Pharmacological evaluation of Moolaroga Chooranam for bleeding piles.
Journal name: World Journal of Pharmaceutical Research
Original article title: Pharmacological evaluation of styptic activity of moolaroga chooranam for the treatment of bleeding piles
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Anbarasan B., Indumathy V., Anbu N. and Kanakavalli K.
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Pharmacological evaluation of styptic activity of moolaroga chooranam for the treatment of bleeding piles
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr201811-12439
Download the PDF file of the original publication
Summary of article contents:
1) Introduction
Haemorrhoids, commonly known as piles, are swollen varicosities of the haemorrhoidal veins, which can lead to significant discomfort and medical complications if untreated. In traditional Siddha medicine, these conditions are referred to as Moola noi, with various types identified, including Rattha Moolam, or bleeding piles. The present study aims to evaluate the styptic activity of a Siddha herbal formulation called Moolaroga chooranam, specifically targeting its effectiveness in prolonging bleeding time, clotting time, and prothrombin time to manage bleeding associated with piles.
2) Efficacy of Moolaroga Chooranam
The investigation employs Wistar albino male rats, segregated into four groups, to examine the pharmacological effects of Moolaroga chooranam. Group III and Group IV received Moolaroga chooranam in doses of 200 mg/kg and 400 mg/kg respectively, after an initial period of aspirin administration, resulting in a notable reduction in bleeding times as compared to the aspirins control group. This suggests that Moolaroga chooranam exhibits significant styptic activity, effectively aiding in the management of bleeding caused by piles by enhancing the body’s clotting mechanisms.
3) Experimental Methodology
The experiment utilized a rigorous methodology to assess the effects of Moolaroga chooranam on bleeding-related parameters. This involved administering specific dosages in controlled conditions and carefully monitoring the bleeding time, clotting time, and prothrombin time. The results indicated a significant decrease in these parameters for the test groups receiving Moolaroga chooranam, demonstrating the formulation's potential efficacy as a styptic agent. Accurate measurements were taken and statistical analysis was performed to ensure the validity of the findings.
4) Ingredients of Moolaroga Chooranam
Moolaroga chooranam is composed of several natural ingredients known for their medicinal properties. The formulation includes plants such as Thuthuvalai (Solanum trilobatum) and Marul kizhangu (Sansevieria roxbhurghiana), which are acknowledged for their astringent characteristics. The presence of tannins in these plants is believed to contribute to the styptic activity of Moolaroga chooranam, highlighting the importance of traditional knowledge in modern pharmacological applications. Understanding the herbal composition aids in comprehending the mechanism of action and potential therapeutic benefits of the formulation.
5) Conclusion
The study demonstrates that Moolaroga chooranam possesses significant styptic activity, indicating its efficacy in managing bleeding associated with piles. With p-values less than 0.05 and 0.01, the results support the use of this Siddha herbal formulation as a viable therapeutic option. In conjunction with lifestyle modifications and dietary changes, Moolaroga chooranam could offer substantial benefits for those suffering from bleeding piles, reflecting the value of traditional medicine in contemporary healthcare practices. Further research and clinical trials may help solidify its standing as an effective treatment modality.
FAQ section (important questions/answers):
What are haemorrhoids, and what causes them?
Haemorrhoids, or piles, are varicosities of the haemorrhoidal veins, causing abnormal sliding of anal cushions. Causes include chronic constipation, straining during defecation, low-fiber diet, and hereditary factors.
What is the objective of the study on Moolaroga Chooranam?
The study aimed to evaluate the styptic activity of Moolaroga Chooranam in stopping bleeding by assessing its effects on bleeding, clotting, and prothrombin times in a rat model.
What were the main findings related to bleeding and clotting times?
The results demonstrated significant decreases in bleeding and clotting times in the groups treated with Moolaroga Chooranam, indicating its potential styptic activity compared to the control group receiving aspirin.
How was the effect of Moolaroga Chooranam tested on rats?
Wistar albino male rats were grouped and treated with aspirin, followed by oral administration of Moolaroga Chooranam. Bleeding, clotting, and prothrombin times were recorded to assess styptic effects.
What ingredients are used in Moolaroga Chooranam?
Moolaroga Chooranam includes several herbs, such as Solanum trilobatum, Sansevieria roxbhurghiana, and Cissus quadrangularis, known for their properties beneficial in treating haemorrhoids.
What is the significance of tannins in Moolaroga Chooranam?
Tannins present in Moolaroga Chooranam provide astringent properties, which may contribute to the formulation's ability to stop bleeding and enhance its efficacy in the treatment of bleeding piles.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Pharmacological evaluation of Moolaroga Chooranam for bleeding piles.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Bleeding:
Bleeding refers to the loss of blood, which is a significant symptom in medical conditions like piles. The study focuses on evaluating the styptic activity of Moolaroga chooranam in reducing bleeding times in rats. Controlling bleeding is crucial for alleviating symptoms associated with bleeding piles.
2) Animal:
Animals in the study refer specifically to the test subjects, Wistar albino male rats, used to evaluate the medicinal effects of Moolaroga chooranam. The role of animals is crucial for preclinical testing, allowing researchers to observe biological responses before considering human applications.
3) Siddha:
Siddha refers to an ancient traditional system of medicine originating in South India. It emphasizes the use of herbal formulations like Moolaroga chooranam for treating ailments such as bleeding piles. Siddha medicine incorporates holistic approaches and studies the effects of various natural substances on health.
4) Drug:
Drug in this context refers to Moolaroga chooranam, a herbal formulation under study for its styptic activity. It plays a significant role in the management of bleeding piles and serves as a therapeutic agent identified through traditional Siddha texts, highlighting the blend of ancient wisdom and modern pharmacology.
5) Study (Studying):
The study is a scientific investigation aimed at assessing the efficacy of Moolaroga chooranam in stopping bleeding. Research studies like this contribute to the validation of traditional medicines using modern scientific methods, bridging the gap between culturally rooted practices and evidence-based medicine.
6) Activity:
Activity refers to the pharmacological effects of Moolaroga chooranam, specifically its styptic activity, which indicates its ability to reduce bleeding. Such evaluations are important in understanding how traditional remedies can achieve desired therapeutic outcomes in various health conditions.
7) Chennai:
Chennai is the location where the research was conducted at the Centre for Lab Animal Technology and Research. Being a major city in South India, Chennai plays a crucial role in advancing Siddha medicine and collaborating with modern scientific communities for research and development.
8) Medicine:
Medicines encompass prescribed, over-the-counter, and traditional remedies used to treat various ailments. This study integrates traditional Siddha medicines with pharmacological methods, reinforcing the need to explore and validate ancient practices in contemporary healthcare settings effectively.
9) India:
India is significant in the context of traditional medicine, hosting diverse healing practices like Siddha. With a large population suffering from conditions like piles, research into effective treatments is essential. This study aligns with India's rich cultural heritage of medicinal knowledge and emphasizes its relevance in modern health.
10) Table:
Table refers to the structured data presentation used to compare the effects of Moolaroga chooranam on bleeding, clotting, and prothrombin times among different test groups. Tables are invaluable in research for summarizing data, enhancing clarity, and aiding in the interpretation of results.
11) Food:
Food is mentioned concerning diet-related factors contributing to conditions like piles. Proper dietary choices can impact health; for instance, a fibrous diet may help alleviate symptoms. The study considers dietary interventions in conjunction with medicinal treatments for a holistic approach to health.
12) Pharmacological:
Pharmacological pertains to the branch of medicine that studies the effects and mechanisms of drugs. In this study, pharmacological evaluation focuses on how Moolaroga chooranam interacts within biological systems to exert its styptic effects, thereby validating its traditional use through scientific inquiry.
13) Water:
Water is considered essential for hydration and overall health. In the context of the study, adequate hydration is crucial for animal welfare during experiments, ensuring that biological responses and the overall integrity of the study results are maintained throughout the research period.
14) Blood:
Blood is a vital bodily fluid linked to various physiological processes, including clotting and healing. In this study, blood parameters are measured to assess the impact of Moolaroga chooranam on bleeding times, directly relating to its potential therapeutic action for managing bleeding piles.
15) Diet:
Diet refers to the consumption patterns of individuals, which can significantly affect health, particularly in managing conditions like piles. The study highlights how dietary choices can complement medicinal treatments, promoting a broader understanding of lifestyle interventions in conjunction with herbal therapies.
16) Male:
Male designates the gender of the Wistar albino rats used in the experiment. Gender can influence biological responses to treatments, and using male rats helps standardize experimental conditions, controlling for variations that might arise if both genders were included in the study.
17) Cynodon dactylon:
Cynodon dactylon, known as Bermuda grass, is one of the ingredients in Moolaroga chooranam. Its inclusion indicates the formulation's reliance on specific plants known for their medicinal properties. Understanding each ingredient helps highlight synergy within traditional blends for treating conditions like piles.
18) Kanakavalli:
Kanakavalli likely refers to one of the authors involved in the research or may pertain to a specific traditional aspect within the Siddha system. Author names often underscore the collaboration and expertise required to conduct thorough and credible scientific investigations in herbal medicine.
19) Discussion:
Discussion in a scientific context involves analyzing and interpreting the results obtained from the study. It allows researchers to contextualize findings within existing literature and explore the implications of the results on traditional practices and future research directions in herbal pharmacology.
20) Nirmulli:
Neermulli, or Hygrophila auriculata, is another ingredient in Moolaroga chooranam. This plant is noted for its medicinal properties in traditional medicine. Its role in the formulation underlines the importance of incorporating various botanicals renowned for their benefits in treating specific health issues.
21) Relative:
Relative in this context may refer to the comparison of group outcomes in the study, highlighting differences in bleeding, clotting, and prothrombin times. Understanding the relationships between different variables is crucial for drawing meaningful conclusions about the efficacy of treatments in research.
22) Disease:
Disease refers to pathological conditions adversely affecting bodily functions. In this study, the focus is on bleeding piles, which is common yet often neglected. Addressing such diseases through effective traditional and modern treatments can enhance patients' quality of life and healthcare outcomes.
23) Rattha:
Rattha refers to a specific type of bleeding piles in Siddha medicine. Recognizing and understanding this classification is essential for tailoring treatments accordingly. The study validates the traditional context and classification of ailments, bridging the gap between ancient knowledge and contemporary research.
24) Family:
Family denotes the classification of botanical species, which is crucial in understanding the properties of plants used in medicines. Each family carries specific traits and potentials, aiding in selecting appropriate herbs and ingredients for creating efficacious formulations like Moolaroga chooranam.
25) Labour (Labor):
Labour refers to the physical exertion involved in daily activities that can contribute to health issues like piles. Understanding lifestyle factors, including labor-intensive work, is important in the context of prevention and management strategies for such conditions within traditional and modern healthcare frameworks.
26) Filling (Filled):
Filled refers to the method of blood collection utilized in the clotting time determination process. Proper blood collection techniques are critical in experimental protocols, ensuring accuracy in measurements and contributing to the reliability and validity of the study's results.
27) Botany:
Botany is the scientific study of plants, essential for understanding the properties, taxonomy, and ecological roles of plants used in traditional medicine. This study involves authenticated plant ingredients, demonstrating how botanical knowledge supports research into the efficacy of herbal medicines like Moolaroga chooranam.
28) Marul:
Marul refers to Marul kizhangu or Sansevieria roxbhurghiana, a plant in the Moolaroga chooranam formulation. The inclusion of such plants emphasizes the rich diversity of traditional knowledge and highlights the importance of specific herbs in addressing health concerns within Siddha medicine.
29) Tamil:
Tamil represents the language spoken in Tamil Nadu, South India, where Siddha medicine originated. The cultural and linguistic context enhances the understanding of traditional practices and formulations, allowing for better communication and dissemination of knowledge related to Siddha healing methods.
30) Anger (Angry):
Angry is mentioned within the context of Siddha perspectives on the etiology of piles. Emotions and mental states are considered important factors in traditional healing systems. Understanding such connections highlights the integrative nature of Siddha medicine in treating bodily ailments and promoting overall well-being.
31) Cage:
Cage refers to the housing used for the rats during the study. Proper animal housing is crucial for ensuring the mental and physical welfare of subjects in research. Attention to animal care standards is essential for ethical compliance and the reliability of experimental outcomes.
32) Pose:
Pose indicates a potential threat or risk. In the study context, untreated piles can pose serious medical issues, emphasizing the need for effective treatments. The focus on the urgent need for solutions showcases the importance of research in addressing prevalent health problems.
33) Rich (Rch):
Rich describes the content and abundance of specific compounds within the Moolaroga chooranam formulation, particularly tannins responsible for its styptic properties. Identifying rich sources of beneficial ingredients in traditional formulations is essential for maximizing therapeutic efficacy in treating ailments.
34) Seat (Seated):
Seat refers to the sitting postures associated with lifestyle factors that potentially contribute to conditions like piles. Understanding the impact of such everyday habits on health helps frame effective preventive and management strategies within culturally relevant practices in traditional medicine.
35) Sour:
Sour alludes to dietary components believed to contribute to conditions like piles in traditional Siddha medicine. The study recognizes the role of specific dietary habits in health and illness, advocating for dietary modifications as part of holistic therapeutic approaches alongside herbal treatments.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Pharmacological evaluation of Moolaroga Chooranam for bleeding piles.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Bleeding piles, Internal piles, Diet and lifestyle, Animal ethical committee, Astringent property, Prothrombin time, Chronic constipation, Haemorrhoidal veins, Clotting time, External Piles, Siddha system of medicine.