Vitamin D's impact on glycemic control in type 2 diabetes.
Journal name: World Journal of Pharmaceutical Research
Original article title: Effect of vitamin d supplementation on glycemic control in type 2 diabetes mellitus patients
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Samah Mohammed Aljohani, Nasser Nafea Alharbi, Hadeel Rajeh Alnashri, Mohammed Abed Bukhari, Rawan Eid Alamri, Rawan Awad S. Alharbi, Ebtehag Faham Alsulami, Ghadah Massad Alharbi, Ahmed Y. O. Abujazar, Abdullah Yahya Alsaghir
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Effect of vitamin d supplementation on glycemic control in type 2 diabetes mellitus patients
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr201913-16463
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Summary of article contents:
1. Introduction
Vitamin D is increasingly recognized not only for its role in maintaining calcium and bone homeostasis but also for its potential influence on various health conditions, including diabetes mellitus. This study aimed to provide cumulative insights into the effects of vitamin D supplementation on glycemic control, particularly in patients with type 2 diabetes mellitus (DM). The research analyzed multiple randomized controlled trials (RCTs) to assess changes in serum vitamin D levels and their relation to HbA1c, a marker for long-term blood glucose levels.
2. Vitamin D and Glycemic Control
The primary finding from the meta-analysis conducted in this study indicated a statistically significant increase in serum vitamin D levels among patients who received supplementation compared to those in a placebo group (p = 0.049). This reinforces the notion that vitamin D may positively affect metabolic processes related to insulin secretion and sensitivity. A total of 245 patients were included from five studies, highlighting that vitamin D supplementation can lead to marked improvements in vitamin D status in individuals with type 2 diabetes, although the clinical significance of these changes warrants further investigation.
3. HbA1c and Vitamin D Supplementation
In relation to secondary outcomes, the study explored the effect of vitamin D supplementation on HbA1c levels, which reflect long-term glycemic control. Contrary to expectations, the analysis found no significant difference in HbA1c levels between the vitamin D and placebo groups (p > 0.05). This outcome implies that while vitamin D can improve serum levels, its direct effect on HbA1c may be limited, suggesting the need for more targeted interventions or combination therapies in managing diabetes effectively.
4. Implications for Clinical Practice
This study highlights the complex relationship between vitamin D levels and diabetes management. While vitamin D supplementation can enhance vitamin D status, its role in improving glycemic control, as indicated by HbA1c levels, remains inconclusive. These findings suggest that healthcare providers should exercise caution when recommending vitamin D solely as a treatment for glycemic control in type 2 diabetes patients, particularly in those with well-managed blood glucose levels. However, for patients with poorly controlled diabetes, vitamin D may still have favorable effects on fasting glucose levels.
5. Conclusion
In summary, the current evidence from RCTs does not support the routine use of vitamin D supplementation for immediate improvements in glycemic control across a heterogeneous population of patients with type 2 diabetes. Nonetheless, there appears to be potential for vitamin D to positively influence fasting glucose levels in specific subgroups, particularly those with poorer glycemic management. Continued research is vital to further clarify these relationships and establish comprehensive recommendations for vitamin D in diabetes care.
FAQ section (important questions/answers):
What is the study’s focus regarding vitamin D and diabetes?
The study investigates the effect of vitamin D supplementation on glycemic control in patients with type 2 Diabetes Mellitus.
How many studies were included in the meta-analysis?
Five studies involving a total of 245 patients were included in the meta-analysis.
What were the primary and secondary outcomes measured in the study?
The primary outcome was the mean change in serum vitamin D. The secondary outcome assessed the effects of vitamin D on HbA1c levels.
What were the results regarding vitamin D supplementation’s effects?
The meta-analysis showed a significant increase in vitamin D levels for the supplemented group, but no significant effect on HbA1c levels compared to the placebo group.
What conclusion was drawn regarding short-term vitamin D supplementation?
The study concludes that current evidence does not support short-term vitamin D supplementation in the general type 2 diabetes population.
Are there specific patient conditions where vitamin D may help?
The study suggests a potential benefit of vitamin D supplementation on fasting glucose in patients with poorly controlled diabetes.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Vitamin D's impact on glycemic control in type 2 diabetes.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Study (Studying):
A study refers to a systematic investigation aimed at discovering or interpreting information regarding a specific phenomenon, in this case, the effect of vitamin D supplementation on glycemic control in patients with type 2 diabetes mellitus. It helps in analyzing data, outcomes, and drawing conclusions based on evidence from various controlled trials and research methodologies.
2) Table:
In the context of the document, a table organizes data related to patient characteristics and study outcomes in a structured format. This allows readers to easily compare and contrast findings from different studies, including demographics, treatment responses, and statistical outcomes, facilitating a clearer understanding of the aggregated results of vitamin D supplementation.
3) Disease:
Disease denotes an abnormal condition affecting the body or mind, commonly characterized by specific symptoms and signs. In this document, type 2 diabetes mellitus is discussed as a metabolic disorder impacting glycemic control. Understanding the disease is vital in evaluating the potential therapeutic effects of vitamin D supplementation on patient management.
4) Science (Scientific):
Sciences encompass a wide variety of disciplines that study natural and physical phenomena. In the context of this study, disciplines such as medicine, biology, and biochemistry contribute to understanding the role of vitamin D in health, particularly its relationship with glycemic control in diabetic patients.
5) Forest:
In research literature, a forest plot is a graphical representation used to display the results of multiple studies in a meta-analysis. It provides a visual of effect sizes and confidence intervals, helping to summarize evidence about the impact of vitamin D supplementation on glycemic control in a concise and interpretable manner.
6) Ovid:
Ovid is a database management system that provides access to a wide array of medical literature, including research articles, reviews, and clinical trial reports. It is used in this study to source relevant RCTs and comparative studies concerning vitamin D supplementation and diabetes management, enhancing the credibility and comprehensiveness of the research.
7) King:
The term 'King' in this context refers to institutions that are named after royal figures, notably in Saudi Arabia, such as King Saud bin Abdulaziz University for Health Sciences. These institutions play a significant role in advancing health sciences education and research, contributing to studies like the one analyzing vitamin D's effects on diabetes.
8) Inflammation:
Inflammation is the body’s immune response to injury or infection, often linked to chronic conditions such as type 2 diabetes. In this study, vitamin D is posited to have immunomodulatory effects that may reduce systemic inflammation, potentially improving insulin sensitivity and glycemic control in diabetic patients.
9) Discussion:
The discussion section of the study interprets the results, compares them with existing research, and delves deeper into the implications of findings regarding vitamin D and type 2 diabetes. This segment critically evaluates the efficacy of vitamin D supplementation, its benefits, and limitations, and provides recommendations for future investigations.
10) Medicine:
Medicine is the field concerned with health, healing, and the diagnosis and treatment of disease. The research on vitamin D supplementation addresses a significant aspect of medical science, focusing on improving patient outcomes in type 2 diabetes management through potential endocrinological interventions.
11) Doubt:
Doubt signifies uncertainty or lack of confidence in a particular outcome or claim. In scientific research, it can lead to stringent evaluations and peer review processes. The study acknowledges the ambiguity surrounding vitamin D supplementation's benefits on glycemic control, particularly how it may or may not significantly impact HbA1c levels.
12) Shana (Sana):
Sanaa is the capital city of Yemen and represents one of the locations of the study's participating general practitioners. Such context is important as it highlights the geographical diversity of medical practices and potentially cultural influences on patient responses to treatment and health interventions, like vitamin D supplementation.
13) Homa:
HOMA refers to the Homeostasis Model Assessment, a method used to estimate insulin resistance and beta-cell function. In diabetes research, such metrics are crucial for evaluating the metabolic status of patients. HOMA may help assess the impact of vitamin D on insulin sensitivity among participants in the studies reviewed.
14) Beta:
Beta cells are the insulin-producing cells found in the pancreas, critical for glucose regulation in the body. The study discusses the potential influence of vitamin D on these cells, as it may enhance insulin secretion or sensitivity, which is vital in managing type 2 diabetes effectively.
15) Sign:
A sign in scientific research often refers to an observable phenomenon or indicator that provides insight into the condition being studied. In this context, signs might relate to the clinical manifestations of diabetes or the biochemical markers influenced by vitamin D supplementation, aiding in understanding patient outcomes.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Vitamin D's impact on glycemic control in type 2 diabetes.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Chronic inflammation, Clinical trial, Placebo controlled trial, Placebo group, Insulin resistance, Metabolic syndrome, HbA1c, Cochrane Library, Glycemic control, Anti-inflammatory effect, Epidemiological studies, Secondary outcome measure, Primary outcome measure, Systematic search, Vitamin D supplementation.