Evaluation of edible oils' anti-diabetic effects on alloxan rats.
Journal name: World Journal of Pharmaceutical Research
Original article title: An evaluation of anti-diabetic effects of edible oils on alloxan induced rats with safety profile analysis
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Nahin Al Alam, Momsad Sakib, Tahani Jashim, Lia Rose Merry D. Cruze, Nadia Afrin and Md. Kamrul Hasan
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: An evaluation of anti-diabetic effects of edible oils on alloxan induced rats with safety profile analysis
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr201913-16292
Download the PDF file of the original publication
Summary of article contents:
Introduction
Diabetes Mellitus (DM) is a prevalent lifestyle disease characterized by abnormalities in carbohydrate metabolism, often due to insufficient insulin levels. Type 2 diabetes (T2D) has been rising steadily, with projections indicating significant growth in its incidence by 2030. Lifestyle changes, including dietary modifications, have been shown to prevent T2D. This study focuses on evaluating the anti-diabetic effects of various edible oils derived from plants and their potential as therapeutic alternatives for managing diabetes mellitus.
Potential of Edible Oils in Diabetes Management
The study highlights the therapeutic potential of plant-derived edible oils in ameliorating diabetic conditions. Conducted on alloxan-induced diabetic rats, the research involved administering different oils at a dose of 2 ml/kg after inducing diabetes via an intraperitoneal alloxan injection. The results indicated significant hypoglycemic effects in diabetic rats treated with selected oils, demonstrating that these oils can effectively lower blood glucose levels over time.
Safety Profile of Edible Oils
Apart from their therapeutic benefits, the safety profile of these edible oils was closely examined. Parameters such as serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), and creatinine levels were evaluated. While all oils improved diabetic conditions, safety assessments indicated that these oils did not significantly alter the physiological states of non-diabetic rats. Thus, the oils appear to be safe for consumption while providing benefits in managing diabetes.
Weight Change Observations
The experiment also recorded changes in the body weight of the test subjects. Observations revealed weight reduction among diabetic rats, aligning with typical diabetic symptoms, while some oil-treated groups displayed weight gain. This indicates that certain edible oils may mitigate one of the common manifestations of diabetes, suggesting a potential avenue for improving weight management in diabetic individuals through dietary adjustments.
Conclusion
This research posits that specific plant-derived edible oils can not only exert anti-diabetic effects but also exhibit an acceptable safety profile, making them a promising alternative therapy for diabetes management. The findings underscore the importance of dietary choices in diabetes treatment and management, paving the way for further exploration of edible oils and their health benefits. Future investigations may focus on the individual components of these oils to better understand their pharmacological properties and potential applications in diabetes care.
FAQ section (important questions/answers):
What was the primary aim of the study on edible oils?
The study aimed to evaluate the anti-diabetic effects of various edible oils on alloxan-induced diabetic rats and analyze their safety profiles.
How was diabetes induced in the rats for this research?
Diabetes was induced in the rats by a single intraperitoneal injection of alloxan at a dosage of 150 mg/kg body weight.
What parameters were measured to evaluate the oils’ effectiveness?
Blood glucose levels, as well as SGOT, SGPT, and creatinine levels, were measured to assess both the hypoglycemic effects and safety profile of the edible oils.
What were the results regarding body weight changes in groups?
Rats treated with edible oils generally showed an increase in body weight, while alloxan-induced rats without oil treatment exhibited a significant decrease in body weight.
Did the edible oils cause any significant changes in healthy rats?
No significant changes were observed in the physiological parameters of healthy rats fed with the oils, indicating their safety and lack of undesired effects.
What conclusion was drawn about the edible oils in diabetes management?
Certain plant-derived edible oils can improve pathological parameters and possess anti-diabetic effects, making them potential alternatives for managing Type I diabetes mellitus.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Evaluation of edible oils' anti-diabetic effects on alloxan rats.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Blood:
Blood is crucial in this study as it serves as a medium to measure glucose levels and assess the effectiveness of edible oils on diabetic rats. Monitoring blood glucose levels helps evaluate the anti-diabetic activity of oils and confirms their potential as therapeutic agents for diabetes management.
2) Oil:
Oils, particularly plant-derived edible oils, are a focal point of the research. They are evaluated for their anti-diabetic properties and safety profiles, providing insight into natural alternatives for diabetes treatment. Understanding the efficacy and safety of these oils is essential for potential therapeutic applications in diabetic patients.
3) Alam (Alaṁ):
Alam, specifically Nahin Al Alam, is the corresponding author of the research article. His contributions reflect the collective effort of the authors in executing the study on the anti-diabetic effects of edible oils. Alam's role signifies the importance of research leadership and communication in scientific reporting.
4) Animal:
The term animals in this context denotes the subjects used in the research, specifically Wistar rats, which are critical for preclinical studies on diabetes treatment. The health and responses of these animals provide valuable data on the potential human applications of the findings.
5) Disease:
The article addresses multiple diseases, with a primary focus on diabetes. It highlights the lifestyle-related nature of diabetes and the potential for certain dietary oils to combat this and possibly other degenerative diseases. This showcases the broader implications of the research for disease prevention and health improvement.
6) Study (Studying):
The study serves to investigate the hypoglycemic effects and safety profiles of various edible oils on alloxan-induced diabetic rats. It aims to provide scientific evidence about these oils' effectiveness and safety, which can inform future research and potential clinical applications in diabetes treatment.
7) Food:
Food, particularly in the context of edible oils, plays a significant role in daily nutrition and health. The study emphasizes the relationship between diet and disease management, highlighting how incorporating specific oils into the diet can potentially ameliorate diabetes symptoms in affected individuals.
8) Cocos nucifera:
Cocos nucifera, or coconut oil, is one of the key oils studied for its anti-diabetic effects. The research investigates its efficacy in lowering blood glucose levels in diabetic rats, exploring its potential as a natural treatment option. Coconut oil's properties make it a valuable subject in dietary studies on diabetes.
9) Activity:
Activity refers to the various effects that the edible oils exhibit on blood glucose levels in diabetic rats. The study aims to measure and analyze the hypoglycemic activity of different oils, which can reveal their potential therapeutic applications in managing diabetes effectively.
10) Diet:
Diet is pivotal to managing and preventing diabetes. The study explores how specific edible oils, when incorporated into natural diets, can influence blood glucose levels. This relationship emphasizes the importance of dietary choices in maintaining health and managing metabolic disorders like diabetes.
11) Pharmacology:
Pharmacology plays an essential role in assessing the efficacy and safety of the edible oils studied. The research involves evaluating the biological effects of these oils as potential therapeutic agents, contributing to the field of pharmacology by providing insights into alternative medicines for diabetes management.
12) Coconut (Cocoanut):
Coconut oil is specifically highlighted in the study for its medicinal and nutritional properties. The research explores its effectiveness in reducing blood glucose levels in diabetic rats, emphasizing its significance as a natural remedy and its potential role in dietary strategies for managing diabetes.
13) House:
House refers to the animal house where the rats were kept for the study. This facility is essential for maintaining controlled environmental conditions necessary for animal welfare and the integrity of experimental results, highlighting the importance of proper facilities in scientific research.
14) Drug:
Drug refers to the potential therapeutic agents derived from edible oils. The research evaluates these oils as alternative treatments for diabetes, examining their effectiveness in modifying physiological conditions. Understanding their pharmacological effects is crucial for developing new diabetes management strategies.
15) Discussion:
Discussion in the paper pertains to the interpretation of results and their implications for diabetes management. This section integrates findings, provides a deeper understanding of the data, and suggests future research directions, emphasizing the importance of contextualizing research outcomes in broader scientific discussions.
16) Quality:
Quality reflects the assessment of edible oils used in the study, encompassing their nutritional and therapeutic properties. Evaluating the quality of oils is crucial for determining their effectiveness and safety in treating diabetic conditions, directly impacting dietary recommendations and health strategies.
17) Science (Scientific):
Science underpins the entire study, emphasizing the systematic investigation of edible oils' effects on diabetes. The research contributes to scientific knowledge by providing experimental evidence, thus promoting further exploration and understanding of dietary influences on metabolic diseases like diabetes.
18) Water:
Water is mentioned in the context of providing a standard diet for the rats. Proper hydration is essential for animal health and ensures accurate results in scientific studies. It highlights the importance of maintaining basic needs in experimental setups to obtain reliable outcomes.
19) Trade:
Trade may refer to the context of the oil market, including the sourcing and commercial aspects of edible oils. Understanding the trade of these oils can inform their availability and influence their use in dietary practices and therapeutic applications.
20) Sah:
Shah refers to Dr. Md. Shah Amran, one of the contributors to the study. His involvement highlights collaborative efforts in research and the importance of multidisciplinary approaches in scientific investigations, enabling comprehensive analysis and success in research endeavors.
21) Rich (Rch):
Rich in this study context refers to the nutritional richness and health benefits of the plant oils examined. The research underscores how these oils may offer substantial health advantages, particularly in diabetic management, reflecting their potential significance in dietary practices.
22) Hand:
Hand may refer metaphorically to the involvement and contribution of the researchers in carrying out the study. It could also suggest the necessity of hands-on experimentation in scientific work, indicating the active participation of the authors in observing and analyzing the results.
23) Male:
Male specifies the gender of the Wistar rats used in the study. Using male rats helps control for gender-related variables in experimental outcomes, ensuring that the results focus on the effects of the treatments without the confounding influence of sex-related physiological differences.