues”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Study (Studying):
The keyword 'Study' signifies the investigation conducted to explore the effects of Garcinia kola stem bark extract on diabetic renal tissues. It emphasizes the methodological approach taken by researchers to obtain empirical data, analyze results, and draw conclusions about the extract's potential therapeutic role in managing diabetes-related kidney damage.
2) Kola:
The word 'Kola' refers to Garcinia kola, a plant known for its medicinal properties. This term is crucial because it identifies the specific botanical subject of the study. The active compounds present in Kola may offer health benefits, particularly in the context of managing diabetes, which is the study's focus.
3) Animal:
The singular term 'Animal' refers to an individual organism from the group of male Wistar rats used in the study. Each animal in the experiment contributes to the overall data set, allowing researchers to observe variations and responses to the Garcinia kola extract, thus validating the study's findings at a biological level.
4) Disease:
The term 'Diseases' refers to the broader category of health conditions that impact individuals, including diabetes. It emphasizes the need to find effective treatments for various ailments, reinforcing the significance of research into natural products' therapeutic potential, such as Garcinia kola, in addressing prevalent health concerns in society.
5) Food:
The keyword 'Food' highlights the dietary implications surrounding diabetes and the importance of nutrition in health management. It suggests that dietary choices significantly affect disease prevalence, particularly in communities where carbohydrate-rich diets are common, stressing the need for integrating medicinal plants into dietary practices for managing diabetes.
6) Science (Scientific):
The keyword 'Scientific' pertains to the evidence-based approach that characterizes the research's methodology. It emphasizes the rigorous testing of hypotheses and the importance of reproducibility in findings. This term underscores the credibility and reliability of the study's conclusions regarding the effects of Garcinia kola on diabetic renal tissues.
7) Drug:
The term 'Drugs' encompasses both synthetic and natural compounds used in disease treatment, signifying the broader scope of therapeutic options available. It indicates the ongoing exploration for effective treatments, suggesting that natural products, such as Garcinia kola, may provide alternatives to conventional pharmaceuticals in managing chronic health issues.
8) Male:
The keyword 'Male' refers to the gender of the Wistar rats used as experimental subjects. This specification is vital as gender can influence biological responses to treatments, thereby affecting the study's results. It underlines the importance of considering gender-specific factors in biomedical research and therapeutic effectiveness.
9) Swelling:
The term 'Swelling' describes a pathological response observed in the kidney tissues of diabetic rats. It indicates tissue edema resulting from damage and inflammation, emphasizing the detrimental effects of diabetes on renal health. Identifying such symptoms is crucial for understanding the impact of treatments like Garcinia kola extract on reversing these effects.
10) Blood:
The keyword 'Blood' refers to the bodily fluid utilized for glucose monitoring in the study. Measuring blood glucose levels is essential for verifying diabetes induction and evaluating the effectiveness of treatments. It underscores the correlation between systemic health and the potential restorative properties of the Garcinia kola extract on renal function.
11) Discussion:
The term 'Discussion' indicates the section of the research where results are analyzed, interpreted, and related to existing literature. It provides a platform to explore the implications of findings, connect them with previous studies, and suggest future research directions. This stage is crucial for contextualizing the importance of the research outcomes.
12) Medicine:
The word 'Medicine' encompasses the field dedicated to diagnosing, treating, and preventing diseases. It reflects the purpose of the study to examine a natural remedy's potential role in medical treatment, emphasizing the need for ongoing research into alternative therapies that could complement or replace conventional medical approaches in disease management.
13) Sugar:
The term 'Sugar' is linked to the metabolic processes involved in diabetes, particularly the role of glucose in energy regulation. It signifies the underlying cause of insulin deficiency that leads to diabetes, highlighting the relevance of understanding these metabolic pathways for developing effective treatments, including natural interventions like Garcinia kola.
14) Tree:
The word 'Tree' specifically indicates the botanical classification of Garcinia kola, reinforcing its importance as a medicinal plant. Understanding the characteristics of the tree contributes to the appreciation of its utilitarian values in traditional and modern medicine, highlighting its relevance in the quest for effective health solutions.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Effects of Garcinia kola bark extract on diabetic rat renal tissues’. Further sources in the context of Science might help you critically compare this page with similair documents:
Homeostasis, Ethical Clearance, Oxidative stress, Alternative therapies, Male Wistar rats, Alloxan-induced diabetic rats, Curative Effect.