A comparative study of different brands of cetirizine hydrochloride tablets
Journal name: World Journal of Pharmaceutical Research
Original article title: A comparative study of different brands of cetirizine hydrochloride tablets
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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CH. Naga Sowjanya, K. Santhi Mounika, L. Maheswari, M. Adilakshmi, M. Pallavi, Dr. Rama Brahma Reddy
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World Journal of Pharmaceutical Research:
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Full text available for: A comparative study of different brands of cetirizine hydrochloride tablets
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20195-14563
Copyright (license): WJPR: All rights reserved
Summary of article contents:
Introduction
Cetirizine hydrochloride (CTZ) is a widely used antihistamine primarily employed for treating various allergic conditions such as seasonal allergic rhinitis and chronic idiopathic urticaria. This study evaluates and compares the quality of different brands of cetirizine hydrochloride tablets available in the local market. The assessment encompasses critical pharmaceutical parameters such as weight variation, hardness, thickness, friability, dissolution, and disintegration. Understanding these properties is crucial for ensuring the effectiveness and safety of the tablets, as well as their compliance with pharmacopoeial standards.
Weight Variation and Hardness
Weight variation is a significant factor in evaluating the uniformity and quality of tablets. The study adhered to established pharmacopeial standards, which specify acceptable deviations based on tablet weight. For instance, tablets weighing 80 mg have a permissible variation of ±10%, while those over 250 mg have a stricter deviation limit of ±5%. In contrast, hardness indicates the mechanical strength of tablets and their ability to withstand manufacturing and handling processes. A Monsanto hardness tester was used to measure the hardness, revealing that normal tablet hardness ranges from 2-4 kg. The results for the various brands showed that despite slight discrepancies in weight and hardness, all products generally conformed to the set specifications.
Friability and Thickness
Friability, a measure of a tablet's ability to withstand abrasion during packaging and transport, was assessed using a friabilator device. The acceptable weight loss for the tablets should not exceed 1.0%, with specific standards provided by the British and United States Pharmacopeias. Analysis of the three different brands indicated that all passed the friability test, meeting the specified limits. Additionally, the thickness of the tablets is crucial for aesthetic appeal and consistency. Measurements taken with a vernier caliper showed that the tablet thickness for all brands remained within the required range of 3.5-4 mm, thereby confirming their quality and manufacturing integrity.
Dissolution Characteristics
Dissolution testing is essential for understanding how quickly and efficiently the active ingredient is released from the tablet into a solution, influencing its bioavailability. The study employed a USP apparatus II to analyze the rate of cetirizine release at various intervals. Results indicated that all brands demonstrated acceptable dissolution rates, with the best-performing brand being Setride. At the 30-minute mark, which simulates physiological availability, Setride achieved an impressive dissolution performance, validating its potential as a reliable choice among the tested brands.
Conclusion
The comparative study of cetirizine hydrochloride tablets from three different brands—Setride, Triz, and Okacet—revealed that all evaluated parameters fell within the acceptable limits as per pharmacopeial standards. Notably, while all brands met specific quality criteria, Setride emerged as the superior brand, demonstrating optimal performance in terms of weight variation, hardness, friability, and rapid drug dissolution. This analysis underscores the importance of thorough quality assessments for pharmaceutical products to ensure safety and efficacy in therapeutic applications.
FAQ section (important questions/answers):
What is cetirizine hydrochloride used for?
Cetirizine hydrochloride is an antihistamine used to treat allergic conditions, such as seasonal allergic rhinitis, chronic idiopathic urticaria, and atopic dermatitis, providing relief with minimal sedation.
What parameters were analyzed in the cetirizine study?
The study analyzed weight variation, hardness, thickness, friability, dissolution, and disintegration of various cetirizine hydrochloride tablet brands to evaluate their quality.
How many brands of cetirizine were compared in the study?
Three different brands of cetirizine hydrochloride tablets were compared: Setride by Wockhardt, Triz by Indoco, and Okacet by Cipla.
What is the significance of tablet hardness testing?
Hardness testing ensures tablets can withstand manufacturing, handling, and transportation without breaking. Normal hardness ranges from 2 to 4 kg.
What dissolution medium was used in the study?
The dissolution test utilized 0.1 M hydrochloric acid as the medium to simulate biological conditions and measure drug release.
Which brand of cetirizine was found to be the best?
Based on the evaluation tests, Setride 10mg was identified as the best brand among the three evaluated.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “A comparative study of different brands of cetirizine hydrochloride tablets”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
'Drugs' are substances used for medical purposes, specifically to diagnose, cure, treat, or prevent diseases. The study focuses on the pharmaceutical analysis of cetirizine hydrochloride tablets, contributing to better understanding and managing conditions related to allergic reactions through effective drug formulations.
2) Table:
In the context of this study, 'Table' refers to dosage forms, specifically tablets, which are a common method for administering medication. Various evaluations such as weight variation and hardness are conducted on cetirizine hydrochloride tablets. These assessments help ensure the tablets are effective and safe for consumer use.
3) Substance:
'Substance' denotes a particular kind of matter with uniform properties. In pharmaceutical research, it often refers to the active ingredients within tablets, such as cetirizine hydrochloride. The characteristics and behavior of the substance directly influence its efficacy, bioavailability, and suitability for treating various conditions.
4) Study (Studying):
'Study' implies conducting a systematic investigation into the properties of cetirizine hydrochloride tablets from different brands. This research aims to analyze parameters like weight, hardness, and dissolution to ensure all formulations meet regulatory standards, thereby affirming their safety and effectiveness for patients.
5) Performance:
'Performance' in this context pertains to how well cetirizine hydrochloride tablets function in terms of release and absorption within the body. Evaluating the performance through tests like dissolution helps determine if the tablets can deliver the intended therapeutic effects efficiently.
6) Observation:
'Observation' relates to the careful monitoring of the results obtained during experiments. In this study, observations are critical to ensuring that each brand of tablet maintains specific quality criteria, influencing the conclusions regarding their effectiveness based on physical and chemical evaluations.
7) Science (Scientific):
'Science' encompasses the methodologies and analytical techniques used in studying the properties of cetirizine hydrochloride tablets. Engaging in scientific inquiry allows researchers to obtain reliable data and insights, leading to informed decisions about the suitability of various brands for clinical use.
8) Nalanda (Nalamda):
'Nalanda' is the name of the institution where the research was conducted. This educational establishment is associated with generating knowledge and expertise in pharmaceutical sciences, contributing to advancements in drug formulation and quality assurance practices within the field of pharmacy.
9) Quality:
'Quality' denotes the standard of the tablets being assessed, including criteria such as weight, hardness, and dissolution. Maintaining high quality in pharmaceutical products is crucial for ensuring patient safety and therapeutic effectiveness, making it a significant focus in this comparative study.
10) Medium:
'Medium' refers to the dissolution medium used in testing solubility and release of the drug. In this study, 0.1 M hydrochloric acid serves as the medium, simulating physiological conditions to evaluate how effectively the drug is released from the tablet for absorption in the body.
11) Naga (Nag):
'Naga' refers to the lead researcher, CH. Naga Sowjanya, who is associated with this comparative study. The work and findings attributed to her highlight the importance of individual contribution in academic research and the broader implications for pharmaceutical practices and drug quality assessments.
12) Discussion:
'Discussion' denotes the section of the study where findings are analyzed and interpreted. It involves comparing results across brands of cetirizine hydrochloride tablets, assessing their implications, and determining which formulation meets quality standards, thereby guiding future research and formulation practices.
13) Meeting:
'Meeting' in a research context often refers to an assembly or gathering to discuss findings and implications. Although this specific study does not mention a meeting, collaboration and communication among scientists are essential for advancing knowledge and addressing challenges in pharmaceutical formulation and evaluation.
14) Brahma:
'Brahma' refers to Dr. Rama Brahma Reddy, one of the authors of the study. His involvement underscores the collaborative nature of scientific research, where contributions from multiple experts help strengthen the validity of the findings and improve the overall understanding of drug quality and safety.
15) Santhi (Shamthi):
'Santhi' denotes K. Santhi Mounika, another contributing author. Her role in the study illustrates how teamwork in research enhances the exploration of pharmaceutical formulations, allowing for a comprehensive analysis that can impact public health through improved medication quality and efficacy.
16) Rama:
'Rama' reflects the name of Dr. Rama Brahma Reddy, emphasizing his contribution to pharmaceutical research. Recognizing authors and their expertise enriches the academic discourse surrounding drug quality and reinforces collaborative efforts needed to advance knowledge in the field of pharmaceutical sciences.
17) Life:
'Life' generally refers to the existence of living organisms, including humans, who benefit from the therapeutic effects of quality pharmaceuticals. In this study, ensuring the efficacy and safety of cetirizine hydrochloride tablets plays a vital role in enhancing the quality of life for individuals suffering from allergies.
Other Science Concepts:
Discover the significance of concepts within the article: ‘A comparative study of different brands of cetirizine hydrochloride tablets’. Further sources in the context of Science might help you critically compare this page with similair documents:
Atopic dermatitis, Quality Control, Active ingredient, Friability test, Weight variation test, Hardness test, Dissolution test, Tablet dosage form, Allergic asthma, Anti-histaminic, Chronic idiopathic urticaria, Seasonal allergic rhinitis, Physical Urticaria, Perennial allergic rhinitis, Thickness test.