A study on therapeutic effects of ultrasound for the treatment of sarcoma cancer
Journal name: World Journal of Pharmaceutical Research
Original article title: A study on therapeutic effects of ultrasound for the treatment of sarcoma cancer
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C. S. Ram, R. K. Saxena, Jayanand, Sonali Gangwar, Maya Datt Joshi and D.V. Rai
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: A study on therapeutic effects of ultrasound for the treatment of sarcoma cancer
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20181-10595
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
Ultrasound therapy is emerging as a novel treatment modality for cancer, particularly due to its non-ionizing nature, which circumvents the harmful effects associated with electromagnetic radiation. This study investigates the therapeutic effects of ultrasound in a rat model of sarcoma cancer induced by the carcinogen 7, 12-dimethyl benz(a)anthracene (DMBA). By evaluating various physiological and biochemical parameters after the application of therapeutic ultrasound, the researchers aim to understand its potential as a cancer treatment.
The Role of Ultrasound in Cancer Treatment
The primary focus of this research centers on the effects of ultrasound therapy on the growth and progression of DMBA-induced sarcoma in rats. The study utilized forty female Wistar rats, dividing them into four groups to assess the changes in body weight, tumor weight, and serum biochemistry post-treatment. The results indicated that ultrasound therapy significantly reduced tumor weight and influenced the general health of the rats by affecting their body weight. This suggests that ultrasound therapy may play a beneficial role in managing tumor growth and supporting overall health in the context of cancer.
Impact on Serum Pathophysiological Enzymes
The research highlighted significant alterations in serum enzyme levels as indicators of pathological changes following ultrasound treatment. The study measured various enzymes, such as AST, ALT, ALP, and LDH, revealing marked increases in enzyme levels in rats undergoing ultrasound therapy compared to control groups. This increase in serum enzymes indicates potential hepatic stress and possible tissue damage, suggesting that while ultrasound therapy may exhibit anti-tumoral effects, it may also trigger oxidative stress and cellular damage in surrounding tissues.
Serum Antioxidants and Oxidative Stress
Further analysis revealed that ultrasound therapy had a detrimental impact on serum antioxidants, including total glutathione, vitamin C, and vitamin E. The findings demonstrated significantly lower levels of these antioxidants in rats treated with ultrasound compared to control groups. This reduction implies that oxidative stress levels increased due to ultrasound exposure, potentially overwhelming the rats' ability to neutralize oxidative damage. The balance between the therapeutic effects of ultrasound and the potential oxidative harm it can cause is a crucial consideration for its application in cancer treatment.
Conclusion
In conclusion, the study underscores the anti-cancer efficacy of ultrasound therapy against DMBA-induced sarcoma in rats while also highlighting the intricate balance between beneficial and adverse effects. The significant decrease in tumor weight and changes in body weight suggest promising therapeutic potential, although the increase in serum pathophysiological enzymes and decrease in antioxidants point to oxidative stress as a notable concern. Further investigations are essential to fully understand the underlying mechanisms and optimize ultrasound therapy as an effective treatment modality for cancer, potentially paving the way for improved therapeutic strategies.
FAQ section (important questions/answers):
What was the aim of the ultrasound study on sarcoma cancer?
The study aimed to evaluate the therapeutic potential of ultrasound in treating DMBA-induced sarcoma in rats, focusing on its effects on body weight, tumor weight, and serum enzymes.
How was sarcoma induced in the rats for the study?
Sarcoma was induced in female Wistar rats using a single dose of 7, 12-Dimethyl benz(a)anthracene (DMBA), which is known to cause tumors, particularly in mammary tissues.
What treatment was given to the sarcoma-bearing rats?
Therapeutic ultrasound was applied at a power setting of 2.6W/cm² for 10 minutes to the sarcoma-bearing rats, aiming to assess its anti-tumor effects.
What significant results were noted from ultrasound treatment in the study?
Ultrasound treatment significantly suppressed tumor growth and altered serum pathophysiological enzyme levels, indicating potential anti-tumor activity while also leading to oxidative stress in cancerous tissues.
What were the observed effects on body weight in different groups?
Control rats maintained higher body weights compared to DMBA-treated rats. Ultrasound treatment showed improvement in body weight for DMBA-induced rats after therapy.
What do the results suggest about ultrasound treatment for cancer?
The findings suggest that ultrasound therapy effectively suppresses DMBA-induced sarcoma in rats, highlighting its potential as a novel therapeutic agent for cancer treatment.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “A study on therapeutic effects of ultrasound for the treatment of sarcoma cancer”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Cancer:
Cancer refers to a group of diseases characterized by the uncontrolled growth and spread of abnormal cells. It poses significant health risks and can lead to death if not treated. The study investigates ultrasound as a potential therapeutic approach to combat cancer, specifically sarcoma, indicating its essential role in medical research.
2) Study (Studying):
The study mentioned is a scientific investigation aimed at understanding the therapeutic effects of ultrasound on sarcoma cancer in rats. It serves to analyze the efficacy of ultrasound treatment, providing insights into possible cancer therapies. Rigorous methods, such as experimental design and statistical analysis, are critical components of the research.
3) Table:
Tables in the document present organized data, specifically illustrating the results obtained from the study. They show variables like body weight and tumor weight, serum enzyme levels, and antioxidant levels in different groups of rats. Tables help summarize complex data, enabling easier comprehension and comparison of experimental results.
4) Animal:
The term animals refers to the group of Wistar rats used in the study. Their use is crucial for conducting reliable preclinical experiments that help researchers understand the implications of therapeutic interventions. Ethical considerations when using animals are essential to ensure humane treatment in scientific experiments.
5) New Delhi:
New Delhi serves as a significant location in the research context, housing institutions involved in biomedical engineering and ethics committees. The presence of advanced medical research facilities in New Delhi contributes to the overall credibility and operational framework of the study, facilitating scientific advancements and ethical oversight.
6) Species:
The term species refers to a specific group of organisms capable of interbreeding. In this study, the focus is on Wistar rats, a species commonly used in laboratory experiments due to their genetic uniformity and well-documented biology. Their use is important for consistent, reproducible research findings.
7) Delhi:
Delhi, as a capital city of India, is significant in the study as it represents a hub for scientific research and education. Institutions in Delhi contribute to advancements in biomedical engineering, facilitating international collaborations and knowledge transfer that are essential for the progress of medical science.
8) India:
India is the geographic and socio-cultural context of the study. It reflects the local significance of cancer research and treatment advancements. The study exemplifies India's emerging role in biomedical research, addressing health challenges through innovative approaches like ultrasound therapy, which could benefit its diverse population.
9) Discussion:
The discussion section of the study interprets and analyzes the results obtained. It contextualizes findings within existing literature, evaluates the mechanisms of ultrasound therapy on sarcoma, and offers insights into future research directions. This portion is crucial for understanding the implications of the study for clinical applications.
10) Activity:
Activity refers to the biological processes and responses evaluated in the study, particularly relating to tumor growth and treatment effects. The term encompasses the metabolic and biochemical changes occurring within treated rats, providing insights into how ultrasound influences cancer pathology and potential therapeutic outcomes.
11) Company:
The mention of the company, Chattanooga Corp, reflects the commercial aspect of the ultrasound equipment used in the study. It signifies reliance on specific brands in research, highlighting the importance of quality equipment in experimental settings which can impact the study's validity and reliability.
12) Nature:
Nature encompasses the biological and physiological aspects of life forms, including the cancer biology investigated in the study. Understanding the nature of cancer cells and the response to ultrasound therapy is fundamental for developing effective treatment strategies. It also underscores the relationship between treatment and biological responses.
13) Saxena (Saksena, Sakshena):
Saxena refers to one of the co-authors of the study, contributing valuable expertise in the field of biomedical engineering. His collaboration is indicative of the interdisciplinary nature of the research, emphasizing the importance of diverse perspectives in scientific investigations and advancing knowledge concerning therapeutic applications.
14) Indian:
Indian highlights the national context of the research, showcasing contributions to global health issues. The study's findings may influence cancer treatment practices within India, promoting local advancements in medical science and the role of indigenous researchers in addressing national health challenges.
15) Joshi (Josi):
Joshi is another co-author involved in the study, contributing specific knowledge and skills essential for the research's execution. Authorial collaboration, as represented by Joshi, illustrates the combined effort of multiple experts, enriching the study with diverse perspectives, methodologies, and analytical approaches to ultrasound therapy.
16) Death:
Death serves as a critical endpoint in the broader discussion of cancer outcomes. The study explores the potential of ultrasound therapy to mitigate life-threatening conditions such as cancer, emphasizing the urgency for effective treatments to prolong life and enhance the quality of care for cancer patients.
17) House:
The term house in this context is related to the Central Animal House where the rats were sourced for the study. Such facilities are crucial for maintaining laboratory animals under controlled conditions, ensuring ethical treatment and proper health protocols essential for credible research outcomes.
18) Blood:
Blood is significant in the study as it is a medium for assessing biochemical markers and enzymatic activity relevant for evaluating the effects of ultrasound therapy. Blood samples provide essential data that aid in understanding the systemic response of the rats to treatment, linking physiological changes to cancer progression.
19) Nakar:
Nagar is part of 'Murad Nagar', the location cited in the context of the author's affiliation. Its mention shows the geographical context of the research team and highlights the importance of local expertise in conducting the study, rooting both the research and its implications within specific communities.
20) Maya (Maya°):
Maya refers to one of the study's authors, indicating the collaborative nature of research in this field. The inclusion of multiple authors such as Maya illustrates the diversity of expertise and perspective necessary for comprehensive research efforts in cancer therapeutics and its implications.
21) Sam (Sham):
Sham denotes a control group in experimental research, used to differentiate the effects of the actual treatment from placebo effects. Its inclusion in the study design is vital for establishing baseline comparisons, ensuring that the effects observed are specifically due to ultrasound therapy rather than other variables.
22) Post:
Post in this context refers to the evaluation of results after treatment. The post-treatment analysis is critical to drawing conclusions from the study, providing insights into the efficacy of ultrasound therapy and establishing a foundation for future investigational research or clinical applications.
Other Science Concepts:
Discover the significance of concepts within the article: ‘A study on therapeutic effects of ultrasound for the treatment of sarcoma cancer’. Further sources in the context of Science might help you critically compare this page with similair documents:
Statistical analysis, Oxidative stress, Reactive oxygen species, Electromagnetic radiation, Therapeutic ultrasound, One-way analysis of variance (ANOVA), Morphological change, Non-enzymatic antioxidant.