Sedative effects of Syzygium cumini leaves in animal models.
Journal name: World Journal of Pharmaceutical Research
Original article title: Assessment of sedative activity of syzygium cumini leaves on animal models – an iv-vivo design
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Akshay Kumar Kompelly, Swathi Kompelly, Shirisha Manchikatla,Vamshi Koyagura, Swetha Naram Reddy and Vasudha Bakshi
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Assessment of sedative activity of syzygium cumini leaves on animal models – an iv-vivo design
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20196-14922
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Summary of article contents:
Introduction
The study presented in this article investigates the sedative activity of the leaf extracts of Syzygium cumini, a medicinal plant traditionally used for various therapeutic purposes. The significance of exploring natural sedatives stems from the increasing demand for alternatives to synthetic sedative-hypnotic drugs that often come with severe side effects. This research utilizes experimental animal models to evaluate the sedative effects via assessments conducted using the Rota rod apparatus and the Hole cross test. Highlighting its constituents and traditional uses, the study aims to contribute to the pharmacological understanding of this plant.
Sedative Effects of Syzygium cumini
Syzygium cumini has shown promise as a natural sedative, with its leaf extracts impacting central nervous system (CNS) activity in trials involving Swiss Albino mice. The experiments revealed that the leaf extracts significantly reduced locomotor activities, suggesting sedative properties comparable to the well-known CNS depressant diazepam. Furthermore, the research indicated a dose-dependent effect with respect to sedation, providing a basis for exploring the medicinal potential of this plant in treating psychiatric disorders, particularly insomnia and anxiety.
Pharmacological Methodology
The methodology encompassed the collection and preparation of Syzygium cumini leaves, followed by extracting the active compounds using Soxhlet extraction with various solvents. Experimental groups of mice were administered different doses of these extracts, alongside a control group receiving distilled water and a standard group receiving diazepam. The Rota rod and Hole board tests assessed the sedative effects by measuring locomotion and exploratory behavior, emphasizing the robust experimental design to scrutinize the pharmacological effects of the plant extracts.
Chemical Composition and Traditional Uses
Traditionally, Syzygium cumini has been utilized for treating various conditions, from diabetes to digestive issues. Its leaves are known to contain a range of bioactive compounds like glycosides, flavonoids, phenolic acids, and terpenoids, which may contribute to its therapeutic properties. This composition not only supports its application in traditional medicine but also underlines the necessity for modern pharmacological research to isolate and understand the specific mechanisms behind its sedative effects.
Conclusion
This research underscores the sedative potential of Syzygium cumini leaf extracts, demonstrating significant CNS depressant activity. The ability of these extracts to induce sedation corroborates their traditional use in herbal medicine for combating insomnia and anxiety disorders. While the findings provide preliminary support for the medicinal benefits of Syzygium cumini, further investigations are essential to isolate the responsible phytochemicals and elucidate their precise pharmacological actions. This exploration may pave the way for developing safer alternatives to synthetic sedatives in the management of psychiatric conditions.
FAQ section (important questions/answers):
What is the purpose of the study on Syzygium cumini leaves?
The study aims to evaluate the sedative activity of Syzygium cumini leaf extracts on animal models, specifically using the Rota rod apparatus and Hole cross test.
What methods were used to assess sedative activity in this research?
Sedative activity was assessed using the Rota rod apparatus and the Hole cross test, which measure locomotor activity and exploratory behavior in mice.
What compounds are found in Syzygium cumini leaves?
The leaves contain various compounds including glycosides, flavonoids, phenolic acids, triterpenoids, myricetin, quercetin, and tannins.
How were the extracts of Syzygium cumini prepared?
The fresh plant leaves were dried, pulverized, and extracted using a Soxhlet apparatus with ethanol over 24 hours, followed by concentration.
What were the results of the Rota rod test?
The results indicated significant reductions in locomotor activity, showing sedative effects across various extracts tested at different doses.
What conclusions were drawn about the effects of Syzygium cumini?
The study concluded that Syzygium cumini extracts exhibit dose-dependent sedative effects, potentially acting through the GABA receptor in the CNS.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Sedative effects of Syzygium cumini leaves in animal models.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
'Drugs' generally refer to substances used to diagnose, cure, treat, or prevent diseases. This study explores the sedative properties of natural extracts as potential alternatives to conventional drugs like diazepam, emphasizing the search for safer, plant-based therapies for anxiety and related conditions.
2) Syzygium cumini:
'Syzygium cumini' is a tropical fruit-bearing tree known for its medicinal properties. The study specifically investigates the sedative effects of this plant's leaf extracts, underlining its cultural significance in traditional medicine and its potential role in addressing modern psychiatric issues.
3) Activity:
In pharmacological studies, 'activity' refers to the effects and interactions of a substance with biological systems. The research aims to evaluate the sedative activity of 'Syzygium cumini' leaf extracts, assessing how these extracts can influence behavior and CNS function in animal models.
4) Animal:
'Animals' refers to the specific organisms used in the study, which are essential for evaluating the effects of the plant extracts in a controlled environment. The use of animals provides insights into the safety and efficacy of herbal treatments before human applications.
5) Study (Studying):
'Study' indicates a systematic investigation into a specific aspect, in this case, the sedative effects of 'Syzygium cumini'. The research is designed to assess how the plant extracts interact with biological systems, contributing to the broader knowledge of herbal pharmacology and potential therapeutic applications.
6) Water:
In the context of the study, 'water' refers to the medium used for extracting compounds from the plant leaves. Water is a standard solvent in phytochemical analysis, illustrating the effectiveness of Simplicity in herbal preparations, supporting the claim of traditional medicine.
7) Pharmacological:
'Pharmacological' relates to the study of drugs and their actions on living organisms. The research examines the pharmacological effects of 'Syzygium cumini' leaf extracts, aiming to understand how these natural compounds can affect the CNS and contribute to the sedation process.
8) Medicine:
'Medicines' denote substances used for treatment and healing. This research seeks to explore herbal medicines as viable options for therapeutic intervention, supporting the tradition of using plants like 'Syzygium cumini' in treating various ailments effectively.
9) Disease:
'Disease' in this context signifies any disruption of normal bodily functions. The research points to the effectiveness of natural extracts in alleviating symptoms related to stress, anxiety, and disorders, underlining the importance of holistic and natural medical approaches.
10) Phytochemical:
'Phytochemical' refers to bioactive compounds found in plants that contribute to their medicinal properties. The study emphasizes the presence of flavonoids and other phytochemicals in 'Syzygium cumini', which are believed to be responsible for its sedative effects and overall therapeutic potential.
11) Depression:
'Depression' is a mood disorder that affects how one feels, thinks, and handles daily activities. This research underlines the potential of herbal remedies, like those derived from 'Syzygium cumini', to serve as alternatives for managing symptoms associated with depression and anxiety disorders.
12) Powder:
'Powder' refers to the form of the plant material used for extraction in the study. The leaves of 'Syzygium cumini' are processed into powder, facilitating the extraction of active compounds, emphasizing the need for standardized preparation methods in herbal medicine.
13) India:
'India' signifies the geographical context of the study, where 'Syzygium cumini' is traditionally used in medicine. The research showcases the integration of traditional and modern approaches to healthcare originating from India's rich herbal traditions and its relevance in global pharmacology.
14) Species:
'Species' refers to a group of organisms capable of interbreeding. In this context, the 'Syzygium' genus comprises various species known for their medicinal properties, emphasizing biodiversity and the potential safety and efficacy of different plant sources in herbal therapy.
15) Anxiety:
'Anxiety' describes a feeling of worry or fear that can be debilitating. The research highlights the potential of 'Syzygium cumini' extracts to address anxiety symptoms naturally, supporting the quest for alternatives to synthetic anxiolytics with fewer side effects.
16) Family:
'Family' relates to the classification of plants. 'Syzygium cumini' is part of the Myrtaceae family, which is noted for its aromatic properties and medicinal uses. Understanding this classification helps contextualize the research within plant-based treatments and their efficacy.
17) Table:
'Table' refers to the organization of data and results within the research. Tables summarize test results from various extracts of 'Syzygium cumini', helping visualize and compare the efficacy of different treatments and their statistical significance in the study.
18) Rich (Rch):
'Rich' in this context describes the abundance of specific compounds within the plant. The study emphasizes that 'Syzygium cumini' leaves are rich in flavonoids and other bioactive constituents, which contribute to their medicinal properties and potential health benefits.
19) Flavonoid:
'Flavonoid' refers to a class of phytochemicals known for their antioxidant and anti-inflammatory properties. The study focuses on flavonoids present in 'Syzygium cumini' and their role in producing sedative effects, promoting further investigation into these compounds in herbal medicine.
20) Field:
'Field' refers to a discipline of study, in this case, pharmacology. The relevance of the study lies in advancing knowledge in the field of medicinal plants, analyzing their effects, and contributing to the development of natural therapies in medicine.
21) Pharmacology:
'Pharmacology' is the branch of science concerned with drugs and their effects. This research contributes significant findings about the sedative properties of 'Syzygium cumini', advocating for further exploration of plant-based therapies within pharmacological frameworks.
22) Discussion:
'Discussion' sections in research synthesize findings and implications. This part of the study interprets results, connects them with existing knowledge, and highlights the importance of 'Syzygium cumini' in the broader context of traditional and modern medicine.
23) Developing:
'Developing' refers to countries or regions that are advancing their medical and pharmacological knowledge. The study aims to enrich the understanding of herbal sedatives in developing nations, addressing the demand for effective, low-cost treatments derived from natural resources.
24) Knowledge:
'Knowledge' signifies the information gained from research. The study seeks to expand knowledge about the therapeutic potentials of 'Syzygium cumini', bridging traditional uses with scientific inquiry to enhance the efficacy of herbal treatments in contemporary medicine.
25) Substance:
'Substance' refers to a material with specific properties. In this study, the various leaf extracts from 'Syzygium cumini' are examined as substances that could exert medicinal effects, particularly in terms of their sedative and pharmacological properties.
26) Centipede:
The mention of 'centipede' relates to traditional remedies where the leaves of 'Syzygium cumini' may be used to counteract venom or poison. This presents a broader understanding of the plant's historical use in treating local ailments, linking folklore with scientific exploration.
27) Shirisha (Sirisa, Shirisa, Sirisha):
'Shirisha' is a name associated with one of the authors of the study. Including author names highlights the collaborative nature of the research and credits those involved in conducting and documenting the study's findings.
28) Toxicity:
'Toxicity' signifies the degree of harmful effects produced by a substance. In assessing the sedative activities of plant extracts, understanding the toxicological profiles ensures the safety and efficacy of 'Syzygium cumini' as a natural remedy.
29) Relative:
'Relative' in this context might refer to the relationship of different extracts' effects compared to standard drugs like diazepam. It helps put the findings in perspective within the spectrum of available sedative therapies.
30) Vasudha (Vasu-dha):
'Vasudha' is another author name linked to the research. Recognizing the contributors serves to acknowledge their roles in the study, while individual contributions collectively enhance the reliability and integrity of the research findings.
31) Quality:
'Quality' refers to the standard of the extracts being studied. The quality of 'Syzygium cumini' extracts impacts their effectiveness, and ensuring high-quality preparation is vital for achieving reproducible and scientifically relevant results in herbal medicine.
32) Muslin:
'Muslin' refers to the type of cloth used during the extraction process. Its inclusion highlights the meticulous techniques employed in preparing plant extracts, necessary for isolating active ingredients while emphasizing practical aspects of traditional pharmacological methods.
33) Vamshi (Vamsi):
'Vamshi' is another named contributor to the research. Mentioning researcher names emphasizes the team effort in conducting the study, reinforcing the collective expertise that informs scientific inquiry and contributes to published findings.
34) Indian:
'Indian' pertains to the geographic and cultural context of the study, as 'Syzygium cumini' is used traditionally in Indian medicine. This connection reinforces the relevance of the research to local healing practices within the framework of modern scientific evaluation.
35) Kumar:
'Kumar' is part of the name of one of the study's authors. Naming authors draws attention to the diverse contributions and collaborative nature of scientific research, indicating the involvement of specific individuals in advancing knowledge in pharmacology.
36) Fever:
'Fever' is a common symptom of various illnesses. The potential use of 'Syzygium cumini' in combating fever illustrates the plant's diverse therapeutic applications and supports the exploration of natural remedies for common health issues.
37) Blood:
'Blood' may refer to the physiological aspect of various diseases that the plant extracts aim to treat. This aspect underlines the importance of exploring herbal treatments for managing blood-related conditions, contributing to holistic health approaches.
38) Genu:
'Genu' appears as a potential error or variant spelling related to 'genus'. This mention suggests a focus on biological classifications within plant studies, essential for investigative research on specific plant-derived compounds' effects.
39) Pain:
'Pain' refers to a symptom often alleviated through various drug therapies. The study aims to explore the sedative effects of 'Syzygium cumini', thereby examining its potential ability to help manage pain conditions through natural means.
40) Oil:
'Oils' refer to extracts used in various medicinal applications. The study suggests that 'Syzygium cumini' may contain volatile oils contributing to its therapeutic effects, exploring how these natural components enhance the efficacy of plant-based remedies.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Sedative effects of Syzygium cumini leaves in animal models.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Medicinal plant, Statistical analysis, Preliminary phytochemical screening, Animal model, Traditional use, Pharmacological action, Swiss albino mice, Diazepam, Clinical pharmacology, CNS depressant, Bioactive compound, Sedative activity, Herbal product, Dosage groups, Chemical constituent, Side effect, GABA receptor.