Review of metabolomics, liquid biopsy, and FoundationOne CDx in cancer.

| Posted in: Science

Journal name: World Journal of Pharmaceutical Research
Original article title: A review on application of metabolomics, liquid biopsy and foundation one cdx in cancer
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:

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Author:

Chaithra Vemparala, Sreenu Thalla and Padmalatha Kantamneni


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: A review on application of metabolomics, liquid biopsy and foundation one cdx in cancer

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr201911-15835


Download the PDF file of the original publication


Summary of article contents:

Introduction

Cancer remains a severe health crisis, primarily due to its capacity to disrupt cellular metabolism, paving the way for innovative diagnostic methodologies aimed at improving early detection and treatment. Recent advancements in molecular sciences—particularly metabolomics, liquid biopsies, and the Foundation One CDx—have shown remarkable promise in revolutionizing the landscape of oncology. Metabolomics involves the comprehensive profiling of metabolites within cells and body fluids, while liquid biopsy allows for the non-invasive analysis of tumor-derived materials. Foundation One CDx, a tool approved by the FDA, specifically targets genetic alterations in tumor cells to guide therapeutic decisions.

Metabolomics in Cancer Diagnosis

Metabolomics plays a crucial role in the identification and understanding of metabolic changes associated with cancer. By analyzing metabolites present in biological samples, researchers can uncover biomarkers that correlate with various cancer stages and types. Recent studies highlight the significance of metabolites in conditions such as hepatocellular carcinoma and colorectal cancer, where specific metabolic fingerprints differentiate cancerous tissues from healthy controls. Furthermore, advanced techniques like Nuclear Magnetic Resonance (NMR) and Mass Spectrometry (MS) allow for accurate measurement and profiling of these metabolites, facilitating insights into the underlying biochemical pathways that drive tumor growth and progression.

Liquid Biopsy as a Diagnostic Tool

Liquid biopsy has emerged as a transformative non-invasive diagnostic tool that enables the detection of circulating tumor cells (CTCs) and cell-free tumor DNA (ctDNA) from body fluids such as blood and urine. This method holds significant advantages, including reduced patient discomfort and the ability to capture real-time changes in tumor dynamics. Various studies demonstrate its efficiency in identifying multiple cancer types, including lung, breast, and colorectal cancers, providing valuable insights into tumor heterogeneity and treatment responses. Cancer SEEK, a diagnostic tool utilizing liquid biopsy, exemplifies this trend by detecting various cancers through innovative analysis of circulating nucleic acids and proteins.

Foundation One CDx and Precision Medicine

The Foundation One CDx (F1CDx) represents a pivotal advancement in tailoring cancer treatment through genomic insights. This next-generation sequencing platform identifies critical genetic alterations in tumor samples, including substitutions, deletions, and copy number changes in over 300 genes. By matching these genetic markers with targeted therapies, F1CDx helps oncologists determine the most effective treatment modalities for patients, addressing specific mutations in cancers such as lung, breast, and colorectal cancers. This technology exemplifies the shift towards precision medicine, ensuring that patients receive personalized therapeutic strategies based on their tumor's unique genetic profile.

Conclusion

In summary, the integration of metabolomics, liquid biopsy, and Foundation One CDx into cancer diagnostics and treatment heralds a new era in oncology marked by precision and personalization. These innovative approaches provide vital tools for early detection, treatment response monitoring, and the development of tailored therapies that adapt to the unique characteristics of each patient's cancer. Continued research and clinical trials are necessary to overcome existing challenges, such as quality control and clinical validation, thus unlocking the full potential of these techniques in transforming cancer care into a more effective and patient-centered approach.

FAQ section (important questions/answers):

What is the role of metabolomics in cancer diagnosis?

Metabolomics is a diagnostic tool focusing on profiling metabolites in body fluids. It helps identify altered metabolic pathways and biomarkers in cancer, enhancing early detection and treatment efficacy.

How does liquid biopsy improve cancer detection?

Liquid biopsy is a non-invasive technique that analyzes body fluids for circulating tumor cells and DNA. This method enables early detection of various cancer types, improving patient outcomes and guiding treatment decisions.

What is Foundation One CDx and its use?

Foundation One CDx is an FDA-approved diagnostic tool. It detects specific genetic alterations in tumor cells across multiple cancer types, assisting in tailored therapy and improving treatment precision.

What diagnostic samples can be used in liquid biopsy?

Liquid biopsies can utilize various body fluids, including blood, saliva, urine, and stool, to detect cancer markers, making the process less invasive and more convenient for patients.

What are key applications of metabolomics in oncology?

Metabolomics aids in identifying cancer biomarkers, understanding metabolic changes, and evaluating treatment responses. Its applications are crucial for precision medicine, ensuring tailored therapies for individual patients.

How does the use of breath biomarkers facilitate cancer detection?

Breath biomarkers reflect metabolic changes in cancerous cells. The analysis of volatile organic compounds in breath can lead to early detection of cancer, potentially reducing unnecessary scans and improving diagnosis.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Review of metabolomics, liquid biopsy, and FoundationOne CDx in cancer.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Cancer:
Cancer is a devastating disease characterized by uncontrolled cell growth and metabolism alterations in the body. Understanding cancer metabolism is crucial for diagnostics, treatment, and developing precision medicine. New techniques like metabolomics and liquid biopsies are pivotal for timely detection and management of cancer, improving survival rates.

2) Study (Studying):
Studying is the process of investigating a subject in detail to gain knowledge. In cancer research, studying metabolic pathways and biomarkers is crucial for developing new diagnostic and therapeutic strategies, enhancing the understanding of cancer and improving patient management in clinical settings.

3) Blood:
Blood serves as a vital fluid in the body that circulates nutrients and oxygen, and it is a primary source for liquid biopsies. Analyzing blood samples enables the detection of circulating tumor cells and cell-free DNA, which are instrumental for early cancer diagnosis and monitoring therapeutic responses.

4) Mutation:
Mutation refers to changes in the DNA sequence that can lead to abnormal cell behavior, often seen in cancer. Genetic mutations are critical for understanding the molecular basis of tumors, providing insights that enable the development of targeted therapies and personalized medicine to treat various cancers.

5) Disease:
Diseases encompass various abnormal conditions affecting health, including cancer. Ongoing research into the mechanisms of diseases like cancer is imperative for developing effective diagnosis and treatment strategies that optimize care and improve survival rates.

6) Medicine:
Medicine encompasses the science and practice of diagnosing, treating, and preventing illness. With cancer treatment evolving rapidly through novel diagnostic tools like metabolomics and targeted therapies, the field strives to facilitate better management of conditions, enhancing the quality of life for patients facing life-threatening diseases.

7) Drug:
Drugs are substances that can induce physiological changes and are vital in the treatment of various health conditions, including cancer. The development and research of new drugs aim to target specific cancer pathways, providing hope for improved treatment options and patient survival.

8) Science (Scientific):
Sciences imply various systematic domains of study, particularly in understanding the natural world, including life sciences like biology and medicine. In oncology, the integration of multiple scientific disciplines is vital for unraveling complex interactions in cancer biology and enhancing treatment methodologies.

9) Field:
Field signifies a particular branch of study or area of expertise. In the context of cancer research, the field involves numerous specialized areas, including metabolomics, liquid biopsy, and pharmacogenomics, each contributing to a collaborative effort in advancing the understanding and treatment of cancer.

10) Arrangement:
Arrangement denotes the specific organization or ordering of elements in a particular system or context. Understanding how genetic arrangements influence cancer progression helps in identifying various treatment options and the potential effectiveness of personalized therapy as a strategic approach in oncology.

11) Vijaya:
Vijaya signifies the Vijaya Institute of Pharmaceutical Sciences for Women, where innovative research in pharmacy practice occurs. The institute plays a role in fostering advancements in pharmaceutical sciences, including cancer research, contributing to educational development and the enhancement of therapeutic solutions for patients.

12) Hand:
Hand represents an aspect of intervention or involvement in a process. In medical terms, a healthcare professional’s hand signifies the direct impact they have on patient care through diagnosis, treatment, and ongoing support for individuals affected by diseases like cancer.

13) Post:
Post refers to the period after a specific event or treatment. In cancer care, post-treatment assessment is crucial for evaluating the effectiveness of therapies, managing side effects, and making adjustments to treatment plans, enhancing patient recovery and longer-term outcomes.

14) Chemotherapy:
Chemotherapy involves the use of drugs to destroy rapidly dividing cancer cells. While effective for many cancers, it can also lead to significant side effects and toxicity. Understanding the metabolomic changes during chemotherapy helps assess treatment efficacy and manage its adverse effects.

15) Vijayawada (Vijayavada, Vijaya-vada):
Vijayawada is a city in Andhra Pradesh, India, housing institutions like the Vijaya Institute. The region contributes to pharmaceutical research and education, equipping future healthcare professionals with knowledge and tools essential for advancing cancer diagnostics and treatment.

16) Evolution:
Evolution signifies gradual change and development over time. In medical science, the evolution of diagnostic techniques like metabolomics and liquid biopsy reflects ongoing improvements in understanding and treating cancer, which facilitates earlier detection and enhances the personal approach to patient care.

17) Suffering:
Suffering represents the physical or emotional distress experienced by individuals with diseases like cancer. Understanding suffering is important in healthcare, driving research towards improving therapies and support systems to alleviate patient pain and enhance their quality of life during treatment.

18) Toxicity:
Toxicity refers to the degree of harmful effects caused by a substance. In cancer treatment, understanding drug toxicity is vital for evaluating treatment regimens and managing side effects, emphasizing the need for personalized medicine approaches to reduce toxicity while maintaining therapeutic efficacy.

19) Quality:
Quality pertains to the standard of something as measured against other things. In oncology, the quality of healthcare processes, diagnostics, and therapies plays a crucial role in patient outcomes, emphasizing the need for continuous improvement in medical practices to enhance treatment efficacy and patient care.

20) Andhra (Amdhra):
Andhra refers to Andhra Pradesh, a state in India, home to various scientific institutions contributing to pharmaceutical and cancer research. The region plays a vital role in forming educational and research platforms, fostering innovation in cancer diagnostics and treatments.

21) India:
India is a country known for its diverse population and advancements in healthcare research. The country’s institutions contribute significantly to pharmaceutical developments, including cancer research, thus impacting global health outcomes through various innovative treatment approaches and diagnostic tools.

22) Diet:
Diet refers to the nutritional intake that can significantly impact health. In cancer research, studies indicate that specific dietary components can influence cancer progression and treatment outcomes, highlighting the growing importance of personalized nutrition as part of comprehensive cancer management.

23) Inflammation:
Inflammation is the body’s response to injury or infection, often observed in cancer. Chronic inflammation is associated with tumor progression, making it a significant area of study that informs therapeutic strategies aimed at mitigating inflammation to improve patient outcomes in oncology.

24) Surrounding:
Surrounding refers to the environment around an organism. In the context of cancer, surrounding tissues and biological factors can significantly influence tumor behavior, treatment responses, and patient outcomes, emphasizing the holistic approach needed in cancer care and research.

25) Collecting:
Collecting denotes the action of gathering samples, such as blood or tissues, vital for diagnostics and research. In oncology, collecting samples through liquid biopsies aids in monitoring disease progression and treatment efficacy, enhancing personalized medicine approaches.

26) Surface:
Surface refers to the outermost layer of materials or tissues. In cancer research, understanding surface markers on cells is critical for developing targeted therapies and diagnostic tools, enabling a more effective approach to personalized medicine.

27) Food:
Food is essential for providing nutrients required for health and well-being. In cancer research, the link between diet and cancer risk has prompted studies that explore how dietary patterns can influence disease onset, progression, and responses to treatment.

28) Meat:
Meat is a significant source of protein in many diets but has been associated with increased cancer risk in some studies. Understanding the impacts of dietary components, including meat consumption, is crucial for developing guidelines aimed at reducing cancer risk and enhancing patient health.

29) Rich (Rch):
Rich refers to a high abundance or concentration of particular substances. In the context of research, biologically rich environments or samples can provide a wealth of information, enhancing the understanding of disease mechanisms and facilitating the development of effective treatments.

30) Line:
Line refers to a particular sequence or progression. In cancer research, establishing lines of investigation is crucial for systematically studying disease pathways, treatment responses, and factors influencing patient outcomes, advancing knowledge and clinical practices in oncology.

31) Pur:
Poor denotes a low quality or deficiency, often concerning health outcomes. In cancer research, understanding the factors contributing to poor outcomes can inform preventive measures, targeted therapies, and support systems aimed at improving the quality of life for affected patients.

32) Life:
Life represents the biological state of living organisms. In oncology, improving the quality of life for cancer patients through effective treatments, supportive care, and holistic approaches is essential. Research focuses on enhancing life quality while managing the physical and emotional burdens of the disease.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Review of metabolomics, liquid biopsy, and FoundationOne CDx in cancer.’. Further sources in the context of Science might help you critically compare this page with similair documents:

Mass spectroscopy, Metastasis, Clinical oncology, Biomarker.

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