Review of analytical methods for estimating doxofylline and terbutaline.

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Journal name: World Journal of Pharmaceutical Research
Original article title: A review on analytical methods for estimation of doxofylline and terbutaline sulphate in pharmaceutical dosage form
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:

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Author:

Rokade Snehal Dattatray and Dr. Bhawar S.


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: A review on analytical methods for estimation of doxofylline and terbutaline sulphate in pharmaceutical dosage form

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20198-15378


Download the PDF file of the original publication


Summary of article contents:

Introduction

The review article focuses on analytical methods for estimating Doxofylline and Terbutaline sulphate in pharmaceutical dosage forms, highlighting their importance in managing asthma. Doxofylline is identified as a novel long-acting oral methylxanthine derivative, while Terbutaline sulphate is recognized as a selective short-acting β2 adrenergic receptor agonist. With their increasing availability in both individual and combination formulations, various analytical techniques have been developed for their accurate estimation.

Analytical Techniques: High-Performance Liquid Chromatography (HPLC)

Among the various analytical methods, High-Performance Liquid Chromatography (HPLC) is emphasized as a crucial technique for quantitative determination in pharmaceutical analysis. HPLC is a separation technique utilizing a solid stationary phase and a liquid mobile phase, allowing for effective separation of components based on adsorption. The article details the methodology of HPLC, including mobile phase compositions and operational parameters, which enhance its application for the analysis of drug mixtures.

Drug Profiles: Doxofylline and Terbutaline

The article provides in-depth profiles of Doxofylline and Terbutaline sulphate, including their chemical structures, molecular formulas, and physical properties. Doxofylline's IUPAC name is noted, along with its solubility and melting point. Similarly, the profile for Terbutaline sulphate includes key metabolic characteristics and its classification as a bronchodilator. This understanding of their chemical properties is essential for developing effective pharmaceutical formulations.

Reported Analytical Methods

A comprehensive list of reported methods for both Doxofylline and Terbutaline sulphate is included, primarily focusing on various HPLC approaches. Each method is detailed with respect to mobile phase components, pH levels, column types, flow rates, and detection wavelengths. This section serves as a valuable resource for researchers and formulators looking to identify and utilize specific methods for the analysis of these drugs in different combinations and formulations.

Conclusion

In conclusion, this review underscores the significance of analytical methods for the effective estimation of Doxofylline and Terbutaline sulphate in combating asthma. Techniques such as HPLC are integral to pharmaceutical analysis, providing vital information to ensure the efficacy and safety of the drug formulations. The summary of reported methods and drug profiles contributes to the ongoing research and development in the field of pharmaceutical sciences, aiding in the advancement of treatment options for asthma patients.

FAQ section (important questions/answers):

What is Doxofylline used for in medicine?

Doxofylline is a long-acting oral methyl xanthine derivative primarily used as a bronchodilator in the treatment of asthma.

How does Terbutaline sulphate function as a medication?

Terbutaline sulphate is a selective short-acting β2 adrenergic receptor agonist that helps relax and open the airways in the lungs, aiding in asthma treatment.

What analytical methods are used for Doxofylline estimation?

Various methods like RP-HPLC, aqueous and non-aqueous titrations are employed to estimate Doxofylline in pharmaceutical dosage forms.

What role does HPLC play in pharmaceutical analysis?

HPLC, or high pressure liquid chromatography, is crucial for separating various substances within mixtures, significantly enhancing the quantitative determination of compounds in pharmaceuticals.

What is the chemical structure of Terbutaline sulphate?

Terbutaline sulphate has the IUPAC name 5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol and a molecular formula of C12H21N2O7S.

What are the reported methods for estimating Terbutaline sulphate?

RP-HPLC methods are commonly used for Terbutaline sulphate estimation, with various mobile phases and columns applied to achieve accurate results.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Review of analytical methods for estimating doxofylline and terbutaline.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Water:
Water is a crucial solvent in pharmaceutical analysis for dissolving compounds, including drugs like Doxofylline and Terbutaline sulphate. Its solubility properties help in developing formulations and analytical methods, making it indispensable in various techniques including HPLC, enabling researchers to quantitatively determine the concentration of active ingredients.

2) Drug:
Drugs are compounds used for treating diseases or alleviating symptoms. The article focuses on specific drugs like Doxofylline and Terbutaline sulphate, emphasizing their role in managing asthma. Understanding their properties and analytical assessment through various methods is crucial for pharmaceutical development and ensuring proper therapeutic use.

3) Field:
Field refers to a specific area of study or practice. In this article, the field of pharmaceutical analysis is discussed, particularly focusing on analytical methods to quantify and analyze Doxofylline and Terbutaline sulphate. This specialization is key for developing effective medications and ensuring quality control.

4) Pune:
Pune is a city in Maharashtra, India, recognized as an educational and research hub, particularly in pharmacy and pharmaceutical sciences. The article mentions Pune in relation to the Savitribai Phule Pune University, highlighting the region's contributions to pharmaceutical education and research, which are crucial for advancing analytical methodologies.

5) Substance:
A substance is a single kind of matter with specific composition and properties. In the context of this article, Doxofylline and Terbutaline sulphate are highlighted as critical substances in asthma treatment. Their analysis is crucial for ensuring accurate dosing and efficacy in pharmaceutical formulations, underscoring their importance in healthcare.

6) Maharashtra (Maharastra, Maha-rashtra):
Maharashtra is a state in India with significant contributions to healthcare and pharmaceutical research. The article references the state in connection with the Pravara Rural College of Pharmacy, emphasizing the importance of Maharashtra as a regional center for pharmaceutical education, which supports advancements in drug analysis and quality assurance.

7) Pravara:
Pravara references the Pravara Rural College of Pharmacy, which plays a vital role in pharmaceutical education and research in Maharashtra. The college's focus on quality assurance and analytical methods contributes to the development of skilled professionals equipped to tackle challenges in pharmaceutical analysis and formulation.

8) Quality:
Quality pertains to the standard of drugs and pharmaceutical products, a critical aspect emphasized in the article. Ensuring quality through rigorous analytical methods is essential for the safety and effectiveness of medications like Doxofylline and Terbutaline sulphate, directly impacting patient health outcomes and therapeutic efficacy.

9) Relative:
Relative refers to the comparative assessment of substances or their properties. In the context of the article, it pertains to how different drugs interact and are analyzed in relation to each other. This relative analysis is essential for developing effective combination therapies for conditions like asthma, enhancing treatment options.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Review of analytical methods for estimating doxofylline and terbutaline.’. Further sources in the context of Science might help you critically compare this page with similair documents:

Analytical method, Quality assurance, Molecular weight, Mobile phase, Melting point, RP-HPLC Method, Pharmaceutical dosage form, Quantitative determination, High-pressure liquid chromatography, Adrenergic receptors.

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