Etoricoxib solid dispersion formulation with hydrophilic polymers.
Journal name: World Journal of Pharmaceutical Research
Original article title: Formulation and in vitro evaluation of etoricoxib solid dispersion by using hydrophilic polymers
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Puja Priyadarshini Pradhan, Truptirekha Sahoo and Sradhanjali Patra
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Formulation and in vitro evaluation of etoricoxib solid dispersion by using hydrophilic polymers
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20189-12108
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
Etoricoxib is categorized as a selective COX-2 inhibitor and belongs to the BCS class II drugs, which are characterized by low solubility and high permeability. The main objective of the study was to improve the dissolution rate and absorption of Etoricoxib by utilizing solid dispersion techniques with various hydrophilic polymers, such as polyethylene glycol (PEG 6000, PEG 4000) and mannitol. The study aimed to evaluate the physicochemical properties and dissolution characteristics of the prepared solid dispersions.
Improvement of Dissolution Rate
A critical aspect of enhancing the performance of insoluble drugs is through the preparation of solid dispersions. In this study, Etoricoxib solid dispersions were created using melting methods at varying ratios of drug to polymer (1:1, 1:3, 1:5). Among these formulations, F3, which combined Etoricoxib with PEG 6000 at a 1:5 ratio, exhibited the most promising results. This specific formulation achieved a significantly improved solubility of 5.32 mg/ml, surpassing the solubility of pure Etoricoxib, which was only 2.29 mg/ml.
Wettability Studies
Wettability is an essential characteristic that influences drug release and absorption. The study included wettability assessments using methylene blue as a dye to analyze the wetting time of different formulations. The results indicated that formulation F3 had a substantially lower wetting time of 33 seconds, compared to the pure drug’s 14 minutes. This fast wetting time suggests that solid dispersions, especially F3, may enhance the dissolution and subsequent bioavailability of Etoricoxib.
Dissolution Profile
Dissolution studies were performed to measure the drug release percentage across various formulations over time. The findings demonstrated that formulation F3 (drug: PEG 6000 in a 1:5 ratio) achieved a remarkable drug release of 99.03% within just 15 minutes, significantly outperforming the other formulations and the pure drug, which only reached 50.80% release in 60 minutes. This emphasizes the effectiveness of combining Etoricoxib with hydrophilic carriers for improved drug release profiles.
Conclusion
The study concluded that the optimal formulation for improving the dissolution rate of Etoricoxib was the solid dispersion of drug with PEG 6000 in a 1:5 ratio, prepared via the melting method. This formulation demonstrated the highest drug release (99.03% in 15 minutes), outperforming both PEG 4000, mannitol, and the pure drug. The dissolution data indicated that the release kinetics followed first-order kinetics, highlighting the potential of solid dispersion techniques in enhancing the bioavailability of poorly soluble drugs like Etoricoxib.
FAQ section (important questions/answers):
What is the main objective of the study on Etoricoxib?
The study aimed to improve the dissolution rate of Etoricoxib using solid dispersion techniques with hydrophilic polymers like PEG 6000, PEG 4000, and mannitol.
How were the solid dispersions of Etoricoxib prepared?
Solid dispersions were prepared by the melting method, combining Etoricoxib with different ratios of polymers, then cooling and solidifying the mixture in an ice bath.
Which formulation showed the highest solubility for Etoricoxib?
The formulation F3, containing Etoricoxib and PEG 6000 in a 1:5 ratio, exhibited the highest solubility at 5.32 mg/ml.
What were the findings from the wetting time studies?
Formulation F3 showed the shortest wetting time at 33 seconds compared to the pure drug, which took 14 minutes, indicating better wettability.
What was the percentage drug release of formulation F3?
Formulation F3 achieved a drug release of 99.03% in just 15 minutes, outperforming other formulations and the pure drug.
What type of kinetics did the dissolution of the preparations follow?
The dissolution of all formulations followed first-order release kinetics, demonstrating a consistent and predictable release profile.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Etoricoxib solid dispersion formulation with hydrophilic polymers.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
In the context of pharmaceutical research, a 'Drug' refers to a substance intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease. In this study, Etoricoxib, a selective COX-2 inhibitor, is the focus, highlighting its importance in improving drug delivery through solid dispersion with hydrophilic polymers.
2) Pradhan:
Pradhan, specifically Puja Priyadarshini Pradhan, is the corresponding author of the research article. As a primary investigator, she represents the University Department of Pharmaceutical Sciences, contributing crucial insights and findings related to the formulation and evaluation of Etoricoxib solid dispersions.
3) Bhubaneswar (Bhubaneshvar, Bhubanesvar):
Bhubaneshwar is the capital city of Odisha, India, where the research was conducted at Utkal University. The city's academic and research facilities provide a conducive environment for pharmaceutical studies, emphasizing the local contribution to advancements in drug formulation and pharmaceutical sciences.
4) Science (Scientific):
The term 'Science' broadly refers to the systematic study of the natural world through observation and experimentation. In this research, it underlines the application of scientific principles to improve the dissolution and absorption of poorly soluble drugs, showcasing the role of empirical methods in pharmaceutical development.
5) India:
India serves as the geographical and cultural context for the study. The country's growing pharmaceutical industry plays a vital role in global healthcare. This research exemplifies India’s focus on innovative drug formulation techniques to improve health outcomes and address the challenges posed by poorly soluble medications.
6) Water:
Water is the medium used in the dissolution studies of the solid dispersions prepared in this research. As a solvent, it is vital for simulating physiological conditions to evaluate the drug's solubility and dissolution rates, which are important parameters for assessing bioavailability.
7) Table:
The 'Table' presented in the article organizes complex data, such as formulation codes, solubility results, wettability times, and drug release percentages. This tabular representation aids in comparing the performance of different polymer ratios, facilitating a clearer understanding of the experimental outcomes.
8) Puja:
Puja Priyadarshini Pradhan, often referred to simply as Puja within the document, is a key author of the study. Her involvement underscores the importance of her contributions to this research, including the methodology and analysis related to the preparation of solid dispersions of Etoricoxib.
9) Pharmacology:
Pharmacology is the branch of medicine that focuses on drugs and their effects on the body. In this study, pharmacological principles are applied to enhance the absorption and efficacy of Etoricoxib. Understanding pharmacology is crucial for developing effective therapeutic strategies in drug formulation.
10) Discussion:
The 'Discussion' section of the article synthesizes findings, interpreting data from solubility and dissolution studies. It compares results against existing literature, providing insights into the effectiveness of various polymer ratios and supporting the conclusion about the optimal formulation for Etoricoxib solid dispersions.
11) Patra:
Sradhanjali Patra, mentioned alongside other authors, contributed to the research findings. As a team member from the University Department of Pharmaceutical Sciences, her involvement indicates collaboration and the multi-faceted contributions essential for comprehensive pharmaceutical research and successful formulation development.
12) Patel:
Haresh M. Patel is cited in the bibliography as a contributor to related pharmacological research. His work informs the current study by establishing a foundation on drug properties, aiding in interpreting results, and enhancing the overall understanding of drug formulation practices.
13) Potta:
A.G. Potta is referenced in the bibliography, suggesting that his research may provide relevant insights into pharmacokinetics, influencing the study's design and methodology. Such references contribute to the body of knowledge necessary for understanding drug delivery systems and therapeutic efficacy.
14) Cina:
The term 'China' appears indirectly in the context of methodological references within the bibliography, indicating international research influences. This highlights the global nature of pharmaceutical sciences and the collaborative efforts across borders to advance drug development methodologies.
15) Dani:
Prateekn Dani is another author mentioned in the bibliography, relating to drug development. His research work will add value to the findings of this study, as it draws on established knowledge in the field of pharmaceutical formulations and the factors affecting drug solubility.
16) Bana:
The reference to Bana, specifically Tachi Bana, also pertains to the bibliography. His contributions to the understanding of colloid chemistry and polymer interactions may have informed aspects of the methodology used for preparing the solid dispersions in this study.
17) Puri:
Vibhab Puri is acknowledged in the bibliography, implying that his research may have influenced the methodologies employed in this investigation. This illustrates the interconnectedness of scientific research and how past studies shape current understanding of drug formulations.
18) Sah:
Shailesh A. Shah is referenced alongside his co-authors, indicating a legacy of research that impacts current studies on drug delivery systems. His work contributes foundational knowledge that helps contextualize the results and discussions presented in the current study.
19) Dish (Dis):
A 'Dish' refers to the china dish used in the melting method to prepare the solid dispersion of Etoricoxib. This choice of equipment plays a role in the accuracy and consistency of the experimental procedures employed to achieve the desired drug-polymer interactions.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Etoricoxib solid dispersion formulation with hydrophilic polymers.’. Further sources in the context of Science might help you critically compare this page with similair documents: