Pharmacognostic and pharmaceutical analysis of Virechana Yoga for psoriasis.
Journal name: World Journal of Pharmaceutical Research
Original article title: Pharmacognostical and pharmaceutical analysis of virechana yoga in the management of ekakustha w.s.r psoriasis
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Ritika Mishra, Prof. A. B. Thakar, Dr. Harisha C. R. and Dr. Shukla V. J.
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World Journal of Pharmaceutical Research:
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Full text available for: Pharmacognostical and pharmaceutical analysis of virechana yoga in the management of ekakustha w.s.r psoriasis
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20188-11953
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Summary of article contents:
Introduction
Psoriasis is a chronic autoimmune skin disease characterized by red, scaly patches that may appear on various body parts. It is associated with an accelerated growth cycle of skin cells and is estimated to coincide with the Ayurvedic condition known as Ekakustha. The treatment of such conditions in Ayurveda often emphasizes a comprehensive approach, particularly through Shodhana therapies that help eliminate accumulated Doshas. The present work focuses on the pharmacognostical and pharmaceutical analysis of Virechana Yoga, a formulation recognized in the Charak Samhita for treating Ekakustha.
The Significance of Virechana Yoga
Virechana Yoga comprises five components: Amalaki, Bibhitaki, Haritaki, Trivrit, and Danti. These herbs are known for their astringent and purgative properties, which are particularly suitable for addressing the imbalances characteristic of Kustha and Ekakustha. The methodology for the preparation of Virechana Yoga involved sourcing these dried ingredients, grinding them into coarse powder, and then combining them to form the final product. The importance of this formulation lies in its traditional recognition for detoxifying the body, especially in cases involving excessive Rakta and Pitta dosha.
Pharmacognostical Analysis
The pharmacognostical study of Virechana Yoga revealed several significant constituents through a detailed microscopy examination. Notable features included the presence of bordered pitted vessels from Danti and Trivrit, oil globules, and stone cells from Bibhitaki and Haritaki. Such microscopic characters affirm the authenticity of the components and contribute to understanding the efficacy of the formulation in treating skin ailments like psoriasis. Organoleptic analysis further provided insights into the product's quality, determining sensory attributes such as color, odor, and taste.
Physico-Chemical Properties
Physico-chemical analysis is crucial for standardizing any medicinal formulation. For Virechana Yoga, key parameters like loss on drying, pH, and ash value were assessed, yielding results that affirm its stability and quality. The pH value of 6.5 and a loss on drying of 9.39% indicate a well-preserved formulation suitable for therapeutic use. Moreover, High-Performance Thin Layer Chromatography (HPTLC) analysis revealed distinct spots indicating the presence of various active compounds within the formulation, hence confirming its complex chemical profile.
Conclusion
The study of Virechana Yoga highlights the need for rigorous quality control in Ayurvedic formulations to ensure their safety and efficacy. The pharmacognostical and physicochemical assessments demonstrated the purity and integrity of the formulation, establishing it as a reliable option for managing diseases like Ekakustha. These findings not only provide a reference for future research but also contribute to the broader understanding of Ayurvedic practices and their relevance in modern herbal therapeutics. Further studies could build on these results, broadening the scope of its application in clinical settings.
FAQ section (important questions/answers):
What is the relation between psoriasis and Ekakustha in Ayurveda?
Psoriasis is correlated with Ekakustha in Ayurveda, characterized by dry, scaly patches resembling psoriatic plaques. Both conditions involve an accumulation of doshas and can be treated with Ayurvedic methods.
What is Virechana Yoga used for in Ayurvedic treatment?
Virechana Yoga is a detoxification treatment aimed at eliminating excess doshas, particularly Pitta and Rakta. It is indicated for conditions like Kushtha, including Ekakustha (psoriasis), to improve overall skin health.
What are the primary components of Virechana Yoga?
Virechana Yoga consists of five key drugs: Amalaki, Bibhitaki, Haritaki, Trivrit, and Danti. These herbs are known for their purgative properties and effectiveness in treating skin diseases.
How was the pharmacognostical study of Virechana Yoga conducted?
The pharmacognostical study included organoleptic assessments and microscopic analysis to identify key characteristics. Microscopic examinations confirmed the presence and authenticity of the active ingredients.
What physicochemical properties of Virechana Yoga were analyzed?
Physicochemical analyses measured loss on drying, ash value, pH, and extractability in solvents. Results confirmed the formulation's quality, indicating its suitability for medicinal use.
What did the HPTLC study reveal about Virechana Yoga?
The HPTLC study revealed eight distinct spots at both 254 nm and 366 nm, indicating the presence of various active constituents in Virechana Yoga and aiding in its standardization.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Pharmacognostic and pharmaceutical analysis of Virechana Yoga for psoriasis.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Yoga:
In the context of Ayurvedic practices, 'Yoga' refers to a therapeutic formulation or method, often involving a combination of herbal ingredients aimed at restoring balance and health. In this study, Virechana Yoga is analyzed for its potential effectiveness in treating Ekakustha, a form of psoriasis.
2) Trivrit (Tri-vrit, Trivrt):
Trivrit, or Operculina turpethum, is an important herb used in Ayurvedic medicine for its purgative properties. In the formulation of Virechana Yoga, Trivrit contributes significantly to the therapeutic effects aimed at alleviating conditions such as Ekakustha by promoting detoxification and clearing the body's doshas.
3) Study (Studying):
The term 'study' in this article encompasses the systematic investigation into the pharmacognostical and pharmaceutical properties of Virechana Yoga. The study aims to establish quality control measures and therapeutic efficacy related to treating Ekakustha, thereby contributing to the broader field of Ayurvedic medicine and research.
4) Danti (Damti, Dantin):
Danti, or Balinospermum montanum, is a root used in Ayurveda for its medicinal properties, particularly its ability to purify the body. In the formulation of Virechana Yoga, Danti plays a critical role in addressing excess pitta and rakta doshas, which are thought to exacerbate skin conditions like Ekakustha.
5) Mishra (Misra):
Dr. Ritika Mishra is the lead author and PG Scholar responsible for conducting the research in this study. Her work focuses on the pharmacognostical analysis of Virechana Yoga, contributing to a greater understanding of its efficacy in the management of Ekakustha and overall Ayurvedic formulations.
6) Pharmacognostical:
Pharmacognostical refers to the study of the medicinal properties of plants and their usage in herbal medicine. In this research, pharmacognostical analysis is employed to evaluate the active constituents of Virechana Yoga, ensuring the formulation's safety, efficacy, and authenticity for treating Ekakustha.
7) Drug:
The term 'drugs' refers to the individual herbal components that make up Virechana Yoga. Each drug contributes specific therapeutic qualities that collectively aid in managing pitta and rakta doshas in conditions like Ekakustha, reflecting the holistic nature of Ayurvedic treatment.
8) Haritaki:
Haritaki, or Terminalia chebula, is a significant herb in Ayurveda, known for its numerous health benefits including detoxification and anti-inflammatory properties. Its inclusion in Virechana Yoga is critical for managing pitta doshas, encouraging balance and alleviating symptoms associated with Ekakustha.
9) Gujarat:
Gujarat, the location of Gujarat Ayurved University, is central to this research, providing the institutional framework for the study. The university's emphasis on traditional Ayurvedic methods contributes to the exploration of Virechana Yoga as a treatment option for chronic skin diseases like Ekakustha.
10) Ayurveda (Ayus-veda):
Ayurveda is an ancient Indian system of medicine focused on holistic health and the balance of mind, body, and spirit. The article emphasizes Ayurvedic principles, particularly in utilizing Virechana Yoga for treating Ekakustha, integrating herbal therapies within a traditional medical framework.
11) Amalaki:
Amalaki, or Emblica officinalis, is a key ingredient in Ayurvedic medicine attributed to its rejuvenating and antioxidant properties. In Virechana Yoga, Amalaki enhances the formulation's effectiveness by helping to balance doshas and improve skin health, particularly in the context of Ekakustha.
12) Kushtha (Kustha):
Kustha refers to a specific category of skin diseases in Ayurveda. Ekakustha is classified under Kustha, and this research seeks to explore how Virechana Yoga can provide a traditional Ayurvedic approach to managing such chronic skin conditions.
13) Table:
Tables in the study present organized data on organoleptic characteristics and physicochemical parameters of Virechana Yoga. These tables facilitate easy comparison and analysis of the formulation's properties, which are crucial for standardizing the drug for therapeutic applications.
14) Ekakushtha (Ekakustha, Eka-kushtha):
Ekakushtha is another spelling variant of the same Ayurvedic term for psoriasis-like skin disorders. The study focuses on this condition to evaluate and validate the effectiveness of Virechana Yoga in managing chronic skin conditions within Ayurvedic practice.
15) Quality:
Quality is central to pharmaceutical formulations and refers to the consistency, effectiveness, and safety of the product. The study emphasizes the importance of quality control in standardizing Virechana Yoga as a viable treatment for Ekakustha.
16) Water:
Water is an essential solvent in the preparation and analysis of Ayurvedic formulations, including Virechana Yoga. Its role is critical during pharmacognostical studies, where water is used to dissolve the herbs for microscopic examination and to evaluate solubility parameters.
17) Shodhana (Sodhana):
Shodhana is a detoxification process in Ayurveda that involves purging excess doshas from the body. It is considered a vital first-line treatment for Ekakustha, highlighting the need for cleaning the body to manage chronic skin conditions effectively.
18) Disease:
In this context, 'disease' references Ekakustha, a chronic skin condition resembling psoriasis. Understanding the disease's nature and its Ayurvedic classification is paramount for developing targeted treatments such as Virechana Yoga to address its symptoms and underlying causes.
19) Purity:
Purity relates to the absence of contaminants and the authenticity of the herbs used in a formulation. The study aims to ensure the purity of Virechana Yoga through pharmacognostical analysis, which is essential for the safety and efficacy of Ayurvedic treatments.
20) Powder:
In Ayurvedic formulations, 'powder' signifies the processed form of herbs used to create medicines. The ingredients of Virechana Yoga are ground into a coarse powder, which is vital for easy dosing and enhanced bioavailability during therapeutic applications.
21) Phala:
Phala translates to 'fruit' in Sanskrit and refers here to the parts used from the herbs in Virechana Yoga. Recognizing the correct parts of each drug, such as Phala from Haritaki and Bibhitaki, is essential for maintaining effectiveness in the formulation.
22) Dosha (Dosa):
In Ayurveda, doshas denote the three fundamental forces—Vata, Pitta, and Kapha—that govern human physiology. The study emphasizes the importance of managing imbalances in doshas, especially pitta and rakta in Ekakustha, through herbal formulations like Virechana Yoga.
23) Observation:
Observation in the study pertains to the systematic assessment of Virechana Yoga's physical and chemical properties. Careful observations made during pharmacognostical studies provide critical data on the formulation's composition and efficacy, guiding future research directions.
24) Samhita:
Samhita refers to classical texts or scriptures in Ayurveda that provide foundational knowledge. The research draws information from Ayurvedic classics, particularly the Charak Samhita, to justify the use of Virechana Yoga in treating Ekakustha and supporting its therapeutic principles.
25) Surface:
Surface characteristics are critical when conducting microscopic analysis of herbal preparations. The study includes surface observations under microscopy to identify unique features of the ingredients in Virechana Yoga, which has implications for determining their efficacy.
26) Nature:
Nature refers to the inherent qualities and characteristics of the ingredients used in Virechana Yoga. Understanding the nature of each component helps in predicting their behavior and effects when combined, particularly in the context of treating Ekakustha.
27) Pitta:
Pitta is one of the three doshas in Ayurveda, associated with heat and metabolism. This study emphasizes the management of pitta dosha, which is believed to be aggravated in Ekakustha, thus requiring attention in the formulation of Virechana Yoga.
28) Rakta:
Rakta, meaning blood in Ayurveda, is another dosha linked to conditions like Ekakustha. The study focuses on the influence of Virechana Yoga in balancing rakta dosha levels, contributing to the management and treatment of skin diseases and overall health.
29) Terminalia chebula:
Terminalia chebula, known as Haritaki in Ayurveda, is a key ingredient in Virechana Yoga known for its detoxifying and rejuvenating properties. Its role is essential for alleviating symptoms associated with pitta dosha excess in conditions like Ekakustha.
30) Accumulation (Accumulating, Accumulate):
Accumulate relates to the gathering of doshas leading to the manifestation of diseases. The study aims to demonstrate how Virechana Yoga functions to accumulate and eliminate excess doshas, thus preventing further progression of Ekakustha.
31) Inflammation:
Inflammation is a biological response linked to chronic conditions like psoriasis. The study explores how Virechana Yoga can help manage inflammation associated with Ekakustha through its cleansing and balancing actions on the body’s doshas.
32) Performance:
Performance in this context refers to the effectiveness of Virechana Yoga in achieving its intended therapeutic outcomes. Evaluating the formulation through pharmacognostical and pharmaceutical analysis reveals its performance in treating skin disorders like Ekakustha.
33) Measurement:
Measurement pertains to quantitative and qualitative assessments made during the analysis of Virechana Yoga. Such assessments are crucial for establishing standards and quality control necessary for effective treatment protocols in Ayurvedic medicine.
34) Discussion:
Discussion in the study encompasses the interpretation of findings from pharmacognostical and physical analyses of Virechana Yoga. It serves to contextualize results within existing Ayurvedic literature and provides implications for future research and practical applications.
35) Vitiation (Vitiated):
Vitiation refers to the alteration or imbalance of doshas, which can lead to disease. The research addresses vitiation in relation to Ekakustha, examining how Virechana Yoga aids in rectifying these imbalances and promoting skin health.
36) Mustadi (Musta-adi):
Mustadi refers to a specific term used in Ayurveda, likely indicating a herbal preparation or method relevant to the study. Its mention may involve comparisons or historical contexts regarding the treatment of skin disorders like Ekakustha.
37) Harisha (Harisa):
Harisha is mentioned as one of the authors of the study. As an expert in the field, their contributions may involve insights into pharmacognosy that are fundamental to understanding the composition of Virechana Yoga and its applications.
38) Vikara:
Vikara, similar to Vikaras, refers specifically to the conditions or changes that indicate disease. The investigation into Vikara through Virechana Yoga seeks to clarify how therapies can address the manifestations of Ekakustha effectively.
39) Ruksha (Ruksa):
Ruksha, meaning dry or rough in Sanskrit, pertains to the characteristics of skin conditions like Ekakustha. The study explores how Virechana Yoga, with its specific properties, can address the Ruksha nature of lesions that are typical of psoriasis.
40) Shukla (Sukla):
Shukla, often associated with clarity or brightness, may refer to the purity of the ingredients used in the formulation. In Ayurvedic practice, ensuring Shukla qualities in treatments like Virechana Yoga is essential for achieving therapeutic success.
41) Sukshma (Suksma, Shukshma):
Suksma refers to the subtle qualities of herbs that contribute to their therapeutic effects. The study emphasizes recognizing Suksma properties of ingredients in Virechana Yoga to better assess their efficacy and role in treating conditions such as Ekakustha.
42) Laghu:
Laghu translates to 'light' and denotes a key property of certain Ayurvedic drugs that enhance digestibility and metabolism. The inclusion of Laghu qualities in Virechana Yoga helps enhance its effectiveness in cleaning the body and managing Ekakustha.
43) Tikta:
Tikta means 'bitter' in Sanskrit and describes a taste associated with certain herbs used in Virechana Yoga. Tikta properties are important for stimulating digestive health and purifying the blood, aligning with the treatment goals of Ekakustha.
44) India:
India is the birthplace of Ayurveda and the context within which this study is situated. The traditional knowledge systems developed in India form the basis of the methods and practices being analyzed, particularly in formulations like Virechana Yoga.
45) Ghana:
Ghana generally refers to density or compactness in Ayurvedic formulations. In the context of the study, it may refer to the substance's characteristics assessed to determine their potential effects on health and the treatment of disorders like Ekakustha.
46) Hand:
Hand refers to the act of manual practice and application of treatments in Ayurvedic medicine. The significance of hand signifies personalized care in treatments like Virechana Yoga, emphasizing the practitioner's role in ensuring effective therapeutic outcomes.
47) Roga:
Roga means disease or illness in Sanskrit. In the context of this study, Roga highlights the focus on skin diseases like Ekakustha, which the formulation Virechana Yoga aims to treat through Ayurvedic principles and practices.
48) Guna:
Guna translates to 'qualities' and is fundamental in Ayurveda, referring to the inherent attributes of substances. Guna influences how herbs affect doshas and health, which is pivotal in evaluating the properties of the drugs included in Virechana Yoga.
49) Sign:
Sign refers to indicators or manifestations of health conditions. In this study, understanding the signs associated with Ekakustha is essential for establishing diagnostic criteria and effective treatment protocols through the use of Virechana Yoga.
50) Line:
Line, in this context, suggests the primary or principal treatment strategy. The study adopts a line of treatment philosophy rooted in Ayurvedic techniques, focusing on detoxification methods such as Shodhana to support health.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Pharmacognostic and pharmaceutical analysis of Virechana Yoga for psoriasis.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Dosha, Pitta, Kushtha, Rakta, Ekakushtha, Chikitsa, Charak Samhita, High performance thin layer chromatography, Physico-chemical analysis, Microscopic study, Pharmacognosy, Chronic autoimmune disease, Organoleptic study, Pharmaceutical analysis, Physicochemical Parameter, Virechana Yoga.