Pharmaceutico-analytical study of kanta lauha bhasma
bio-synthesized traditional nanoparticles using classical and modern methods
Journal name: World Journal of Pharmaceutical Research
Original article title: Pharmaceutico-analytical study of kanta lauha bhasma
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Subtitle: bio-synthesized traditional nanoparticles using classical and modern methods
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Dr. Nikhil Chaudhari and Dr. Ninad Sathe
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Pharmaceutico-analytical study of kanta lauha bhasma
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20189-12066
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
The study presented examines the preparation and analysis of Kanta Lauha Bhasma, a traditional Ayurvedic formulation that involves the processing of magnetite iron ore. The objective was to compare two different methods of producing this formulation: the classical method of Gajaputa and the modern Electromagnetic Field (EMF) technique. The researchers aimed to evaluate the quality of both Bhasmas through various pharmaceutical and analytical tests after completing multiple incineration cycles.
The Importance of Proper Preparation
The preparation of Lauha Bhasma is a complex procedure that involves detoxifying the iron to ensure its biocompatibility and proper absorption in the body. Any poorly prepared Bhasma can lead to hazardous health effects, making the quality of the final product critically important. The study meticulously outlines the processes involved in the initial purification (Shodhana) of Kanta Lauha, including both general and special treatments to detoxify the metal. The aim is to make a Bhasma that is safe and effective for addressing various health issues.
Evaluation of Bhasma Quality
The efficacy of Kanta Lauha Bhasma relies heavily on its physical properties, such as particle size and surface area, which influence bioavailability in the gastrointestinal tract. In this research, Kanta Lauha was prepared using two distinct methods, and qualitative analysis revealed that the Bhasma produced via the Gajaputa method exhibited a smaller particle size (22.1 nm) compared to the EMF method (27.5 nm) after the tenth incineration cycle. These findings suggest that the Gajaputa method may yield a more effective formulation due to enhanced absorption characteristics.
Analytical Techniques and Findings
The final product of Kanta Lauha Bhasma was analyzed using various classical and advanced analytical techniques, including scanning electron microscopy (SEM) and traditional organoleptic tests. The results showed that both samples passed necessary quality assessments; however, the Gajaputa sample consistently demonstrated superior physical attributes. For instance, the particles of Gajaputa Bhasma were more uniform and smaller in size, possibly contributing to its better quality as compared to the EMF sample.
Conclusion
The comparative analysis of Kanta Lauha Bhasma prepared using classical Gajaputa and modern EMF methods underscores the significance of traditional practices in the field of nanotechnology in contemporary medicine. The study reinforces the notion that proper manufacturing techniques can drastically affect the therapeutic quality of Ayurvedic formulations. Ultimately, the research supports the continued exploration and integration of traditional methodologies in modern scientific validation processes, highlighting their relevance in developing effective healthcare solutions.
FAQ section (important questions/answers):
What is the main objective of the study on Kantalauha Bhasma?
The study aimed to evaluate the quality of Kantalauha Bhasma prepared using two methods: classical Gajaputa and modern Electric Muffle Furnace (EMF), by comparing their pharmaceutical and analytical characteristics.
What materials were used in the preparation of Kantalauha Bhasma?
Raw Kantalauha was used, along with Kaddalikanda (Musa paradisiaca corm), Gomutra (cow urine), Goghrita (cow ghee), and Triphala Bharada (coarse powder) during the preparation process.
What are the outcomes of the laboratory analysis for both samples?
The SEM analysis revealed that the Kantalauha Bhasma prepared via Gajaputa had a particle size of 22.1nm, while the EMF sample had 27.5nm, indicating a finer quality for the Gajaputa method.
How were the organoleptic characters of Kantalauha Bhasma evaluated?
Organoleptic parameters such as color, taste, touch, and odor were assessed throughout the 10 puta processes, demonstrating changes that align with the desired characteristics of refined Bhasma.
What is the significance of 'Bhasmikarana' in the preparation process?
'Bhasmikarana' refers to the incineration of metals into a detoxified, biocompatible form, which enhances bio-absorption. Proper execution is crucial for producing safe and effective medicinal formulations.
Which preparation method yielded better quality Kantalauha Bhasma?
Kantalauha Bhasma prepared using the classical Gajaputa method demonstrated better quality, with reduced particle size and superior characteristics compared to that made using the Electric Muffle Furnace method.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Pharmaceutico-analytical study of kanta lauha bhasma”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Kantalauha (Kanta-lauha):
Kanta-lauha is another designation for kantalauha, denoting specific qualities derived from traditional iron preparations in Ayurveda. It emphasizes the focus on particular iron sources like magnetite, which are processed to derive effective bhasma for medicinal use, showcasing a nuanced approach to Ayurvedic formulations.
2) Bhasma (Bhasman):
Bhasma is a term for the incinerated and detoxified form of metals in Ayurveda, representing a key factor in the preparation of medicinal compounds. It emphasizes safety, biocompatibility, and enhanced absorption when converted into very fine particles, which facilitates its therapeutic application in treating diverse health conditions.
3) Puta:
Puta refers to the incineration process used in preparing bhasma. It denotes the stages of heating and treating raw materials until they reach an ash-like form, thus transforming metals into a safer, bioavailable state for use in Ayurvedic medicines while preserving their therapeutic properties.
4) Gajaputa (Gaja-puta):
Gajaputa is a classical incineration method mentioned in ancient Ayurvedic texts. It involves the use of cow dung cakes in a designated pit for heating and processing metals into bhasma. This traditional method is believed to result in a superior quality of bhasma compared to modern methods.
5) Shodhana (Sodhana):
Shodhana signifies the purification processes undertaken before the preparation of bhasma in Ayurveda, encompassing techniques that eliminate toxins and enhance the safety of raw materials. It is crucial for transforming crude metals into a therapeutically viable form by ensuring they are detoxified before further processing.
6) Goghrita (Goghrta, Go-ghrita):
Goghrita, or cow ghee, is a fundamental ingredient in Ayurvedic formulations, valued for its nourishing properties and ability to facilitate the absorption of herbs and minerals. It is also used in specific processes like marana, where it is involved in the heating and preparing of kantalauha bhasma.
7) Lauha:
Lauha is the Sanskrit term for iron, often referenced in Ayurvedic texts regarding its use in medicinal forms. It is significant for its therapeutic properties and is transformed into bhasma, becoming integral in formulating remedies for various ailments based on its healing potential.
8) Pariksha (Pariksa):
Pariksha means examination or testing in Ayurveda, signifying the evaluation of various parameters that determine the quality and efficacy of prepared medicines. It ensures that bhasma meets specified standards before use, confirming its safety and therapeutic benefits through organoleptic and classical assessments.
9) Marana:
Marana refers to the incineration or calcination process through which metals, including lauha, are transformed into bhasma. It plays an essential role in Ayurveda to ensure the material is detoxified and made biocompatible, allowing it to be safely consumed for therapeutic purposes.
10) Triphala (Tri-phala):
Triphala is a popular Ayurvedic formulation made from three fruits: Amalaki, Bibhitaki, and Haritaki. Known for its detoxifying and rejuvenating properties, it is often used in the process of bhavana or wet trituration with herbal powders, enhancing absorption and therapeutic effectiveness.
11) Sharava (Sarava):
Sharava refers to an earthen saucer used in Ayurvedic practices, particularly during the sealing and thermal processing of herbal preparations. It is crucial for maintaining the integrity of the substances being processed during incineration or other heating methods to prevent contamination.
12) Samanya:
Samanya means general or common in the context of shodhana, denoting a classic purification method applied to raw materials like kantalauha. It implies employing well-documented techniques to ensure the detoxification process is thorough before the metal is further processed into bhasma.
13) Table:
Table signifies organized representations of data in the study, highlighting specific findings and observations related to the quality, physicochemical parameters, and outcomes of the bhasma preparation processes. It serves to effectively communicate results in a structured and easily understandable manner.
14) Study (Studying):
Study refers to the systematic investigation conducted to evaluate the quality of kantalauha bhasma prepared through classical gajaputa and modern EMF methods. It aims to provide scientific validation for Ayurvedic practices, contributing valuable insights into the effectiveness of traditional formulations.
15) Vishesha (Visesa):
Vishesha means specific or particular, especially in the context of shodhana, where particular purification techniques are applied to enhance the detoxification of substances like kantalauha. This term highlights the importance of tailored methods to ensure the safety and efficacy of Ayurvedic preparations.
16) Lauhabhasma (Lauha-bhasma):
Lauha-bhasma refers specifically to the bhasma prepared from iron. It indicates the transformed state of lauha after undergoing rigorous purification, incineration, and analytical evaluations, ensuring its therapeutic efficacy and safety for clinical applications in Ayurvedic medicine.
17) Quality:
Quality in this context refers to the standards met by the bhasma throughout its preparation and testing phases. It encompasses purity, efficacy, and bioavailability, which are critical for confirming the safety and therapeutic benefits of Ayurvedic medicines derived from metals like kantalauha.
18) Visheshashodhana (Visesasodhana, Vishesha-shodhana):
Vishesha-shodhana is a specific purification process in Ayurveda aimed at detoxifying and refining metals or minerals for medicinal use. It signifies in-depth, specialized methods that ensure raw materials like kantalauha are adequately prepared for safe incorporation into therapeutic formulations.
19) Varitara:
Varitara refers to one of the quality checks in the bhasma pariksha evaluating the hydrophilicity of the prepared bhasma. This parameter indicates whether the bhasma properly disperses in water, suggesting its potential effectiveness upon ingestion and relevance in Ayurveda for absorption in the gastrointestinal tract.
20) Bhavana (Bha-vana):
Bhavana denotes the wet trituration or levigation process in Ayurvedic medicine used to enhance the potency and efficacy of herbal formulations by mixing them with liquids, often to attain the desired texture and bioavailability in products like bhasma, significantly improving therapeutic action.
21) Pungent:
Pungent refers to one of the organoleptic properties that describe the sharp, strong taste associated with certain substances in Ayurvedic medicine. It is one of the sensory evaluations performed during the quality assessment of prepared bhasma, providing insights into its potential therapeutic effects.
22) Powder:
Powder refers to the fine form in which bhasma is finally obtained after the incineration and processing of raw materials. The particle size is crucial for ensuring effective bioabsorption and therapeutic action in the body, making it an important aspect of Ayurvedic preparations.
23) Rasashastra (Rasa-shastra, Rasasastra):
Rasashastra is the branch of Ayurveda that deals with the preparation of mineral and metal-based medicines. It encompasses techniques for purification, incineration, and formulation, bridging traditional practices with modern scientific understanding and validation, crucial for developing effective Ayurvedic treatments.
24) Bhaishajya (Bhaisajya):
Bhaishajya means 'medicine' in Sanskrit, representing the therapeutic substances prepared from herbal, mineral, and animal sources in Ayurveda. It underlines the holistic approach of Ayurveda, emphasizing the importance of safe and efficacious formulations made from carefully processed ingredients.
25) Science (Scientific):
Scientific refers to the methodological approach employed in the study of kantalauha bhasma, emphasizing the incorporation of rigorous testing, quantifiable analyses, and evidence-based assessments to validate the efficacy and safety of traditional Ayurvedic practices in contemporary medicine.
26) Mardana:
Mardana is the process of levigation in Ayurveda which involves grinding or triturating substances, enhancing their surface area for better absorption. This technique is significant for preparing bhasma, ensuring optimal consistency and effectiveness of the final product when consuming.
27) Gomutra (Go-mutra):
Gomutra refers to cow urine, recognized in Ayurveda for its purifying properties. It is often used in the preparatory processes of Ayurvedic formulations, particularly in shodhana, contributing to the detoxification and purification of ingredients like kantalauha for safe medicinal use.
28) Kalpana:
Kalpana signifies the preparation or formulation practices pursued in Ayurveda to create effective remedies. It reflects traditional knowledge and methodologies employed in crafting diverse medicinal products, including the meticulous processes of detoxifying and formulating bhasma like kantalauha.
29) Varna:
Varna means 'color' and is one of the organoleptic characteristics assessed during the quality examination of bhasma. It indicates the physical appearance of the product, which can provide insights into the processing integrity and quality assurance of the Ayurvedic preparation.
30) Ghi (Ghee):
Ghee, or clarified butter, is a staple in Ayurvedic formulations known for its nourishment and medicinal properties. It enhances the absorption of herbs and incorporated metals during traditional preparation, proving invaluable in the processes of bhavana and marana for kantalauha bhasma.
31) Samdhibandhana (Sandhibandhana, Sandhi-bandhana, Samdhi-bandhana):
Sandhibandhana refers to the sealing process in the preparation of bhasma, typically using clay or matted fabrics to prevent contamination and ensure proper processing during incineration. It is a vital step in maintaining the integrity and quality of Ayurvedic medicines like kantalauha bhasma.
32) Purification:
Purification in the context of Ayurvedic medicine involves methods emphasized during the preparation of substances like kantalauha. It ensures that raw materials are detoxified, made safe for use, and elevated to a state conducive to bioavailability, thus impacting their therapeutic effectiveness.
33) Observation:
Observation signifies the systematic recording of data and results noted during the study of kantalauha bhasma preparation. It encompasses various parameters evaluated throughout the experimental process, critical for ensuring reproducibility and understanding the quality of the final product.
34) Raktavarna (Rakta-varna):
Raktavarna, meaning 'red color,' refers to the specific hue often associated with kantalauha, derived from magnetite iron ore. This attribute is crucial for identifying the quality and type of iron being processed in Ayurvedic practices for medicinal formulations.
35) Bharjana:
Bharjana refers to roasting techniques in Ayurvedic medicine, wherein substances are subjected to high heat to promote detoxification and enhance the medicinal properties during the marana process. It is a critical step to convert raw materials into potent bhasma.
36) Nirvapa:
Nirvapa is a term describing the process of heating a substance to a red-hot state followed by rapid cooling to achieve detoxification in Ayurveda. This method is applied in shodhana to ensure the safety of metals like kantalauha before further processing to bhasma.
37) Shuddha (Suddha):
Shuddha refers to the term for 'pure' in Ayurveda, implying the desired state of detoxified substances after undergoing purification processes like shodhana. It indicates that the material is made safe for therapeutic use in formulations like bhasma and confirms its efficacy.
38) Surface:
Surface refers to the area of the bhasma particles which is significantly enlarged post-processing, enhancing bioavailability and absorption in the gastrointestinal tract. This is a critical factor explored in the study of kantalauha bhasma and its effectiveness in treatment applications.
39) Phala:
Phala means 'fruit' in Sanskrit, often used metaphorically in Ayurvedic texts to refer to the expected benefits or outcomes of using medicinal preparations. It suggests the therapeutic results anticipated from properly processed and formulated substances like kantalauha bhasma.
40) Darvi:
Darvi refers to a specific grinding instrument used in the mardana process of Ayurvedic preparations, crucial for achieving the desired consistency of powdered substances. Its use in the preparation of kantalauha ensures that the product meets necessary physical parameters for effective application.
41) Jambu:
Jambu refers to the fruit known for its medicinal properties, often used in Ayurveda as part of various formulations. In the context of the study, it highlights the holistic incorporation of herbal elements into bhasma preparation, enriching the therapeutic potential of kantalauha.
42) Sour:
Sour denotes a specific taste assessed during the organoleptic evaluation of Ayurvedic formulations. It reflects the flavor profile of certain components, contributing to their medicinal properties and demonstrating how various tastes are crucial in the holistic approach of Ayurveda towards healing.
43) Musa paradisiaca:
Musa paradisiaca is the scientific name for the banana plant, particularly its corm (underground stem), used in creating kaddalikanda swarasa (juice). In Ayurveda, it is essential for purification processes and contributes nutritional and therapeutic benefits in formulations involving kantalauha.
44) Cow urine (Cow's urine):
Cow urine, referred to as gomutra in Ayurveda, is utilized for its purifying properties in shodhana and other preparation processes. Its incorporation aids in the detoxification of metals like kantalauha, ensuring safer medicinal formulations in traditional Ayurvedic practices.
45) Cow dung:
Cow dung is integral to many traditional practices in Ayurveda, notably as a fuel source for incineration methods like gajaputa. Its use in these processes aids in managing the thermal environment necessary for transforming raw materials into effective herbal medicines.
46) Ayurvedaprakasha (Ayurvedaprakasa, Ayurveda-prakasha):
Ayurveda-prakasha is a foundational text that outlines various Ayurvedic principles and treatments, emphasizing the importance of proper formulation and safety when using bhasmas and other metal-based medicines. It serves as a reference for understanding the historical context of Ayurvedic practices.
47) Sharavasamputa (Sharava-samputa, Saravasamputa):
Sharava-samputa refers to the sealed condition of the earthen vessels after bhasma preparation. This critical step ensures the content is protected during the incineration process, maintaining the purity and enhancing the transformation of raw materials into therapeutic forms.
48) Khalvayantra (Khalva-yantra):
Khalvayantra refers to a specific grinding apparatus used in Ayurvedic practice for the mardana process. Employing this tool assists in finely grinding ingredients, enabling the preparation of powders with suitable consistency for effective therapeutic application in formulations like kantalauha bhasma.
49) Bhasmikarana:
Bhasmikarana refers to the process of making bhasma, transforming substances through incineration and purification. This essential procedure is central to Ayurvedic practices, representing the meticulous crafting needed to convert raw materials like metals into bioavailable forms suitable for therapeutic use.
50) Inflammation:
Inflammation signifies a potential side effect to consider when preparing Ayurvedic formulations. Recognizing how certain metals react during processing is essential to avoid adverse reactions, ensuring that the final medicinal products remain safe and effective for treating various conditions.
51) Discussion:
Discussion entails the analysis and interpretation of the findings after the experimentation phase of kantalauha bhasma preparation. It critically evaluates results, identifies correlations, and suggests implications for the efficacy of traditional methods in contemporary scientific contexts, aiming for enhanced understanding.
52) Ayurveda (Ayus-veda):
Ayurveda is an ancient system of medicine rooted in Indian philosophy and holistic health practices. It emphasizes the balance of body, mind, and spirit, offering comprehensive techniques for prevention and treatment using natural substances, including herbs, minerals, and therapies, for overall well-being.
53) Lakshana (Laksana):
Lakshana translates to 'characteristics' or 'signs'. In the context of Ayurveda, it defines the physical attributes or therapeutic properties exhibited by medicinal preparations. Recognizing lakshana is essential for assessing quality and efficacy, enabling practitioners to deliver effective treatments.
54) Prakasha (Prakasa):
Prakasha refers to the illumination or disclosure of knowledge in Ayurveda. It encompasses texts that expound on Ayurvedic principles, practices, and formulations, contributing to the understanding and application of traditional medicine in contemporary health contexts.
55) Putapaka (Puta-paka):
Putapaka is another term associated with the incineration process involved in bhasma preparation. It highlights the various stages of heating substances, crucial for achieving detoxification and the desired ash-like state for safe therapeutic usage in Ayurvedic formulations.
56) Disease:
Disease refers to the disruption of normal physiological functions requiring treatment or management. In Ayurveda, understanding the underlying imbalances leading to disease informs the formulation of tailored remedies like kantalauha bhasma, which aims to restore health through holistic means.
57) Samhita:
Samhita refers to classical texts of Ayurveda that compile essential knowledge regarding herbal medicine, formulations, and therapeutic practices. These texts serve as important references for practitioners and scholars in understanding and preserving traditional Ayurvedic approaches.
58) Sparsha (Sparsa):
Sparsha signifies touch as one of the organoleptic parameters evaluated during quality assessment. The tactile feedback provides insights into the texture and consistency of the bhasma, aiding in assessing whether the product meets necessary therapeutic standards.
59) Heating:
Heating is a critical process in the preparation of bhasma, which encompasses various stages of incineration and cooking necessary to transform raw materials into a medicinally active form. Controlled heating ensures adequate detoxification and enhances the efficacy of the final product.
60) Siddhi:
Siddhi indicates the achievement of success or desired goals in the Ayurvedic context, particularly signifying the accomplishment of optimal therapeutic properties in formulations. It ensures that the preparations undergo sufficient processing to fulfill the expected medicinal outcomes for health enhancement.
61) Gandha (Gamdha):
Gandha refers to the aroma or odor assessed during quality evaluations of Ayurvedic formulations. It contributes to the organoleptic profile and is crucial for determining the acceptance and efficacy of medicinal products, influencing user experience and treatment compliance.
62) Kanta (Kamta):
Kanta relates to quality attributes associated with materials in Ayurveda, particularly concerning their texture and processing. This aspect emphasizes the sensory evaluations that contribute to determining the suitability and effectiveness of herbal and metal-based formulations.
63) Avami:
Avami refers to the noticeable side effects or adverse reactions that may occur following the consumption of a medicinal substance. In Ayurvedic practices, understanding avami helps ensure that formulations like kantalauha bhasma are safe and free from harmful impacts.
64) Rasa (Rasha):
Rasa translates to taste and is fundamental in Ayurvedic formulations. It acts as a guiding factor in selecting herbs and preparing remedies, as different tastes have distinct therapeutic qualities, influencing absorption, digestion, and overall efficacy in treating various conditions.
65) Puti:
Puti designates a state of physical form obtained post-processing, particularly in the context of bhasma preparation. It underscores the structural integrity and consistency required for effective therapeutic applications in Ayurvedic medicine after proper incineration.
66) Musha (Musa, Musá):
Musa refers to the banana genus, which holds significance in Ayurvedic medicine, often employed in various preparations. Its components are valued for their nutritional and therapeutic contributions, particularly in processes like purification or preparing formulations for enhanced health benefits.
Other Science Concepts:
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Gajaputa, Siddhilakshana, Samanya shodhana, Classical method, Triphala kwatha, Marana process, Bhasma Pariksha, Physicochemical Parameter, SEM analysis, Modern Method.