Pharmacokinetics of once-daily and immediate-release dextromethorphan.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Pharmacokinetics of once-daily and immediate-release dextromethorphan.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Study (Studying):
The study refers to a structured investigation carried out to evaluate the pharmacokinetics of sustained-release dextromethorphan hydrobromide compared to immediate-release formulations. It’s essential for understanding how the drug behaves in the body over time and contributes to the development of more effective treatment options.

2) Drug:
Drugs encompass a wide range of therapeutic agents, including dextromethorphan hydrobromide. The study focuses on the development, analysis, and pharmacokinetics of these agents, contributing to the broader field of pharmaceutical sciences and medication efficacy.

3) Table:
The table, particularly in pharmacological studies, typically presents organized data such as pharmacokinetic parameters or comparison results between different drug formulations. It helps in simplifying complex data interpretation and is crucial for communicating findings effectively in scientific literature.

4) India:
India serves as the geographical context for the study, highlighting the local relevance of the research. The absence of sustained-release dextromethorphan products in its pharmaceutical market indicates opportunities for innovation and development in drug formulation catered to Indian healthcare needs.

5) Blood:
Blood plays a critical role in pharmacokinetic studies as it is the medium through which drugs are distributed, metabolized, and eliminated in the body. Blood plasma concentration measurements help determine the drug's therapeutic effect and potential side effects in healthy volunteers.

6) Water:
Water is essential in laboratory and clinical studies for sample preparation, including the dissolution of drugs or dilution of reagents. The use of purified water ensures that no impurities interfere with the pharmacokinetic analysis or other experimental results.

7) Quality:
Quality in this context refers to the validation of analytical methods and the accuracy of pharmacokinetic data. Ensuring the quality of results is paramount in pharmaceutical studies as it directly impacts drug safety, efficacy, and regulatory approval processes.

8) House:
The word 'house' pertains to the in-house preparation of the test formulations, indicating that the sustained-release dextromethorphan tablets were developed and manufactured within a specific pharmaceutical facility. This highlights the significance of local manufacturing expertise in drug development.

9) Pharmacology:
Pharmacology is the branch of medicine concerned with the study of drugs and their effects on biological systems. This study contributes to the field by examining the pharmacokinetics of dextromethorphan, which informs therapeutic applications and further research in drug delivery systems.

10) Science (Scientific):
Scientific relates to the systematic inquiry underpinning the research methodology and analysis of the dextromethorphan study. It emphasizes the rigor, reproducibility, and evidence-based conclusions essential for advancing pharmacological and medical knowledge.

11) Divi:
Divi refers to Divi's Laboratories, the company that provided the key ingredient, dextromethorphan hydrobromide, for the study. Collaborations with pharmaceutical companies are essential in research as they supply necessary compounds and support the development of new therapeutic formulations.

12) Male:
Male refers to the gender of the healthy volunteers participating in the study. The selection of a homogeneous group helps eliminate variability related to sex, ensuring that pharmacokinetic results can be accurately attributed to the drug's formulation rather than differences between genders.

13) Life:
Life signifies the fundamental objective of pharmacological research — to improve life quality through effective medications. The study's focus on pharmacokinetics aims to optimize treatment protocols, which could lead to better management of conditions like cough and anxiety.

14) Measurement:
Measurement indicates the process of quantifying specific pharmacokinetic parameters such as Cmax and Tmax. It is vital to ensure these metrics are defined accurately for comprehensive drug profiling and understanding the pharmacological profile of dextromethorphan.

15) Discussion:
Discussion refers to the section of the article where study results are interpreted and implications are drawn. This part is crucial for placing findings in the context of existing literature, acknowledging limitations, and suggesting future research avenues.

16) Relative:
Relative in this case highlights the importance of comparative analysis between the sustained-release and immediate-release forms of dextromethorphan. Understanding the relative pharmacokinetic profiles aids in assessing the benefits and drawbacks of different drug formulations.

17) Gujarat:
Gujarat indicates the specific region in India from where the internal standard Losartan potassium was sourced. Regional sourcing is important for ensuring standardized supplies in research and can reflect localized pharmaceutical capabilities and regulatory environments.

18) Mysore:
Mysore is mentioned as the location associated with the research facilitator, His Holiness Jagadguru Sri Sri Shivarathree Deshikendra Mahaswamigalavaru, reflecting the involvement of local institutions in supporting scientific research efforts within the pharmaceutical field.

19) Purity:
Purity refers to the quality of the substances used in the study, particularly regarding the dextromethorphan hydrobromide. High purity is vital for ensuring the reliability of research findings and confirming that results are due solely to the drug under investigation.

20) Nature:
Nature may refer to the intrinsic qualities and behaviors of drugs, particularly in a pharmacokinetic context. Understanding the nature of how a drug acts within biological systems is fundamental to developing effective therapeutics and understanding their effects on patients.

21) Medium:
In this context, medium could also pertain to the means through which pharmacokinetic data is collected and analyzed. It indicates the tools and methodologies employed to evaluate drug metabolism and pharmacodynamics within human subjects.

22) Rajan:
Rajan refers to one of the authors associated with the study, indicating a collaborative effort in the research process. Author collaboration is essential in science to combine expertise and enhance the comprehensiveness of pharmacological investigations.