Neuropharmacological evaluation of sesbania sesban using experimental animals

| Posted in: Science

Journal name: World Journal of Pharmaceutical Research
Original article title: Neuropharmacological evaluation of sesbania sesban using experimental animals
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
This page presents a generated summary with additional references; See source (below) for actual content.

Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

M. S. Kale, S. U. Kolhe and Dr. S. V. Tembhurne


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Neuropharmacological evaluation of sesbania sesban using experimental animals

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr201812-12613

Copyright (license): WJPR: All rights reserved


Download the PDF file of the original publication


Summary of article contents:

Introduction

The recent increase in life expectancy and the ageing population has led to a rise in chronic neurological disorders, prompting the exploration of medicinal plants that may provide therapeutic benefits with fewer side effects. This study investigates the neuropharmacological effects of the ethanolic extract of Sesbania sesban using various experimental animal models. The research aims to evaluate the anxiolytic, nootropic, and addiction potential of this plant extract, as well as its influence on dopamine levels in the rat brain, thus providing insight into its neuropharmacological properties.

Anxiolytic Activity of Sesbania sesban

The anxiolytic effects of Sesbania sesban were assessed using the Elevated Plus Maze (EPM) test, where the behavior of mice in response to the presence of the extract was measured. Mice treated with two different doses (100 mg/kg and 300 mg/kg) displayed a significant increase in the time spent in open arms of the maze, indicating reduced anxiety levels compared to control groups. Interestingly, while the higher dose showed significant changes, the lower dose's effects were not as pronounced, suggesting a dose-dependent relationship in the anxiolytic activity of the extract.

Nootropic Activity Evaluation

The study also delved into the nootropic effects of Sesbania sesban through the Radial Arm Maze test. This assessment was designed to measure cognitive function related to memory and learning over an 11-day period. Results indicated that the extract exhibited some nootropic activity, particularly at the higher dosage of 300 mg/kg, where it improved the time taken by animals to reach food pellets and reduced the frequency of re-entries into previously visited arms. However, the overall nootropic activity was minimal, reflecting the need for further investigation into the mechanisms underlying these observations.

Addiction Potential Assessed by Conditioned Place Preference

To evaluate the potential for addiction, the Conditioned Place Preference (CPP) test was employed. This test segmented the rats into zones based on the association of drug administration with specific environmental settings. Ultimately, it was found that the subjects exhibited a preference for the saline-paired environment over the drug-paired chamber, thereby suggesting that Sesbania sesban extract does not induce addictive behaviors. This lack of conditioned place preference implies a potential therapeutic role for the plant without the risks commonly associated with addiction.

Conclusion

The findings presented in this study indicate that Sesbania sesban possesses notable anxiolytic properties, a degree of nootropic activity, and is non-addictive when tested in animal models. The slight increase in brain dopamine levels could not be conclusively attributed to the extract, necessitating further research into the plant's biochemical mechanisms. Overall, these results highlight the potential of Sesbania sesban as a source of therapeutic agents for managing anxiety and cognitive disorders, warranting more extensive studies to explore its pharmacological applications and effectiveness.

FAQ section (important questions/answers):

What was the objective of the study on Sesbania sesban?

The study aimed to evaluate the neuropharmacological activities of ethanolic extract of Sesbania sesban using experimental animal models, addressing chronic neurological disorders.

What animal models were used for neuropharmacological evaluation?

The study utilized elevated plus maze, radial arm maze, and conditioned place preference chamber tests to assess neuropharmacological effects.

What were the findings regarding the anxiolytic properties of the extract?

The extract exhibited significant anxiolytic effects by increasing open arm entries and time spent in the open arms during the elevated plus maze test.

How did the extract perform in the radial arm maze test?

The extract displayed partially significant nootropic activity, particularly in reducing re-entries and influencing time taken to reach food pellets.

What were the results of the conditioned place preference test?

The extract was non-addictive, as animals preferred the saline-paired chamber, indicating no conditioned place preference for the drug-paired chamber.

What was observed regarding dopamine levels after administration of the extract?

Minor increases in brain dopamine levels were observed, but these were not conclusively attributed to the extract itself, warranting further research.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Neuropharmacological evaluation of sesbania sesban using experimental animals”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Animal:
Animals in this context emphasize the broader category of living organisms used in research. They are important subjects for evaluating the pharmacological effects of medicinal plants on neurological functions, as their biological responses can provide insights into possible therapeutic applications for human health and mental disorders.

2) Drug:
The term 'Drug' signifies a substance used for therapeutic purposes. In this study, drugs are crucial for comparing the effects of natural extracts like Sesbania sesban against established pharmacological agents. Understanding drug actions helps in evaluating safety, efficacy, and potential applications in treating neurological conditions.

3) Activity:
Activity pertains to the specific effects or roles that substances, particularly drugs, have on biological systems. In the study, various activities, such as anxiolytic and nootropic effects, are assessed, allowing researchers to evaluate how effective the medicinal extract is in modulating neurological functions and behaviors in experimental setups.

4) Food:
Food highlights the nutritional context necessary for animal subjects in studies, ensuring they are well-nourished for accurate behavioral assessments. In pharmacological studies, especially those involving cognition and activity, food intake could influence results, making it crucial to control for dietary factors during experimentation.

5) Visit:
Visit refers to the action taken by animals in experimental tasks, like visiting different arms of a maze. This term is significant as it describes the exploration behavior that can indicate memory, learning, or anxiety levels, essential for evaluating the neuropharmacological effects of the plant extracts.

6) Anxiety:
Anxiety is a psychological state characterized by excessive fear or worry. It is a key focus in neuropharmacological research, particularly when assessing the anxiolytic properties of substances. Understanding anxiety helps researchers evaluate how interventions may alleviate symptoms associated with anxiety disorders in humans.

7) Study (Studying):
Study refers to the systematic investigation carried out to gain knowledge about the effects of certain substances. It is relevant as it underpins the scientific approach taken to explore the neuropharmacological actions of Sesbania sesban and its potential therapeutic benefits for neurological disorders.

8) Table:
Table represents a method of organizing data systematically for clearer comparison and reference. In research, tables summarize experimental results, enhancing comprehension of findings related to pharmacological effects and facilitating efficient data interpretation regarding drug efficacy and animal behavior.

9) Pune:
Pune is a geographic reference that indicates the location of the study. It is relevant as it establishes the context of research conducted within India, where traditional medicine practices like using herbal medicines are prevalent. Local flora is often investigated for potential therapeutic applications.

10) Medicine:
Medicines are drugs or compounds used for therapeutic purposes. In this research, the evaluation and potential application of plant-derived medicines underscore the importance of traditional knowledge alongside modern pharmacology in addressing health issues, particularly in neurological contexts.

11) Pharmacological:
Pharmacological pertains to the study of drugs, their mechanisms of action, therapeutic effects, and potential side effects. This term is essential for understanding how the extracts from plants like Sesbania sesban interact with biological systems and their potential therapeutic applications in treating neurological disorders.

12) Disease:
Diseases encompass a range of pathological conditions affecting the body. This term is crucial in the study's context, as the evaluation of natural extracts directly relates to their ability to combat various diseases, particularly those pertaining to neurological imbalances and disorders.

13) India:
India signifies the country context for the research, highlighting its rich tradition of using medicinal plants in Ayurveda and other traditional practices. This context emphasizes the potential significance of local species like Sesbania sesban and their exploration for modern pharmacological applications.

14) Fear:
Fears represent emotional responses to perceived threats, related to anxiety disorders. Understanding the impact of herbal extracts on fears can inform researchers about potential anxiolytic properties, reinforcing the therapeutic value of natural substances in treating anxiety-related conditions.

15) Mental disorder:
Mental disorders encompass a variety of psychological or emotional conditions affecting cognitive functioning and behavior. This term's relevance lies in the focus of the study on exploring natural remedies to alleviate symptoms of such disorders through neuropharmacological activities.

16) Substance:
Substances denote the various materials, primarily chemical compounds, being tested or studied for pharmacological effects. The study focuses on evaluating the properties of natural substances derived from plant material, exploring their potential impacts on mental health and cognitive functions.

17) Species:
Species indicates biologically distinct groups of organisms. In pharmacology, understanding species differences is essential when studying drug responses in various animal models, as this knowledge influences the translation of research findings to humans and enhances the understanding of medicinal plant properties.

18) Water:
Water refers to the solvent used in the extraction process of active compounds from plants. Its relevance lies in its critical role in preparing plant extracts for pharmacological assessments, impacting the bioavailability and efficacy of the therapeutic compounds being studied.

19) Pharmacology:
Pharmacology is the branch of medicine that focuses on the study of drugs, their effects and interactions within biological systems. This term is fundamental to the research, framing the investigation into how plant-derived substances can affect neurological functions and mental health.

20) Flavonoid:
Flavonoid is a type of phytochemical compound often found in plants, known for its antioxidant properties. Its relevance in this context ties into the potential effects of plant extracts on health, especially when evaluating therapeutic benefits and mechanisms of action in neuropharmacological studies.

21) Toxicity:
Toxicity refers to the degree to which a substance can harm living organisms. It is a critical consideration in pharmacological studies to ensure that medicinal extracts are safe for use, thus guiding appropriate dosing and evaluation of adverse effects in experimental animal models.

22) Road:
Road refers to the pathways related to the research or methodologies used in pharmacological studies. Its relevance could encompass metaphoric connections regarding the journey of discovery in medicinal plant research for neuropharmacological activities and the path ahead for continued investigation.

23) Mud:
Mood signifies the emotional state or disposition of an individual, which can influence behavior and mental health. In this context, assessing mood-related effects of medicinal extracts is essential for understanding their potential roles in managing conditions such as anxiety and depression.

24) Life:
Life pertains to the biotic aspect of existence that can be affected by mental and physical health. Understanding the ways in which medicinal plants can improve the quality of life through their therapeutic effects ties directly into the study's aim of enhancing health outcomes.

25) Phytochemical:
Phytochemical refers to bioactive compounds extracted from plants, which may provide health benefits. In the neuropharmacological evaluation, the exploration of phytochemicals like flavonoids highlights the potential of natural products in promoting mental health and treating neurological disorders.

26) Transmission:
Transmission refers to the process of conveying signals in biological systems, particularly between neurons. It is essential to understand neurotransmission pathways when studying the effects of drugs, offering insights into how plant extracts can modulate signaling mechanisms related to mental health.

27) Calculation:
Calculation relates to the quantitative analysis involved in evaluating pharmacological results. It emphasizes the importance of statistical methods in research for interpreting data accurately and ensuring that conclusions drawn from experimental work are reliable and valid.

28) Performance:
Performance refers to the effectiveness of an animal in completing tasks during experiments. In this study, evaluating the performance of animals in behavioral assays sheds light on the potential cognitive and anxiolytic benefits of medicinal extracts under investigation.

29) Discussion:
Discussion denotes the analytical interpretation of results in research. It is significant as it provides insights, hypotheses, and implications regarding therapeutic properties, allowing researchers to contextualize their findings within the existing body of knowledge in neuropharmacology.

30) Developing:
Developing refers to the process of creating and optimizing new compounds or therapies. In pharmacology, it underscores the ongoing efforts to translate traditional knowledge into modern medicinal applications, especially concerning the evaluation of herbal medicines for neurological health.

31) Obsession:
Obsession describes an overwhelming preoccupation with specific thoughts or behaviors, often linked to anxiety disorders. Understanding obsession is relevant in assessing psychological responses during the study of neuropharmacological effects and evaluating the potential therapeutic benefits of the plant extracts.

32) Delusion (Deluded):
Delusion denotes a specific type of persistent erroneous belief often encountered in psychiatric conditions. Its relevance is particularly important in assessing the psychological impact of drugs or plant extracts, facilitating evaluations of their potential in treating complex mental health issues.

33) Ayurveda (Ayus-veda):
Ayurveda is a traditional system of medicine originating from India that emphasizes the use of herbs. Its relevance in this study underlines the importance of traditional healing practices in contemporary pharmacological research, particularly regarding the exploration of local plant species' therapeutic properties.

34) Training:
Training pertains to the preparatory processes used in animal studies to familiarize subjects with their experimental environments. Its significance lies in ensuring that animals are adequately prepared for tasks, which contributes to the validity of behavioral assessments in research.

35) Learning:
Learning describes the acquisition of knowledge and skills, often assessed through behavioral testing in animal models. This term emphasizes the importance of cognitive function in understanding the efficacy of neuropharmacological agents and their potential benefits for memory enhancement.

36) Entering:
Entering refers to the act of animals moving into designated areas during behavioral trials. This term's relevance lies in observing exploratory behavior, providing insights into anxiety levels or cognitive functions as assessed in various neuropharmacological tests.

37) Epilepsy:
Epilepsy is a neurological disorder characterized by recurrent seizures. The reference to epilepsy highlights the significance of investigating treatments for neurologically-based disorders, underlining the importance of understanding herbal remedies as potential therapeutic interventions in seizure management.

38) Quality:
Quality in this context refers to the overall effectiveness and safety of therapeutic agents, including herbal extracts. Research aims to enhance the quality of life for individuals suffering from mental and neurological disorders through effective treatments derived from natural substances.

39) Powder:
Powder refers to the physical form of plant material post-extraction, often used for dosage preparation. Its relevance in pharmacology lies in its role in enabling standardized dosing forms for evaluating the therapeutic potentials of herbal medicines in experimental settings.

40) Firing:
Firing pertains to the neural activity or electrical impulses that occur during neurotransmission. Understanding firing in the context of pharmacology is essential for assessing the effects of drugs on brain functions and how treatments may influence neurological activity.

41) Field:
Field denotes a specific area of study, such as pharmacology or neuropharmacology. This term establishes the scope of research, offering insights into the specialized investigation of medicinal plants and their impacts on mental health and neurological disorders.

42) Fever:
Fever represents an elevated body temperature often due to infection. It is relevant in pharmacological research as it reflects an immune response, and understanding how medicinal plants can affect fever-related symptoms expands potential therapeutic applications for various health issues.

43) Death:
Death relates to the cessation of biological functions and is the ultimate outcome of severe health conditions. The relevance lies in the rationale for developing effective treatments that mitigate fatal diseases, underscoring the importance of research into medicinal plants' therapeutic benefits.

44) House:
House refers to the controlled environment where animal studies are conducted. It is crucial for ensuring ethical treatment and appropriate conditions for the animals involved in research, directly affecting the validity and reproducibility of experimental results.

45) Blood:
Blood is vital fluid within organisms, crucial for various physiological functions. In pharmacology, understanding blood parameters is significant as many drugs affect biochemical pathways in the bloodstream. Hence, blood may be analyzed to assess the pharmacodynamic effects of studied substances.

46) Pain:
Pain signifies unpleasant sensory experiences that can arise from various physical or psychological disorders. The study's relevance lies in evaluating the analgesic properties of medicinal plants, contributing to the understanding of how certain extracts may help alleviate physiological discomfort.

Other Science Concepts:

[back to top]

Discover the significance of concepts within the article: ‘Neuropharmacological evaluation of sesbania sesban using experimental animals’. Further sources in the context of Science might help you critically compare this page with similair documents:

Medicinal plant, Statistical analysis, Animal model, Nootropic activity, Anxiolytic properties, Elevated plus maze test, Herbal therapy, Neurotransmitter dopamine, Conditioned place preference, Phytochemical constituent.

Let's grow together!

I humbly request your help to keep doing what I do best: provide the world with unbiased sources, definitions and images. Your donation direclty influences the quality and quantity of knowledge, wisdom and spiritual insight the world is exposed to.

Let's make the world a better place together!

Like what you read? Help to become even better: