In-vitro carminative effects of the polyherbal “poduthalai kudineer.”

| Posted in: Health Sciences Science Journals

Journal name: World Journal of Pharmaceutical Research
Original article title: In-vitro carminative activity of a polyherbal siddha medicine “poduthalai kudineer
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:

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Author:

Dr. R. Rajalakshmi, Dr. R. D. Indumathi, Dr. A. M. Amala Hazel, Dr. N. J. Muthu Kumar


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: In-vitro carminative activity of a polyherbal siddha medicine “poduthalai kudineer

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr201912-16119

Copyright (license): WJPR: All rights reserved


Summary of article contents:

Introduction

The study presented in the World Journal of Pharmaceutical Research explores the in-vitro carminative activity of a polyherbal Siddha medicine known as Poduthalai Kudineer. Siddha medicine is an ancient Indian healing system recognized for its efficacy and minimal side effects. This research focuses on the carminative properties of Poduthalai Kudineer, which is specifically indicated for treating constipation in children, a prevalent condition characterized by infrequent bowel movements and digestive discomfort. The paper emphasizes the need for scientific evaluation of traditional remedies, particularly those that have been used in Siddha texts like Balavagadam.

Carminative Properties of Poduthalai Kudineer

Carminatives are natural substances known for their ability to facilitate the expulsion of gas from the digestive tract. Poduthalai Kudineer is derived from a combination of several herbal ingredients, each possessing potential digestive and carminative benefits. The primary components include Poduthlai eerkku, Vembu eerkku, and Ma eerkku, among others. These ingredients are acknowledged for their stomachic, carminative, and laxative properties, reflecting their traditional medicinal use. However, a review of existing literature indicates that the specific carminative potential of Poduthalai Kudineer has not been thoroughly investigated, prompting this research initiative.

Methodology for Evaluating Carminative Activity

The evaluation of the carminative activity of Poduthalai Kudineer was performed using a modified method adapted from previous studies. This involved preparing an extract of the herbal formulation and employing an acid-base titration method to measure the amount of carbon dioxide evolved during the reaction. Various volumes of Poduthalai Kudineer were tested, with the results indicating a measurable quantity of carbon dioxide production corresponding to the volume of the sample, thereby establishing its carminative effects quantitatively. Controlled experiments ensured the reliability of the data collected.

Results of the Study

The results demonstrated that Poduthalai Kudineer exhibited significant carminative properties, with carbon dioxide production increasing with larger volumes of the sample. Specifically, 10 ml resulted in an average of 18.73 g of carbon dioxide, while 40 ml produced an average of 49.85 g. These results are indicative of the drug's effectiveness in facilitating gas expulsion from the gastrointestinal tract, validating its traditional use as a remedy for conditions like constipation and bloating. Such findings affirm the potential of this herbal formulation as a beneficial dietary supplement in enhancing digestive health.

Conclusion

The study concludes that Poduthalai Kudineer possesses promising carminative properties, even at lower doses, and demonstrates a potent ability to alleviate digestive issues such as constipation. The extract's efficacy in expelling gas from the intestines supports its application in traditional Siddha medicine, marking a valuable contribution to both herbal pharmacology and clinical practice. The findings advocate for further research to validate and expand upon the benefits of this polyherbal formulation, emphasizing the importance of integrating traditional medicinal wisdom with modern scientific inquiry.

FAQ section (important questions/answers):

What is the primary purpose of Poduthalai Kudineer?

Poduthalai Kudineer is a polyherbal Siddha medicine primarily used to treat constipation and improve digestive health, particularly in children.

Which ingredients are present in Poduthalai Kudineer?

Poduthalai Kudineer consists of various herbs, including Poduthlai eerkku, Vembu eerkku, Ma eerkku, and several others known for their stomachic and carminative properties.

How was the carminative activity of Poduthalai Kudineer evaluated?

The carminative activity was assessed using a modified acid-base titration method, measuring the amount of carbon dioxide evolved from the reaction mixture.

What were the significant findings regarding Poduthalai Kudineer's carminative effect?

Results showed that Poduthalai Kudineer produced notable amounts of carbon dioxide, indicating significant carminative properties at varying doses.

What are carminatives and their relevance to Poduthalai Kudineer?

Carminatives are agents that help expel gas from the stomach and intestines. Poduthalai Kudineer acts as a carminative, aiding in digestive health.

Is Poduthalai Kudineer safe and effective for children?

Siddha medicine is generally regarded as safe with minimal side effects. Poduthalai Kudineer is specifically indicated for use in children to alleviate constipation.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “In-vitro carminative effects of the polyherbal “poduthalai kudineer.””. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Siddha:
Siddha is an ancient system of Indian medicine that emphasizes natural healing methods and the use of herbal remedies. It is known for its holistic approach, focusing on the balance between body, mind, and soul. This traditional practice underscores the significance of natural ingredients in treatments, particularly for gastrointestinal issues.

2) Activity:
In the context of medicinal studies, 'activity' refers to the biological effects or therapeutic functions exhibited by a substance. The carminative activity mentioned highlights how a drug, like Poduthalai Kudineer, aids in relieving symptoms such as gas and bloating, showcasing its potential benefits for digestion.

3) Drug:
The word 'drugs' pertains to various substances, especially those derived from natural or synthetic origins, used to diagnose, cure, or prevent diseases. In the study provided, attention is given to the multiple herbal drugs used to formulate Poduthalai Kudineer, which aims to enhance digestive health.

4) Chennai:
Chennai, a major city in India, serves as the location for the National Institute of Siddha, where the research was conducted. It is renowned for its traditional medicine practices and institutions dedicated to the study and promotion of Siddha medicine, contributing to the preservation and advancement of these ancient healing methods.

5) Sharman (Sarma, Sharma, Sarman):
The name 'Sharma' in this context refers to a researcher, Swapnil Sharma, whose modified method for evaluating carminative activity is employed in the study. This highlights the importance of established methodologies in scientific research to validate the effects of traditional formulations like Poduthalai Kudineer on digestion.

6) Medicine:
Traditionally, 'medicine' refers to substances or practices that heal or alleviate diseases. Siddha medicine specifically incorporates natural ingredients and holistic practices, emphasizing prevention and treatment of ailments through herbal formulations. The study of Poduthalai Kudineer exemplifies this tradition of using natural medicines for gastrointestinal health.

7) Nocci:
Nochi, scientifically known as Vitex negundo, is one of the key ingredients in Poduthalai Kudineer. It is recognized for its medicinal properties, including anti-inflammatory and gastrointestinal benefits. Its inclusion in the formulation underscores the importance of individual herbs in enhancing the overall carminative effects.

8) Puli:
Puli, or Tamarindus indica, is another significant herb in the Poduthalai Kudineer. Recognized for its sour flavor and digestive benefits, it aids in improving bowel regularity. Its role in traditional medicine highlights the synergy of various herbs in the formulation of effective treatments for digestive issues.

9) Ulli:
Ulli refers to Allium sativum, commonly known as garlic. It is appreciated for its medicinal properties, including carminative effects that relieve gas and bloating. Incorporating Ulli in Poduthalai Kudineer enhances the formulation's overall efficacy, demonstrating how traditional ingredients work together to promote digestive health.

10) Container:
Container in this context refers to the apparatus used to conduct the in-vitro carminative activity tests. Utilizing a well-designed container allows for proper measurement of the carbon dioxide produced, which serves as an indicator of the carminative effects of the herbal formulation being studied.

11) Study (Studying):
The term 'study' pertains to the scientific investigation conducted to evaluate the carminative properties of Poduthalai Kudineer. It emphasizes the rigorous process of testing traditional formulations, lending credibility to Siddha practices through systematic research, analysis, and validation of their health benefits.

12) Azadirachta indica:
Azadirachta indica, commonly known as neem, is a key ingredient in Poduthalai Kudineer. Renowned for its health benefits, including antimicrobial and digestive properties, neem's inclusion reflects the reliance on traditional herbs in Siddha medicine to support gastrointestinal health and well-being.

13) Mangifera indica:
Mangifera indica, or mango, is listed as a significant component of Poduthalai Kudineer. Beyond its culinary appeal, mango has been traditionally valued for its digestive aids, showcasing the integration of such fruits into Siddha formulations for enhancing overall health and digestive comfort.

14) Piper longum:
Piper longum, known as long pepper, contributes to the efficacy of Poduthalai Kudineer. This herb is recognized for its carminative properties, which help to alleviate digestive issues. Its presence in the formulation emphasizes the use of diverse botanicals in holistic healing practices.

15) Tamarindus indica:
Tamarindus indica, referred to as Puli, plays a crucial role in Poduthalai Kudineer. Its sour properties are not only a flavor enhancer but also contribute to digestive health, facilitating the ease of evacuation and reducing constipation, which is central to the study's focus.

16) Tiruvannamalai (Thiruvannamalai):
Thiruvannamalai is the district from which the raw materials for Poduthalai Kudineer were sourced. Its geographical significance emphasizes the local connections and biodiversity that contribute to traditional medicine, underscoring the importance of regional plant species in Siddha therapeutic practices.

17) Allium sativum:
Allium sativum, or garlic, is integral to the formulation of Poduthalai Kudineer, known for its strong medicinal properties. The garlic's role as a carminative herb pinpoints its effectiveness in promoting digestion and alleviating gastrointestinal discomfort, demonstrating the health benefits of incorporating it into traditional medicine.

18) Vomiting:
Vomiting is a symptom associated with gastrointestinal dysfunction and is often experienced alongside constipation. Understanding the connection between these symptoms highlights the importance of herbal formulations like Poduthalai Kudineer that aim to relieve such ailments by promoting healthy digestion.

19) Village:
The term 'village' relates to the origin of the raw drugs for the study, specifically Sirumoor village, where traditional knowledge and practices might influence local herbal formulations. This connection underscores the community-based knowledge that often forms the foundation of Siddha medicine.

20) Disease:
The term 'disease' denotes any deviation from normal physiological function. The focus on constipation as a disease in the study highlights the significance of addressing functional gastrointestinal disorders through traditional remedies like Poduthalai Kudineer, which aims to restore normal digestive health.

21) Powder:
Powder refers to the form in which the herbal ingredients of Poduthalai Kudineer were prepared for the study. Creating a coarse powder allows for better extraction of active components during testing, demonstrating the importance of preparation methods in evaluating the efficacy of herbal remedies.

22) Indian:
The term 'Indian' situates the context of the study within Indian culture, particularly in reference to the Siddha system of medicine. This identification emphasizes the traditional practices and rich heritage of Ayurvedic and Siddha medicine that utilize local herbal biodiversity for health benefits.

23) Kumar:
Kumar, referring to Dr. N. J. Muthu Kumar, serves as one of the authors involved in the research indicated in the publication. His expertise contributes to the credibility of the study and enhances the collaborative efforts in promoting and validating traditional medicinal practices.

24) Amala:
Dr. A. M. Amala Hazel, one of the authors involved in the study, indicates the collaborative nature of scientific research in Siddha medicine. Her role emphasizes the importance of interdisciplinary approaches in understanding and improving traditional therapeutic practices through modern scientific methods.

25) Water:
Water in this context signifies the solvent used in the experimental setup to dissolve the Poduthalai Kudineer for testing. Its critical role underscores the scientific method in the study, allowing for the observation and measurement of carminative effects through the reactions observed.

26) Muttu:
As part of the research team, Dr. N. J. Muthu Kumar's involvement highlights collaborative contributions in the study of Poduthalai Kudineer. His expertise enriches the investigation and lends authority to the traditional practices examined within the context of Siddha medicine.

27) Pain:
Pain serves as a significant symptom of gastrointestinal disorders like constipation. The study exploring the carminative properties of Poduthalai Kudineer aims to alleviate such pains associated with digestive issues, showcasing how traditional herbal formulations address common health concerns.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘In-vitro carminative effects of the polyherbal “poduthalai kudineer.”’. Further sources in the context of Science might help you critically compare this page with similair documents:

Significant result, Pediatric Population, Traditional Siddha medicine, Carminative activity, Gastrointestinal organ.

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