To study efficacy of palash pushp raskriya varti anjan in blepharitis

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Journal name: World Journal of Pharmaceutical Research
Original article title: To study efficacy of palash pushp raskriya varti anjan in blepharitis
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Author:

Prajakta A. Chachre, Santosh S. Mulik and Sarita S. Mulik


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: To study efficacy of palash pushp raskriya varti anjan in blepharitis

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20189-12015

Copyright (license): WJPR: All rights reserved


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Summary of article contents:

Introduction

Blepharitis is a prevalent ocular condition characterized by inflammation of the eyelid margins, resulting in symptoms such as itching, redness, lid edema, and foreign body sensation. This chronic disease has a high recurrence rate, complicating management strategies. Current treatments primarily involve a combination of antibiotic and steroid eye ointments, which can lead to complications, including antibiotic resistance and steroid-related side effects. The study presented in the article evaluates the efficacy of Palash Pushp Raskriya Varti, a traditional Ayurvedic formulation, against standard treatment with Neosporin-H eye ointment in patients with blepharitis.

Efficacy of Palash Pushp Raskriya Varti

Palash Pushp Raskriya Varti is derived from the Palash flower, known for its therapeutic properties according to Ayurvedic principles. This formulation is suggested for managing conditions relating to Kapha and Pitta doshas. The study examines its local effects on blepharitis symptoms. Acharya Sushrut's ancient texts highlight the benefits of the Palash plant, which possesses anti-inflammatory, astringent, and antimicrobial properties. The research demonstrates that although Palash Pushp provides benefits, it is less effective compared to the antibiotic combination found in Neosporin-H in addressing symptoms such as itching and redness.

Challenges in Management of Blepharitis

The management of blepharitis poses numerous challenges due to its multifactorial nature and the complexities involved in its etiology and treatment protocols. Symptoms often do not correlate well with clinical signs, complicating diagnosis and management. Whimsical remissions and recurrences are commonplace, necessitating continuous patient monitoring and sometimes indefinite treatment. The research emphasizes the need for effective, long-lasting treatment options to manage this chronic condition without leading to further complications, reinforcing the importance of exploring traditional alternatives like Ayurvedic therapies.

Comparative Analysis of Treatments

In the study, a randomized controlled trial was conducted involving 30 patients divided into two groups—one receiving Palash Pushp Raskriya Varti and the other Neosporin-H eye ointment. Statistical analyses confirmed the efficacy of both treatments, but results indicated that Neosporin-H provided significantly better relief across all measured parameters, including itching, lid edema, foreign body sensation, and redness of eyes. The findings suggest that while the Ayurvedic treatment showed promise, the conventional antibiotic treatment was notably more effective in managing blepharitis symptoms in the study population.

Conclusion

The investigation underscores the relevance of integrating traditional Ayurvedic practices into modern treatment paradigms for ocular diseases like blepharitis. Although Palash Pushp Raskriya Varti demonstrated some efficacy, it is essential to recognize the superior effectiveness of conventional antibiotic treatments in managing acute symptoms. The study suggests that while there are safe, cost-effective, and easily accessible options in traditional medicine, further research is needed to establish long-term effectiveness and safety before considering routine incorporation in clinical settings. Future explorations should also focus on larger sample sizes and additional Ayurvedic therapies to provide comprehensive insights into managing chronic conditions like blepharitis.

FAQ section (important questions/answers):

What is blepharitis and what causes it?

Blepharitis is a common ocular disease characterized by inflammation of the lid margin, leading to symptoms like itching, redness, and discomfort. Its causes are complex, involving factors such as bacterial infection, seborrheic dermatitis, and allergies.

What is Palash pushp raskriya varti?

Palash pushp raskriya varti is an Ayurvedic formulation described by Acharya Sushrut, which aims to treat conditions like blepharitis. It is believed to possess Kapha-Pitta-Rakta balancing properties, making it effective for relieving symptoms associated with inflammation.

How is Palash pushp raskriya varti administered?

The varti is administered through the Anjana technique, where a paste made from the drug is applied to the lower lid margin. This application is recommended twice daily for 15 days to allow for optimal absorption and effect.

What was the study's aim regarding Palash pushp raskriya varti?

The study aimed to evaluate the efficacy of Palash pushp raskriya varti anjan in managing blepharitis, comparing its effects to those of Neosporin-H eye ointment in alleviating symptoms such as itching, redness, and lid edema.

What results were found between the two treatment groups?

The study showed that both treatments significantly improved symptoms, but Neosporin-H eye ointment was found to be more effective than Palash pushp raskriya varti in relieving itching, lid edema, and redness associated with blepharitis.

What recommendations were made for future research on blepharitis?

Future studies should involve larger sample sizes and investigate the long-term effects of Palash pushp raskriya varti, as well as explore different treatment methods for blepharitis other than the Anjana technique.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “To study efficacy of palash pushp raskriya varti anjan in blepharitis”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Varti (Vartin):
The term 'Varti' refers to a specific form of Ayurvedic medication, typically in the shape of a small wick or cylindrical preparation used for ocular treatments. In this study, Palash Pushp Raskriya Varti is assessed for its effectiveness in treating blepharitis, illustrating the significance of traditional Ayurvedic remedies in modern clinical practices.

2) Study (Studying):
The term 'Study' denotes the systematic investigation and research conducted to evaluate the efficacy of Palash Pushp Raskriya Varti in managing blepharitis. The study follows a structured methodology, comparing traditional Ayurvedic treatments with contemporary medical options, thereby contributing to the ongoing dialogue between alternative and modern medicine.

3) Table:
The term 'Table' refers to the organized presentation of data, crucial for illustrating the results of the research study. Tables facilitate the comparison of symptoms between different treatment groups (Palash Pushp Raskriya Varti and Neosporin-H eye ointment), offering a clear visualization of efficacy and outcomes.

4) Praklinna:
In Ayurvedic context, 'Praklinna' refers to a condition characterized by specific symptoms related to doshic disturbances. The study correlates blepharitis with the Praklinna Vartma condition, enhancing understanding of the traditional roots of such disorders and supporting the use of Ayurvedic treatments in alleviating associated symptoms.

5) Disease:
'Diseases' denote the pathological conditions affecting health, specifically focusing on blepharitis in this context. The study aims to explore and compare treatment modalities for this common ocular disease, contributing to the broader understanding of health management.

6) Itching:
'Itching' is a primary symptom of blepharitis characterized by irritation and discomfort in the eyes. The study assesses the reduction of itching in patients receiving Palash Pushp Raskriya Varti, underscoring the need for effective treatments to alleviate such distressing symptoms associated with ocular diseases.

7) Vartma (Vatrma):
'Vartma' in Ayurveda refers to the pathway or expressible manifestation of a disease. This study draws connections between the concept of Vartma and blepharitis, illustrating how traditional Ayurvedic terminology enhances our understanding of ocular ailments and their management through tailored treatment strategies.

8) Samhita:
'Samhitas' are authoritative texts detailing Ayurvedic theories and practices. They form the basis of Ayurvedic knowledge, underscoring the study's reliance on classical foundations in evaluating treatments for blepharitis.

9) Edema (Oedema):
'Edema' specifically refers to the swelling response in tissues, which is a significant symptom of blepharitis examined in the study. Evaluating the reduction of edema is crucial for determining the effectiveness of treatments applied in the trial.

10) Kapha:
'Kapha' is one of the three doshas in Ayurveda, associated with water and earth elements, representing qualities such as stability and moisture. The study examines how imbalances in Kapha contribute to ocular conditions like blepharitis, linking Ayurvedic theory with clinical practice and healing methods.

11) Shalakyatantra (Salakyatantra, Shalakya-tantra, Shalakyatamtra):
'Shalakya-tantra' is the branch of Ayurveda focused on diseases above the clavicle, specifically pertaining to ailments of the head, eyes, ears, nose, and throat. This aspect of Ayurveda is vital in the study, highlighting the specialized approach to managing ocular diseases within traditional Indian medicine.

12) Tantra (Tamtra, Tantrism):
'Tantra' in this context refers to a specific branch of knowledge or a methodology in Ayurveda. The study embodies the principles of Shalakya Tantra, illustrating how ancient Ayurvedic practices inform contemporary treatments for eye-related ailments such as blepharitis.

13) Pitta:
'Pitta' is another dosha in Ayurveda associated with fire and transformation, representing metabolic processes. The research highlights how Pitta disturbances may influence blepharitis, demonstrating the interconnectedness of doshic balances in the prevention and treatment of ocular diseases in Ayurveda.

14) Water:
'Water' signifies a crucial component in the preparation of Ayurvedic remedies, including the formulation of Palash Pushp Raskriya Varti. Its usage underscores the practical aspects of Ayurvedic treatments and their reliance on natural elements, reinforcing the blend of nature and science in medicine.

15) Drug:
'Drug' refers to the medicinal compound under study, specifically the Palash Pushp Raskriya Varti and Neosporin-H eye ointment. This research examines their therapeutic effects in treating blepharitis, emphasizing the critical role of drug efficacy in clinical practice.

16) Dosha (Dosa):
'Dosha' signifies the biological energies in Ayurveda that govern physical and mental processes. The analysis of imbalances in Kapha and Pitta doshas contextualizes the symptoms and treatment strategies for blepharitis, highlighting the relevance of Ayurvedic principles in modern medical evaluations.

17) Pune:
'Pune' refers to the geographic location of the study, where the research and clinical practices occur. This city is a hub for Ayurvedic education and medical research in India, underlining its significance in bridging traditional practices with contemporary healthcare.

18) Hand:
'Hands' symbolize the manual skills involved in treatment application, especially in Ayurveda. Training patients to perform eye ointment applications exemplifies this hands-on approach, emphasizing the role of patient engagement in effective medical care.

19) Pittarakta (Pitta-rakta):
'Pitta-rakta' refers to related dosha imbalances involving Pitta and blood (Rakth), which can contribute to diseases like blepharitis. Understanding these interactions provides insight into the Ayurvedic framework for diagnosing and treating ocular disorders effectively.

20) Antibiotic (Antibacterial):
'Antibiotic' signifies modern pharmacological agents used to treat bacterial infections, relevant in this research as a control comparison. The study assesses the efficacy of traditional Ayurvedic treatments against established antibiotic therapies, enriching the discourse on integrated approaches to healthcare.

21) Ayurveda (Ayus-veda):
'Ayurveda' denotes the ancient system of medicine from India, emphasizing holistic health and balance. This study explores Ayurvedic treatments for blepharitis, enriching the dialogue between ancient practices and modern medical approaches in addressing ocular diseases.

22) Sanskrit:
'Sanskrit' is the ancient language in which many Ayurvedic texts are written. Familiarity with Sanskrit is essential for understanding historical medical concepts and practices, reassuring the cultural and educational foundation of the Ayurvedic system in contemporary research.

23) Karma (Karman):
'Karma' signifies action or performance of tasks, including therapeutic actions in medicine. In the study, it refers to the processes employed in treatment applications, linking Ayurvedic procedures with patient outcomes and emphasizing the philosophy of intentional healing.

24) Rakta:
'Rakta' refers to blood in Ayurveda and its significance in health and disease. The study connects the principles of Rakta with the doshic imbalances seen in blepharitis, showcasing how traditional understanding informs treatment options for ocular conditions.

25) Guna:
'Gunas' refer to the qualities or properties of substances, essential in Ayurvedic pharmacology for understanding the efficacy of herbs and treatments. Evaluating Gunas of Palash Pushp enriches knowledge regarding its application in ocular diseases.

26) Sign:
'Sign' pertains to observable symptoms in patients, critical for both diagnosis and assessment in the research. The study carefully documents clinical signs of blepharitis, evaluating treatment effectiveness through rigorous observation and analysis of outcomes.

27) Bharati:
'Bharati' refers to Bharati Vidyapeeth, the institution conducting the research. This academic setting is pivotal for integrating Ayurvedic education with clinical practice, fostering innovation and research in traditional medical systems.

28) Maharashtra (Maharastra, Maha-rashtra):
'Maharashtra' is the Indian state where the research is conducted, underscoring its relevance in the cultural and educational landscape of Ayurveda. The state is a center for Ayurvedic practice and research, enhancing the integration of traditional and modern medicine.

29) Kaphapitta (Kapha-pitta):
'Kapha-pitta' denotes a specific imbalance between the two doshas, which may manifest in conditions like blepharitis. Understanding this interplay informs treatment strategies tailored to restore balance and alleviate symptoms, demonstrating the nuanced approach of Ayurvedic medicine.

30) Cotton:
'Cotton' signifies the material used for hygienic practices, particularly in eye care. It emphasizes the importance of cleanliness and proper hygiene in managing conditions like blepharitis, merging Ayurvedic principles with practical preventative measures.

31) Tikta:
'Tikta' refers to the bitter taste associated with certain herbs in Ayurveda. Understanding Tikta's properties in formulations like Palash Pushp Raskriya Varti relates to their therapeutic effects and how they align with Ayurvedic principles of balancing doshas.

32) Virya:
'Virya' signifies the potency or energy of a substance in Ayurveda. This concept is fundamental to evaluating the effectiveness of therapeutic agents, further informing the study's exploration of traditional remedies for treating blepharitis.

33) India:
'India' refers to the cultural and geographical context where Ayurveda originated and evolved. Its relevance lies in understanding how traditional practices are integrated with modern healthcare systems through research and education.

34) Rasa (Rasha):
'Rasa' refers to the taste profile of substances in Ayurveda, directly related to their therapeutic properties. The study examines the relationship between Rasa and the efficacy of Palash Pushp as a treatment for ocular conditions, grounding the research in traditional wisdom.

35) Sushruta-samhita (Susruta-samhita):
'Sushruta-samhita' is a foundational text in Ayurveda, offering comprehensive insights into surgical and medical practices. The study draws upon this text for methodologies regarding eye diseases, highlighting the significance of classical literature in contemporary research.

36) Kaphadosha (Kaphadosa, Kapha-dosha):
'Kapha-dosha' refers to one of the three fundamental energies in Ayurvedic medicine, implicated in various health conditions. The study evaluates how imbalances in Kapha influence blepharitis symptoms, emphasizing the importance of dosha assessments in management strategies.

37) Observation:
'Observation' is a critical component of the study, involving careful monitoring of patient responses to treatments. Systematic observation provides data necessary for assessing treatment efficacy and understanding the dynamics of Ayurvedic and conventional therapeutic approaches.

38) Lakshana (Laksana):
'Lakshana' refers to the signs or symptoms characteristic of a disease in Ayurveda. The study correlates clinical lakshanas of blepharitis with Ayurvedic principles, reinforcing the importance of recognizing symptomatology for effective treatment planning.

39) Medicine:
'Medicine' embodies the science and practices used to treat ailments. This study bridges traditional Ayurvedic medicine and modern pharmacology, exploring the effectiveness of herbal remedies compared to conventional treatments for ocular diseases.

40) Avaleha:
'Avaleha' refers to a semi-solid Ayurvedic formulation made by reducing a herbal decoction. The preparation process of the Palash Pushp Raskriya Varti exemplifies how Avaleha is utilized within traditional practices for effective dosing and delivery to affected areas.

41) Pradhan:
'Pradhan' indicates a principal or predominant factor, often used in Ayurveda to describe the primary dosha or influence involved in a disease. The study assesses the Pradhan dosha in blepharitis, facilitating targeted Ayurvedic interventions for symptom management.

42) Hygiene (Hygienic):
'Hygiene' emphasizes cleanliness, crucial in managing conditions like blepharitis. The study incorporates recommendations for lid hygiene practices, showcasing how preventative measures play a vital role in conjunction with therapeutic treatments in eye care.

43) Science (Scientific):
'Science' signifies the systematic approach to studying and understanding phenomena. The research embodies a scientific inquiry into Ayurvedic treatments, advocating for the integration of traditional wisdom with evidence-based practices in health management.

44) Anjana (Amjana):
'Anjana' is a method of applying medicinal substances to the eyes in Ayurveda. The study explores Anjana techniques using Palash Pushp Raskriya Varti, highlighting the specific application processes and their significance in treating ocular ailments.

45) Netra:
'Netra' refers to the eyes in Ayurvedic terminology. It's the focal point of the study, emphasizing the care and treatment of ocular health as a vital aspect of overall well-being, rooted in ancient Ayurvedic practices.

46) Roga:
'Roga' denotes disease in Ayurveda, illustrating the concept of health and illness. The research investigates 'Roga' from both modern and traditional perspectives, aiming to enhance understanding of conditions like blepharitis and their management.

47) Katu:
'Katu' refers to the pungent taste associated with certain herbs. Its categorization in Ayurvedic formulations relates to their therapeutic characteristics, with studies showing how Katu properties can potentially alleviate certain symptoms, like those in ocular conditions.

48) Bala:
'Bala' means strength or potency in the context of Ayurvedic medicine. The study examines how herbal treatments can bolster the health and functioning of the eyes, emphasizing the importance of strength in recovery from diseases like blepharitis.

49) Line:
'Line' refers to a treatment pathway or methodology followed in managing diseases. This study correlates with different lines of treatment for blepharitis while assessing their efficacy in comparison to conventional therapies.

50) Inflammation:
'Inflammation' is a biological response to harmful stimuli, significant in the pathology of blepharitis. The study addresses inflammation as a primary characteristic of the disease, exploring treatment options aimed at alleviating associated symptoms.

51) Tamrapatra (Tamra-patra):
'Tamra-patra' refers to a copper vessel used in Ayurvedic preparations. Its use in the study context embodies traditional methods for formulating medicines, emphasizing the role of specific materials in enhancing the efficacy of Ayurvedic treatments.

52) Netraroga (Netra-roga):
'Netraroga' specifically refers to eye diseases defined in Ayurveda. The study focuses on this category of disorders, particularly blepharitis, assessing treatment effectiveness through the lens of traditional Ayurvedic perspectives.

53) Katutikta (Katu-tikta):
'Katu-tikta' combines pungent and bitter tastes associated with certain Ayurvedic herbs. These tastes are linked to therapeutic properties, making them pivotal in formulations intended to treat ailments, including those affecting eye health.

54) Kandughna (Kandu-ghna):
'Kandughna' indicates the property of alleviating itching or irritation. The study assesses how Palash Pushp Raskriya Varti addresses this symptom, demonstrating its connection to Ayurvedic pharmacology and treatment efficacy in managing blepharitis.

55) Rasakriya (Rasa-kriya):
'Rasakriya' signifies a process in Ayurveda for preparing medicines, often involving the extraction of active compounds. This method is vital for ensuring the effectiveness of treatments, particularly in eye care preparations like Varti.

56) Container:
'Container' signifies the physical vessel used to store prepared medicines. Proper storage is essential to maintain drug potency and effectiveness, highlighting the importance of material choices in Ayurvedic formulations.

57) Varanasi (Varanashi):
'Varanasi' is a city known for its historical significance in Indian culture and Ayurvedic medicine. Mention of this city highlights the geographical context in which traditional practices are studied and their relevance in modern healthcare.

58) Vyadhin (Vyadhi):
'Vyadhi' denotes disease or disorder in Ayurveda, linking to the overall theme of the study concerning understanding and managing conditions like blepharitis. Comprehending 'Vyadhi' frameworks helps direct effective treatment strategies.

59) Reason:
'Reason' refers to the rationale behind the adoption of certain therapeutic methods or herbal remedies. The study presents the underlying reasons for selected treatments, bridging the gap between traditional knowledge and modern medical reasoning.

60) Laghu:
'Laghu' refers to the lightness or ease of a substance in Ayurvedic theory. It indicates specific qualities of herbs or compounds that may enhance their therapeutic efficacy, which is explored in the context of managing blepharitis.

61) Tamra:
'Tamra' refers to copper, known for its auspicious qualities in Ayurvedic practices. Usage of Tamra-patra in drug preparation emphasizes how traditional materials contribute to the healing process and effectiveness of treatments.

62) Patra:
'Patra' means a vessel or container in Sanskrit, relevant in Ayurvedic medicine for the preparation and storage of formulations. The material characteristic of these vessels may influence the efficacy of medicinal preparations.

63) Delhi:
'Delhi' denotes the national capital of India, emphasizing the geographic context for research institutions and healthcare practices. Its mention highlights the urban cultural and educational aspects influencing the dissemination of Ayurvedic knowledge.

64) Shri (Sr, Sri):
'Shree' is an honorific prefix in Indian culture, often used before names to denote respect. Its usage in referencing authors or practitioners highlights the esteemed lineage and tradition within Ayurvedic medicine.

65) Male:
'Male' indicates one of the genders represented in the study population. Gender analysis is significant in medical research for understanding variations in disease prevalence or response to treatments in conditions like blepharitis.

66) Life:
'Life' encompasses the holistic focus of Ayurveda on well-being and health management. The study foregrounds the importance of managing ocular diseases not only for treatment but also for enhancing the overall quality of life.

67) New Delhi:
'New Delhi' signifies the capital city, representing governmental and educational centers focused on health initiatives. Its mention may illustrate the broader context of healthcare policy impacting Ayurvedic practices and research in India.

68) Pharmacological:
'Pharmacological' refers to the study of drug action and its effects on biological systems. This term indicates the integration of Ayurvedic medicine with contemporary scientific evaluation, contributing insights into the efficacy of therapies for conditions such as blepharitis.

69) Paschat-karma:
'Paschat-karma' refers to the procedures following a therapeutic application. This highlights the holistic approach in Ayurveda where aftercare is considered essential to ensure the effectiveness and safety of treatments administered.

70) Pratishthana (Pratisthana, Pratishthan):
'Pratishthan' refers to establishment or foundation. Mention of this term reflects the importance of solid grounding in Ayurvedic principles and practices that form the basis for conducting meaningful clinical research.

71) Bhaishajya (Bhaisajya):
'Bhaishajya' signifies medicine or remedies in Ayurveda. This study evaluates specific bhaishajya (medicinal) applications in treating blepharitis, emphasizing the relevance of traditional formulations in contemporary healthcare practices.

72) Shothaghna (Sothaghna, Shotha-ghna):
'Shothaghna' denotes properties related to reducing swelling or inflammation. This is significant in the context of treating blepharitis, as it aligns with Ayurvedic principles of alleviating symptomatic discomfort in ocular conditions.

73) Discussion:
'Discussion' represents the analytical commentary on research findings. This section synthesizes observations from the study, offering critical insights that contribute to a deeper understanding of the efficacy of Palash Pushp Raskriya Varti in managing blepharitis.

74) Kaphaghna (Kapha-ghna):
'Kaphaghna' signifies a property that mitigates Kapha dosha imbalances. The study emphasizes this quality of Palash Pushp, outlining its importance in treating conditions associated with Kapha tri-doshic disturbances in Ayurveda.

75) Knowledge:
'Knowledge' pertains to the understanding gained through research, emphasizing the importance of integrating traditional wisdom with modern medical practices. The study contributes to the overall body of knowledge regarding blepharitis management and the role of Ayurveda.

[Note: The above list is limited to 75. Total glossary definitions available: 109]

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