Ethanolic leaf extract of Solanum torvum: analgesic and anti-inflammatory.
Journal name: World Journal of Pharmaceutical Research
Original article title: Analgesic and anti-inflamatory properties of ethanolic leaf extract of plant solanum torvum
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Dr. Prasanna Kumar Kar
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Analgesic and anti-inflamatory properties of ethanolic leaf extract of plant solanum torvum
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr201911-15832
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
The study investigates the analgesic and anti-inflammatory properties of the ethanolic leaf extract of Solanum torvum, a member of the economically significant Solanaceae family. This research specifically assesses the extract's efficacy through various experimental models, including acetic acid-induced writhing and pressure tests to evaluate antinociceptive effects, along with carrageenan-induced paw edema to analyze its anti-inflammatory capacity. Preliminary findings suggest that S. torvum is widely used in traditional medicine for treating various ailments, emphasizing its potential value in pharmacology.
Analgesic Effects of S. torvum Extract
The analgesic effects of the ethanolic leaf extract of S. torvum were predominantly measured using the acetic acid-induced writhing test. Results indicated that doses of 300 mg/kg and 600 mg/kg significantly reduced the number of writhing responses by 23% and 26%, respectively. This suggests that the extract has a dose-dependent analgesic effect. It was also comparable to known analgesic drugs such as morphine and tramadol, implicating the extract's potential as an effective analgesic that may work through the inhibition of pain mediators like prostaglandins.
Inflammation and S. torvum
In evaluating the anti-inflammatory properties, the study utilized the carrageenan-induced paw edema model. The results showed that the ethanolic extract of S. torvum significantly inhibited paw swelling, with the most notable effects observed at 2 and 4 hours post-administration. Although the anti-inflammatory effect was not strictly dose-dependent, the extract demonstrated a significant response when compared to the control group. This indicates that S. torvum efficiently manages inflammation, potentially by suppressing the activity of enzymes like cyclooxygenase, involved in the inflammatory responses.
Comparison with Established Analgesics
The study further highlighted the extract's analgesic effects through comparative analysis with established analgesics such as morphine, tramadol, and aspirin. While S. torvum exhibited significant antinociceptive activity comparable to morphine and tramadol, aspirin did not show similar effects in certain tests, reinforcing the potency of S. torvum in managing both mechanical pain and inflammatory conditions. This positions S. torvum as an interesting alternative in pain management, especially considering the side effects commonly associated with synthetic analgesics.
Conclusion
The findings of this study support the folkloric use of Solanum torvum in traditional medicine, confirming its analgesic and anti-inflammatory properties through empirical evidence. The effective inhibition of pain and inflammation points to the potential of S. torvum as a source of therapeutic agents. This study emphasizes the importance of exploring natural sources for pharmacologically active compounds and underlines the need for further research into the mechanisms underlying the medicinal properties of this plant, which could pave the way for new treatment modalities in pain management and inflammation.
FAQ section (important questions/answers):
What is the main focus of the study on Solanum torvum?
The study investigates the analgesic and anti-inflammatory properties of the ethanolic leaf extract of Solanum torvum using various animal models.
How was the extract from Solanum torvum made?
Fresh leaves were collected, dried, ground into powder, and extracted with ethanol using a soxhlet apparatus. The extract was concentrated for further analysis.
What models were used to test analgesic effects?
Analgesic effects were investigated using acetic acid-induced writhing and pressure tests, which represent peripheral and central antinociceptive effects.
What were the findings related to acetic acid-induced pain?
The S. torvum extract showed a dose-dependent decrease in writhing responses, indicating analgesic properties similar to standard pain relief medications.
How effective was Solanum torvum in reducing inflammation?
The extract significantly reduced paw swelling induced by carrageenan, confirming its anti-inflammatory effects, though not as effective as Indomethacin.
What conclusion can be drawn from the study?
The leaf extract of Solanum torvum exhibits notable analgesic and anti-inflammatory properties, supporting its traditional use in folk medicine.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Ethanolic leaf extract of Solanum torvum: analgesic and anti-inflammatory.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Animal:
'Animals' reiterates the inclusion of living subjects, emphasizing the ethical treatment and scientific rigor applied in experiments. The results derived from 'animals' provide a foundational understanding of the plant's efficacy, translating findings to potential applications in human medicine and enhancing pharmacological research.
2) Pain:
'Pain' is a crucial concept in pharmacology and medicine, particularly when assessing the effectiveness of analgesic therapies. The study focuses on the ability of Solanum torvum extract to alleviate 'pain' induced by various chemical and mechanical stimuli, which is vital for understanding its therapeutic potential.
3) Drug:
'Drugs' refer to all substances under investigation or comparison in various doses, including both the plant extract and established medications like aspirin and morphine. The term highlights pharmacological interactions and efficacy when evaluating therapeutic properties, contributing to broader implications in medicinal chemistry.
4) Prasanna:
'Prasanna' is the name of the lead researcher, Dr. Prasanna Kumar Kar, whose expertise in pharmacology lends credence to the study. His involvement ensures that scientific methodologies are adhered to and contributes to the research's credibility, ultimately impacting its acceptance in academic and medical communities.
5) Study (Studying):
'Study' represents the structured investigation carried out to explore the properties of the Solanum torvum extract. Defined by specific aims, methodologies, and analysis, the 'study' is essential for advancing knowledge in pharmacognosy and establishing evidence for traditional medicinal use within the scientific framework.
6) Activity:
'Activity' in this context relates to the pharmacological effects observed from the application of Solanum torvum extract. The term underlines the various biological responses elicited upon administration—both analgesic and anti-inflammatory—indicating the potential therapeutic applications of the extract in managing pain and inflammation.
7) Edema (Oedema):
'Edema' reiterates the focus on tissue swelling resulting from inflammation, specifically in the context of evaluating the efficacy of Solanum torvum. Monitoring 'edema' provides quantitative assessment for anti-inflammatory research, providing crucial endpoints for interpretation of therapeutic actions.
8) Inflammation:
'Inflammation' is a biological response characterized by swelling, redness, and pain, which the study aims to mitigate using Solanum torvum extract. Understanding inflammatory mechanisms is crucial for developing effective interventions in pain management and for expanding the knowledge of the plant's potential medicinal properties.
9) Jeypore:
'Jeypore' indicates the geographical location where the research was conducted and where the plant specimens were collected. This context underlines the significance of local flora in traditional medicine and contributes to the cultural relevance of the study's findings, promoting bioprospection in regional pharmacology.
10) Water:
'Water' is referenced as a solvent used in the extraction process of the plant leaves, as well as for administering treatments to laboratory animals. The quality and source of 'water' can impact experimental outcomes, emphasizing the need for controlled environments in pharmacological studies.
11) Table:
'Table' denotes the organized presentation of data summarizing findings from various tests conducted within the study. Such structured representations facilitate comparison and clarity in understanding results, enabling readers to grasp the effectiveness of the plant extract more comprehensively.
12) Hind:
'Hind' references the specific anatomical location of the rat's paw involved in the inflammation and pain studies, particularly related to the carrageenan-induced edema. Specifying 'hind' distinguishes it from other body parts, ensuring clarity in experimental design and interpretation of results.
13) Species:
'Species' identifies the scientific classification of Solanum torvum within the broader genus Solanum. Recognition of 'species' is critical to understanding the medicinal properties and phytochemical composition of the plant, contributing to informed selection for pharmacological research.
14) Powder:
'Powder' refers to the derived form of the dried leaves of Solanum torvum after being ground, which is utilized in extraction methods. The processing into 'powder' allows enhanced interaction with solvents, facilitating efficient extraction of bioactive compounds for subsequent biological evaluation.
15) Family:
'Family' pertains to the taxonomic classification of Solanaceae, encompassing numerous medicinal plants. Recognizing its 'family' context aids in understanding the shared characteristics and possible array of pharmacological properties inherent to plants within this economically significant group.
16) Genu:
'Genu' may refer to the knee or a particular joint area relevant to pain studies, yet its context within this document is limited. In pharmacological research, anatomical terms like 'genu' can be significant, especially in assessing pain and functional responses in a targeted manner.
17) Pharmacological:
'Pharmacological' refers to the active investigation into bioactive compounds and their interactions within biological systems. This term underscores the importance of understanding underlying mechanisms of drugs or extracts and their potential applications in pain relief and inflammation management in medicine.
18) Pharmacology:
'Pharmacology' is the discipline that examines the effects of drugs on living organisms, crucial for establishing safe and effective therapeutic protocols. This study contributes to the field by exploring the pharmacological properties of Solanum torvum, providing scientific validation for its traditional uses.
19) Measurement:
'Measurement' involves the processes of quantifying specific parameters during the study, such as pain responses or paw volume changes. Rigorous 'measurement' protocols are paramount for ensuring that any observed effects of treatments are statistically valid and reproducible.
20) Substance:
'Substance' refers to any specific chemical or compound under scrutiny, bridging both natural extracts like those from plants and synthetic drugs. Identifying 'substance' is crucial for understanding pharmacodynamics and therapeutic roles in medicinal and pharmaceutical contexts.
21) Medicine:
'Medicines' encompasses a broader collection of substances—both natural and synthetic—used for treating ailments. Exploring the analgesic and anti-inflammatory properties of Solanum torvum enhances the understanding of alternative 'medicines', informing potential integration into contemporary healthcare practices.
22) India:
'India' is significant in this study as the geographical origin of Solanum torvum and the cultural context from which its medicinal uses emerge. Recognizing India's diversity in flora and traditional medicine highlights the need for bioprospecting and research focused on local species.
23) Kumar:
'Kumar' is part of the researcher's name, Dr. Prasanna Kumar Kar, emphasizing his personal contribution and expertise in the study. Names in academic work underscore the importance of authorship, enhancing accountability and fostering collaboration within scientific research.
24) Food:
'Food' is indirectly relevant as the experimental animals were allowed access to it before treatment, which plays a role in maintaining their health and wellbeing during the study. This aspect underscores the importance of proper animal care in research for valid results.
25) Calculation:
'Calculation' refers to the process used to derive important metrics in the study, such as pain inhibition percentages and volume changes in edema. Precise 'calculation' is essential in analyzing and interpreting experimental data to draw meaningful conclusions from the research.
26) Discussion:
'Discussion' represents the section where the researchers interpret and analyze results, integrating findings with existing literature to highlight the significance of the study. This part provides critical insights into the implications of the results and suggestions for future research pathways.
27) Toxicity:
'Toxicity' assesses the potential harmful effects of substances administered during studies, essential for evaluating safety profiles of plant extracts or any drugs. Understanding 'toxicity' is crucial for ensuring that potential therapeutic applications do not pose significant risks to consumers.
28) Swelling:
'Swelling' describes the increase in size or volume associated with inflammation, particularly focused on its measurement in the carrageenan-induced edema model. Investigating 'swelling' assists in gauging the effectiveness of treatments, emphasizing the role of the Solanum torvum extract in alleviating such responses.
29) Surface:
'Surface' indicates the exterior of biological tissues relevant in studies measuring pain responses or drug interactions. Parameters defining 'surface' characteristics can influence the absorption and effectiveness of treatments, which is key to drug formulation and delivery.
30) Killing (Killed):
'Killing' in a pharmacological context may refer to the ability of certain compounds or extracts to alleviate pain or inflammation, leading to the overall 'killing' or reduction of harmful biological processes. This word denotes an outcome sought in the quest for effective remedies.
31) Malaya:
'Malaya' signifies a geographic region where Solanum torvum is distributed. Recognizing its regional distribution enhances the understanding of local usage, traditional medicinal practices, and biodiversity's role in the pharmacological investigation of plants utilized for herbal remedies.
32) Sugar:
'Sugar' may refer to the organic compounds found within the plant extract being studied. The presence of 'sugar' can influence metabolic activities and bioavailability of active ingredients, marking its relevance in assessing nutritional and therapeutic profiles for human application.
33) House:
'House' refers to the controlled environment where the animals were kept during the study, which is essential for ensuring adequate living conditions and experimental consistency. The term emphasizes the importance of ethical and environmental elements in scientific research.
34) Cina:
'China' is part of the geographic distribution mentioned for Solanum torvum, suggesting its widespread occurrence and the potential for ethnopharmacological studies in various cultures, revealing the significance of global biodiversity in the pursuit of medicinal plants.
35) Hair:
'Hair' refers to fine structures on the surface of the plant, which can influence interactions such as absorption or deterring herbivory. These 'hair' properties can affect the pharmacological profiles of the plant extracts utilized in the research.
36) Tree:
'Tree' designates the structural form in which Solanum torvum grows, indicating its biological classification and potential environmental adaptations. Understanding the 'tree' aspect highlights the botanical characteristics that may be linked to its medicinal utility.
37) Ripe:
'Ripe' is an important term when discussing fruit development concerning Solanum torvum, emphasizing the conditions under which the best active compounds might be harvested. This concept is significant for optimal extraction processes in enhancing therapeutic effectiveness.
38) Hand:
'Hand' may refer to the methodology or the tactile assessment involved in handling the extracts or the plant during research. The term denotes the human element in experimentation, highlighting the importance of careful procedure in pharmacological studies.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Ethanolic leaf extract of Solanum torvum: analgesic and anti-inflammatory.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Control group, Pharmacological activities, Anti-inflammatory properties, Analgesic effect, Carrageenan-induced paw edema, Tail flick test, Hot plate test, Acetic acid-induced writhing, Ethanolic leaf extract, Wistar rat, Ethno-pharmacological studies, Formalin test, Swiss mice, Inflammatory mediator.