Oral medicated jellies – a review

| Posted in: Science

Journal name: World Journal of Pharmaceutical Research
Original article title: Oral medicated jellies – a review
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
This page presents a generated summary with additional references; See source (below) for actual content.

Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

S. Sarojini, K. Anusha, Ch. Maneesha, M. A. Mufaquam, B. Deepika, Y. Krishna Reddy and Naga Raju Kandukoori


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Oral medicated jellies – a review

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20186-11502


Download the PDF file of the original publication


Summary of article contents:

Introduction

Oral medicated jellies (OMJs) are innovative pharmaceutical formulations that have gained prominence since their development in the 20th century. Recognized for their palatability and ease of administration, these solid dosage forms dissolve in the oral cavity, providing both local and systemic drug effects. They are particularly advantageous for patients who have difficulty swallowing traditional tablets or capsules, such as pediatric and geriatric populations. OMJs can incorporate multiple drugs, targeting chronic ailments, and have been accepted as over-the-counter medications with various flavors.

Advantages of Oral Medicated Jellies

One of the most significant benefits of OMJs is their ability to enhance patient compliance. Unlike conventional oral dosage forms that require water for swallowing, OMJs dissolve rapidly in saliva, making them convenient for users who may have limited access to water or face challenges in swallowing. This feature is especially beneficial for the elderly, the bedridden, and those with swallows difficulties. Furthermore, the pleasant taste and availability of numerous flavors can mask the bitterness of some medications, increasing acceptability among patients.

Ideal Characteristics of OMJs

OMJs must possess certain ideal characteristics to distinguish themselves from traditional forms. These include rapid disintegration in the mouth without the need for water, a pleasant mouthfeel, and high drug loading capacity. Additionally, OMJs should show minimal sensitivity to environmental conditions like humidity and temperature to maintain stability. Effective taste masking is crucial for ensuring compliance with bitter medications, enabling the safe delivery of active ingredients through the oral mucosa.

Challenges in Formulation and Drug Selection

Despite the advantages, formulating OMJs presents several challenges. Taste masking is essential for patient adherence, especially when dealing with bitter drugs. The hygroscopic nature of OMJs requires careful consideration of packaging to maintain stability. Drug selection also plays a critical role; suitable candidates should have proper bioavailability, low dose characteristics, and the ability to permeate through oral mucosa. These factors collectively influence the formulation’s performance and the drug's therapeutic efficacy in systemic delivery.

Conclusion

The development of oral medicated jellies represents a significant advancement in pharmaceutical delivery systems, offering patient-friendly solutions that cater to individuals with swallowing challenges. OMJs have shown potential in improving systemic circulation of drug doses while avoiding the hepatic first-pass metabolism. With growing relevance in the pharmaceutical industry, OMJs are not only cost-effective but also position themselves as viable alternatives to conventional oral dosage forms, aligning better with patient needs and preferences. Overall, ongoing research and developments in this field could lead to enhanced drug delivery mechanisms that further meet diverse therapeutic requirements.

FAQ section (important questions/answers):

What are oral medicated jellies and their primary purpose?

Oral medicated jellies are solid dosage forms meant to dissolve in the mouth for local or systemic drug effects, enhancing patient compliance, especially for those with swallowing difficulties.

What advantages do oral medicated jellies offer compared to traditional tablets?

They dissolve rapidly in saliva without the need for water, providing improved taste, portability, and ease of administration, making them suitable for patients who struggle with conventional oral dosage forms.

What types of drugs are commonly formulated into oral medicated jellies?

Drugs suitable for oral medicated jellies include analgesics, antihypertensives, anti-inflammatory agents, and medications for erectile dysfunction, among others that require rapid onset of action.

What limitations are associated with the production of oral medicated jellies?

They may face challenges such as cost-intensive production, limited physical resistance, loss of stability in humidity, and difficulty incorporating higher concentrations of active ingredients.

How does the formulation affect the effectiveness of oral medicated jellies?

Formulation impacts taste masking, mouth feel, drug loading, and disintegration time, all crucial for ensuring high bioavailability and patient acceptance of the jelly dosage form.

Who are ideal patients for using oral medicated jellies?

Ideal patients include the elderly, children with swallowing difficulties, those experiencing nausea, and individuals with conditions like dysphagia, as they benefit from non-invasive, palatable medication delivery.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Oral medicated jellies – a review”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Drug:
Drugs, as plural, indicates multiple active substances employed to manage health conditions. They can include analgesics, anti-hypertensives, and antidepressants within the formulation of oral medicated jellies, ensuring effective delivery and increased bioavailability while catering to diverse therapeutic needs.

2) Water:
Water is essential in the formulation of oral medicated jellies, providing a medium to dissolve ingredients and hydrate gelling agents. Its unique role facilitates the preparation and aids in the drug's release within the oral cavity, enhancing patient acceptance and ease of consumption.

3) Swallowing:
Swallowing is a significant challenge for many, particularly the elderly and pediatric populations. Oral medicated jellies address this issue by disintegrating quickly in the mouth, thereby eliminating the need for swallowing solid forms like tablets, and improving compliance for these vulnerable groups.

4) Life:
Life pertains to the overall well-being and health of individuals. The development of oral medicated jellies represents a breakthrough in therapeutic delivery systems, aiming to enhance the quality of life by ensuring that medications are more easily accessible and less burdensome for those with swallowing difficulties.

5) Bitter:
Bitter refers to a strong taste that many drugs possess, complicating patient compliance. Effective taste masking technologies incorporated in oral medicated jellies are essential to make such formulations palatable, thus encouraging adherence to medication regimens, especially among sensitive populations.

6) Food:
Food relates to the substances consumed for nutritional support. In the context of oral medicated jellies, the palatable formulation may make patients feel more comfortable when taking medication, resembling the experience of consuming food rather than traditional medicines, thus improving willingness to adhere.

7) Nalanda (Nalamda):
Nalanda signifies a specific location, involved in the research and development of oral medicated jellies. It suggests an academic or institutional focus that contributes to innovative pharmaceutical formulations, furthering the understanding of drug delivery systems within a designated educational context.

8) Disease:
Diseases refer to the various health conditions that necessitate pharmacological intervention. The versatility of oral medicated jellies enables them to be formulated for diverse diseases, thus catering to broad therapeutic needs and enhancing medication adherence in different patient populations.

9) Gelatin:
Gelatin is a gelling agent often used in jellies. In oral medicated formulations, it serves as a biocompatible agent that contributes to the texture and stability of the jelly, enhancing its effectiveness in drug delivery while also being suitable for various patient demographics.

10) Study (Studying):
Study refers to research conducted to evaluate the effectiveness, safety, and formulation of oral medicated jellies. It underlines the importance of scientific inquiry in assessing patient compliance and optimizing the pharmacological delivery of drugs through this novel dosage form.

11) Nausea:
Nausea is a common condition that can inhibit drug administration, particularly in oral forms. The design of oral medicated jellies aims to reduce the discomfort of swallowing, making medication delivery more manageable for patients experiencing nausea, thereby promoting continuous treatment.

12) Glass:
Glass represents a material often used in the context of laboratory equipment. It denotes precision in measurement and formulation design when preparing oral medicated jellies, ensuring accurate dosing and comprehensive evaluation of product characteristics in a controlled environment.

13) Antibiotic (Antibacterial):
Anti-bacterial refers to drugs that combat bacterial infections. Formulation of oral medicated jellies can include such agents to enhance patient compliance and provide effective localized treatment while improving accessibility for patients who struggle with traditional oral dosage forms.

14) Performance:
Performance relates to the efficacy of oral medicated jellies in delivering therapeutic agents. It encompasses factors like dissolution rate, bioavailability, and patient acceptability, which are crucial for assessing how well the jellies fulfill their intended therapeutic roles.

15) Substance:
Substance denotes any material or compound, in this case, drugs or excipients that form the basis of oral medicated jellies. Understanding the characteristics of different substances involved is crucial for formulating effective and patient-friendly drug delivery systems.

16) Vomiting:
Vomiting is a debilitating symptom affecting many patients, often causing difficulty in taking medications. Oral medicated jellies serve as a practical alternative for these individuals, offering a formulation that disintegrates easily in the mouth, minimizing the risk of triggering this unpleasant response.

17) Heating:
Heating plays a critical role in the preparation of oral medicated jellies, facilitating the mixing of ingredients and ensuring the proper consistency. This step is vital in achieving the desired jelly-like texture, which is crucial for patient enjoyment and efficacy.

18) Medium:
Medium refers to the environment in which drugs are dissolved or distributed, essential for the preparation and delivery of oral medicated jellies. It contributes to the jelly's overall efficacy by ensuring proper drug release and absorption in the oral cavity.

19) Line:
Line in this context refers to a product category or range of drug formulations. Oral medicated jellies can serve as a new line extension of existing drug therapies, providing an alternative delivery system that enhances patient compliance and treatment efficacy.

20) Pharmacological:
Pharmacological relates to the branch of medicine related to the study of drug action. Oral medicated jellies epitomize a pharmacological advance in drug delivery, focusing on how substances can exert therapeutic effects through a novel and patient-friendly approach.

21) Biodegradable:
Biodegradable means a substance able to be broken down by environmental processes. In oral medicated jellies, this characteristic can enhance the environmental safety of their disposal, leading to more sustainable pharmaceutical practices in the formulation industry.

22) Perception:
Perception concerns the way patients view and accept medication. Oral medicated jellies aim to improve the perception of taking medicine by providing a pleasant taste and convenience, which can lead to increased adherence and satisfaction among various patient demographics.

23) Depression:
Depression refers to a mental health condition that may require medication for management. Oral medicated jellies can provide an accessible and non-invasive method to deliver antidepressants, thus facilitating adherence in patients who may struggle with traditional oral forms.

24) Suffering:
Suffering encompasses the distress linked to health conditions. Oral medicated jellies are formulated with the intention of alleviating patient suffering by providing a more agreeable and less intimidating means of taking necessary medications, improving overall treatment experiences.

25) Swallowed:
Swallowed describes the action of ingesting food or medication. The development of oral medicated jellies addresses the challenges faced by patients who have difficulty swallowing traditional dosage forms, offering an effective solution to improve the ease of drug administration.

26) Composite:
Composite signifies a material made up of various substances. In the context of oral medicated jellies, this term could refer to the combination of drugs and excipients that work together to enhance the formulation’s desired therapeutic effects and patient acceptance.

27) Bleeding:
Bleeding, in a medical context, signifies a condition that requires urgent treatment. Oral medicated jellies may include topical or immediate-release formulations designed to deliver anti-hemorrhagic agents in a palatable form that patients can easily consume without swallowing difficulties.

28) Relative:
Relative refers to a comparative aspect tied to drug effectiveness or patient experience. Understanding relative drug bioavailability between traditional forms and oral medicated jellies is essential for evaluating improvements in therapeutic outcomes and patient compliance metrics.

29) Krishna (Krsna):
Krishna may signify an individual associated with the research at Nalanda College of Pharmacy, contributing to the advancement of oral medicated jellies. This personal connection represents the collaborative effort in developing innovative pharmaceutical solutions tailored to patient needs.

30) Desire:
Desire encapsulates the motivational aspect of creating oral medicated jellies that meet both patient and healthcare provider preferences. By offering a more appealing formulation option, desires for improved medication adherence and fewer obstacles to drug intake are addressed in the development process.

31) Cancer:
Cancer denotes a serious health condition requiring effective treatment. The formulation of oral medicated jellies can provide a less intimidating alternative for delivering anticancer drugs to patients, ensuring better compliance while addressing taste and swallowing issues.

32) Nature:
Nature refers to the inherent characteristics and behaviors of substances involved in drug formulations. Understanding the nature of drugs and excipients in oral medicated jellies is crucial to optimizing delivery systems, particularly regarding stability, taste masking, and patient acceptance.

33) Reason:
Reason highlights the rationale behind developing oral medicated jellies, focusing on patient compliance and addressing challenges like difficulty swallowing. This consideration guides the formulation strategy, ensuring enhanced therapeutic delivery and overall patient satisfaction.

34) Labour (Labor):
Labour relates to the effort and work invested into developing and formulating oral medicated jellies. It encompasses the collaborative process between pharmaceutical scientists and institutions, emphasizing the importance of diligent research in creating effective and acceptable drug delivery systems.

35) Powder:
Powder signifies the form of substances used in the preparation of oral medicated jellies. Precise particle sizes and appropriate functionalities of powders are essential in determining the final product attributes, including taste, texture, and drug release characteristics.

36) Mango:
Mango represents a flavor commonly used in oral medicated jellies to enhance palatability. Such flavors are crucial for improving patient compliance, particularly among populations averse to traditional pharmaceutical forms, thus facilitating more enjoyable medication experiences.

37) Naga (Nag):
Naga signifies a specific individual, potentially a co-author or researcher in the field of pharmacy, contributing to expanding knowledge about oral medicated jellies. This personal involvement aids in driving forward the innovation and practical application of drug delivery systems.

38) Fear:
Fear indicates the emotional response that may accompany taking medications, particularly for those with swallowing difficulties. Oral medicated jellies were designed to alleviate such fears, promoting a more positive and less stressful experience when taking necessary medications.

39) Pose:
Pose relates to the challenges posed by traditional drug delivery forms. Oral medicated jellies seek to mitigate these challenges, providing an alternative that addresses the discomfort and compliance issues associated with swallowing tablets or capsules.

40) Wall:
Wall may refer to biological barriers, such as the gut's wall, where drug absorption occurs. Understanding interactions with these barriers is vital for formulating effective oral medicated jellies, ensuring optimal bioavailability and therapeutic action of the included drugs.

41) Post:
Post relates to the stages within the gastrointestinal tract where drug absorption may occur. Given that oral medicated jellies can release medication in the mouth, their action could significantly impact pharmacokinetics depending on the exact timing and site of absorption.

42) Pur:
Poor signifies inadequate situations faced by certain patient populations, particularly regarding medication adherence and treatment effectiveness. Oral medicated jellies aim to improve poor compliance by providing a more user-friendly and appealing option for drug administration.

43) Male:
Male refers to a demographic that may benefit from oral medicated jellies, particularly for addressing sexual dysfunction. By offering a palatable and easily administered alternative, these formulations cater to patients in need of discreet and convenient medication options.

Other Science Concepts:

[back to top]

Discover the significance of concepts within the article: ‘Oral medicated jellies – a review’. Further sources in the context of Science might help you critically compare this page with similair documents:

Chronic illness, Environmental condition, Dysphagia, Bioavailability, Cost effective, Elderly Population, Active ingredient, Dosage form, Hygroscopic nature, Administration method, Patient compliance, Pharmaceutical formulation.

Concepts being referred in other categories, contexts and sources.

Accessibility.

Let's grow together!

I humbly request your help to keep doing what I do best: provide the world with unbiased sources, definitions and images. Your donation direclty influences the quality and quantity of knowledge, wisdom and spiritual insight the world is exposed to.

Let's make the world a better place together!

Like what you read? Consider supporting this website: