Sustained-release matrix tablet of indomethacin via wet granulation
Journal name: World Journal of Pharmaceutical Research
Original article title: Formulation and evaluation of sustained release matrix tablet of imdomethacin by wet granulation method
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:
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Dr. Amit B. Patil, Dr. Vikas Jain, Dr. D. V. Gowda and Shweta Betala
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Formulation and evaluation of sustained release matrix tablet of imdomethacin by wet granulation method
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20197-15140
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
Indomethacin is a well-known non-steroidal anti-inflammatory drug (NSAID) frequently prescribed for its effectiveness in treating conditions such as arthritis, bursitis, and corneal abrasion. The objective of this research was to formulate and evaluate sustained-release matrix tablets of Indomethacin using the wet granulation technique. The study explored the impact of different concentrations of Hydroxypropyl Methylcellulose (HPMC K100M) on the drug release profile, aiming to provide patients with a consistent therapeutic effect through controlled drug delivery.
Sustained Release Matrix Tablets
The essence of the study lies in the formulation of sustained-release matrix tablets that improve therapeutic outcomes by slowly releasing the drug into circulation. Utilizing wet granulation, the researchers created tablets with varying concentrations of HPMC K100M, facilitating a controlled release of Indomethacin. The physical and chemical properties of the tablets were rigorously evaluated, with results indicating good flow characteristics and desirable mechanical strength, as evidenced by tests measuring bulk density, hardness, and friability.
Drug Release Kinetics
The drug release studies demonstrated a clear relationship between the concentration of HPMC K100M and the percentage of drug released over time. Specifically, it was observed that increased HPMC concentration led to a reduction in the drug release rate, suggesting that formulations with higher viscosity polymers might effectively prolong therapeutic action. The release kinetics indicated that the tablets followed zero-order and first-order kinetics, aligning more closely with the Higuchi model, which is indicative of a diffusion-based release mechanism.
Stability of Formulations
Stability studies conducted over a 30-day period highlighted the robustness of the formulated matrix tablets. Regardless of varying storage conditions, including room temperature and elevated humidity, the drug content remained within acceptable limits, affirming the stability of the tablets. The findings indicated that the formulations could withstand different environmental factors, which is a critical aspect in pharmaceutical development to ensure product efficacy and safety over time.
Conclusion
In conclusion, the experiments successful in demonstrating that Indomethacin can be effectively formulated into sustained-release tablets using HPMC K100 as a key polymer via the wet granulation method. The various formulations yielded satisfactory physical properties and consistent drug release profiles, promoting improved patient compliance. The study's outcomes advocate for the potential of sustained-release formulations in enhancing the therapeutic application of Indomethacin, underscoring the importance of optimizing excipient concentrations for desired release characteristics.
FAQ section (important questions/answers):
What is the main purpose of this study?
The study aimed to develop a sustained release matrix tablet of Indomethacin using the wet granulation technique, enhancing therapeutic effects and patient compliance by maintaining drug release over an extended period.
What is Indomethacin and its common use?
Indomethacin is a non-steroidal anti-inflammatory drug (NSAID) prescribed for conditions such as arthritis, bursitis, and gout by inhibiting prostaglandin production.
What were the significant findings on drug release rates?
The drug release studies showed that formulations FA to FE had decreasing drug release rates as the concentration of HPMC K100 increased, indicating the effects of polymer concentration on drug release.
What techniques were employed in the formulation of tablets?
The formulation utilized the wet granulation technique, followed by compression using a 10-station Rimek mini press, ensuring the right consistency and tablet strength.
How was the stability of Indomethacin matrix tablets evaluated?
Stability testing involved storing tablets under various conditions and measuring drug content at different time intervals, confirming stability as drug content remained within acceptable limits after 30 days.
What release kinetics were observed for the formulations?
The release kinetics indicated that the matrix tablets followed Zero order and then First order kinetics, with a strong inclination towards Higuchi model, suggesting diffusion-controlled drug release.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Sustained-release matrix tablet of indomethacin via wet granulation”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
A drug is a substance used for medical treatment, which Indomethacin exemplifies as a non-steroidal anti-inflammatory drug (NSAID). It works by inhibiting prostaglandin production to alleviate conditions like arthritis and pain. Understanding its properties and formulations is crucial for effective therapeutic use and patient compliance.
2) Patil:
Dr. Amit B. Patil is a significant contributor to pharmaceutical research, particularly in the formulation of sustained release matrix tablets. His work demonstrates the importance of developing effective drug delivery systems, enhancing the pharmacological properties of Indomethacin, and ensuring the stability and efficacy of the product.
3) Table:
In the context of this study, a table is a systematic way to present numerical data related to formulation composition, physicochemical properties, and drug release profiles. Tables facilitate the comparison of results and help summarize complex data to enhance the clarity of research findings.
4) Powder:
Powder refers to the form of the raw materials used in the formulation process, including Indomethacin and excipients. The properties of the powder, such as flowability and compressibility, significantly influence the manufacturing processes and quality of the final matrix tablets, including their efficacy and stability.
5) Study (Studying):
The study refers to the systematic investigation carried out to develop sustained release matrix tablets of Indomethacin. It encompasses various methodologies, evaluations, and analyses geared towards optimizing the formulation and understanding the drug's release kinetics, ultimately aiming for improved therapeutic outcomes.
6) Gaura:
Gaur gum is used in the formulation as a thickening and stabilizing agent due to its non-toxic nature. Its properties are essential for creating a suitable matrix for Indomethacin in sustained release formulations, influencing drug release rates and enhancing the overall effectiveness of the tablet.
7) Mysore:
Mysore is the location of JSS College of Pharmacy, where the research was conducted. It reflects the regional commitment to higher education and pharmaceutical research in India, showcasing how local institutions contribute to advances in drug formulation and development within the field of pharmaceutics.
8) India:
India is known for its rapidly advancing pharmaceutical industry and research capabilities. The country plays a vital role in global medication manufacturing and development, with organizations like JSS University contributing to innovative formulation strategies, including those for sustained release medications like Indomethacin.
9) Nakar:
SS Nagar refers to the locality in Mysore where the JSS College of Pharmacy is situated. This emphasizes the geographical significance of the research institution in driving advancements in pharmaceutical education and research, as well as its impact on the local community and beyond.
10) Miṇi (Mini):
The term 'Mini' refers to the Rimek Mini Press, a specific type of tablet compression machine used in the study. This equipment is vital in producing consistent and high-quality matrix tablets, showcasing the importance of advanced technology in pharmaceutical manufacturing processes.
11) Calculation:
Calculation in this context involves quantitative assessments needed for evaluating various formulation parameters, such as drug content, release kinetics, and physicochemical properties. Accurate calculations are crucial for determining the formulation’s effectiveness and compliance with pharmaceutical standards, ensuring therapeutic safety and efficacy.
12) Discussion:
The discussion section of the study interprets the results, drawing conclusions from the data collected. It provides insights into the implications of the research findings, exploring how they relate to existing knowledge and their potential impact on future drug formulation practices and therapeutic applications.
13) Transformation (Transform, Transforming):
Transform typically refers to the process of changing substances into different forms or compositions, such as turning raw ingredients into a sustained-release tablet. This aspect is fundamental in pharmaceutical manufacturing, where precise transformations directly influence drug bioavailability and patient outcomes.
14) Swelling:
Swelling is a property of certain excipients, like Gaur gum, used in the formulation of sustained release tablets. It is crucial for controlling the drug release rate and ensuring that the tablet maintains its integrity over time, ultimately contributing to the therapeutic efficacy of the medication.
15) Purity:
Purity indicates the absence of contaminants in the active pharmaceutical ingredient and excipients used in the formulation. High purity is fundamental in pharmaceutical formulations, affecting the drug's stability, safety, and efficacy. It is critical for compliance with regulatory standards in drug development.
16) Nature:
Nature in this context refers to the inherent characteristics of the materials used in the formulation, such as HPMC and Gaur gum. Understanding the nature of these excipients is essential for predicting their behavior in the matrix tablet, influencing drug release profiles and product stability.
17) Medium:
Medium here refers to the dissolution media used in the drug release studies, such as 0.1N HCl and phosphate buffer pH 7.4. The selection of appropriate medium is vital for simulating physiological conditions and accurately assessing the drug's release characteristics and bioavailability.
18) Water:
Water is a common solvent and medium relevant to both the dissolution and the solubility of many drugs. Understanding the solubility characteristics of Indomethacin in water and other solvents is essential for evaluating its pharmacokinetics and developing effective formulations in drug delivery.
19) Blood:
Blood is a critical component of the human body that is involved in drug distribution. An understanding of how drugs like Indomethacin interact with blood is essential for predicting their pharmacokinetic behavior, therapeutic effects, and overall safety when administered to patients.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Sustained-release matrix tablet of indomethacin via wet granulation’. Further sources in the context of Science might help you critically compare this page with similair documents:
Stability study, Physicochemical properties, Micromeritic properties, Hardness test, Carr's Index, Fourier transform Infrared Spectroscopy (FTIR), Angle of repose.