Critical review of Arka in "Bruhat Nighanturatnakara" vs. modern pharmacology.

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Journal name: World Journal of Pharmaceutical Research
Original article title: Critical review on arka(an ayurvedic dosage form) w.s.r. to “bruhat-nighanturatnakara” in relation with modern pharmacology
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Author:

Kinjal P. Unadkat, Dr. Neha Parmar, Ditiksha Chaudhari and Janki Lukhi


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Critical review on arka(an ayurvedic dosage form) w.s.r. to “bruhat-nighanturatnakara” in relation with modern pharmacology

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr201910-15833

Copyright (license): WJPR: All rights reserved


Summary of article contents:

Introduction

Ayurveda is an ancient and experiential science focused on maintaining health and treating diseases through various methods, including different drug dosage forms. One significant dosage form in Ayurveda is Arka kalpana, which is derived from the distillation of liquids or drugs soaked in water. This preparation is thought to enhance drug potency, reduce required doses, and improve shelf life. The Bruhatnighanturatnakara, a key Ayurvedic text, identifies 188 different Arka formulations with specific therapeutic indications. Recent investigations have correlated the traditional uses with modern pharmacological evaluations, yielding evidence of efficacy for various individual Arka preparations.

The Significance of Arka Kalpana

Arka kalpana represents an essential dosage form in Ayurveda due to its enhanced effectiveness compared to other formulations. While it is not cited directly in the ancient texts known as Bruhattrayi, it first appears in Gadanigraha by Acharya Shodhal in the 12th century. The efficacy of Arka kalpana is attributed to its properties of increased potency and faster action, making it a versatile choice for various health conditions. This preparation aligns with modern scientific principles as its process of distillation can be compared to the creation of aqueous extracts, establishing a connection between traditional Ayurvedic practices and contemporary pharmacology.

Pharmacological Validation of Arka Extracts

The research highlights the pharmacological actions of various Arka extracts that correspond with classical Ayurvedic indications. For example, Amalaki (Emblica officinalis) is used for its antidepressant effects demonstrated in animal models, while Pippali (Piper longum) has been validated for its anti-arthritic properties. Other examples include Jeeraka (Cuminum cyminum), known for its anti-infertility effects, and Gokshura (Tribulus terrestris), recognized for its diuretic action. Each of these formulations shows pharmacological activities that align with their traditional applications in Ayurveda, providing a basis for their usage in contemporary medicine.

Therapeutic Applications and Efficacy

Several Arka formulations have been linked to specific therapeutic effects supported by modern pharmacological studies. For instance, Katphala (Myrica esculenta) has been noted for its antiasthmatic activity, while Vajree (Euphorbia neriifolia) exhibits wound healing properties. Additionally, extracts such as Dronapushpi (Leucas cephalotes) have demonstrated significant anti-inflammatory effects. These findings fortify the traditional uses of these plants and their preparations, suggesting that longstanding Ayurvedic practices can indeed contribute valuable insights into contemporary pharmacological understanding and drug development.

Conclusion

The review emphasizes the profound relationship between Ayurvedic literature and modern pharmacological validations concerning Arka kalpana. By correlating traditional uses with pharmacological evidence, these Arka formulations showcase the potential for modern drug discovery informed by ancient wisdom. Despite the established efficacy of several extracts, further research on the remaining Arka preparations is necessary to fully unveil the potential of Ayurvedic practices in contemporary health solutions. This endeavor not only aims to enrich modern therapeutic approaches but also advocates for the integration of traditional knowledge within modern medicinal frameworks.

FAQ section (important questions/answers):

What is Arka in Ayurvedic medicine?

Arka is a vital dosage form in Ayurveda obtained through distillation, where liquid or drug is soaked in water, extracted using Arkayantra, and is noted for its therapeutic benefits.

What are the benefits of Arka kalpana?

Arka kalpana enhances potency, reduces dosage, improves shelf life, and accelerates action compared to other Ayurvedic preparations, hence performing effectively in various therapeutic applications.

How does Arka relate to modern pharmacology?

Research has validated several pharmacological effects such as anti-inflammatory and antidepressant activities of Arka's aqueous extracts, aligning with traditional Ayurvedic claims.

Which Ayurvedic texts mention Arka preparations?

The Bruhatnighanturatnakara lists 188 varieties of Arka, detailing single drugs and their respective indications in Ayurvedic practice.

What is the historical significance of Arka in Ayurveda?

Arka kalpana was first mentioned in the 12th century by Acharya Shodhal in Gadanigraha and was extensively discussed by Ravan in Arkaprakasha.

What further research is suggested on Arka?

Further evaluation of the remaining 175 Arka extracts mentioned in ancient texts is recommended to explore their potential pharmacological benefits.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Critical review of Arka in "Bruhat Nighanturatnakara" vs. modern pharmacology.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Drug:
Substances used to treat or prevent disease, varying from synthetic to natural origins. In Ayurveda, drugs encompass herbal formulations and traditional remedies that address a wide array of health conditions, reflecting the comprehensive understanding of healing.

2) Arka:
A specific Ayurvedic dosage form defined as a liquid preparation obtained by distilling or infusing medicinal herbs in water, often considered to have potent therapeutic effects. Arka is mentioned in classical texts as effective for treating various ailments, is easily absorbed, and facilitates rapid action due to its concentrated nature.

3) Activity:
Refers to the biological effect or therapeutic action exhibited by a drug or substance against a specific condition or disease. In the pharmacological context, understanding the activity of herbal extracts is crucial to validating their traditional uses and guiding modern therapeutic applications.

4) Kalpana:
Plural of kalpana, which in Ayurveda refers to various preparation methods for medicinal substances. Kalpanas are tailored to enhance the efficacy and absorption of herbs, reflecting the intricate knowledge of herbal formulations in traditional Ayurvedic practice.

5) Pharmacological:
Pertaining to pharmacology, the science that studies drug action and how drugs interact with biological systems. This encompasses understanding the mechanisms, effects, and therapeutic roles of substances like those used in Ayurveda. It integrates knowledge from chemistry, biology, and medicine to elucidate how herbal remedies function.

6) Ayurveda (Ayus-veda):
An ancient Indian system of medicine that emphasizes balance among body, mind, and spirit for optimal health. Ayurveda encompasses various practices and principles for maintaining health, including diet, lifestyle, and herbal preparations, aiming to prevent diseases and promote longevity through holistic healing.

7) Rasa (Rasha):
In Ayurveda, rasa refers to the taste or flavor of a substance, which is fundamental in determining its therapeutic properties. There are six primary rasas: sweet, sour, salty, bitter, pungent, and astringent, each influencing the body and mind differently and guiding treatment strategies.

8) Pharmacology:
The branch of medicine that deals with the study of drugs, their properties, effects, and mechanisms of action in living organisms. It explores how drugs can alter physiological functions, formulating the basis for developing new therapies and understanding traditional remedies within a scientific framework.

9) Science (Scientific):
Refers to the systematic study of the structure and behavior of the physical and natural world through observation and experimentation. In the context of Ayurvedic practices like 'Arka', scientific methods are used to explore and verify the efficacy and mechanisms of traditional treatments.

10) Katu:
This Sanskrit term translates to 'pungent' and describes one of the six tastes in Ayurveda that, when present in herbs, is said to stimulate digestion and metabolism. Katu flavors are believed to increase the action of digestive enzymes and enhance the therapeutic efficacy of certain medications.

11) Dravyaguna (Dravya-guna):
The branch of Ayurveda focusing on the study of medicinal substances (dravyas) and their qualities (gunas). It encompasses the classification, properties, and indications of herbs, guiding their application in traditional medicine and supporting the understanding of their potential pharmacological effects.

12) Katurasa (Katu-rasa):
Refers to the 'pungent taste' in Ayurveda, recognized for its stimulating effects on digestion and metabolism. Plants with Katurasa are valued for their potential to alleviate issues like gas and bloating, contributing to their classification in healing practices and formulations.

13) Water:
A fundamental solvent and medium for many biological processes, including those involved in herbal medicine extraction. In Ayurvedic context, water acts as a vehicle in preparing various dosage forms like Arka, which is derived from the distillation or infusion of medicinal plants in water.

14) Piper longum:
A medicinal plant known as 'Pippali' in Ayurveda, valued for its numerous health benefits. It's classified as a stimulant and carminative, recognized for its role in enhancing digestion and respiratory health, and has demonstrated pharmacological activities such as anti-arthritic effects.

15) Bhaishajya (Bhaisajya):
The term for medicinal formulations and substances in Ayurveda, encompassing all forms of medicines like herbal remedies, powders, and liquids. It reflects the comprehensive approach of Ayurveda towards health and healing, including preventive and therapeutic practices based on individual constitution.

16) Sophahara (Shophahara, Shopha-hara):
An Ayurvedic term describing substances that alleviate swelling or inflammation. This quality allows certain herbs to be utilized in treating various conditions associated with inflammation or excess fluid retention, demonstrating the integrative understanding of disease management in Ayurveda.

17) Incision:
In the medical context, this refers to a surgical cut made in the skin or body tissue. In Ayurveda, the concept might extend to the practices surrounding surgeries or therapeutic interventions aimed at treating ailments, reflecting the traditional understanding of injury and healing.

18) Pippali (Pippalin):
A renowned herb in Ayurveda, specifically referred to as 'Piper longum', known for its potent medicinal properties. Pippali is frequently employed to enhance digestion, support respiratory health, and reduce inflammation, exemplifying the synergy between traditional knowledge and contemporary pharmacological validation.

19) Gujarat:
A state in western India; relevant for its rich cultural heritage, including the practice of Ayurveda. It houses many institutions and practitioners engaged in traditional medicine, significantly contributing to the field's advancement in modern research and integration with contemporary healthcare.

20) Disease:
Pathological conditions resulting from considerable disturbance in bodily functions. In Ayurveda, understanding the types and causes of ailments leads to treatment strategies that focus on restoring balance and promoting natural healing using herbal preparations and lifestyle modifications.

21) Tikta:
A Sanskrit term meaning 'bitter', one of the six tastes in Ayurveda known for its detoxifying and cleansing properties. Herbs with Tikta rasa are employed in detoxification therapies and are believed to support liver function, digestion, and overall health.

22) India:
The country of origin for Ayurveda, providing a historical and cultural context for its philosophical foundations and practices. India remains at the forefront of Ayurvedic education, practice, and research, bridging ancient medicine with modern scientific exploration and application.

23) Edema (Oedema):
A medical condition characterized by an excess of watery fluid collecting in tissues, often leading to swelling. Ayurvedic principles offer various remedies and treatments for edema, focusing on balancing the body's doshas to prevent fluid retention and associated health issues.

24) Guna:
In Ayurveda, 'guna' refers to the inherent qualities or properties of substances involved in healing. The understanding of guna helps practitioners categorize herbs and their effects on different doshas, forming a basis for treatment strategies tailored to individual constitutions and health conditions.

25) Male:
Referring to the male sex, often used in clinical studies to specify gender populations. In the context of Ayurveda and pharmacological studies, gender-specific responses to treatment, such as efficacy or side effects, can provide insightful data in developing herbal remedies.

26) Life:
The condition that distinguishes animals and plants from inorganic matter, including the capacity for growth, reproduction, and functional activity. In Ayurveda, life and its preservation through healthful practices and treatments underscore the intrinsic connection between well-being, vitality, and nature.

27) Shankhapushpi (Sankhapuspi, Samkhapuspi):
An Ayurvedic herb known for its cognitive enhancing and neuroprotective properties. Often employed in treatments for memory improvement and stress-related conditions, Shankhapushpi exemplifies the integration of traditional herbal knowledge with modern pharmacological studies demonstrating its efficacy.

28) Tridoshahara (Tridosahara, Tridosha-hara):
A term in Ayurveda referring to substances or treatments that balance the three doshas—Vata, Pitta, and Kapha. This balance is vital for maintaining health, and herbs with Tridoshahara properties are sought after for their potential to restore equilibrium in bodily functions.

29) Inflammation:
A biological response to harmful stimuli illustrated by redness, swelling, pain, and heat, indicating tissue injury. In Ayurveda, understanding inflammation and its underlying causes helps determine appropriate herbal treatments to mitigate symptoms and restore health.

30) Garbhashaya (Garbhasaya, Garbha-ashaya):
This Ayurvedic term translates to the womb or the site of reproduction in women. In traditional practices, certain herbs are classified as supportive for female reproductive health, addressing issues related to fertility and womb-related conditions.

31) Dronapushpi (Dronapuspi):
An Ayurvedic herb known for its soothing and healing properties, often utilized in the management of various inflammatory conditions. Dronapushpi's pharmacological activity aligns with traditional uses in Ayurveda, demonstrating its role in natural remedies.

32) Arkayantra (Arka-yantra):
A traditional apparatus used in Ayurveda for preparing 'Arka' through distillation methods, symbolizing the artisanal knowledge of ancient herbal preparations. This device underscores the importance of methodology in creating concentrated extracts for therapeutic use.

33) Shothahara (Sothahara, Shotha-hara):
A term used to describe remedies that alleviate swelling or inflammation. Shothahara substances help reduce symptoms associated with various health issues, showcasing Ayurveda’s comprehensive strategy for treating and managing conditions related to edema and pain.

34) Pittadosha (Pittadosa, Pitta-dosha):
Referring to one of the three doshas in Ayurveda, primarily associated with metabolic functions, heat, and transformation in the body. The balance of Pittadosha is crucial for health; imbalances can lead to conditions such as inflammation and digestive disturbances.

35) Discussion:
In academic and research contexts, discussion refers to the analysis and interpretation of data, findings, or therapeutic implications. In the context of Ayurveda, discussing treatment efficacy and aligning traditional knowledge with modern scientific understanding provides insight into the relevance of herbal remedies.

36) Depression:
A mental health disorder characterized by persistent feelings of sadness and loss of interest in activities. Ayurvedic treatments aim to restore balance among the doshas and may involve the use of specific herbs known for their antidepressant effects and ability to enhance mood.

37) Kaphaghna (Kapha-ghna):
An Ayurvedic term signifying the property of substances that reduce Kapha dosha. These substances can alleviate conditions related to excess mucus or heaviness in the body, underscoring Ayurveda’s holistic approach to disease management and balance.

38) Rasanjana (Rasa-anjana, Rasamjana):
An Ayurvedic preparation derived from the Berberis plant, utilized for its wound healing properties. It symbolizes the application of herbal extracts in traditional medicine, reflecting the potential to manage various health issues effectively using natural compounds.

39) Visahara (Vishahara, Visha-hara):
Refers to substances or herbs that neutralize or counteract poison or toxicity. Used in Ayurveda, Vishahara preparations and compounds demonstrate the traditional understanding of toxicology and remedies for treating envenomations and exposures.

40) Tiktarasa:
An Ayurvedic designation for the bitter taste, related to detoxification and purifying properties. Herbs exhibiting Tiktarasa are often included in formulations targeting liver health and digestive support, emphasizing the traditional classification based on taste and therapeutic action.

41) Gokshura (Goksura, Go-kshura):
A well-known herb, scientifically termed 'Tribulus terrestris', often classified as a diuretic in Ayurveda. Gokshura promotes fluid excretion while addressing conditions associated with urinary complications, reflecting its importance in traditional herbal formulations.

42) Prabhava:
The unique potency or specific action that a drug or herb may have, often considered distinct from its rasa or guna. In Ayurveda, understanding Prabhava helps in tailoring treatments for specific conditions based on the unique qualities and effects of each herb.

43) Vatahara (Vata-ahara):
Indicating substances that pacify Vata dosha, which is associated with movement, dryness, and irregularity. Agents with Vatahara properties can alleviate symptoms related to Vata imbalance, such as anxiety and digestive issues, underscoring Ayurveda's focus on restoring balance.

44) Katphala:
An Ayurvedic herb recognized for its therapeutic properties relating to respiratory health. Katphala is utilized for its anti-asthmatic effects, aligning traditional practices with modern pharmacological validation of herbal treatments aimed at alleviating breathing difficulties.

45) Medicine:
Refers to substances used to prevent or treat diseases or conditions. In Ayurveda, medicine encompasses a wide range of natural compounds, including herbs and minerals, employed based on their therapeutic properties to restore health and well-being.

46) Madhura:
This term translates to 'sweet' in Ayurveda, one of the six primary tastes that can have a soothing and nourishing effect on the body. Substances with Madhura rasa are often used for their calming properties and are believed to promote longevity.

47) Shastra (Sastra):
Knowledge or scripture, in this context referring to texts that document Ayurvedic theories and practices. Ayurvedic shastras provide a foundational understanding of herbs, their uses, and methods of treatment, acting as crucial references for both practitioners and researchers.

48) Amalaki:
Referring to the herb 'Emblica officinalis', a cornerstone in Ayurvedic medicine, known for its antioxidant and rejuvenating properties. Amalaki is included in numerous formulations, underscoring its importance in maintaining health and combating diseases, aligning with classical and modern pharmacological research.

49) Snigdha:
An Ayurvedic term referring to substances that are 'unctuous' or 'oily'. These substances are recognized for their roles in promoting lubrication and nourishment in the body. Snigdha properties are often sought after in treatments for dry or vitiated conditions.

50) Amavata (Ama-vata):
An Ayurvedic term for rheumatoid arthritis, characterized by joint pain and inflammation. Treatments for Amavata focus on balancing the doshas and alleviating pain through herbal remedies, reflecting the comprehensive Ayurvedic approach to joint disorders.

51) Kashaya (Kasaya):
Refers to an astringent taste in Ayurveda, with drying properties that can be used to manage various conditions. Herbal substances with Kashaya rasa are believed to be beneficial in diarrhea and disorders related to fluid imbalance, central to treatment formulations.

52) Quality:
In the context of Ayurvedic medicine, refers to the characteristics or inherent properties of a drug or herb that determine its therapeutic efficacy. Understanding the quality of substances is essential in formulating effective treatments and ensuring their safety and effectiveness.

53) Animal:
Refers to living organisms used in research for testing the effects of herbal medicines. Understanding the impact of Ayurvedic drugs on animals helps validate the efficacy and safety of these treatments in human healthcare through controlled studies.

54) Shvasa (Svasa, Svasha):
An Ayurvedic term for respiratory conditions, particularly asthma or breathing difficulties. Treatments for Shvasa involve specific herbs and formulations aimed at clearing the airways and restoring normal respiratory function, reflecting the holistic approach of Ayurveda to health management.

55) Nakuli:
Mentioned in Ayurveda, commonly associated with certain medicinal plants recognized for their health benefits. Nakuli's significance may relate to specific preparations or uses within classical texts, demonstrating the depth of knowledge surrounding herbal medicine in traditional practices.

56) Prabha:
Often denotes a radiance or brightness in Ayurvedic literature, attributing properties to substances that can enhance vitality. Substances with Prabha qualities are typically sought for their rejuvenating and health-promoting effects, forming part of the holistic approach in Ayurvedic medicine.

57) Vipaka:
This term relates to the post-digestive effect of a substance, indicating how a drug may act after consumption. Understanding Vipaka is crucial in Ayurveda as it guides the selection of herbs based on their long-term effects post-digestion in varying conditions and doshas.

58) Medhya:
Referring to substances recognized for their cognitive-enhancing properties. Medhya herbs support memory, concentration, and overall mental health, showcasing the traditional focus on the holistic relationship between mental faculties and physical well-being in Ayurveda.

59) Repair:
In the context of Ayurvedic and modern medicine, refers to healing processes restoring tissues or organ functions post-injury or illness. Various Ayurvedic formulations aim to enhance these repair processes through their nourishing and regenerative properties.

60) Karma (Karman):
In Ayurveda, karma pertains to the actions or properties associated with substances, guiding their therapeutic applications. Understanding the karma of herbal drugs informs the selection and use of specific formulations in treatment plans for various conditions.

61) Ushna (Usna):
A Sanskrit term for 'hot' or 'warm', this quality of a substance in Ayurveda is often associated with its ability to stimulate digestion and metabolism. Ushna herbs are used to treat conditions related to coldness and sluggishness in the body.

62) Bhogin (Bhogi):
In Ayurveda, this term often relates to subjects focusing on physical enjoyment and pleasure, including the acceptance of bodily comforts. In health practices, it emphasizes the balance required for well-being and can influence lifestyle choices in relation to dietary habits.

63) Vrana:
Referring to a wound or injury in Ayurvedic terminology. The management of Vrana involves herbs and treatments aimed at promoting healing and preventing infection, showcasing Ayurveda’s comprehensive approach to injury care and recovery.

64) Blood:
An essential fluid in the body responsible for transporting nutrients and oxygen. Ayurveda considers blood quality and composition vital for health, influencing treatments to restore balance, promoting circulation, and addressing issues related to blood disorders.

65) Study (Studying):
The examination and analysis of a particular subject or phenomenon. In biomedical and Ayurvedic contexts, studies help validate traditional knowledge, exploring the therapeutic potential of herbal substances through rigorous research methodologies.

66) Anta (Amta):
Often referred to as the endpoint or resolution in an Ayurvedic context, emphasizing the need for holistic understanding at the conclusion of treatment. The term may relate to the eventual effects of a medication or therapy and its overall impact on health.

67) Luta:
An Ayurvedic term associated with loss or decline, which may relate to various health conditions or the deterioration of well-being. It underscores the necessity of addressing root causes and balancing doshas in order to restore health.

68) Moha:
This term describes a state of delusion or confusion in Ayurvedic philosophy. Understanding Moha is essential for addressing mental and emotional health, advocating for remedies that enhance clarity and balance mental faculties through herbal treatments.

69) Naga (Nag):
Referring to certain plants or herbs known for their medicinal properties in Ayurveda. The classification and understanding of Naga reinforce the principles of plant-based treatments and their therapeutic potentials.

70) Vata:
One of the three doshas in Ayurveda representing qualities of movement and air. Vata's balance is crucial for overall health; disturbances can lead to various health issues, and treatment strategies often focus on pacifying Vata through specific dietary and herbal interventions.

71) Pain:
Referring to an unpleasant sensory experience associated with actual or potential tissue damage. Ayurvedic treatments often employ specific herbs and formulations aimed at alleviating various types of pain, emphasizing the holistic management of health by addressing both physical and emotional aspects.

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Discover the significance of concepts within the article: ‘Critical review of Arka in "Bruhat Nighanturatnakara" vs. modern pharmacology.’. Further sources in the context of Science might help you critically compare this page with similair documents:

Gadanigraha, Mental health, Anti-inflammatory activity, Rasa-panchaka, Bhaishajya kalpana, Ayurvedic pharmacology, Research article, Aqueous extract, Anti-arthritic effect, Arka Kalpana, Modern Pharmacology, Wound Healing Effect, Anti-asthmatic activity.

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