Antioxidant and antimicrobial activity of Ophiocoma and Ophiomastrix.
Journal name: World Journal of Pharmaceutical Research
Original article title: Antioxidant and antimicrobial activity of ethanolic extract from ophiocoma erinaceus and ophiomastrix annulosa
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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S. Senthikumari and K. Revathi
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Antioxidant and antimicrobial activity of ethanolic extract from ophiocoma erinaceus and ophiomastrix annulosa
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr201813-12621
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Summary of article contents:
Introduction
The research conducted by S. Senthikumari and K. Revathi explores the antioxidant and antimicrobial activities of ethanolic extracts from two brittle star species, Ophiocoma erinaceus and Ophiomastrix annulosa. Emphasizing the potential of natural marine products in pharmaceutical applications, the study leverages various assays to characterize the bioactive components derived from these echinoderms. With promising applications in managing diseases, particularly those related to oxidative stress and microbial infections, their findings contribute valuable insights into marine-derived medicinal resources.
Antioxidant Activity of Marine Extracts
The study employed different assays, including the DPPH radical scavenging assay, hydroxyl radical scavenging activity, nitric oxide radical scavenging assay, and ferric reducing antioxidant power (FRAP), to evaluate the antioxidant potential of the brittle star extracts. The results indicated that O. erinaceus exhibited superior antioxidant activity, with an IC50 value of 55.37±4.76 µg/mL for DPPH scavenging. In comparison, O. annulosa displayed notable antioxidant activity, particularly through hydroxyl radical scavenging (51.21±1.32 µg/mL). These findings underscore the efficacy of these extracts in combating oxidative stress, highlighting their potential therapeutic applications in managing various diseases associated with free radicals.
Antimicrobial Properties
The antimicrobial efficacy of O. erinaceus and O. annulosa extracts was tested against several human pathogens, including Bacillus sp., Pseudomonas aeruginosa, Proteus sp., and E. coli. The results demonstrated that O. erinaceus showed a maximum zone of inhibition of 4 mm against Pseudomonas aeruginosa, while O. annulosa displayed a maximum inhibition zone of 3 mm against Bacillus sp. The study's findings indicate that both brittle star species possess broad-spectrum antibacterial properties, which can be attributed to the presence of various bioactive compounds within the extracts, marking them as potential candidates for developing novel antimicrobial agents.
Bioactive Compounds
The research highlights the diverse array of secondary metabolites generated by marine organisms, particularly echinoderms, which include compounds such as steroids and terpenoids. These substances not only serve as defensive mechanisms for the organisms but also exhibit a range of biopharmaceutical properties. The study suggests that the bioactive compounds found in O. erinaceus and O. annulosa could be instrumental in the development of new drugs, given their significant antioxidant and antimicrobial activities. The complexity of these metabolites presents an exciting opportunity for further research aimed at isolating and understanding their individual mechanisms of action.
Conclusion
The exploration of Ophiocoma erinaceus and Ophiomastrix annulosa in this study underscores the importance of marine biodiversity as a source of novel bioactive compounds with significant therapeutic potential. The findings reveal the remarkable antioxidant and antimicrobial properties of these brittle star extracts, advocating for further research to identify and exploit their bioactive constituents. As the global health landscape faces increasing challenges from resistant pathogens and oxidative stress-related diseases, marine invertebrates like brittle stars represent a promising frontier in the quest for effective natural drugs.
FAQ section (important questions/answers):
What are the main objectives of the study on brittle stars?
The study aimed to evaluate the antioxidant and antimicrobial activities of ethanolic extracts from two brittle stars, Ophiocoma erinaceus and Ophiomastrix annulosa, to explore their potential as bioactive compounds.
How were the antioxidant activities measured in the study?
Antioxidant activities were measured using various assays, including DPPH radical scavenging, hydroxyl radical scavenging, nitric oxide radical scavenging, ferric reducing/antioxidant power (FRAP), and ABTS radical scavenging methods.
What microorganisms were tested against the brittle stars' extracts?
The ethanolic extracts were tested for antibacterial activity against human pathogens such as Bacillus spp., Pseudomonas aeruginosa, Proteus spp., and E. coli using the disc diffusion method.
What were the results of the antibacterial activity tests?
Ophiocoma erinaceus extract showed maximum inhibition against Pseudomonas aeruginosa, while Ophiomastrix annulosa exhibited notable inhibition against Bacillus spp. The study indicates the potential of these extracts in combating bacterial infections.
What is the significance of antioxidant properties in this research?
Antioxidants are crucial for managing diseases caused by free radicals and oxidative stress. The study highlights the potential of brittle star extracts as sources of natural antioxidants in biomedical applications.
What conclusions were drawn about the use of these brittle stars?
The study concludes that Ophiocoma erinaceus and Ophiomastrix annulosa contain bioactive compounds with significant antioxidant and antibacterial properties, suggesting they could be valuable sources for developing new medicinal agents.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Antioxidant and antimicrobial activity of Ophiocoma and Ophiomastrix.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
Activity refers to the range of biological actions exhibited by the ethanolic extracts of brittle stars, specifically their antioxidant and antibacterial properties. The study investigates how effectively these extracts can scavenge free radicals and inhibit the growth of various pathogens, which is critical for evaluating their therapeutic potential.
2) Antibiotic (Antibacterial):
Antibacterial activity pertains to the ability of a substance to inhibit bacterial growth or kill bacteria. In this study, the ethanolic extracts from brittle stars, Ophiocoma erinaceus and Ophiomastrix annulosa, demonstrated significant antibacterial activity against human pathogens, showcasing their potential as natural antibacterial agents in medicine.
3) Disease:
Diseases encompass a broad range of pathological conditions that can affect human health. The study highlights how the antioxidant and antibacterial properties of marine extracts could potentially be utilized to combat various diseases, particularly those associated with oxidative stress and antibiotic resistance.
4) Table:
Tables in scientific research are used to organize and present data clearly. In this study, tables summarize important findings, such as IC50 values for antioxidant activities of the extracts compared to a control. This structured presentation aids in the comprehension of results and facilitates comparison within the data.
5) Drug:
Drug refers to any substance that causes a physiological change in the body, often utilized in treating diseases. The compounds extracted from marine organisms hold promise as potential new drugs due to their biological activities, thus playing a significant role in the search for effective pharmaceutical agents.
6) Water:
Water is a vital solvent in biological systems and is used extensively in the extraction processes during the study. It acts as a medium for chemical reactions and helps dissolve various substances, making it essential for carrying out assays and preparing samples for antioxidant and antibacterial testing.
7) Food:
Food refers to the substances consumed to provide nutrition and sustenance. In the context of this study, understanding the antioxidant properties of marine extracts can lead to their application in food products, enhancing nutritional value and preventing oxidative damage in food preservation.
8) Substance:
A substance is a form of matter that has specific properties. In this study, the focus is on the bioactive substances extracted from brittle stars, which may exhibit antioxidant and antibacterial properties, thereby offering potential applications in drug development and health promotion.
9) Chennai:
Chennai is a major city in India where the research was conducted. The geographical context is significant as it reflects local biodiversity, including the marine species studied. It also emphasizes the relevance of the research to the regional ecosystem and its potential medicinal resources.
10) Species:
Species refers to a group of organisms capable of interbreeding and producing fertile offspring. The study involves specific marine species, Ophiocoma erinaceus and Ophiomastrix annulosa, highlighting their unique biological properties and their importance in biodiversity and ecological research.
11) Zoology:
Zoology is the scientific study of animals, covering their biology, behavior, and ecology. This research falls within the zoological domain, as it examines marine invertebrates, focusing on their bioactive compounds and their implications for health and disease treatment, thereby contributing to zoological knowledge.
12) Pharmacological:
Pharmacological refers to the branch of medicine concerned with the uses and effects of drugs. The study investigates the pharmacological properties of marine extracts, examining their antioxidant and antibacterial potential, which could lead to the development of new pharmacological therapies derived from natural resources.
13) Knowledge:
Knowledge in this context pertains to the understanding gained from research about the biological activities and potential health applications of marine extracts. The findings contribute to the broader field of pharmacology and natural medicine, enriching our understanding of bioactive compounds from marine organisms.
14) Animal:
Animals encompass a wide range of living organisms, with the study focusing on marine invertebrates. Understanding the biological activities of these organisms is vital for biodiversity conservation and harnessing their potential for pharmaceutical development.
15) Study (Studying):
Study refers to the systematic investigation conducted to understand a specific phenomenon. In this case, the study evaluates the antioxidant and antibacterial activities of brittle star extracts. The findings aim to promote further exploration into marine bioactive compounds and their therapeutic potential.
16) Shand (Sand):
Sand serves as a natural substrate in the marine environment. The study includes minor aspects related to the collection of brittle stars, emphasizing the significance of habitat in biological research. Understanding the environment where organisms thrive is critical in assessing their biological properties and potential.
17) Surrounding:
Surrounding refers to the environmental context in which the brittle stars live. The marine ecosystem surrounding these organisms influences their biochemical properties and adaptations, making it crucial to consider ecological factors when researching bioactive compounds and their applications in medicine.
18) Discussion:
Discussion in a research paper synthesizes and interprets findings, contextualizing them within existing scientific literature. This section highlights the implications of the study, providing insights into the significance of the observed antibacterial and antioxidant activities of the studied extracts.
19) Developing:
Developing refers to the process of creating or advancing something—here, it pertains to the progress in research focusing on marine bioactive compounds. The study aims to inform the development of new drugs derived from marine organisms for disease prevention or treatment.
20) Education:
Education is critical for disseminating knowledge gained from research. This study contributes to educational resources about marine biodiversity and pharmacology, informing future studies and collaborations. Increased awareness can inspire new research avenues and applications in medicine and conservation.
21) Parvati:
Parvathi is referenced in the context of a citation, indicating the collaborative work and contributions of various researchers in understanding marine natural products. Acknowledging contributions fosters a comprehensive view of scientific progress in the field of marine pharmacology.
22) Company:
Company refers to entities or organizations involved in research and development. In the context of this study, it reflects the importance of collaborative efforts among academic and industrial partners in advancing marine pharmacological research and the development of new therapeutic agents.
23) Guindy:
Guindy is a locality in Chennai, India, significant for its educational institutions involved in biological research. The location is pertinent as it provides a context for the study, emphasizing the role of local academic institutions in advancing marine biology and pharmacology.
24) Family:
Family in biological classification refers to a group of related species. The study addresses different species within the phylum Echinodermata, enriching understanding of their biological relationships and the diversity of bioactive compounds that may be harnessed for pharmacological purposes.
25) Cancer:
Cancer refers to a group of diseases characterized by uncontrolled cell growth. Antioxidants have potential roles in cancer prevention and treatment. By investigating the antioxidant activities of brittle star extracts, this study contributes to the exploration of new therapeutic agents against cancer.
26) Nature:
Nature encompasses the physical world, including diverse ecosystems and organisms. The study emphasizes the potential of natural resources, particularly marine organisms, in providing bioactive compounds, showcasing the importance of conserving nature for future pharmaceutical discoveries.
27) Cotton:
Cotton might be incidental or related in this context when discussing materials or experimental methods. While the study primarily focuses on marine species, discussions of substrate or mediums may involve cotton in laboratory settings, especially in relation to filtration or absorbent materials during experiments.
28) Field:
Field refers to the area of study or discipline. This research is situated within the scientific field of pharmacology, marine biology, and zoology, exploring the intersection of these disciplines to uncover the potential medicinal properties of marine organisms.
29) Blood:
Blood is a vital fluid in animals and is often a focus in medical studies regarding disease and health. Although not directly addressed, the antioxidant properties investigated may have implications for diseases affecting the bloodstream, emphasizing the importance of research in this area.
30) Jacob:
Jacob may refer to a co-author or contributor within the context of the study. The significance of individuals like Jacob in research is essential, as collaborative efforts contribute to scientific advancements, particularly in exploring the medicinal properties of marine bioactive compounds.
31) Sima (Shima):
Sima is likely another reference to an author or researcher related to the study's context. This highlights the collaborative approach in scientific research, emphasizing how team efforts enrich the findings and understanding of marine natural products and their potential applications.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Antioxidant and antimicrobial activity of Ophiocoma and Ophiomastrix.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Comprehensive list, Free radical scavenging activity, Antimicrobial agent, Secondary metabolite, Ethanolic extract, Multidrug resistance, Nutrient agar, Antioxidant potential, Bioactive compound, Extraction method, Antibacterial assay.