Comparative study of vishama jwara with herbal formulations.
Journal name: World Journal of Pharmaceutical Research
Original article title: A comparative clinico-pathological study of vishama jwara (malaria fever) with herbal formulations dronapuspi ghana vati„a‟ (leucas aspera) & „b‟ (leucas cephalotes)
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Dr. Kerketta Anima, Prof. Dr. Panda Pradip Kumar and Dr. Nayak Utkalini
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: A comparative clinico-pathological study of vishama jwara (malaria fever) with herbal formulations dronapuspi ghana vati„a‟ (leucas aspera) & „b‟ (leucas cephalotes)
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20195-14519
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
The study described evaluates the effectiveness of two Ayurvedic herbal formulations, Dronapuspi Ghana Vati 'A' (Leucas aspera) and Dronapuspi Ghana Vati 'B' (Leucas cephalotes), in treating Vishama Jwara, which is an intermittent and complex type of fever resembling malaria fever caused by Plasmodium vivax. Conducted on 14 patients diagnosed with malaria at the Govt. Ayurvedic College and Hospital in Balangir, Odisha, the study aimed to identify non-reactive herbal alternatives to conventional antimalarial treatments and to assess the clinical features associated with this Ayurvedic condition.
Effectiveness of Treatment
The results of the clinical trial showed notable improvements in both groups receiving the herbal treatments. In Group A (Leucas aspera), an 84.59% improvement in clinical symptoms was observed, while Group B (Leucas cephalotes) reported an even higher improvement of 89.35%. Both groups exhibited statistically significant reductions in fever, chills, headache, and body aches after 10 days of treatment. These findings suggest that both herbal formulations are effective in alleviating the symptoms of Vishama Jwara, with the formulation containing L. cephalotes demonstrating superior efficacy.
Clinical Parameters and Observation
The study monitored several clinical parameters such as fever, chill with rigor, headache, and body ache. The evaluation included both subjective assessments reported by the patients and objective tests, including blood samples for plasmodium positivity. Group A showed a decrease in parasitemia in 50% of patients, while Group B had a 62% reduction, indicating an improvement in clinical pathology. Most notable was the high statistical significance observed in the symptom relief across both groups, affirming the potential of these herbal treatments in managing symptoms of malaria.
Potential and Properties of the Herbal Medicines
The herbal drugs utilized in this study possess distinct therapeutic properties characterized by their composition and effects. Dronapuspi Ghana Vati 'A' is noted for its properties like deepana (appetizer) and jwarahara (fever-reducing), contributing to improved digestion and immune function. Dronapuspi Ghana Vati 'B' holds similar but differing effects, including being kaphapittahara and tridoshasamaka, helpful in balancing doshas and treating fevers effectively. The favorable outcomes observed highlight the importance of understanding the holistic and multifaceted properties of these Ayurvedic formulations.
Conclusion
The trial concluded that both herbal formulations Dronapuspi Ghana Vati 'A' and 'B' are effective, safe alternatives to treat Vishama Jwara or malaria fever with no adverse effects reported during the study. The significant improvements in clinical symptoms and blood parameters suggest the potential for these traditional treatments in managing malaria, calling for expanded research with larger sample sizes and longer durations to further validate these findings and support Ayurvedic practices in contemporary medicine.
FAQ section (important questions/answers):
What is Vishama Jwara and how does it relate to malaria fever?
Vishama Jwara is an intermittent and complex type of fever similar to malaria. It manifests with symptoms like fever, chills, headaches, and malaise, resembling Plasmodium vivax malaria in its clinical presentation.
What herbal formulations were compared in the clinical study?
The study compared two herbal formulations: Dronapuspi Ghana Vati 'A' (Leucas aspera) and Dronapuspi Ghana Vati 'B' (Leucas cephalotes) for treating Vishama Jwara in malaria patients.
How many patients participated in the clinical study, and how were they divided?
Fourteen patients participated in the clinical study, divided into two groups: Group A with 6 patients receiving Leucas aspera and Group B with 8 patients receiving Leucas cephalotes.
What were the main findings from the treatment outcomes?
Group B (Leucas cephalotes) showed greater improvement, with 89.35% clinical improvement. In contrast, Group A (Leucas aspera) exhibited 84.59% improvement, indicating that Leucas cephalotes may be a more effective treatment.
Were there any adverse effects observed during the study?
No adverse effects were reported during the treatment with either Dronapuspi Ghana Vati formulations, suggesting they may be safe for patients with Plasmodium vivax malaria.
What was the duration of the treatment for the patients?
The treatment duration for both groups was 10 days, during which the effectiveness and patient outcomes were assessed and recorded.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Comparative study of vishama jwara with herbal formulations.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
The term 'Drugs' encompasses various medicaments that can include both synthetic and natural substances utilized in the treatment of illnesses. In this study, drugs from Ayurvedic medicine, specifically herbal formulations targeting malaria symptoms, are discussed, highlighting the therapeutic potential of traditional remedies.
2) Dronapushpi (Dronapuspi):
Dronapuspi, a variation of Dronapushpi, emphasizes the plant Leucas aspera's importance in Ayurvedic formulations. This highlights the focus on specific herbs and their unique properties in treating conditions like Vishama Jwara, thereby showcasing traditional medicine's role in modern healthcare.
3) Ghana:
'Ghana' in Ayurvedic terminology refers to a concentrated form of herbal preparations. In this study, it denotes that the Dronapushpi Ghana Vati is a concentrated medication derived from herbs, emphasizing the application of traditional methods to enhance therapeutic effectiveness against malaria.
4) Fever:
Fever is a significant symptom in many medical conditions, including malaria. In this study, various types of fever, particularly Vishama Jwara, are examined, focusing on how the Ayurvedic formulations impact the body's febrile response, aiming to provide relief from high temperatures.
5) Vati:
In Ayurveda, 'Vati' refers to a solid dosage form of medicine, typically in the form of tablets or pills. Dronapushpi Ghana Vati, for example, suggests that the formulation is made into a tablet to facilitate easy consumption for patients suffering from malaria fever.
6) Vishama (Visama):
The word 'Vishama' translates to 'irregular' or 'complex' in English and pertains to an intermittent type of fever in Ayurveda, particularly linked to malaria. This study emphasizes the distinctive features of Vishama Jwara in clinical terms, making a case for the effectiveness of herbal remedies.
7) India:
India is the geographical context for the study, representing a significant region affected by malaria. The high prevalence of Plasmodium vivax cases calls for effective treatments. The research underlines the need for alternative medical approaches using Ayurvedic principles in an endemic environment.
8) Table:
In the context of research, 'Table' refers to a systematic presentation of data. It is essential for summarizing findings, showing improvement in clinical features, and effectively communicating the results of the study. Tables help visualize the impact of herbal treatments on patients' health metrics.
9) Study (Studying):
'Study' refers to the scientific investigation detailed in the text aimed at evaluating the effectiveness of traditional Ayurvedic treatments on malaria. It encompasses the design, methodology, findings, and conclusions that contribute to the understanding of herbal medicine and its utility.
10) Sweating (Sweat):
Sweating is one of the physiological responses observed in fever conditions, including malaria. In the study, it is assessed as a symptom in patients, and the efficacy of the Ayurvedic treatments on sweating as a clinical parameter is specifically measured for therapeutic outcomes.
11) Blood:
In medical research, 'Blood' is a critical component for diagnosis and monitoring health. In this study, blood tests are utilized to confirm the presence of Plasmodium vivax, as well as to monitor hematological parameters, showcasing the integration of traditional medicine with scientific diagnostics.
12) Rasa (Rasha):
'Rasa' refers to the taste or essence of a substance and is fundamental to Ayurvedic pharmacology. The study highlights different Rasas associated with the herbs used, which influence their therapeutic qualities, thereby affecting their efficacy against malaria symptoms.
13) Samhita:
The term 'Samhita' denotes a collection or compendium of texts in Ayurveda. The references to classic texts like Charaka Samhita emphasize the traditional knowledge underpinning the Ayurvedic practices evaluated in the study, encapsulating centuries of medical wisdom.
14) Nidana:
'Nidana' signifies the diagnosis and understanding of the cause of ailments in Ayurveda. This term is relevant as the study explores the pathogenesis of Vishama Jwara, linking symptoms of malaria to Ayurvedic concepts and presenting an integrated approach to treatment.
15) Katu:
Katu translates to 'pungent' and refers to one of the six tastes recognized in Ayurveda. It is associated with specific therapeutic effects that include enhancing digestion and alleviating fever symptoms, thereby playing a significant role in the efficacy of the formulations tested in the study.
16) Ayurveda (Ayus-veda):
Ayurveda is a holistic system of medicine that originated in India and focuses on balancing the body, mind, and spirit to promote health. The study centers around Ayurvedic practices, presenting their effectiveness in treating malaria, thus highlighting the contemporary relevance of traditional healing methods.
17) Madhura:
Madhura translates to 'sweet' in Ayurvedic terms and is one of the six tastes that also have specific medicinal properties. In the study, it reflects the properties of certain herbs used in formulations, emphasizing how taste influences therapeutic effects in the treatment of malaria.
18) Sign:
'Sign' in medical terms often refers to objective indicators of disease or recovery. This term is significant in the study as it pertains to clinical signs of improvement in patients receiving the herbal formulations, assessing their relevance in the context of malaria treatment.
19) Medicine:
'Medicine' encapsulates the science and practice of diagnosing, treating, and preventing disease. In the context of the study, it emphasizes the use of Ayurvedic formulations as a form of alternative medicine aimed at improving clinical features of malaria fever.
20) Sharman (Sarma, Sharma, Sarman):
Sharma likely refers to one of the authors or researchers involved in the study. It contextualizes the academic contributions of professionals in the field, indicating the collaborative effort in bringing together traditional and scientific approaches to medicine.
21) Ushna (Usna):
'Ushna' means 'hot' or 'warming' in Ayurveda and indicates properties of certain medicines that generate heat within the body. This concept is vital in understanding how Ayurvedic remedies are used to treat conditions like fever and their overall effectiveness in managing symptoms.
22) Roga:
In Ayurvedic terminology, 'Roga' means disease or illness. The study investigates the clinical manifestations of Roga, specifically Vishama Jwara, and evaluates the effectiveness of traditional treatments in alleviating symptoms associated with malaria fever.
23) Vipaka:
'Vipaka' refers to the post-digestive effect of a substance and is critical in understanding how different foods and medicines interact with the body once digested. This concept helps in evaluating and classifying the herbs used in the study and their long-term effects on health.
24) Nausea:
Nausea is an unpleasant sensation often accompanying fever and various illnesses, including malaria. The study assesses nausea as a symptomatic parameter in patients, measuring the effectiveness of the Ayurvedic treatments in alleviating discomfort associated with this fevers.
25) Indian:
'Indian' pertains to the cultural and geographical significance of the study context, highlighting its relevance to traditional medicine in India. It emphasizes the incorporation of local herbal knowledge into scientifically validated treatment protocols for diseases like malaria.
26) Dhatu:
In Ayurveda, 'Dhatu' refers to the fundamental bodily tissues. The study evaluates how treatments interact with various Dhatus affected by illness, particularly in the context of malaria, thereby exploring deeper physiological principles underlying Ayurvedic medicine.
27) Guna:
'Guna' signifies the properties or qualities of substances in Ayurveda, influencing how they interact with the body. Recognition of Guna is essential in determining the therapeutic actions of the herbs discussed in the study, underpinning their efficacy in treating malaria.
28) Phytochemical:
'Phytochemical' refers to the bioactive compounds derived from plants that have health benefits. The study assesses the phytochemical properties of the herbs used in treatments, emphasizing their potential as antimalarial agents within traditional medicinal frameworks.
29) Observation:
'Observation' in research refers to the careful monitoring and recording of clinical outcomes and patient responses to treatments. In the study, observations are crucial for data collection, providing evidence of efficacy for the Ayurvedic formulations assessed against malaria fever.
30) Kamalahara (Kamala-hara):
'Kamalahara' refers to the property of alleviating symptoms related to discoloration or 'lotus' conditions (abscesses). This term highlights the multifaceted nature of the Ayurvedic formulations used in the study, showcasing their broader therapeutic applications beyond just treating fever.
31) Bhedaniya:
'Bhedaniya' is a term indicating certain qualities of herbs that can cause separation or division in pathological processes. This concept underscores the pharmacological actions of the examined Ayurvedic formulations, examining their potential in managing conditions like malaria effectively.
32) Annamalai:
Annamalai's mention likely refers to a place or institution within the academic or research domain, emphasizing the contributions of different regions to Ayurvedic studies and the broader public health implications of such research in managing diseases.
33) Shothahara (Sothahara, Shotha-hara):
'Sothahara' indicates the property of alleviating swelling or edema. This aspect of the herbs used in the study reinforces the comprehensive benefits these Ayurvedic formulations present, contributing to their potential effectiveness in treating malaria symptoms.
34) Katurasa (Katu-rasa):
'Katu-rasa' refers to the 'pungent taste', which is crucial in Ayurveda for its digestive and anti-inflammatory properties. Understanding Katu-rasa helps in evaluating the traditional remedies and their applications for managing conditions, such as intermittent fever in malaria.
35) Vomiting:
Vomiting is a severe symptom often accompanying high fever and can indicate advanced illness. In this study, it is considered one of the clinical features evaluated in patients, further underscoring the need for effective herbal treatments to alleviate such distressing symptoms.
36) Activity:
'Activity' refers to the effectiveness and function of herbal agents in a clinical setting. The study examines the biological activities of the Ayurvedic treatments, demonstrating their efficacy in alleviating malaria symptoms, thereby validating their role in modern medicine.
37) Sanskrit:
Sanskrit is the classical language of Ayurveda, forming the backbone of much of the traditional medical literature. The study frequently references Sanskrit texts that contain foundational Ayurvedic knowledge, highlighting how these ancient teachings inform contemporary research and practice.
38) Account:
'Account' refers to a structured narrative or report on research findings, observations, or events. It encompasses how results are documented in the study, emphasizing transparency and academic rigor in presenting the outcomes of Ayurvedic treatments for malaria.
39) Kalpana:
Kalpana refers to the preparation methodology of Ayurvedic formulations. Understanding Kalpana is vital in the study as it underscores how traditional methods contribute to the efficacy of treatments for conditions like malaria, emphasizing the importance of preparation in herbal medicine.
40) Disease:
'Disease' is a broad term denoting any deviation from health. The context of the study focuses primarily on malaria as a relevant tropical disease impacting many, calling for a nuanced understanding of traditional and alternative treatment strategies.
41) Dipika:
Dipika often refers to commentaries or elucidations of Ayurvedic texts. The mention of Dipika within the study highlights the interpretative traditions in Ayurveda, showcasing how commentaries enhance the understanding of ancient texts and their application in modern research.
42) Pacana:
'Pacana' denotes the property of digestion and is important in Ayurvedic treatments as many remedies aim to enhance digestive strength. The study highlights how such properties impact the overall efficacy of treatments against fever, particularly in malaria cases.
43) Karma (Karman):
'Karma' indicates the action or effect of substances in Ayurveda. The study assesses the Karma of the herbal formulations to determine their therapeutic actions, which are essential in understanding their use in alleviating malaria symptoms effectively.
44) Asthi (Ashthi):
'Asthi' signifies bony tissues in Ayurveda. This term may indicate how specific treatments can affect the body's various Dhatus, including Asthi, and how the appropriate herbal combinations can be formulated to support overall health during illnesses like malaria.
45) Laghu:
'Laghu' translates to 'light' and describes substances that are easy to digest or have a weakening effect. This attribute highlights the importance of Laghu in herbal formulations that promote health and balance, particularly in treating conditions like Vishama Jwara.
46) Tikta:
'Tikta' signifies the bitter taste, which has beneficial effects on digestion and detoxification. In the study, Tikta is relevant for examining how bitter herbal properties can alleviate symptoms of malaria, aligning with traditional Ayurvedic principles of treatment.
47) Majja:
'Majja' refers to the supportive tissue or bone marrow in Ayurveda. Understanding how certain medicines work with Majja can be critical in examining their effectiveness in comprehensive treatments for diseases like malaria and their influence on overall health.
48) Kumar:
Kumar may refer to one of the contributors or researchers involved in the study. It emphasizes individual efforts and expertise within the research team that enhances the examination of Ayurvedic treatments and their effects on malaria.
49) Nakar:
Nagar likely refers to a geographical area or institution linked with Ayurvedic education or research. This contextualizes the study's geographical significance, especially in relation to herbal medicine practices prevalent in specific regions.
50) Guru:
'Guru' signifies a teacher or expert in Ayurveda. Mentions of Gurus in the study correlate with how traditional knowledge is passed down, enriching the interpretation and application of Ayurvedic practices for treating diseases like malaria.
51) New Delhi:
New Delhi represents the capital city of India, often a hub for medical research and education. Its inclusion illustrates the broader context of the study, highlighting societal and healthcare frameworks that support alternative medicine research in an urban setting.
52) Vriddhajivakiyatantra (Vrddhajivakiyatantra, Vriddhajivakiya-tantra):
Vrddhajivakiya-tantra refers to an Ayurvedic text focusing on rejuvenation and longevity. Its mention signifies the integration of classical texts into modern research, underscoring the enduring relevance of traditional knowledge in understanding and treating health conditions.
53) Kashyapasamhita (Kasyapasamhita, Kashyapa-samhita):
'Kasyapa-samhita' is an ancient text in Ayurveda that provides insights into various medical conditions and treatments. Its reference underscores the reliance on historical knowledge to inform contemporary practices and validates the ancient wisdom contained within Ayurvedic literature.
54) Vriddhajivakiya (Vrddhajivakiya, Vriddha-jivakiya):
Vrddhajivakiya reflects the nurturing aspect of Ayurveda, focusing on health preservation. The study’s connection to this text signifies an understanding of holistic healing principles, crucial in evaluating effective treatment routes for diseases like malaria.
55) Siddhisthana (Siddhi-sthana):
Siddhi-sthana refers to a section of Ayurvedic texts dealing with the attainment of success or mastery in treatments. Its mention highlights the broader quest for efficacy within Ayurvedic practices, asserting the significance of achieving intended health outcomes through researched interventions.
56) Antibiotic (Antibacterial):
'Antibacterial' describes agents that counteract bacterial infections. The study hints at the properties of certain herbal formulations, noting their potential beyond treating malaria to include antibacterial effects, demonstrating the diverse therapeutic roles of traditional remedies.
57) Madhurarasa (Madhura-rasa):
'Madhura-rasa' refers to the sweet taste and its associated therapeutic properties in Ayurveda. Its mention indicates that certain formulations examined in the study may have balancing effects on health due to the properties of Madhura-rasa being beneficial in treatment outcomes.
58) Rasashastra (Rasa-shastra, Rasasastra):
Rasashastra refers to the branch of Ayurveda focusing on alchemical processes and the use of metals and minerals. The text emphasizes the significance of ancient practices and substances to further validate treatment methodologies explored in the study.
59) Rasadhatu (Rasa-dhatu):
'Rasa-dhatu' is the primary bodily fluid in Ayurveda, representing a crucial component for understanding health and disease processes. Its consideration in the study points to the interconnectedness of bodily elements and their role in responding to treatments.
60) Dravyaguna (Dravya-guna):
Dravyaguna involves the study of the properties of substances used in Ayurveda. Its relevance in the study underscores the evaluation of herbal materials, contributing to a nuanced understanding of how specific properties influence treatment outcomes for malaria.
61) Bhaishajya (Bhaisajya):
'Bhaishajya' represents medicinal formulations in Ayurveda. The reference is significant since the study is concerned with illustrating the efficacy of various Ayurvedic preparations, laying the groundwork for integrating traditional medicine into broader healthcare practices.
62) Tridoshaja (Tridosaja):
Tridoshaja indicates conditions or diseases arising from an imbalance in the three doshas (Vata, Pitta, Kapha). The study's connection to Tridoshaja emphasizes how Ayurvedic formulations aim to restore balance in bodily systems to combat malaria and related fevers effectively.
63) Discussion:
'Discussion' in research is a critical analysis section where findings are interpreted and contextualized. In this study, it elaborates on the implications of results regarding the effectiveness of Ayurvedic treatments for malaria and aligns them with existing knowledge in the field.
64) Tamilnadu (Tamil-nadu):
Tamil Nadu is a state in India known for its rich cultural heritage and traditional medicine practices. Its mention highlights the geographical significance related to the study, indicating where alternative treatment methodologies are prevalent and culturally accepted.
65) Science (Scientific):
'Scientific' pertains to the systematic and evidence-based approach of the study, stressing the importance of empirical validation of Ayurvedic treatment practices. This underscores the aspiration of integrating traditional medicine with modern scientific principles for broader acceptance and application.
66) Shrikantha (Srikantha, Shri-kantha, Shrikamtha):
'Srikantha' may refer to a prominent researcher or scholar involved in Ayurvedic medical literature. Highlighting contributions of individuals like Srikantha signifies collaborative efforts in advancing Ayurvedic studies and their interplay with scientific methodologies.
67) Dridhabala (Drdhabala):
Drdhabala is significant in Ayurvedic literature, representing a revered scholar or author. Mentioning Drdhabala in the study points to the credibility and historical depth of the Ayurvedic knowledge base, as well as its interpretation in contemporary research.
68) Vatadosha (Vatadosa, Vata-dosha):
'Vatadosha' refers to one of the fundamental energies in Ayurveda that is linked to movement and communication in the body. Its relevance in the study illustrates how imbalances in Vatadosha can manifest in conditions like Vishama Jwara, thus necessitating specific treatment approaches.
69) Education:
'Education' emphasizes the importance of training and knowledge dissemination in Ayurveda. It encapsulates the scholarly efforts made to integrate traditional practices with modern healthcare training, advancing the understanding of remedies for illnesses such as malaria.
70) Vitiation (Vitiated):
'Vitiation' refers to the derangement of natural body processes or rhythms, often leading to illness. In the study, it discusses how imbalances contribute to conditions like Vishama Jwara, underscoring the need for corrective treatments through holistic approaches like Ayurveda.
71) Lakshana (Laksana):
'Lakshana' signifies the characteristics or symptoms of a disease. The study analyzes the specific Lakshana of Vishama Jwara to develop effective Ayurvedic treatment protocols, illustrating the importance of symptom recognition in the healing process.
72) Varanasi (Varanashi):
Varanasi is a city in India known for its spiritual and educational traditions, particularly in Ayurveda. Its mention contextualizes the cultural significance of Ayurvedic practices, linking them to historical roots that inform modern research like this study.
73) Mandagni (Manda-agni, Mamdagni):
'Mandagni' refers to weak digestive fire in Ayurveda, which can lead to a variety of health issues, including fevers. The study's reference to Mandagni highlights the importance of strengthening Agni through herbal treatment to alleviate conditions like Vishama Jwara.
74) Agnivesha (Agnivesa, Agni-vesha):
Agnivesa was an ancient scholar in Ayurveda who authored one of the foundational texts. Mentioning Agnivesa situates the study within a rich tradition, emphasizing the reliance on historical figures and their contributions to the understanding of medical practices today.
75) Pregnant:
'Pregnant' reflects the consideration of specific populations in medical studies. The exclusion of pregnant women from the study signifies ethical considerations in research, ensuring the safety and health of vulnerable groups in testing treatment efficacy.
[Note: The above list is limited to 75. Total glossary definitions available: 106]
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