Glucose distribution of hiv patients co-infected with mycobacterium tuberculosis
Journal name: World Journal of Pharmaceutical Research
Original article title: Glucose distribution of hiv patients co-infected with mycobacterium tuberculosis
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Anwara Ogbonnaya, Humphrey Osadolor Benedo, Edeogu Chucks Oswald, Akinpelu Moronkeji, Patrick Manafa Onochie
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Glucose distribution of hiv patients co-infected with mycobacterium tuberculosis
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr201910-15529
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
The study conducted by Anwara Ogbonnaya and colleagues examines the serum glucose levels in patients infected with Human Immunodeficiency Virus (HIV), Mycobacterium tuberculosis (TB), and those co-infected with both. It addresses the alarming intersection of diabetes mellitus (DM), HIV, and TB, particularly regarding the implications of hyperglycemia in these vulnerable populations. Diabetes is characterized by hyperglycemia stemming from defective insulin secretion or action. Recognizing the health risks associated with these conditions is critical, as HIV and TB can exacerbate metabolic disorders like diabetes, leading to severe complications.
Hyperglycemia in Co-infected Patients
One of the critical findings of this study is the prevalence of hyperglycemia among HIV/TB co-infected patients. The study revealed a significant hyperglycemic index in those co-infected (37.0%), higher than in subjects with only TB (28.0%) or those with just HIV (22.7%). This puts co-infected individuals at twice the risk of hyperglycemia compared to patients with HIV alone. The research highlights a pressing need for routine diabetes screening in high-risk groups, given that adults aged 30-69 showed the highest incidence of HIV, TB, and co-infection. The findings underscore the complexity and interrelationship between these conditions, highlighting the greater need for healthcare strategies tailored to these patients.
Demographic Disparities in Infection Rates
The study also explored demographic disparities in infection rates, revealing that males had a higher prevalence of TB and co-infection compared to females. Specifically, 58.0% of TB positive subjects and 57.0% of HIV/TB co-infected subjects were male. However, HIV was more prevalent among females (60.7%). These gender differences suggest biological and social factors that may increase vulnerability to infections, pointing to the importance of gender-sensitive approaches in public health strategies. The study emphasizes the need to identify and address the unique risks that different demographics face in order to manage and treat these infectious diseases effectively.
The Importance of Screening and Interventions
Given the link between diabetes and increased susceptibility to TB and HIV, the study recommends implementing routine screening for diabetes mellitus in patients diagnosed with HIV and TB. Early detection and management could lead to better health outcomes and reduce the burden of disease within these already vulnerable populations. Additionally, utilizing advanced diagnostic tools like the Gene-Xpert machine may enhance the identification and management of co-infections, thus enabling more effective treatment regimens. Establishing targeted programs aimed at high-risk groups can significantly improve patient care and provide preventive measures against disease progression.
Conclusion
The study presents compelling evidence of the significant overlap between HIV, TB, and diabetes mellitus, emphasizing the need for integrated healthcare approaches. With a notable rate of hyperglycemia found among co-infected patients, there is an urgent requirement for health systems to prioritize screening and tailored interventions. By recognizing the interplay between these diseases and addressing the specific needs of different populations, health practitioners can enhance disease management and health outcomes for those affected. Future research should further explore glycemic regulation among HIV and TB patients, advancing knowledge and informing effective treatment protocols.
FAQ section (important questions/answers):
What is the purpose of the study conducted by Ogbonnaya et al.?
The study aimed to assess serum glucose levels in patients infected with HIV, Mycobacterium tuberculosis, and those co-infected with both to determine the prevalence of hyperglycemia in these groups.
How many subjects were involved in this study?
A total of 400 subjects participated, including 150 HIV-positive, 150 with M. tuberculosis, and 100 co-infected with both HIV and M. tuberculosis.
What were the main findings regarding hyperglycemia in subjects?
HIV/TB co-infected subjects had the highest hyperglycemic index at 37.0%, followed by those infected with M. tuberculosis at 28.0% and HIV-only individuals at 22.7%.
What is the recommended screening for patients with these infections?
The study recommends that all patients with HIV, M. tuberculosis, and co-infection be screened for diabetes mellitus to avoid complications.
What statistical methods were used to analyze the data in this study?
Data analysis employed SPSS Version 24.0 using chi-square and student’s t-test with significance set at P ≤ 0.05.
Why is the relationship between diabetes mellitus and TB significant in this study?
The coexistence of diabetes mellitus with HIV and TB has implications for treatment, emphasizing the need for targeted screening and intervention strategies for affected patients.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Glucose distribution of hiv patients co-infected with mycobacterium tuberculosis”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Tuberculosis:
Tuberculosis (TB) is a contagious bacterial infection caused by Mycobacterium tuberculosis. It primarily affects the lungs but can spread to other parts of the body. TB is a significant public health challenge, especially among immunocompromised individuals, such as those with HIV, highlighting the importance of joint efforts in diagnosing and treating these infections.
2) Study (Studying):
The study mentioned explores the impact of tuberculosis co-infection on glucose levels in HIV patients. It emphasizes the importance of research for understanding the interplay between these diseases, aiding in the identification of at-risk populations and informing healthcare strategies for effective management and treatment approaches for affected individuals.
3) Blood:
Blood sampling is a critical procedure for diagnosing various health conditions, including glucose levels in patients. In the study, blood glucose levels were measured to assess metabolic dysfunction in individuals infected with HIV and/or TB, providing insights into the broader implications of these infections on overall health and wellbeing.
4) Drug:
The term 'drugs' refers to pharmaceutical agents used to prevent, diagnose, or treat diseases. The study examines the impact of antiretroviral and anti-TB medications on patients' health, emphasizing the interaction between these treatments and their side effects on metabolic functions, such as blood glucose levels.
5) Table:
Tables in research studies act as concise data presentations summarizing findings, such as demographic information and glucose levels. In this study, tables illustrate the distribution of hyperglycemia in different patient groups, facilitating quick visual interpretation and comparison of crucial data in understanding the study results.
6) Male:
The study reports a notable gender disparity, with a higher prevalence of TB infections among male subjects. Understanding such demographic differences is crucial for tailoring public health interventions and awareness campaigns that address gender-specific risk factors and health outcomes related to TB and HIV.
7) Viru:
This term appears to be a fragment and likely refers to 'virus' in the context of HIV, a significant focus of the study. HIV is a viral infection that severely impacts the immune system, making patients more susceptible to opportunistic infections like tuberculosis. Understanding viral interactions is essential for managing these co-infections.
8) Disease:
The term disease refers to abnormal bodily conditions that disrupt normal functioning. The study focuses on the interplay between diseases like HIV and TB, which can exacerbate each other, leading to higher morbidity and complicating treatment strategies for co-infected patients.
9) Developing:
Developing nations often face higher disease burdens, including HIV and TB, due to factors like limited healthcare resources, socioeconomic challenges, and public health infrastructure. The study highlights the importance of understanding the impact of these diseases in such contexts to inform targeted interventions and improve health outcomes.
10) India:
India is highlighted in the study related to the prevalence rates of diabetes and TB, illustrating the public health challenges faced in a densely populated country. The statistics serve as a critical reminder of the need for effective health interventions to combat these interconnected diseases in specific geographic regions.
11) Family:
Family history plays a significant role in understanding the risk of diseases like diabetes. Individuals with a family background of diabetes may be at a higher risk. The study indirectly touches on this aspect by discussing the increased prevalence of diabetes in populations affected by TB and HIV.
12) Reason:
Reasoning behind the observed health patterns, such as the increased prevalence of diabetes among TB patients, is crucial for formulating public health strategies. Understanding causative factors can lead to more effective screening and management practices within at-risk populations.
13) Gold (Golden):
Gold relates to a specific rapid HIV test kit used in the study for accurate diagnosis. Such test kits are essential for quick and reliable identification of HIV-infected individuals, facilitating timely intervention and treatment initiation, which are critical for managing the disease effectively.
14) Container:
The study involves blood sample collection in specific containers designed to preserve the integrity of the samples for analysis. Proper handling and storage techniques are vital for obtaining reliable results, illustrating the importance of methodology in clinical research.
15) Mutation:
Mutations in pathogens like Mycobacterium tuberculosis can lead to drug resistance, complicating treatment protocols. Understanding mutation rates and patterns is crucial for designing effective therapeutic strategies and controlling the spread of resistant TB strains, especially in co-infected populations.
16) Line:
Line in this context likely refers to the standard therapeutic protocols for treating TB. First-line and second-line drugs are essential concepts in understanding treatment regimens and their effectiveness against various strains of Mycobacterium tuberculosis in infected patients.
17) Malnutrition:
Malnutrition can weaken the immune system and increase susceptibility to infections, including TB and HIV. The study potentially connects malnutrition as a risk factor contributing to severe outcomes in co-infected patients, highlighting the needs for nutritional interventions in clinical management.
18) Accumulation (Accumulate, Accumulating):
In a medical context, accumulation can refer to the buildup of substances, such as glucose or toxins, in the body. The study mentions this in reference to hyperglycemia, potentially linking it to the metabolic disturbances in patients suffering from TB and HIV.
19) Inflammation:
Inflammation is a biological response to infection that can affect metabolic processes. The study examines how chronic inflammation from diseases like TB can impact glucose metabolism, contributing to conditions such as hyperglycemia in co-infected individuals.
20) Measurement:
Measurement is a fundamental aspect of the study, as it quantifies key health indicators like blood glucose concentrations. Accurate measurement techniques are essential for deriving meaningful conclusions and ensuring the reliability of research findings.
21) Discussion:
The discussion section of a research paper synthesizes findings and their implications, contextualizing the results within existing knowledge. In this study, the discussion highlights critical connections between HIV, TB, and diabetes, suggesting future directions for research and public health strategies.
22) Education:
Education plays a pivotal role in improving health outcomes. Enhancing awareness and knowledge about HIV, TB, and diabetes management through targeted education strategies can empower individuals to seek timely treatment and adopt healthy lifestyle choices.
23) Training:
Training for healthcare workers is essential for effective disease management, particularly in handling co-infections like TB and HIV. Providing adequate training ensures that professionals are equipped with the latest knowledge and skills to implement best practices in patient care.
24) Teaching:
Teaching refers to imparting knowledge, which is key in health promotion. By educating communities about the intersections between diabetes, TB, and HIV, public health initiatives can foster better understanding, leading to preventive measures and improved health literacy.
25) Science (Scientific):
Science is foundational for advancing knowledge and medical practices. The study relies on scientific inquiry to explore relationships between diabetes, HIV, and TB, aiming to improve patient outcomes through evidence-based research.
26) Kumar:
Kumar is likely a reference to an author or a researcher in the cited works. Citing reputable sources and established researchers lends credibility to studies, highlighting the collaborative nature of science and the importance of building on existing knowledge.
27) Death:
Death is a critical outcome of diseases like TB and HIV, particularly in co-infections, as morbidity rates are often higher. The study's examination of glucose levels could shed light on factors influencing mortality in impacted populations.
28) Cina:
Like India, China faces high rates of TB and diabetes, making it a significant area for research. Understanding disease prevalence in such populous countries assists in tailoring public health strategies to address the specific needs of their populations.
29) Post:
Post may refer to post-treatment or post-diagnosis conditions, highlighting the ongoing health implications for individuals recovering from HIV or TB. Understanding the long-term effects is vital for comprehensive patient care and management strategies.
30) Pur:
The term 'poor' often relates to socioeconomic status, which can correlate with limited access to health resources. Socioeconomic challenges can exacerbate the prevalence of diseases like HIV and TB, necessitating targeted interventions for vulnerable populations.
31) Life:
Life, in this context, refers to the overall quality and well-being of individuals suffering from diseases like HIV and TB. The study aims to enhance understanding of the factors affecting life outcomes in co-infected patients, informing better healthcare strategies.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Glucose distribution of hiv patients co-infected with mycobacterium tuberculosis’. Further sources in the context of Science might help you critically compare this page with similair documents:
Diabetes mellitus, Statistical analysis, Significant difference, Insulin resistance, Anti Retroviral Therapy, Serum glucose level, Microvascular complications, Human immunodeficiency virus, Sputum sample, Mycobacterium tuberculosis, Age and gender distribution, HIGHLY ACTIVE ANTIRETROVIRAL THERAPY, Risk factors for diabetes.