Review of horse gram's phytochemical and pharmacological profile.

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Journal name: World Journal of Pharmaceutical Research
Original article title: A review on phytochemical pharmacological and pharmacognostical profile of horse gram
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:

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Author:

T. Sampath Kumar, P. Muthusamy, R. Radha and K. Ilango


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: A review on phytochemical pharmacological and pharmacognostical profile of horse gram

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20195-14730

Copyright (license): WJPR: All rights reserved


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Summary of article contents:

Introduction

Macrotyloma uniflorum, commonly known as horse gram, is an underutilized legume primarily cultivated in India and other tropical regions. Recognized for its rich nutritional profile, horse gram is packed with proteins, carbohydrates, minerals, vitamins, and bioactive compounds. These constituents not only provide nutritional benefits but also contribute to various health-promoting activities, making it significant in alternative medicine. Historically, it has been used to treat ailments such as kidney stones, obesity, diabetes, and other conditions, emphasizing its importance in traditional medicinal systems.

Nutritional and Phytoconstituents

Horse gram is notably high in protein, being one of the richest lentils available, and contains a lower glycemic index than many cereals. The seeds consist primarily of carbohydrates and are noted for their low cholesterol and saturated fat levels. Nutritionally significant components include essential fatty acids like linoleic acid, and high levels of dietary fiber, which support digestive health. Moreover, horse gram boasts a wealth of phytoconstituents, including phenolic acids, flavonoids, and various bioactive compounds, which contribute to its medicinal properties and potential health benefits.

Pharmacological Properties

The pharmacological applications of horse gram are extensive, particularly its antihyperglycemic and antioxidant properties. Studies have demonstrated that extracts of Macrotyloma uniflorum exhibit the ability to inhibit alpha-amylase, crucial for regulating blood glucose levels, thus presenting a promising option for diabetes management. Additionally, the antioxidant activities of the plant's extracts have been shown to combat oxidative stress, with mechanisms that involve scavenging various radical species and enhancing the activity of antioxidant enzymes. This multifaceted action positions horse gram as a potential natural supplement for reducing diabetes-related complications.

Antimicrobial and Anti-Inflammatory Effects

Research has identified horse gram as possessing considerable antimicrobial and anti-inflammatory characteristics. The plant extracts have demonstrated effectiveness against various bacterial and fungal strains, illustrating its role in enhancing immune responses. Moreover, its anti-inflammatory properties were evidenced through studies showing that supplementation with horse gram led to increased activity of antioxidant enzymes while dampening inflammatory mediators, suggesting a protective effect against inflammation-related health issues. Thus, horse gram holds potential not only in infection management but also in the reduction of chronic inflammatory conditions.

Conclusion

In conclusion, Macrotyloma uniflorum stands out not only for its nutritional excellence but also for its myriad pharmacological effects, including antioxidant, anti-inflammatory, and antimicrobial activities. As an underutilized source of nutrients, it offers substantial health benefits that can complement both diets and therapeutic practices. Continued exploration into its phytochemical constituents and their biological activities could further solidify the significance of horse gram as a valuable asset in modern dietary and medicinal applications.

FAQ section (important questions/answers):

What are the nutritional benefits of Horse Gram?

Horse gram is rich in protein, calcium, iron, and dietary fiber. It contains a variety of vitamins and minerals, making it an excellent source of nutrition, especially for low-income populations.

What medicinal properties does Macrotyloma uniflorum possess?

Macrotyloma uniflorum has multiple pharmacological properties, including anti-inflammatory, antimicrobial, anti-diabetic, and antioxidant effects. It is traditionally used to treat conditions like kidney stones, obesity, and diabetes.

How is Horse Gram typically consumed in diets?

Horse gram is commonly consumed as boiled seeds, sprouts, or in curries. It can also be roasted or ground into flour to enhance its nutritional quality.

What are the main bioactive compounds found in Horse Gram?

Horse gram contains phenolic acids, flavonoids, and various antioxidants, contributing to its health benefits. These compounds are responsible for its therapeutic properties and overall nutritional value.

Where is Horse Gram primarily cultivated?

Horse gram is primarily cultivated in India, Sri Lanka, and various Southeast Asian countries. It thrives in tropical climates and is often grown in low-altitude regions.

What are the anti-nutritional factors present in Horse Gram?

Horse gram contains anti-nutritional factors like phytic acid and saponins, which can interfere with nutrient absorption. However, these compounds also exhibit antioxidant properties beneficial for health.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Review of horse gram's phytochemical and pharmacological profile.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Horse:
Horses, referenced in relation to horse gram, establish the plant's historical role as animal feed. The connection reinforces the agricultural practices where horse gram is an essential component in sustaining livestock nutrition.

2) Horse gram:
Horse gram, scientifically known as 'Macrotyloma uniflorum', is an underutilized legume recognized for its high nutritional value, including protein, iron, and minerals. It is primarily cultivated in tropical regions and is acknowledged for its health benefits, making it an essential food source for low-income communities.

3) Activity:
In the context of pharmacology, 'Activity' pertains to the biological effects that compounds, such as those found in horse gram, exhibit, including antioxidant and anti-inflammatory properties. This term is crucial in understanding how natural substances interact with the human body and their potential health implications.

4) India:
India is a significant region for the cultivation of horse gram, which has deep cultural and historical roots in traditional diets. The diverse agricultural practices and regional preferences highlight the importance of horse gram as both a nutritional and cultural staple in Indian society.

5) Silver:
In this context, 'Silver' refers to the process of synthesizing silver nanoparticles using horse gram extract. This innovative approach in nanotechnology showcases the versatility of horse gram derivatives and their potential applications in fields such as medicine, electronics, and environmental science.

6) Food:
The term 'Food' is critical as horse gram serves as a nutritious dietary option, offering proteins, carbohydrates, and essential nutrients. Its inclusion in various traditional dishes underscores its significance in food security and nutrition, especially in rural and low-income populations.

7) Pharmacological:
Pharmacological pertains to the study of drugs and their effects on living organisms. The pharmacological properties of horse gram demonstrate its potential as a natural remedy, providing insights into how plant-based substances can contribute to healthcare and disease management.

8) Disease:
The term 'Diseases' encompasses various health conditions that affect human well-being. The involvement of horse gram in preventing and treating diseases, especially chronic conditions such as diabetes and obesity, exemplifies its significance in herbal medicine and functional foods.

9) Ulcer:
Ulcers, such as peptic ulcers, represent a significant health concern. The traditional use of horse gram for treating ulcers demonstrates its role in herbal medicine and the potential benefits of its bioactive components in gastrointestinal health.

10) Pulse:
Pulses are a type of legume harvested for their dry seeds. The classification of horse gram as a pulse underlines its nutritional attributes and its contribution to sustainable agriculture as a source of protein and fiber.

11) Dolichos biflorus:
Dolichos biflorus is a synonym for horse gram in the scientific community. This designation emphasizes the taxonomic classification of the plant and aids researchers in identifying its specific properties and applications in various fields of study, including botany and pharmacology.

12) Flavonoid:
Flavonoids are a class of plant secondary metabolites known for their antioxidant properties. The presence of flavonoids in horse gram contributes to its health benefits, offering protective effects against oxidative stress and reducing the risk of chronic diseases.

13) Sugar:
Sugar refers to carbohydrates that provide energy but can lead to health issues if consumed excessively. The low glycemic index of horse gram makes it a suitable food choice for managing blood sugar levels, particularly for diabetics.

14) Rich (Rch):
In this context, 'Rich' describes the high concentration of essential nutrients found in horse gram, such as proteins, iron, and other minerals. Its rich nutritional profile makes it an important food source, particularly for populations with limited access to diverse foods.

15) Pur:
The term 'Poor' often describes individuals or communities with limited access to quality nutrients. Horse gram is known as a 'poor man's pulse' due to its affordability and rich nutrient profile, providing essential sustenance for low-income populations.

16) Family:
In botanical terms, 'Family' refers to a group of related plants. Horse gram belongs to the Fabaceae family, which includes various legumes recognized for their nutritional benefits and ecological importance in sustainable farming practices.

17) Madra:
The term 'Madra' could refer to a cultural or regional aspect associated with horse gram within the Indian context. Understanding such connections helps in recognizing the cultural significance and historical uses of this pulse in local culinary practices.

18) Bile:
Bile is a digestive fluid produced by the liver. The ability of horse gram to influence bile formation and secretion underlines its role in digestive health, highlighting its application in traditional remedies for conditions related to bile production.

19) Crop:
Crops are cultivated plants valued for food, fodder, and other uses. Horse gram, as a multi-purpose crop, highlights its agricultural utility for both human and animal nutrition, reinforcing the importance of biodiverse farming systems.

20) Medicine:
The term 'Medicine' encompasses substances used to prevent or treat diseases. Horse gram's use in traditional and alternative medicinal practices speaks to its potential therapeutic properties and its role in the broader context of herbal medicine.

21) Mineral:
Mineral refers to a naturally occurring inorganic substance essential for human health. The mineral profile of horse gram, being rich in calcium and iron, is vital for various physiological functions and is especially relevant in diets aiming to prevent deficiencies.

22) Surface:
Surface, singular and in this context, can denote the outer layer of biological materials where various reactions, including nutrient absorption, take place. Surface properties may influence the effectiveness of horse gram's health benefits at the molecular level.

23) Quality:
Quality in food refers to the inherent characteristics that meet specific standards, including nutritional content and safety. The quality of horse gram is paramount in ensuring its benefits are fully realized in dietary applications and health interventions.

24) Species:
Species is a taxonomic rank used to classify organisms. Horse gram belongs to the species Macrotyloma uniflorum, which helps in highlighting its unique characteristics and differentiating it from other legumes and pulses in research and agriculture.

25) Science (Scientific):
Sciences refer to the systematic enterprise that builds and organizes knowledge. The study of horse gram within various scientific disciplines informs its nutritional benefits and therapeutic applications, showcasing the interplay between traditional knowledge and modern science.

26) Cancer:
Cancer refers to a group of diseases characterized by abnormal cell growth. The potential anti-cancer properties of the phytochemicals found in horse gram highlight the significance of this pulse in diets aimed at reducing cancer risk through natural means.

27) Indian:
The term 'Indian' connects directly to the cultural and geographical origins of horse gram. It emphasizes the significance of local agricultural practices and dietary habits in India, showcasing how traditional knowledge encapsulates the health benefits of indigenous crops.

28) Lanka (Lamka, Lànkà):
Lanka, referring to Sri Lanka, indicates the geographical distribution of horse gram cultivation. Its use in both India and Sri Lanka highlights the cultural commonalities in the usage of horse gram as a food and medicinal resource.

29) Kumar:
Kumar, a common surname in India, represents the authorship of the review paper. The contribution of researchers like T. Sampath Kumar to the understanding of horse gram illustrates the importance of academic discourse in validating traditional knowledge.

30) Water:
Water is vital for life and is crucial in the cultivation of crops. The relationship between horse gram cultivation and water availability underscores the importance of sustainable agricultural practices, especially in regions facing water scarcity.

31) Tamil:
Tamil refers to both a language and an ethnic group in Southern India. The association of horse gram with Tamil culture signifies its role in local diets and traditional practices, contributing to the linguistic and cultural diversity of the region.

32) Genu:
The term 'Genu' could refer to a typographical error and may represent 'Genus.' Understanding the correct terminology is vital in botanical classification, emphasizing the importance of accurate scientific communication in plant taxonomy.

33) Diet:
Diet refers to the habitual intake of food. The incorporation of horse gram into diets highlights its role in promoting nutrition and health, particularly in vegetarian and health-conscious communities, emphasizing sustainability and natural food sources.

34) Drug:
Drug refers to a substance used to diagnose, cure, mitigate, treat, or prevent disease. The pharmacological properties of horse gram position it as a natural product that could be explored further in the development of alternative therapeutic agents.

35) Pharmacognostical:
Pharmacognostical pertains to the study of medicinal drugs derived from plants or other natural sources. The pharmacognostical profile of horse gram demonstrates its potential as a source of active compounds for future drug development.

36) Phytochemical:
Phytochemicals are bioactive compounds produced by plants, recognized for their therapeutic properties. Horse gram is rich in phytochemicals, such as flavonoids and phenolic acids, emphasizing its potential use as a functional food with health benefits.

37) Kancipura (Kancipuram, Kanchipuram, Kamcipura, Kanci-pura, Kamci-pura):
Kancheepuram is a district in Tamil Nadu, India, known for its rich agricultural tradition. The association of horse gram with this district showcases its cultural significance and the local agricultural practices that contribute to food security.

38) Purification:
Purification refers to the process of separating substances to achieve a desired quality. In the context of horse gram, purification can relate to extracting bioactive compounds for medicinal use, highlighting the importance of refining natural products for scientific applications.

39) Accumulation (Accumulating, Accumulate):
Accumulation implies the gradual gathering or increase of substances. In the case of horse gram, accumulation of beneficial compounds during growth and processing emphasizes the potential health benefits and nutritional value of this legume.

40) Developing:
Developing in this context refers to enhancing the utilization of horse gram for better nutrition and health outcomes. It highlights the ongoing need for research and innovation to optimize its benefits in various applications, from food to medicine.

41) Tamilnadu (Tamil-nadu):
Tamilnadu represents the state in India recognized for its significant agricultural output, including horse gram cultivation. The emphasis on locally grown crops highlights the importance of regional agricultural practices in food security and nutrition.

42) Substance:
Substance, singular, denotes any material with a defined composition. The pharmacological research on horse gram emphasizes the significance of its active substances that contribute to its health benefits, enhancing the understanding of traditional medicinal practices.

43) Karnataka:
Karnataka is another state in India where horse gram is cultivated and consumed. The state's agricultural diversity and cultural practices related to food underscore the importance of region-specific knowledge in harnessing the benefits of horse gram.

44) Kulattha:
Kulattha is a Sanskrit term often used to refer to horse gram in traditional contexts. This term anchors horse gram in its historical and cultural uses, indicating its importance in Ayurvedic medicine and dietary practices.

45) Sanskrit:
Sanskrit is an ancient language of India, often associated with historical texts, including those on medicine. Understanding horse gram's Sanskrit nomenclature reinforces its longstanding significance in traditional Indian practices and medicinal systems.

46) Kannada:
Kannada is a language spoken in Karnataka, India, where horse gram is also cultivated. The linguistic diversity highlights the cultural significance of horse gram across different regions of India, emphasizing its role in local diets and traditions.

47) Chennai:
Chennai, formerly known as Madras, is a city in Tamil Nadu where horse gram is part of traditional cuisines. This association underscores the importance of urban centers in the dissemination and appreciation of regional agricultural products.

48) Madhya:
Madhya could refer to Madhya Pradesh, a state in India where horse gram is cultivated. The agricultural diversity of this region contributes significantly to the understanding of horse gram's properties and its role in local diets.

49) Andhra (Amdhra):
Andhra, referring to Andhra Pradesh, is another Indian state where horse gram is grown. The cultural and agricultural practices in this region highlight the importance of horse gram as a staple food in southern Indian diets.

50) Nepali:
Nepali refers to the language and culture of Nepal, where horse gram is also recognized and utilized. This highlights the cross-regional significance of horse gram within South Asian cuisines and traditional practices.

51) Nature:
Nature encompasses the physical world and its phenomena. The investigation into the natural properties of horse gram underscores the relationship between the environment and health, emphasizing the importance of utilizing natural resources for food and medicine.

52) Kanam:
Kaanam is the Tamil name for horse gram, indicating its local significance and utility in regional diets. This name anchors horse gram in cultural practices, emphasizing traditional knowledge surrounding its cultivation and usage.

53) Panda (Pamda):
Panda refers to researchers who have investigated the pharmacological properties of horse gram. Their contributions highlight the importance of scholarly work in validating and documenting the medicinal uses of specific herbs in alternative medicine.

54) Radha:
Radha may refer to another contributor to research on horse gram. Acknowledging multiple researchers illustrates the collaborative nature of scientific inquiry and the shared goal of understanding the properties and benefits of herbal medicines.

55) Bihar:
Bihar is a state in India where horse gram can be found. The geographical cultivation of horse gram in different states emphasizes its agricultural significance and versatility across various regional cuisines.

56) Kollu:
Kollu is the name for horse gram in Tamil, underscoring its cultural significance in traditional diets. This local nomenclature reflects the integral role of horse gram in community eating habits and nutritional practices.

57) Hindi (Himdi):
Hindi, as a major language in India, is associated with various cultural practices, including food terminology. The reference to horse gram in Hindi reflects the linguistic diversity and regional variations in recognizing the pulse's importance in diets.

58) Fever:
Fever is a condition often treated with traditional remedies. The potential of horse gram in managing fever illustrates the intersection of food and medicinal applications, reinforcing its role in grassroots healthcare practices.

59) Worm:
Worm signifies parasitic organisms that can cause health issues in humans. Horse gram's anthelmintic properties provide an alternative natural treatment, illustrating its role in maintaining health through vegetarian diets.

60) Nadu:
Nadu refers to 'land' or 'nation' often used in the context of Indian states like Tamil Nadu. This designation underscores the regional identity of horse gram as a staple crop linking culture and agriculture.

61) Beta:
Beta, in various contexts, can refer to beta-carotene or as a designation for compounds. Examination of horse gram reveals its nutritional properties, including the presence of beneficial carotenoids that contribute to health.

62) Ghat (Gham):
Ghat refers to a series of steps leading down to a body of water, often found in hilly regions. The growth of horse gram in mountainous terrains highlights its adaptability and the role of diverse ecosystems in agriculture.

63) Pain:
Pain is a manifestation of discomfort or suffering. The role of horse gram in managing conditions like inflammation and its potential analgesic properties underline its significance in traditional and herbal medicine.

64) Male:
In biological contexts, 'Male' typically refers to the sex that produces small, mobile gametes (sperm). Understanding the reproductive biology of horse gram contributes to agricultural practices aimed at improving crop yield and genetic diversity.

Other Science Concepts:

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