Formulation and in vitro evaluation of aceclofenac sustained released tablet
Journal name: World Journal of Pharmaceutical Research
Original article title: Formulation and in vitro evaluation of aceclofenac sustained released tablet
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Ayushi Pradhan, Snehalata Behera and Sradhanjali Patra
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Formulation and in vitro evaluation of aceclofenac sustained released tablet
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20189-12081
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
The design of appropriate dosage regimens plays a crucial role in ensuring the safety, stability, efficacy, and convenience of pharmaceutical products. This study focuses on the formulation and in vitro evaluation of sustained-release aceclofenac tablets. With a specific emphasis on matrix-based controlled-release systems, the research aims to investigate the use of hydrophilic and hydrophobic polymers in prolonging drug release and mitigating adverse effects.
Improved Dissolution Rate
One of the primary objectives of the investigation was to enhance the dissolution rate of aceclofenac by developing sustained drug delivery systems utilizing various grades of polymers, particularly HPMC K4M and HPMC K100M. The researchers utilized wet granulation to prepare six different tablet formulations, which were then evaluated for their physiochemical properties and dissolution characteristics. This approach aimed to optimize the formulation to achieve better therapeutic outcomes by improving the bioavailability of aceclofenac.
Experimental Methods
The experimental procedures involved preparing tablets that were characterized by direct compression using two viscosity grades of HPMC as matrix formers. The formulation process commenced with the mixing of aceclofenac and other additives, excluding magnesium stearate and talc, which were incorporated later. Following thorough mixing, the resultant granules were compressed into tablets. Each tablet contained 200 mg of aceclofenac and underwent various evaluations, including weight uniformity, swelling index, hardness, and friability.
In Vitro Release Evaluation
An essential part of the study was the in vitro evaluation of the drug release from the sustained-release tablets using the USP type (II) rotating paddle method at controlled conditions. The dissolution rates were measured at predetermined time intervals, and the amount of drug released was quantified using a spectrophotometer. The results indicated varying dissolution rates among the different formulations; specifically, the formulation utilizing HPMC K4M displayed the highest release rate compared to HPMC K100M.
Conclusion
The findings from this research underscore the potential to develop a stable 'once daily' sustained-release aceclofenac tablet formulation, with a preference for employing HPMC K4M as the matrix material. The study demonstrated that the dissolution behavior of the formulations adhered to Higuchi release kinetics, indicating a non-Fickian diffusion mechanism was at play. Overall, this work paves the way for enhancing the therapeutic efficacy of aceclofenac through innovative formulation strategies.
FAQ section (important questions/answers):
What is the purpose of the study on aceclofenac tablets?
The study aims to enhance the dissolution rate of aceclofenac by formulating sustained release tablets using different grades of polymers, specifically HPMC K4M and HPMC K100M.
What methods were used for formulating the tablets?
Tablets were formulated using the wet granulation method, followed by direct compression. Different viscosity grades of HPMC were utilized as matrix formers in the tablet formulations.
How were the release characteristics of aceclofenac evaluated?
The release characteristics were evaluated using the USP type (II) rotating paddle method, with phosphate buffer pH 7.4 at 37°C. Samples were taken at specified intervals.
What were the results of the in vitro dissolution studies?
The in vitro dissolution study indicated 58.80% drug release for pure aceclofenac, while formulations with HPMC K4M showed 78.6% release, and those with HPMC K100M exhibited 51.02% release.
Which formulation showed the lowest dissolution rate?
Formulation F6 demonstrated the lowest dissolution rate at 51.02% over eight hours compared to other formulations in the study.
What conclusion was drawn from the study's results?
The study concluded that a stable 'once daily' sustained release aceclofenac tablet can be achieved using HPMC K4M as a matrix material, with drug release following Higuchi order kinetics.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Formulation and in vitro evaluation of aceclofenac sustained released tablet”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
In the context of the article, 'drug' refers to aceclofenac, a nonsteroidal anti-inflammatory drug (NSAID) being formulated into a sustained-release tablet. The focus on drug formulation highlights the importance of optimizing delivery systems to enhance therapeutic efficacy while minimizing side effects, ultimately improving patient compliance and treatment outcomes.
2) Pradhan:
'Pradhan' is the surname of the lead author, Ayushi Pradhan, who contributed to the research presented in the article. Researchers often publish in collaboration, and the mention of individual authors is critical in attributing credit for study findings and contributions to science within academia and healthcare.
3) India:
India is the country of the institution where the research was conducted. The Indian pharmaceutical sector plays a crucial role in global drug manufacturing, emphasizing the country’s significance in developing affordable and effective medications like aceclofenac. Research conducted in India contributes to the global understanding of pharmaceutical sciences.
4) Bhubaneswar (Bhubaneshvar, Bhubanesvar):
Bhubaneshwar is the capital city of the Indian state of Odisha, where the University Department of Pharmaceutical Sciences is located. This geographic detail indicates the research's local context and showcases the university's role in contributing to scientific advancements and education in the pharmaceutical field.
5) Swelling:
'Swelling' refers to the increase in size of the matrix tablet during the absorption of the dissolution medium. This property is crucial in sustained-release formulations, as it affects the drug release profile. Monitoring swelling behavior ensures that the tablet behaves predictably in terms of drug delivery.
6) Science (Scientific):
Science is the methodological approach to investigating phenomena, which in this paper applies to the formulation and evaluation of aceclofenac tablets. The scientific method ensures the reliability of findings through objective testing and assessments, leading to advancements in drug development and therapeutic strategies for effective treatment.
7) Discussion:
'Discussion' is a critical section in research papers where authors interpret their findings, compare them with previous studies, and propose implications. This part contextualizes the results within the broader scientific literature, providing insights into the significance of the findings and potential future research directions.
8) Behera:
'Behera' is another co-author's surname, highlighting collaboration in this study. A multi-authored work indicates the importance of diverse expertise in conducting research, where each author contributes unique skills or perspectives, thereby enhancing the credibility and depth of the findings presented.
9) Indian:
The term 'Indian' refers to the nationality associated with the authors and the research conducted in India. This context suggests that local regulatory, cultural, and healthcare factors may influence pharmaceutical research, emphasizing the need for region-specific drug formulations to cater to diverse populations.
10) Patra:
'Patra' is the last name of another co-author involved in the study. The inclusion of co-authors signifies collaboration and teamwork in research efforts, pointing to the shared responsibility for the outcomes and findings presented in the publication, as well as their interdisciplinary contributions.
11) Table:
In this context, 'Table' refers to a structured presentation of data summarizing various formulation results of aceclofenac. Tables in scientific writing serve to organize complex information, making it more accessible for readers to grasp key insights and compare results across different formulations efficiently.
12) Study (Studying):
'Study' denotes the systematic investigation conducted by the researchers to understand the sustained-release formulation of aceclofenac. It embodies the structured approach to gathering data, analyzing results, and deriving conclusions to contribute valuable knowledge to the field of pharmaceutical sciences.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Formulation and in vitro evaluation of aceclofenac sustained released tablet’. Further sources in the context of Science might help you critically compare this page with similair documents:
Dissolution rate, Wet granulation method, Swelling Index, Direct compression, Sustained release tablet.