Phytochemical and antifungal activity of cleome rutidosperma plant extracts

| Posted in: Science

Journal name: World Journal of Pharmaceutical Research
Original article title: Phytochemical and antifungal activity of cleome rutidosperma plant extracts
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
This page presents a generated summary with additional references; See source (below) for actual content.

Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

Mullai Nila K. and Karthikeyan J.


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Phytochemical and antifungal activity of cleome rutidosperma plant extracts

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20181-10509

Copyright (license): WJPR: All rights reserved


Download the PDF file of the original publication


Summary of article contents:

Introduction

The study investigates the antifungal properties of methanol and aqueous leaf extracts of Cleome rutidosperma, commonly known as the "Fringed Spider Flower." Conducted by Mullai Nila K. and Karthikeyan J., this research aims to address the increasing threat posed by fungal infections and the need for effective natural antifungal agents. The study highlights the significance of medicinal plants in traditional medicine as sources of therapeutic compounds, particularly in combating microbial resistance to synthetic drugs.

Antifungal Activity of Cleome rutidosperma

The research employed the disc diffusion method to evaluate the antifungal activity of Cleome rutidosperma extracts against three fungal species: Aspergillus niger, Mucor indicus, and Rhizopus microsporus. The results indicated a significantly higher antifungal efficacy of the methanol extract compared to the aqueous extract. Within the methanol extract, the concentration of 100 mg/ml showed the largest zones of inhibition, thus suggesting a robust antifungal potential due to the presence of specific phytochemicals. In contrast, the aqueous extract demonstrated minimal antifungal activity, underscoring the superior antimicrobial properties associated with the methanol solvent.

Phytochemical Analysis

Preliminary phytochemical screening of the leaf extracts revealed the presence of various bioactive compounds, including alkaloids, flavonoids, steroids, and phenolic compounds in the methanol extract. Notably, flavonoids and phenolic compounds were identified as the primary constituents likely responsible for the observed antifungal activity. Conversely, the aqueous extract was found to primarily contain phenols and saponins, which correlated with its lower antifungal effectiveness. The study implies that the varied phytochemical composition of these extracts can significantly influence their biological activities.

Importance of Natural Antifungals

The findings of this study are critical amid rising antifungal resistance globally. Given that current antifungal therapies often fall short against invasive fungal infections, the potential of natural compounds derived from medicinal plants presents a promising avenue for developing new treatments. The bioactive compounds in Cleome rutidosperma, particularly phenolics, may act by disrupting cellular processes in fungi, thereby providing a safer and environmentally friendly alternative to conventional antifungal agents that are increasingly facing resistance issues.

Conclusion

In conclusion, Cleome rutidosperma exhibits significant antifungal activity through its methanol leaf extract, with key components believed to be phenolic compounds. The research underlines the potential for isolating and characterizing these antifungal agents for medicinal use, thereby contributing valuable insights into the development of new therapeutic options against fungal diseases. The study advocates for further exploration of natural plant extracts, enhancing their relevance in modern pharmacology for their untapped medicinal potential.

FAQ section (important questions/answers):

What plant was studied for its antifungal activity?

The study focused on *Cleome rutidosperma*, commonly known as Fringed Spider Flower, and its potential antifungal properties against specific fungi.

What method was used to test antifungal activity?

The disc diffusion method was employed to test the antifungal activity of both methanol and aqueous extracts of *Cleome rutidosperma* against various fungi.

Which fungi were tested in this study?

The antifungal activity was tested against *Aspergillus niger, Mucor indicus,* and *Rhizopus microsporus*.

What extracts showed significant antifungal activity?

The methanol extract displayed considerable antifungal activity, while the aqueous extract showed minimal or no activity against the tested fungi.

What compounds were found in the methanol extract?

The methanol extract contained alkaloids, flavonoids, cardiac glycosides, phenols, tannins, and proteins, which may contribute to its antifungal activity.

What is the potential application of this research?

Isolation and characterization of the phenolic compounds may lead to new therapeutic agents for treating fungal diseases, leveraging their antifungal properties.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Phytochemical and antifungal activity of cleome rutidosperma plant extracts”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Activity:
The term 'activity' in a scientific context often refers to a measurable effect or response exhibited by a substance, like the antifungal activity observed in the study. Here, it denotes the ability of Cleome rutidosperma extracts to inhibit the growth of specific fungal pathogens, highlighting its potential as an antifungal agent in research and therapeutic applications.

2) Flavonoid:
Flavonoids are a class of plant secondary metabolites known for their wide range of biological activities, including antifungal properties. In the study, their presence in the methanol extract of Cleome rutidosperma suggests they play a crucial role in mediating antifungal activity, making them a point of interest for drug discovery.

3) Water:
Water serves as the solvent for aqueous extraction of plant materials, highlighting its importance in the study's methodology. The study contrasts the antifungal efficacy between methanol and water extracts, demonstrating how solvent choice influences the extraction of bioactive compounds and their subsequent biological activities.

4) Table:
Tables in research articles organize and present data clearly, allowing for easy comparison and interpretation of results. In this study, tables detail the antifungal activities of the different extracts on specific fungi, providing essential quantitative insight into the effectiveness of Cleome rutidosperma's extracts.

5) Phytochemical:
Phytochemicals are bioactive compounds derived from plants that exhibit health benefits, including antimicrobial effects. The study emphasizes the phytochemical screening of Cleome rutidosperma extracts, highlighting the research focus on understanding which compounds are responsible for observed antifungal activity and their potential therapeutic applications.

6) Chennai:
Chennai, the capital of Tamil Nadu, India, is significant as the geographic location where the plant Cleome rutidosperma was collected for the study. Understanding regional biodiversity contributes to identifying and utilizing local medicinal plants for potential health benefits, such as the antifungal properties explored in this research.

7) Disease:
The plural term 'diseases' encompasses various conditions caused by pathogens, including fungal infections. The highlighted research aims to find effective treatments for such diseases through the antifungal properties of Cleome rutidosperma, addressing the global challenge of treating resistant strains of infectious diseases.

8) Study (Studying):
In a scientific context, 'study' refers to a systematic investigation aimed at discovering new knowledge or confirming existing information. This document encompasses a study on the antifungal activity of Cleome rutidosperma, exploring the plant's medicinal potential, methodology, and implications for future drug development.

9) India:
India is recognized for its rich biodiversity and numerous indigenous medicinal plants. The study emphasizes the importance of exploring Indian flora, specifically Cleome rutidosperma, to discover natural alternatives to conventional antifungal agents, thus contributing to global health efforts and sustainable medicinal practices.

10) Tamilnadu (Tamil-nadu):
Tamil Nadu is a state in India famed for its extensive traditional medicine practices and rich biodiversity. The relevance of this study stems from its focus on a plant indigenous to this region, showcasing the potential of Tamil Nadu's flora in contributing to modern medical science.

11) Nature:
In this context, 'nature' refers to the natural world and its abundant resources, specifically medicinal plants. The study's emphasis on extracting therapeutic compounds from Cleome rutidosperma underscores the importance of nature in providing solutions to health issues like fungal infections.

12) Powder:
The term 'powder' describes the form in which the dried leaves of Cleome rutidosperma were processed. This fine powder was critical for extraction procedures, as it increases the surface area for solvent interaction, ultimately leading to a more effective extraction of bioactive phenolic compounds.

13) Tamil:
Tamil refers to the language spoken predominantly in Tamil Nadu, India. While not directly related to the scientific content, this cultural aspect ties to regional identity and highlights the study's local focus, affirming the significance of native medicinal plants within Tamil culture and health practices.

14) Drug:
The singular form 'drug' indicates a specific substance used for medical purposes. In the context of this research, the study seeks to identify natural compounds from Cleome rutidosperma that could function as effective antifungal agents, potentially leading to new drug development and therapeutic applications.

15) Nadu:
Nadu is part of 'Tamil Nadu,' referring to the state in India where the study took place. The significance lies in the local biodiversity and the wealth of medicinal plants available for research, including Cleome rutidosperma, which is crucial for understanding regional sources of alternative medicines.

16) Substance:
The term 'substances' refers to the various chemical compounds identified in the study, specifically those analyzed during phytochemical screening. Understanding these substances is crucial for recognizing their potential health benefits, particularly in combating infections through the antifungal properties of Cleome rutidosperma extracts.

17) Heating:
Heating is a physical process often used in extraction methods to enhance solvent activity and dissolve bioactive compounds. In this study, controlled heating is employed during the aqueous extraction of Cleome rutidosperma to facilitate the release of phytochemicals, which directly impacts the extract's efficacy against fungi.

18) Zoology:
Zoology, the study of animals, is the academic department associated with the authors of the study. The relevance lies in the interdisciplinary approach this research represents, merging plant sciences with zoological studies, reflecting the broad range of applications of medicinal plants across biological fields.

19) Antibiotic (Antibacterial):
Antibacterial refers to the capability of a substance to fight against bacterial infections. While the focus of this study is antifungal activity, previous findings on Cleome rutidosperma's antibacterial properties encourage further exploration of its broader antimicrobial potential and applications in treating various infectious diseases.

20) Chemotherapy:
Chemotherapy typically refers to the treatment of diseases, especially cancer, using chemical substances. Although the term is most commonly associated with cancer treatments, it connects to this study by emphasizing the need for effective and non-toxic alternatives to current therapies, highlighting the potential of plant-derived compounds.

21) Purification:
Purification is a process of isolating specific compounds from a mixture. In this study, the purification of bioactive compounds from Cleome rutidosperma is critical for identifying and characterizing those that exhibit antifungal properties, promoting the development of new therapeutic agents based on natural extracts.

22) Discussion:
The discussion section of a research paper interprets and contextualizes findings. In this study, it emphasizes the implications of the antifungal activity of Cleome rutidosperma extracts and situates these findings within existing literature, enhancing the understanding of the plant's potential in combating fungal infections.

23) Container:
A 'container' refers to a vessel used for holding substances during experimentation. In this study, containers are used for the extraction process of Cleome rutidosperma leaves, facilitating the separation of active compounds from the plant material, which are essential for assessing antifungal activity.

24) Medicine:
The term 'medicine' encompasses the field of health care involving the treatment of illnesses through various means. This study contributes to the field by examining the antifungal potential of Cleome rutidosperma, which may serve as a foundation for developing new medicinal formulations against fungal infections.

25) Species:
In biological classification, 'species' refers to a group of organisms capable of interbreeding. Cleome rutidosperma is identified as a species within the Cleomaceae family, and the study focuses on its unique properties and potential applications in medicine, particularly concerning its antifungal activity.

26) Mullai:
Mullai Nila K. is one of the authors of the study, and her contribution is significant in establishing credibility and guiding the research presented. Understanding the background and expertise of contributors helps readers appreciate the study's depth and context within the scientific community.

27) Family:
In biological taxonomy, 'family' is a classification rank used to group related species. Cleome rutidosperma belongs to the Cleomaceae family, and understanding family relationships is essential for exploring phylogenetic traits, ecological roles, and the broader medicinal potential of related plant species.

28) Spider:
In this context, 'spider' relates to the common name 'Fringed Spider Flower' for Cleome rutidosperma, which visually resembles a spider due to its flower structure. This nomenclature highlights the significance of common names in conveying botanical characteristics and fostering public interest in plant-based research.

29) Karka:
Karka, or in full form 'Cleome karka,' refers to another species within the Cleome genus. The inclusion of Karka suggests a comparative aspect in understanding the variation among species in the Cleomaceae family, potentially uncovering diverse medicinal applications and benefits.

30) Sugar:
Sugar denotes a type of carbohydrate that can be tested for in plant extracts. In the study, the presence of reducing sugars was analyzed as part of the phytochemical screening process, indicating the nutritional and therapeutic properties that may enhance the health benefits of the plant extracts.

31) Nila:
Nila is a part of Mullai Nila K., one of the authors of the study. The mention of individual contributors underscores the significance of collaborative research in advancing knowledge within the field and highlights the importance of interdisciplinary efforts in the exploration of medicinal plants.

32) Viru:
While the term 'Viru' does not appear explicitly in the given text, it could refer to elements in the study related to pharmacological or biological aspects of plants. It symbolizes the underlying themes of exploring life sciences and the medicinal properties derived from nature for health advancements.

Other Science Concepts:

[back to top]

Discover the significance of concepts within the article: ‘Phytochemical and antifungal activity of cleome rutidosperma plant extracts’. Further sources in the context of Science might help you critically compare this page with similair documents:

Medicinal plant, Disc diffusion method, Zone of inhibition, Antifungal activity, Aqueous extract, Secondary metabolite, Phytochemical studies, Aspergillus niger, Methanol extract, Bioactive compound, Extraction procedure, Synthetic drug, Phenolic compound, Preliminary chemical analysis, Natural plant.

Let's grow together!

I humbly request your help to keep doing what I do best: provide the world with unbiased sources, definitions and images. Your donation direclty influences the quality and quantity of knowledge, wisdom and spiritual insight the world is exposed to.

Let's make the world a better place together!

Like what you read? Help to become even better: