Phytochemical and Therapeutic Potential of Calotropis gigantea Linn
a phytochemical potential
Journal name: World Journal of Pharmaceutical Research
Original article title: Calotropis gigantea
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Subtitle: a phytochemical potential
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Siddharth Deshpande, Kalpita Deshpande and Ekta Tomar
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World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Calotropis gigantea
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr201811-12458
Copyright (license): WJPR: All rights reserved
Summary of article contents:
Introduction
Calotropis gigantea Linn, commonly known as milkweed, is a medicinal herb with a long history of use in traditional Indian medicine. This plant possesses a range of therapeutic properties, including antioxidant, anti-inflammatory, analgesic, and antimicrobial effects. Research literature reviewed up to 2017 highlights the significance of C. gigantea in the development of plant-based pharmaceuticals. The comprehensive understanding of its phytochemical compositions and various medicinal applications underscores its potential as an alternative source for drug development.
Phytochemistry of Calotropis gigantea
The plant exhibits a rich diversity of phytochemicals across its various parts. The stem bark contains compounds such as giganteol and calotroposides, while the roots feature a variety of terpenoids and naphthalene derivatives. Seeds are rich in fatty acids like palmitic and oleic acids, and the latex presents significant components, including caoutchouc and several glycosides. This phytochemical richness supports the wide-ranging ethnic and therapeutic uses of the plant, firmly establishing its relevance in both folk and modern medicine.
Therapeutic Applications and Efficacy
C. gigantea has demonstrated significant therapeutic efficacy in several pharmacological studies. Its anticancer properties were highlighted through the isolation of anhydrosophoradiol-3-acetate, which showed considerable tumor-inhibiting capabilities in animal models. Furthermore, it exhibited anti-asthmatic effects and ovicidal activity against agricultural pests, indicating its multifaceted applications. The research illustrates that the herb not only aids human health conditions but can also serve agricultural needs, showcasing its versatile therapeutic potential.
Anti-inflammatory and Analgesic Properties
The anti-inflammatory and analgesic effects of C. gigantea are noteworthy. Studies reveal that the herbal extracts exhibit significant inhibition of albumin denaturation, comparable to established anti-inflammatory drugs such as Ibuprofen. Additionally, the plant's flowers demonstrated analgesic properties when tested in mice, showing peak effectiveness within 90 minutes post-administration. These findings reinforce the potential use of C. gigantea as an effective treatment option for pain and inflammation.
Conclusion
Calotropis gigantea Linn emerges as a valuable herbal medicine with extensive applications in traditional and modern therapeutic practices. The plant's diverse phytochemical profile and its established pharmacological effects underscore its significance in drug development. As research continues, the potential for C. gigantea to contribute to new medicinal formulations remains significant, highlighting the importance of integrating traditional knowledge with scientific inquiry for the benefit of health and agriculture.
FAQ section (important questions/answers):
What is Calotropis gigantea and its common names?
Calotropis gigantea, commonly known as milkweed, is a flowering plant from the Apocynaceae family. It has various vernacular names, including Aak in Hindi and Sodom apple in English.
What medicinal properties does Calotropis gigantea possess?
Calotropis gigantea is known for numerous medicinal properties, including antioxidant, analgesic, anti-inflammatory, antidiarrhoeal, anticancer, and antimicrobial activities, making it significant in traditional medicine.
What are the major phytochemicals found in Calotropis gigantea?
This plant contains various phytochemicals, such as calotropins, glycosides, terpenes, and tannins in different parts, including roots, leaves, flowers, and latex.
How does Calotropis gigantea exhibit anticancer activity?
Research indicates that anhydrosophoradiol-3-acetate (A3A) from Calotropis gigantea significantly inhibits tumor growth in mice by decreasing viable tumor cell count.
In what conditions does Calotropis gigantea grow optimally?
Calotropis gigantea grows well in semi-arid regions with annual rainfall between 150 and 1000 mm, adapting to various soil textures and conditions.
What are some traditional uses of Calotropis gigantea?
Traditionally, Calotropis gigantea is used to treat various ailments, including leprosy, ulcers, and respiratory conditions, and is recognized in Unani and Ayurvedic medicine.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Phytochemical and Therapeutic Potential of Calotropis gigantea Linn”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
Activity refers to the actions or functions that a substance or organism exhibits. In the context of Calotropis gigantea, 'activity' often describes the various therapeutic effects of its extracts, such as anti-inflammatory, analgesic, or antiviral properties that can benefit patients in traditional medicine.
2) Rasashastra (Rasa-shastra, Rasasastra):
Rasashastra is a branch of Ayurveda focusing on alchemy and medicinal preparations from minerals and herbs. It emphasizes the transformation of substances for therapeutic purposes. The practitioners in Rasashastra apply the principles to enhance the efficacy of treatments derived from plants like Calotropis gigantea.
3) Hair:
Hairs are the fine filaments that grow from the skin of mammals, which can serve various biological and sensory functions. The reference to 'hairs' in this context emphasizes studies exploring Calotropis gigantea’s potential effects on hair growth and scalp health.
4) India:
India is the native land of Calotropis gigantea and a hub for ancient medicinal practices. The diversity in flora and the rich traditions of Ayurveda in India facilitate the use of local plants for therapeutic purposes, making it vital for studies involving indigenous medicinal herbs.
5) Ayurveda (Ayus-veda):
Ayurveda is a traditional Indian system of medicine that seeks to balance the body, mind, and spirit through natural means. Calotropis gigantea, utilized in Ayurveda, showcases the connection between herbal treatment and holistic wellness, emphasizing prevention and healing through natural resources.
6) Patil:
Patil refers to the family name associated with the authors of the study. In the context of this manuscript, it underlines the collaborative research efforts of scholars from D.Y. Patil University in exploring the phytochemical and therapeutic potentials of medicinal plants like Calotropis gigantea.
7) Drug:
A drug is a chemical substance used for medical treatment, either to cure, alleviate, or prevent diseases. Calotropis gigantea has been explored as a source of new drugs and formulations for various health conditions, highlighting the relevance of herbal medicine in modern pharmacology.
8) Phytochemical:
Phytochemicals are naturally occurring compounds in plants known for their health benefits. The various phytochemicals identified in Calotropis gigantea contribute to its therapeutic properties, playing crucial roles in anti-inflammatory and antimicrobial activities, justifying its usage in traditional and modern medicine.
9) Medicine:
Medicine encompasses a broad range of practices and treatments aimed at restoring health. In relation to Calotropis gigantea, it signifies the plant's integral role in herbal medicine as a source of active compounds used in various remedies to treat illnesses and promote health.
10) Disease:
A disease is a disorder of a structure or function in a human, often manifested through symptoms. The study of Calotropis gigantea’s efficacy in combating diverse diseases underlines the importance of plant-based therapies in providing holistic health solutions.
11) Family:
In biological taxonomy, family secures a level of classification that groups related plants or organisms. The family Asclepiadaceae to which Calotropis gigantea belongs provides insights into shared characteristics and medicinal potentials among related species and their applications in herbal treatments.
12) Tree:
A tree is a perennial plant characterized by an elongated stem or trunk supporting branches and leaves. Describing Calotropis gigantea as a tree or shrub showcases its ecological significance and adaptability in various habitats, influencing its utility in traditional medicine.
13) Milk:
Milk refers to the creamy liquid produced by the mammary glands of mammals. In the context of Calotropis gigantea, the term 'milk' originates from its milky latex, which possesses medicinal properties and is utilized in various traditional remedies for health benefits.
14) Soil:
Soil is the upper layer of earth where plants grow, consisting of organic matter, minerals, gases, liquids, and organisms. Understanding the soil conditions where Calotropis gigantea thrives is crucial for cultivating this medicinal herb and ensuring effective phytochemical production.
15) Pharmacological:
Pharmacological pertains to the study of interactions between drugs and living systems. The pharmacological evaluations of Calotropis gigantea indicate its therapeutic potentials, leading to insights about its mechanisms of action, safety, and efficacy for various health applications.
16) Toxicity:
Toxicity refers to the degree to which a substance can harm humans or animals. The study of Calotropis gigantea includes investigations into its toxic effects, ensuring safety while exploring its benefits, especially since many medicinal plants have varying toxicity profiles.
17) Leprosy:
Leprosy is a chronic infectious disease primarily affecting the skin, peripheral nerves, and mucous membranes. Calotropis gigantea has been historically utilized in traditional medicine practices to treat conditions like leprosy, illustrating the importance of herbal remedies in disease management and treatment.
18) Species:
A species is the basic unit of biological classification, representing a group of organisms capable of interbreeding. In the context of Calotropis gigantea, understanding its species classification aids in exploring its characteristics, uses, and relation to other similar plants in medicinal practices.
19) Indian:
Indian pertains to anything associated with India, including its culture, history, and traditional practices. The relevance of Calotropis gigantea in Indian medicine showcases the country’s rich botanical heritage and highlights the role of local plants in developing indigenous health care solutions.
20) Water:
Water is an essential, transparent liquid that is vital for all known forms of life. The reference to water in the study of Calotropis gigantea emphasizes its necessity for irrigation and cultivation, which impacts the availability and efficacy of its medicinal properties.
21) Genu:
Genu refers to the knee or the angular bend, particularly in the context of anatomy. However, in traditional medicine or herbology, it may allude to particular applications or relevance in treating conditions related to joint or structural health influenced by herbal remedies.
22) Katu:
Katu is a Sanskrit term that translates to 'pungent' or 'bitter.' In Ayurvedic terminology, it describes the taste of substances used in medicine, reflecting the organoleptic properties of Calotropis gigantea, which can influence its therapeutic effects and applications in treatments.
23) Bronchial asthma:
Bronchial asthma is a chronic respiratory condition characterized by airway inflammation and difficulty in breathing. Calotropis gigantea’s reported antiasthmatic properties indicate its potential role in mitigating symptoms and fostering respiratory health, aligning with holistic approaches in Indian traditional medicine.
24) Antibiotic (Antibacterial):
Antibacterial refers to substances that inhibit bacterial growth or kill bacteria. The identification of Calotropis gigantea’s antibacterial properties showcases its potential application in treating infections and reinforcing the plant's relevance in both traditional and modern pharmaceutical formulations.
25) Dravyaguna (Dravya-guna):
Dravyaguna is a branch of Ayurveda focused on the analysis of herbal substances and their therapeutic properties. It involves studying the qualities and effects of plants like Calotropis gigantea, helping practitioners employ them effectively for various health issues based on traditional wisdom.
26) Arkaparṇa (Arkaparna, Arka-parna):
Arkaparna is a Sanskrit term referring to a particular herb or component in traditional medicine. In association with Calotropis gigantea, it emphasizes the cultural and medicinal value attributed to the plant in Ayurvedic texts, underscoring the connection between local plants and their applications.
27) Substance:
Substance refers to a particular kind of matter with uniform properties. In pharmacology, it often pertains to active compounds derived from plants like Calotropis gigantea, which are studied for their medicinal properties, safety, and potential therapeutic applications in treating various health conditions.
28) Fragrance:
Fragrance denotes a pleasant, sweet smell, often used in the context of flowers or essential oils. While Calotropis gigantea is noted for its non-fragrant flowers, fragrance may relate to the olfactory character of herbal preparations and their appeal in traditional medicine products.
29) Language:
Language serves as a medium for communication and is essential in conveying cultural heritage and knowledge. In the context of Calotropis gigantea, the different vernacular names and terms underline the linguistic diversity surrounding traditional uses and ethnobotanical significance.
30) Mantaram:
Mandaram is a vernacular name often associated with Calotropis gigantea in various regions. Such local nomenclature highlights the plant's cultural importance and its identification within traditional medicine systems, emphasizing the community-based knowledge surrounding herbal treatments.
31) Sanskrit:
Sanskrit is an ancient language of India often used in religious and philosophical texts. Its use in Ayurvedic literature and terminology places a significance on understanding traditional medicine practices, including the medicinal properties of plants like Calotropis gigantea.
32) Kalpita:
Kalpita may refer to a name or term linked to a specific author or researcher associated with studies on Calotropis gigantea. This highlights individual contributions to the ongoing exploration of traditional herbal medicine and the documentation of plant properties.
33) Marathi:
Marathi is an Indian language spoken predominantly in the Maharashtra region. The mention of Marathi in the context signifies the regional vernacular names or traditional uses of Calotropis gigantea, establishing a connection to local customs and cultural lore in herbal medicine.
34) Bengali:
Bengali is an Eastern Indian language; its reference indicates the presence of Calotropis gigantea in Bengali culture and its traditional uses among Bengali-speaking populations. This showcases the diversity in the understanding and utilization of the plant across different regions.
35) Habitat:
Habitat refers to the natural environment where a plant or species grows and thrives. Specifying the habitat of Calotropis gigantea enriches the understanding of its ecological adaptations, influences on its medicinal properties, and implications for cultivation in herbal medicine.
36) Science (Scientific):
Science pertains to the systematic study of the structure and behavior of the physical and natural world through observation and experiment. The scientific research surrounding Calotropis gigantea underscores the importance of evidence-based evaluations of herbal remedies in modern medicine.
37) Tapana:
Tapana is a Sanskrit term that translates to 'heat' or 'warmth'; in Ayurvedic context, it can refer to properties related to body temperature. This concept may relate to the effects of Calotropis gigantea when used therapeutically within traditional practices.
38) Ruksha (Ruksa):
Ruksha is a Sanskrit term meaning 'dry' or 'rough,' often used in Ayurveda. It describes the qualities of certain herbs, indicating properties they possess which can influence their use in treatments, characterizing Calotropis gigantea in terms of its medicinal attributes.
39) Alarka:
Alarka, a term in Sanskrit, is another vernacular name tied to Calotropis gigantea. This highlights the integration of culturally specific nomenclature within herbal medicine practice, expressing the plant’s identity across various traditional health systems.
40) Vasuka:
Vasuka is a term that may refer to another vernacular name or concept linked with the therapeutic applications of Calotropis gigantea in local traditions and Ayurvedic practices, reinforcing the relevance of indigenous knowledge in understanding herbal properties.
41) Aureus:
Aureus is often a term associated with golden color or quality, but in biological terms, it might relate to certain species, such as Staphylococcus aureus, and its implications in antibacterial studies. It underscores the importance of addressing associated pathogens in research.
42) Ulcer:
An ulcer is a localized injury to the skin or mucous membrane caused by loss of tissue. The implication of the term shows its relevance in understanding how Calotropis gigantea may provide remedies for ulcer treatment within traditional medicine.
43) Laghu:
Laghu is a Sanskrit term meaning 'light' or 'subtle.' In Ayurvedic medicine, it describes the properties of certain herbs or foods. Relating this to Calotropis gigantea indicates its potential lightness in action within medicinal frameworks.
44) Tikta:
Tikta is Sanskrit for 'bitter,' describing the taste of many therapeutic herbs. The inclusion of Tikta emphasizes how the taste profile of Calotropis gigantea may interact with bodily functions and contribute to its therapeutic effects within Ayurvedic principles.
45) Virya:
Virya translates to 'potency' or 'strength' in Ayurvedic terminology, indicating how effective a substance can be in therapeutic applications. This term signifies the importance of understanding Calotropis gigantea's virya in determining its medicinal efficacy.
46) Surya (Shurya):
Surya is the Sanskrit term for the sun, often associated with energy and vitality in Ayurveda. Its inclusion with respect to Calotropis gigantea might reflect its symbolic significance or its association in traditional texts with healing properties connected to natural light.
47) Hindi (Himdi):
Hindi is one of the official languages of India, and its mention reflects the linguistic diversity involved in the study and documentation of Calotropis gigantea's traditional uses, further emphasizing the role of local language in promoting indigenous knowledge.
48) Study (Studying):
Study refers to the detailed analysis and examination of a particular subject. In the context of Calotropis gigantea, numerous studies investigate its therapeutic potential, phytochemistry, and applications in medicine, providing a scientific basis for its traditional use.
49) Nila:
Neela refers to the color blue in Sanskrit, which might signify specific cultural or symbolic meanings. In the context of Calotropis gigantea, this could represent the plant's aesthetic attributes, cultural significance, or its connections to various herbal remedies.
50) Arka:
Arka is a Sanskrit term for another name associated with Calotropis gigantea. This emphasizes the importance of cultural recognition and the nomenclature of plants within Ayurvedic medicine, establishing a bridge between traditional practices and contemporary understanding.
51) Rasa (Rasha):
Rasa denotes the 'taste' or 'essence' of a substance in Ayurvedic terminology. It reflects the fundamental properties of herbs like Calotropis gigantea and their effects on bodily systems, guiding practitioners in choosing suitable treatments based on taste profiles.
52) Guna:
Guna refers to qualities or characteristics of a substance in Ayurveda. Understanding the guna of Calotropis gigantea plays a crucial role in evaluating its efficacy and applications within therapy, impacting its adoption in traditional and holistic medicine approaches.
53) Pain:
Pain refers to an unpleasant sensory experience associated with actual or potential tissue damage. The indication of pain management through Calotropis gigantea highlights its role in developing herbal remedies aimed to alleviate discomfort and support health recovery.
54) Wind:
Wind can signify various interpretations, including movement or change in environment. In traditional medicine, it may refer to 'vata,' a concept related to bodily functions. Calotropis gigantea’s applications could be informed by such principles in Ayurveda.
55) Salt (Salty):
Salt refers to a mineral composed primarily of sodium chloride, significant in various biological functions. Its relation to Calotropis gigantea points to the environmental conditions in which the plant thrives and how such conditions may affect its medicinal properties.
56) Coma:
Coma translates to a state of deep unconsciousness; in herbal and therapeutic contexts, it may relate to specific effects of compounds derived from plants like Calotropis gigantea, emphasizing the importance of understanding all possible impacts of herbal medications on health.
Other Science Concepts:
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