Meta-analysis of psoriasis and cardiovascular risk factors
Journal name: World Journal of Pharmaceutical Research
Original article title: Meta-analysis of psoriasis and cardiovascular risk factors
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Wasan Rwaibeh Al Qurashi, Joud Abdulshakur Basfar, Zainab Mansour Abualsaud, Raja Mohsin S. Alibrahim, Dr. Abdullah Nasser Alomair, Dr. Nawaf Fawzan Alfawzan, Nujud Muteb Alshammari, Ghadah Mohammed Alnajjar, Seham Saad ALQahtani, Zahra Shaker Al Kalaif
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Meta-analysis of psoriasis and cardiovascular risk factors
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr201913-16345
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
Psoriasis is a chronic inflammatory skin disease that affects approximately 2% to 3% of the population in the United States. Recent studies highlight its systemic nature, linking psoriasis with various comorbidities, particularly cardiovascular disorders. The disease is associated with a heightened risk of acute vascular events, such as myocardial infarction (MI) and stroke, and is characterized by an increased prevalence of cardiovascular risk factors, including hypertension, diabetes, dyslipidemia, obesity, and metabolic syndrome. This paper aims to aggregate data examining the impact of cardiovascular risk factors on patients with psoriasis.
Increased Cardiovascular Risk in Psoriasis Patients
The systematic review and meta-analysis included five studies involving a total of 1,255,118 patients, which compared a psoriasis group to a control group. Key findings reveal a significantly higher rate of ischemic heart disease (IHD) in the psoriasis group (odds ratio [OR] = 1.46, p < 0.01). Additionally, previous research corroborates these findings, suggesting that psoriasis is associated with a 29% to 55% increased risk of developing MI, largely attributed to systemic inflammation and the presence of traditional cardiovascular risk factors.
Atherosclerosis and Its Importance
The analysis demonstrated a marked increase in the prevalence of atherosclerosis among psoriasis patients compared to controls, with the random-effects model revealing an OR of 1.79 (p < 0.01). Researchers have established a direct link between chronic inflammation in psoriasis and the development of atherosclerosis, emphasizing that the inflammatory state exacerbates adverse cardiovascular conditions. The elevated rates of atherosclerosis can translate into a higher incidence of serious cardiovascular events in this population.
Hypertension and Its Correlation
In terms of hypertension (HTN), the studies reviewed showed a significant association with psoriasis patients, with the meta-analysis indicating an OR of 2.06 (p = 0.001). This finding aligns with prior observational studies that reported a higher prevalence of traditional cardiovascular risk factors, such as hypertension, among individuals with psoriasis. The heightened incidence of hypertension in psoriatic patients contributes to their overall increased cardiovascular risk, as it is a notable factor leading to both IHD and other vascular complications.
Conclusion
This meta-analysis reinforces the strong association between psoriasis and an increased prevalence of cardiovascular risk factors, leading to an elevated likelihood of major cardiovascular events, including ischemic heart disease, atherosclerosis, and hypertension. The evidence supports the notion that psoriasis is more than a skin condition; it is a significant risk factor for serious cardiovascular issues. Clinicians should therefore be vigilant in monitoring cardiovascular health in patients with psoriasis, considering it a systemic disease linked to broader health challenges.
FAQ section (important questions/answers):
What is the main focus of this research study?
The study investigates the association between psoriasis and cardiovascular risk factors, highlighting the increased prevalence of conditions such as ischemic heart disease, atherosclerosis, and hypertension among psoriasis patients.
How many studies were included in the meta-analysis?
A total of five studies were included, analyzing data from 1,255,118 patients, with 32,171 in the psoriasis group and 1,222,947 in the control group.
What were the primary and secondary outcomes measured?
The primary outcome was the rate of ischemic heart disease (IHD). Secondary outcomes included rates of atherosclerosis and hypertension (HTN) in psoriasis patients compared to controls.
What significant results were found regarding ischemic heart disease?
The study found a highly significant increase in ischemic heart disease in the psoriasis group compared to the control group, with a p-value less than 0.01.
How did psoriasis patients compare in terms of hypertension prevalence?
Psoriasis patients showed a highly significant increase in hypertension rates compared to controls, with a reported odds ratio of 2.06 and a p-value of 0.001.
What conclusion can be drawn from this research study?
There is a strong association between psoriasis and cardiovascular risk factors, which leads to higher incidences of major cardiovascular events in psoriasis patients.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Meta-analysis of psoriasis and cardiovascular risk factors”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Study (Studying):
In research, a 'study' refers to a structured investigation aimed at discovering or verifying knowledge related to specific phenomena, in this case, the relationship between psoriasis and cardiovascular risk factors. Studies can vary in design, such as randomized controlled trials or meta-analyses, providing critical evidence for clinical practices.
2) Disease:
'Diseases' are pathological conditions characterized by specific signs and symptoms. The study focuses on two primary diseases: psoriasis and cardiovascular conditions, exploring their interactions and the heightened risks associated with their coexistence, emphasizing the importance of interrelated health consequences.
3) King:
'King' typically refers to a monarch, but in the context of this document, it refers to King Abdulaziz University in Saudi Arabia, where several authors are medical interns. This association establishes their academic background and the credible environment in which the research was conducted.
4) Developing:
'Developing' in this context refers to the process of becoming or evolving over time. It relates to the emergence of systemic issues in psoriasis patients regarding cardiovascular health, referencing the growing recognition of their increased risk for diseases like heart issues and hypertension.
5) Inflammation:
'Inflammation' is a biological response initiated by the immune system to injury or infection, characterized by redness, heat, swelling, and pain. This study discusses the role of inflammation in psoriasis and its link to cardiovascular diseases, illustrating how systemic inflammation can contribute to health complications.
6) Forest:
In medical research, 'forest' often pertains to a 'forest plot,' a graphical representation used in meta-analyses to show the individual and overall effects of studies. It visually summarizes data, allowing immediate comprehension of findings related to ischemic heart disease in psoriasis patients compared to control groups.
7) Table:
The term 'table' in the context of research refers to a structured arrangement of data, often used to summarize key results and demographic information of study participants. Tables enhance clarity and allow for quick reference and comparison across different categories, aiding in the interpretation of findings.
8) Blood:
'Blood' is a vital fluid in the body that transports oxygen and nutrients to cells and removes waste products. The relevance of blood in this study is tied to its role in hypertension and overall cardiovascular health, indicating how psoriasis patients may have altered cardiovascular risk factors.
9) Male:
'Male' refers to the biological sex characterized by specific genetic and physiological traits. In this study, sex is significant for analyzing the demographic data of participants, which can influence the prevalence and impact of cardiovascular diseases among psoriasis patients. It highlights the role of gender in health disparities.
10) Stiffness:
'Stiffness' generally refers to rigidity or a lack of flexibility. In cardiovascular research, this term often describes arterial stiffness, which can indicate the presence of atherosclerosis. The paper discusses how stiffness correlates with psoriasis duration and the ensuing cardiovascular risks, emphasizing the systemic nature of the disease.
11) Ovid:
'Ovid' refers to a research database used for accessing various medical literature and studies. Its inclusion indicates the comprehensive resources utilized in this research, as Ovid houses a multitude of peer-reviewed articles necessary for conducting systematic reviews and meta-analyses in healthcare research.
12) Rheumatoid arthritis:
'Rheumatoid arthritis' is a chronic inflammatory autoimmune disease that affects joints, often resulting in pain and disability. The relevance in this study lies in highlighting the shared cardiovascular risks with psoriasis, emphasizing the systemic inflammatory nature of both diseases and their compounded effects on patient health.
13) Discussion:
'Discussion' is a key section in scholarly articles where authors interpret their findings, reconcile them with existing literature, and address implications. This section of the paper elaborates on the observed cardiovascular risks in psoriasis patients, contextualizing the results within the broader framework of cardiovascular health.
14) Medicine:
'Medicine' pertains to the science and practice of diagnosing, treating, and preventing diseases. It is the overarching field within which this study is situated, focusing on the intersection of dermatology, cardiology, and clinical risk assessment for patients with psoriasis and associated comorbidities.
15) Science (Scientific):
'Science' denotes the methodical pursuit of knowledge through observation, experimentation, and analysis. This research exemplifies scientific inquiry within healthcare, seeking to elucidate connections between psoriasis and cardiovascular events through meta-analysis and systematic reviews, underlining evidence-based approaches in medical practice.
16) Doubt:
'Doubt' signifies uncertainty or lack of conviction. In research, addressing doubt is vital, particularly when interpreting results and ensuring rigor in research methodologies. This term reminds researchers to critically assess findings and consider various interpretations before drawing conclusions from their studies.
17) Death:
'Death' refers to the cessation of all biological functions sustaining a living organism. The study connects cardiovascular diseases, influenced by psoriasis, to increased mortality risks. Understanding these associations is crucial for developing strategies to mitigate risks and enhance the quality of life for affected patients.
18) Raja:
'Raja' is likely a personal name, possibly referring to Raja Mohsin S. Alibrahim, one of the contributors to the study. Authors’ names serve to attribute their intellectual contributions to the research and indicate the collaboration among medical professionals in advancing understanding of psoriasis-related cardiovascular risks.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Meta-analysis of psoriasis and cardiovascular risk factors’. Further sources in the context of Science might help you critically compare this page with similair documents:
Comparative studies, Clinical trial, Atherosclerosis, Prevalence rate, Meta analysis, Cochrane Library, Hypertension, PubMed, Ischemic Heart Disease, Cardiovascular risk factor, Systemic inflammation, Traditional cardiovascular risk factors, Average age, Risk of developing.