Synthesis and study of Co, Ni, Cu complexes with novel tetradentate ligand.
Journal name: World Journal of Pharmaceutical Research
Original article title: Designing, synthesis and spectroscopic studies of co(ii), ni(ii) and cu(ii) transition metal complexes with nitrogen donor tetradentate, novel macrocyclic schiff’s base ligand
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Sumedha Gupta, Dr. Usha Bansal and Dr. Bhupendra Kumar Sarma
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Designing, synthesis and spectroscopic studies of co(ii), ni(ii) and cu(ii) transition metal complexes with nitrogen donor tetradentate, novel macrocyclic schiff’s base ligand
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20189-12187
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
This research paper discusses the synthesis, characterization, and spectral studies of novel macrocyclic Schiff base ligands and their transition metal complexes, specifically Co(II), Ni(II), and Cu(II). The Schiff base ligand, 3,11-dibromo-1,5,9,13-tetraazacyclohexadeca-1,4,9,12-tetraene, is derived from the condensation of bromomalonaldehyde and 1,3-diaminopropane. The study emphasizes the importance of these complexes in various applications, such as catalysis, biological models, and photochemistry, and provides detailed analyses through techniques like elemental analysis, magnetic susceptibility, and various spectral studies.
Spectral Characterization of Ligands
The macrocyclic Schiff base ligand was characterized using a combination of techniques, including IR, 1H NMR, and mass spectrometry. The IR spectrum indicated important functional groups, such as azomethine (C=N) at 1599 cm-1, confirming successful condensation. The 1H NMR spectrum further delineated proton environments, indicating the presence of -C=N- linkages and other molecular characteristics. These findings validate the structure of the synthesized ligand and its potential utility in forming stable metal complexes.
Transition Metal Complex Formation
The study systematically investigates the formation of transition metal complexes such as [M(L)X₂] with M being Co(II), Ni(II), or Cu(II), and X being various anions like Cl⁻, CH₃COO⁻, and SO₄²⁻. Each complex was synthesized by refluxing the corresponding metal salt with the Schiff base ligand in ethanol. Physical characteristics, including yield percentages and melting points, were recorded, and elemental analysis confirmed the anticipated compositions. The complexes exhibited non-electrolytic behavior based on their molar conductance measurements, indicative of the ligand's coordination to metal ions through nitrogen donor atoms.
Magnetic and Electronic Properties
Magnetic susceptibility measurements and electronic spectral studies provided insights into the geometries of the transition metal complexes. Co(II) and Ni(II) complexes displayed octahedral geometries, whereas the Cu(II) complexes were analyzed to possess a tetragonal geometry, with the [Cu(L)(SO₄)] complex potentially exhibiting square pyramidal or trigonal bipyramidal characteristics. The study also evaluated ligand field parameters, demonstrating significant covalent character in the complexes, signified by values of the Nephelauxetic parameter (β). EPR studies further confirmed the geometrical arrangements and electronic behavior of the metal ions in solid-state complexes.
Conclusion
In conclusion, the synthesized macrocyclic Schiff base ligands and their corresponding transition metal complexes exhibit promising properties for various scientific applications. The thorough characterization through multiple analytical techniques confirms that the ligands coordinate effectively with metal ions, forming stable complexes. The research contributes valuable insights into the potential use of these metal complexes in catalysis and biological systems, with ongoing implications for drug design and molecular modeling. Future studies may explore the biological activities of these complexes, expanding their applicability in medicinal chemistry.
FAQ section (important questions/answers):
What is the focus of the study conducted by Gupta et al.?
The study focuses on the design, synthesis, and characterization of Co(II), Ni(II), and Cu(II) transition metal complexes with a novel macrocyclic Schiff base ligand.
How were the Schiff base ligands synthesized in this research?
The ligands were synthesized through the condensation of 1,3-diaminopropane with bromomalonaldehyde, followed by refluxing in ethanolic solution for 14 hours.
What techniques were used to characterize the synthesized complexes?
Characterization techniques included elemental analysis, IR spectroscopy, UV-Vis spectroscopy, EPR spectra, and magnetic susceptibility measurements.
What is the coordination mode of the synthesized ligand?
The ligand coordinates to metal ions in a tetradentate manner through four nitrogen atoms from the azomethine groups.
What geometries were assigned to the complexes based on spectral studies?
Cobalt and nickel complexes were assigned octahedral geometry, while copper complexes proposed various geometries, including five-coordinated trigonal bipyramidal for [Cu(L)SO₄].
What applications are associated with the macrocyclic Schiff base complexes?
These complexes have potential applications in catalysis, photochemistry, biological systems, and as models for biologically important proteins and enzymes.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Synthesis and study of Co, Ni, Cu complexes with novel tetradentate ligand.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Gupta:
Gupta refers to Sumedha Gupta, the lead author of the research article. Her contributions include the synthesis and characterization of macrocyclic Schiff base ligands and their metal complexes. This research is crucial in the field of coordination chemistry and understanding the applications of these complexes in biological systems and pharmaceuticals.
2) Table:
Tables are used in scientific research to present data clearly and concisely. In this article, various tables summarize analytical results, physical properties, and spectral data of synthesized complexes. Proper organization of data in tables aids readers in quickly grasping key findings and comparisons between different compounds.
3) Nature:
Nature often refers to the inherent characteristics of materials or substances being studied. In this context, it is relevant to the non-electrolytic nature of the synthesized macrocyclic Schiff base complexes, indicating their behavior in solution and potential applications in various chemical processes.
4) Field:
Field can refer to a scientific discipline or area of study. The research presented resides within the field of chemistry, particularly coordination chemistry and the characteristics of transition metal-ligand complexes. Understanding these fields is essential for applications in catalysis, drug development, and materials science.
5) Delhi:
Delhi, the capital of India, is home to many educational and research institutions. The authors suggest that the affiliations, such as Zakir Husain Delhi College, reflect the academic environment where collaborative research like this takes place, contributing to the advancement of scientific understanding in the region.
6) India:
India is the country where this research was conducted. The local chemical industry and academic institutions play a significant role in developing and synthesizing chemical compounds, including drugs and complexes. India's diverse flora and fauna also provide a rich source for biological activities related to these compounds.
7) Measurement:
Measurements, the plural of measurement, encompass various quantitative assessments taken during experiments. They include techniques like molar conductance measurements, which indicate the electrolytic nature of complexes. Accurate measurements are fundamental in chemistry, influencing the understanding of metal-ligand interactions and their applications in different fields.
8) Study (Studying):
Study denotes the in-depth research and investigation conducted by the authors regarding macrocyclic Schiff base ligands and their complexes. It involves synthesizing, characterizing, and analyzing these compounds to elucidate their properties and potential applications in pharmaceuticals, which is significant for advancing chemical science.
9) Chittorgarh:
Chittorgarh is a city in Rajasthan, India, where one of the authors is affiliated, specifically Mewar University. The city's educational institutions contribute to research and development in chemistry, fostering academic collaborations that lead to studies like this one on macrocyclic Schiff base ligands.
10) Discussion:
Discussion in a research article is where authors interpret their findings, elaborate on the significance of their results, and relate them to previous work. In this paper, the discussion addresses the implications of synthesized compounds and how structural characteristics correlate with observed properties.
11) Rajasthan:
Rajasthan is a state in India where the research was conducted. The geographic and cultural aspects of Rajasthan may influence local academic institutions and their research focuses. The cooperation between various universities in Rajasthan enhances the scientific exchange of knowledge and advancements in fields like chemistry.
12) Salt (Salty):
Salt, in this context, refers to the metal salts used to synthesize the metal-ligand complexes, such as Co(II), Ni(II), and Cu(II) salts. The choice of salts is crucial as they serve as the primary source of metal ions in coordination chemistry, influencing the properties of the final complexes.
13) Bombay:
Bombay, now known as Mumbai, is where IIT Bombay is located. This prestigious institution provides advanced analytical services, including EPR spectroscopy. Collaborations with institutions like IIT Bombay enhance the research by offering access to sophisticated technology and expertise vital for characterizing complex compounds.
14) New Delhi:
New Delhi is the capital city of India and a significant center for academic and research institutions. It is relevant as the article mentions affiliations with institutions located in New Delhi, which enhances the research collaboration between various universities and contributes to advancements in chemical research.
15) Antibiotic (Antibacterial):
Antibacterial refers to the biological properties of certain compounds that inhibit bacterial growth. In the research context, the macrocyclic Schiff base ligands may exhibit antibacterial activities, which makes them potential candidates for drug development. The exploration of biological activities is crucial for medicinal chemistry advancements.
16) Calculation:
Calculation in scientific research involves deriving specific numerical values or parameters based on experimental data. In this paper, calculations relate to ligand field parameters, magnetic susceptibility, and electronic spectral data, which are essential for understanding the electronic environment around metal ions in complexes.
17) Sharman (Sarma, Sharma, Sarman):
Sarma refers to Dr. Bhupendra Kumar Sarma, one of the co-authors of the study. His role, along with other authors, highlights collaborative efforts in conducting and authoring the research, signifying the importance of teamwork in scientific endeavors to produce comprehensive findings and analyses.
18) Kumar:
Kumar is a common surname in India, and in this paper, it is associated with Dr. Bhupendra Kumar Sarma. It signifies the role of the co-author in the research team, emphasizing the collaborative nature of scientific studies where multiple researchers contribute their expertise.
19) Drug:
Drug, in this context, refers specifically to pharmaceutical compounds that aid in diagnosing, curing, or preventing diseases. The synthesized ligand complexes are explored for their potential therapeutic applications, emphasizing the importance of drug development in the broader context of biomedical sciences.
20) Usa (Usha):
Usha refers to Dr. Usha Bansal, a co-author of the research work. Like other authors, she contributes academic expertise to this research, underlining collaborative efforts in the synthesis and characterization of pharmaceutical compounds, which further the field of coordination chemistry.
21) Miṇi (Mini):
Mini here likely refers to the Shimadzu Mini UV-Visible spectrophotometer used in the study for measuring electronic spectra. The miniaturization of analytical equipment allows researchers to conduct experiments with higher efficiency and portability, which is especially valuable in laboratory environments.
22) Line:
Line, in a scientific context, could refer to a line of data, graphical representation, or a specific output result for measurements and spectrums, such as absorption lines in spectral data. The clarity in representing data points aids in analyzing and understanding complex results.
23) Hand:
Hand may symbolize the traditional methods or basic manual techniques involved in chemical synthesis or analysis. In this research context, it emphasizes the blend of modern instrumentation and classical methodologies, illustrating how both are essential in scientific research and laboratory work.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Synthesis and study of Co, Ni, Cu complexes with novel tetradentate ligand.’. Further sources in the context of Science might help you critically compare this page with similair documents: