Transfersome for treatment of herpes zooster of antiviral drugs

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Journal name: World Journal of Pharmaceutical Research
Original article title: Transfersome for treatment of herpes zooster of antiviral drugs
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Author:

Amit Yadav, Sailesh Narayan, Vishnu Raj and Reena Malviya


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Transfersome for treatment of herpes zooster of antiviral drugs

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20199-15404

Copyright (license): WJPR: All rights reserved


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Summary of article contents:

Introduction

Transfersomes are ultra-deformable vesicles introduced in 1991 by Gregor Cevc, aimed at enhancing transdermal drug delivery. Their unique composition, which includes a lipid bilayer surrounding a watery core, results in properties that enable them to effectively penetrate the skin barrier. The term "Transfersome" is derived from the Latin "transferre," meaning "to carry over," and the Greek "soma," meaning "body." These vesicles have garnered significant interest in pharmaceutical research and applications due to their ability to transport both hydrophilic and lipophilic drugs efficiently.

Skin Penetration Mechanism

One of the most important attributes of transfersomes is their ability to improve drug penetration through the skin. Transfersomes can squeeze through narrow intercellular spaces within the stratum corneum, the outermost layer of the skin, significantly enhancing transdermal delivery. This deformability allows them to adapt and navigate through the lipid matrix of the skin while maintaining high entrapment efficiency. The current study highlights the potential of transfersome formulations for delivering acyclovir transdermally, demonstrating that these vesicles provide an effective solution for overcoming barriers to drug permeation.

Advantages of Transfersomes

Transfersomes offer several advantages over conventional drug delivery systems. They are amphiphilic, allowing versatile accommodation of various drug types, whether hydrophilic or lipophilic, thus making them suitable for diverse therapeutic applications. The vesicles also ensure a prolonged and controlled drug release, avoiding the rapid fluctuations in drug concentration commonly observed with standard drug delivery methods. Their biodegradability and biocompatibility further underscore their appeal as a drug delivery system. They can also serve as carriers for both low and high molecular weight drugs, ensuring a broad application spectrum.

Limitations of Transfersomes

Despite their benefits, transfersomes are not without limitations. Their chemical stability can be a concern, as they may be prone to oxidative degradation and less purity of phospholipids. Additionally, production costs remain a significant consideration, limiting widespread use. Stability issues, particularly during storage, might also affect their performance, necessitating careful consideration in formulation and packaging. Addressing these limitations is essential for maximizing the clinical utility of transfersome technology in transdermal applications.

Conclusion

In summary, transfersomes represent a promising advancement in transdermal drug delivery systems. Their unique flexibility and ability to navigate through skin barriers enable enhanced drug absorption, particularly for challenging molecules like acyclovir. While they present compelling advantages in terms of drug delivery efficiency, challenges related to stability and production costs must be overcome to fully realize their potential. Future research and development efforts aimed at addressing these limitations could pave the way for broader application and acceptance of transfersomes in clinical practice.

FAQ section (important questions/answers):

What are Transfersomes and their primary purpose?

Transfersomes are ultra-deformable vesicles designed for efficient transdermal drug delivery. Their unique structure allows them to overcome skin barriers, making them suitable carriers for various drugs, including acyclovir.

What advantages do Transfersomes offer for drug delivery?

Transfersomes can encapsulate hydrophilic and lipophilic drugs, ensuring prolonged drug release. They enhance the delivery of medications through the skin while protecting drugs from metabolic degradation and enabling targeted delivery.

How are Transfersomes different from traditional liposomes?

Transfersomes have a more flexible and adaptive membrane than standard liposomes, allowing them to penetrate the stratum corneum more effectively. This unique property enhances their ability to deliver drugs through the skin.

What is the significance of acyclovir in Transfersome formulations?

Acyclovir is an antiviral drug, commonly used to treat herpes zoster. The study demonstrated enhanced transdermal delivery of acyclovir using Transfersome formulations, indicating their potential as effective drug carriers.

What methods are used to prepare Transfersomes?

Transfersomes are prepared by dissolving phospholipids in ethanol, combining with drug solutions, and mixing to form vesicular dispersions. This process optimizes factors like lipid ratio and stirring time to enhance efficiency.

What factors affect the performance of Transfersomes in drug delivery?

Factors such as lipid concentration, drug concentration, and stirring time significantly influence the average vesicle size and entrapment efficiency, which are critical for the success of Transfersome formulations in drug delivery.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Transfersome for treatment of herpes zooster of antiviral drugs”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Drug:
Drugs refer to multiple substances used in the diagnosis, treatment, or prevention of diseases. The study involves various formulations of drugs, such as acyclovir in transfersomes, showcasing their potential for enhanced skin permeation and transdermal delivery methods in pharmaceutical research.

2) Water:
Water acts as a universal solvent in various biological and chemical processes, including drug solubility and formulation. In the preparation of transfersomes, water serves as a hydration medium, allowing for the mixing and interaction of ingredients while influencing drug release profiles in pharmaceutical applications.

3) Table:
A table organizes data systematically, providing clear comparisons across multiple parameters. In pharmacological research, tables summarize findings like drug release rates, entrapment efficiencies, or comparative formulations, making it easier for researchers to analyze results and draw conclusions from experimental data.

4) Soya:
Soya, particularly in the context of lecithin, is used as a phospholipid source in transferosomes. It plays a critical role in enhancing the structural integrity and flexibility of vesicles, which is crucial for effective drug delivery across biological membranes like the skin.

5) Powder:
In pharmacy, powder refers to a finely ground solid used for drug formulation. Acyclovir, for example, is processed into powder form to facilitate its incorporation into transfersomes, ensuring a uniform distribution of the drug for consistent therapeutic efficacy when applied transdermally.

6) Study (Studying):
Studying pertains to detailed examination and exploration of a specific subject. In pharmaceutical research, studying the properties and performance of transfersomes helps in developing effective drug delivery systems, enhancing the understanding of their interactions with biological tissues.

7) Measurement:
Measurements are repeated quantifications of specific experimental parameters. They are crucial in pharmaceutical research, helping validate the consistency and reliability of results regarding drug absorption, entrapment efficiency, and the overall effectiveness of various formulations in drug delivery systems.

8) Surface:
The surface relates to the outermost layer of a material, impacting interactions with the environment. In pharmacology, the surface properties of transfersomes are critical for enhancing skin penetration and optimizing drug release rates, allowing for more efficient transdermal drug delivery.

9) Nature:
Nature refers to the inherent characteristics of substances. Understanding the nature of lipids involved in transfersome formulation helps researchers tailor drug delivery systems to exploit natural permeation pathways, improving transdermal absorption and therapeutic outcomes for drugs like acyclovir.

10) Blood:
Blood plays a crucial role in systemic drug delivery, transporting therapeutic agents throughout the body. Studies on transfersomes indicate their potential for both local and systemic effects, minimizing first-pass metabolism in the liver and maintaining drug levels in circulation.

11) Animal:
Animals are often used in research to study the effects and safety of pharmaceutical compounds. Testing formulations like transfersomes in animal models provides crucial data on their efficacy, safety, and potential therapeutic applications in humans.

12) Bile:
Bile aids in the digestion and absorption of fats and fat-soluble vitamins in the intestine, influencing drug formulations. Understanding its composition can help develop transferosome formulations that optimize the absorption of lipophilic drugs in gastrointestinal applications.

13) Food:
Food provides essential nutrients and can also influence drug absorption and metabolism. In drug formulation, understanding food interactions is vital in developing transferosomes, especially for oral medications, ensuring they maintain efficacy when consumed with or without food.

14) Inflammation:
Inflammation is a biological response to harmful stimuli, often associated with conditions requiring pharmacological intervention. Transfersomes can deliver anti-inflammatory drugs transdermally, targeting localized inflammation while minimizing systemic side effects, enhancing patient comfort and treatment efficacy.

15) Substance:
Substances are varying materials with unique properties, critical in pharmaceutical formulations. Understanding the interaction between various substances, including excipients and active ingredients, helps researchers develop effective transfersomes for improved drug delivery and enhanced therapeutic effects.

16) Toxicity:
Toxicity refers to the harmful effects a substance can have on living organisms. In drug development, assessing the toxicity of various formulations, including transfersomes composed of specific lipids, is vital to ensure patient safety and compliance in clinical settings.

17) Medicine:
Medicines consist of various agents that treat or prevent diseases. The development of innovative delivery systems, such as transfersomes, focuses on optimizing the effectiveness of medicines like acyclovir by enhancing their absorption through the skin during treatment.

18) Relative:
Relative measurements provide comparative insights into the properties of different formulations. In pharmaceutical studies, relative comparisons between various transferosome compositions help determine the most effective formulations for target drug delivery systems, guiding research and development.

19) Castor:
Castor oil is a natural oil derived from castor beans, often used in pharmaceutical applications for its emollient properties. It may be incorporated in formulations, affecting viscosity and enhancing the skin's permeability to drug-loaded transfersomes.

20) Medium:
A medium refers to a substance or environment in which processes occur. In drug formulation, the hydration medium is essential for creating transfersomes, allowing effective interaction between lipids and drugs, thereby influencing the resulting vesicle characteristics and performance.

21) Glass:
Glass is a common material for containers in scientific experiments due to its inert nature. In pharmacy, glass vials are used to store drug formulations, such as transfersomes, preserving their stability and preventing contamination until they are utilized.

22) Soma:
Soma, derived from Greek meaning 'body', in pharmacology relates to the concept of drug delivery systems that navigate through bodily tissues. The term underscores the relevance of transfersomes as carriers that traverse cellular membranes for effective drug transport.

23) Lamp:
Lamps provide illumination crucial for laboratory settings, particularly during analytical procedures like spectral analysis. Proper lighting facilitates accurate observation of results in drug studies, such as evaluating the effectiveness of various formulations including transfersomes.

24) Milk:
Milk is a nutrient-rich liquid from mammals that can influence drug absorption when consumed. Understanding the interactions between drugs and components in milk is vital for formulating medications, particularly when considering how they may affect drug bioavailability.

25) Biodegradable:
Biodegradable substances can be broken down by biological processes. In pharmaceutical formulations, using biodegradable materials like phospholipids in transfersomes ensures environmental safety and patient biocompatibility, aligning with modern concerns for sustainable and responsible drug delivery systems.

26) Observation:
Observation is the act of monitoring specific phenomena during experiments. In drug studies, careful observation is crucial for identifying changes in drug effectiveness or side effects when evaluating transfersomes, enabling researchers to refine formulations for better therapeutic outcomes.

27) Science (Scientific):
Science is the systematic pursuit of knowledge through empirical investigation. In pharmaceuticals, scientific principles guide the formulation and development of advanced drug delivery systems, like transfersomes, aimed at improving therapeutic effectiveness and patient outcomes.

28) Container:
A container is an object that holds or stores another substance. In pharmaceutical applications, containers are critical for maintaining the stability of drug formulations, including transfersomes, ensuring they remain effective and safe until administered to patients.

29) Colouring (Coloring):
Colouring refers to the addition of dyes or pigments to substances. In drug formulation, coloring agents might be included for identification or aesthetic purposes, but considerations about their safety and potential impact on drug delivery systems like transfersomes are vital.

30) Activity:
Activity refers to the effectiveness of a drug in eliciting a desired response. In the study of transfersomes, assessing the activity of encapsulated drugs is crucial to confirm their bioavailability and therapeutic potential when delivered transdermally.

31) Fixation:
Fixation in research generally refers to processes that preserve biological samples. In the context of drug studies, proper fixation during microscopy allows accurate visualization of drug dispersion within delivery systems like transfersomes, crucial for analytical assessments.

32) Channel:
A channel is a specific pathway or route through which substances flow or pass. In cellular biology, channels facilitate the movement of molecules across membranes, a fundamental principle in designing drug delivery systems like transfersomes that exploit these pathways.

33) Heating:
Heating involves raising temperature to induce changes in substances. In drug formulation, controlled heating can facilitate the mixing of components, ensuring proper interaction in creating effective transfersomes, which rely on optimal conditions for stability and drug encapsulation.

34) Disease:
Disease represents disorders impacting normal bodily functions. The study of transfersomes aims to provide improved treatment options for diseases by enhancing the delivery and efficacy of drugs like acyclovir in managing viral infections effectively.

35) Methane:
Methane is a simple hydrocarbon gas that is often studied for its environmental impact. While not directly related to pharmaceuticals, understanding such compounds contributes to the broader context of biochemistry and may indirectly influence drug delivery studies.

36) Vishnu (Visnu):
Vishnu, in this context, likely refers to a co-author's name associated with the study. It signifies the collaborative nature of scientific research, where multiple contributors bring their expertise to investigate complex topics like transfersome formulations in drug delivery.

37) Purity:
Purity relates to the absence of contaminants or impurities in a substance. In pharmaceutical formulations, ensuring the purity of ingredients like phospholipids is essential for the safety and effectiveness of drug delivery systems like transfersomes.

38) Reason:
Reason entails the justification for actions or decisions in a study. In the context of transfersomes, reasons for using specific ingredients or methods are vital to ensure optimal drug delivery and to achieve desired therapeutic outcomes.

39) Indian:
Indian may refer to the Indian Pharmacopoeia or other standards that guide pharmaceutical practices in India. Adhering to regional guidelines in drug development, such as those for transfersomes, ensures compliance and efficacy of drug formulations.

40) Sugar:
Sugar refers broadly to carbohydrates that can influence metabolism and drug absorption. Understanding the effects of sugar in formulations might contribute to optimizing drug delivery systems like transfersomes for better management of metabolic conditions.

41) Cina:
China may reference traditional medicinal practices and modern pharmaceutical advancements. Understanding developments in drug delivery, including transfersomes, in various cultural contexts, enriches the global perspective on effective therapeutic strategies and innovative research.

42) Miṇi (Mini):
Mini typically refers to smaller versions of items, such as miniaturized equipment in laboratory settings. In pharmaceutical research, miniaturization can facilitate high-throughput experiments and detailed assessments of formulations like transfersomes for enhanced drug delivery.

43) Rich (Rch):
Rich can describe substances containing a high concentration of specific components. In the context of drug formulation, a rich formulation might enhance the therapeutic effectiveness of transfersomes by ensuring an appropriate concentration of active pharmaceutical ingredients.

44) Pain:
Pain is a common symptom associated with various diseases and conditions. Effective management often requires pharmaceutical intervention, making formulations like transfersomes particularly valuable as they can deliver analgesic medications directly to the site of pain for rapid relief.

45) Oil:
Oils are viscous substances used in many applications, including pharmaceuticals. In the context of transfersomes, oils may play a role in influencing the fluidity and permeability of the lipid bilayer, affecting drug release and absorption in therapeutic formulations.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Transfersome for treatment of herpes zooster of antiviral drugs’. Further sources in the context of Science might help you critically compare this page with similair documents:

Controlled drug delivery, Centrifugation method.

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