A review of clerodendrum philippinum
Journal name: World Journal of Pharmaceutical Research
Original article title: A review of clerodendrum philippinum
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Sheelam Anjali and Dr. Challa Pradeep Kumar
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: A review of clerodendrum philippinum
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr201814-12910
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Summary of article contents:
Introduction
The genus Clerodendrum, particularly Clerodendrum philippinum, is widely recognized for its therapeutic applications across various indigenous medicinal systems. The genus consists of over 500 species distributed globally, with numerous species documented for treating serious health conditions. This review focuses on the phytochemical constituents and pharmacological properties of C. philippinum, emphasizing its use in traditional medicine and its bioactive compounds that exhibit significant health benefits.
Phytochemical Constituents of C. philippinum
Clerodendrum philippinum is rich in various phytochemicals, including flavonoids, alkaloids, phenols, terpenoids, saponins, tannins, glycosides, proteins, and steroids. These components were identified through standard qualitative methods in several studies. Notably, the extraction processes involved different solvents like ethyl acetate, petroleum ether, ethanol, and water, with results indicating that the ethanolic extract had the highest yield of phytoconstituents. The presence of these secondary metabolites correlates with the plant's medicinal properties, making C. philippinum a subject of interest for further pharmacological studies.
Pharmacological Activities: Antidiabetic Effects
One of the most significant findings regarding C. philippinum is its antidiabetic potential. Research conducted using streptozotocin-induced diabetic rats demonstrated that various extracts of C. philippinum, particularly the methanolic extract, effectively reduced blood glucose levels. The study investigated multiple doses and found a notable decrease in glucose levels, supporting the traditional use of this plant in managing diabetes. This highlights the potential for C. philippinum extracts to serve as a natural alternative in diabetes treatment regimens.
Pharmacological Activities: Antibacterial and CNS Effects
In addition to its antidiabetic properties, C. philippinum exhibits notable antibacterial and central nervous system (CNS) depressant effects. The ethanolic extracts demonstrated significant antibacterial activity against pathogens such as Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Bacillus subtilis, indicating its therapeutic potential as an antibacterial agent. Furthermore, studies on the plant's flowers revealed CNS depressant effects in behavioral models, suggesting its utility in treating anxiety and related disorders. Both these activities enhance the appeal of C. philippinum for broader medicinal applications.
Conclusion
Though many species of the Clerodendrum genus exist, C. philippinum stands out for its extensive phytochemical and pharmacological profiles. The plant's varying biological activities, including antidiabetic, antibacterial, and anti-anxiety effects, demonstrate its significant potential in traditional and modern medicine. Future research efforts could explore the isolation and development of specific active compounds from C. philippinum for therapeutic use, promoting its integration into contemporary clinical practices.
FAQ section (important questions/answers):
What is Clerodendrum philippinum and its significance?
Clerodendrum philippinum, part of the Lamiaceae family, is used in traditional medicine for various ailments. Its phytochemical constituents contribute to its therapeutic properties, making it significant in herbal medicine.
What are the main chemical constituents of Clerodendrum philippinum?
Clerodendrum philippinum contains flavonoids, alkaloids, triterpenoids, glycosides, phenolic compounds, saponins, and steroids, which are responsible for its various pharmacological activities.
What pharmacological activities are associated with Clerodendrum philippinum?
Research has shown that Clerodendrum philippinum exhibits anti-diabetic, anti-anxiety, central nervous system depressant, and antibacterial activities, indicating its potential as a therapeutic agent.
How is the anti-diabetic activity of Clerodendrum philippinum evaluated?
Anti-diabetic activity is evaluated using streptozotocin-induced diabetic rats. Various extracts show significant blood glucose level reduction, with methanol extract exhibiting the highest effect.
What antibacterial properties does Clerodendrum philippinum possess?
The ethanolic leaf extract of Clerodendrum philippinum shows antibacterial activity against bacteria like E. coli and Staphylococcus aureus, highlighting its potential use in treating infections.
What traditional uses does Clerodendrum philippinum have in medicine?
Clerodendrum philippinum has been traditionally used for treating asthma, rheumatism, kidney dysfunctions, and skin problems, making it a valuable plant in folk medicine.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “A review of clerodendrum philippinum”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
Activity refers to the biological or pharmacological actions exerted by compounds present in plants or extracts, such as anti-diabetic or antibacterial effects. Understanding the activity of a substance provides insight into its potential therapeutic uses and mechanisms of action in treating various ailments or diseases.
2) Genu:
Genu is a Latin term meaning 'knee.' In the biological context, it may not directly apply here; however, it's important to clarify that taxonomy relies on precise terminology for describing relationships between biological entities, potentially influencing discussions on anatomical or functional aspects related to a plant or organism.
3) Antibiotic (Antibacterial):
Anti-bacterial is another term for antibacterial, highlighting the capability of certain compounds or extracts to combat bacterial infections. This attribute is significant when discussing Clerodendrum philippinum, which has shown antibacterial properties in studies, supporting its traditional medicinal use against various pathogens.
4) Species:
Species is a fundamental category in biological classification that comprises individuals sharing common traits and capable of breeding. The reference to species in the context emphasizes the diversity of Clerodendrum species studied for their medicinal properties and potential therapeutic applications, particularly in traditional and folk medicine.
5) Phytochemical:
Phytochemical refers to bioactive compounds derived from plants, which can have health benefits or pharmacological activity. In the reviewed studies, various phytochemicals found in Clerodendrum philippinum contribute to its traditional uses and validate the significance of researching plant-derived compounds for medical applications.
6) Silam:
Anjali Sheelam is one of the authors of the review article. Her inclusion as a corresponding author indicates contributions to the research and study of Clerodendrum philippinum, emphasizing the collaborative nature of scientific endeavors in exploring the therapeutic potential of medicinal plants.
7) Medicine:
Medicine encompasses the science and practice of diagnosing, treating, and preventing illness. Traditional medicine often employs natural remedies from plants, like those derived from Clerodendrum philippinum, illustrating the continued relevance of herbal approaches in contemporary health care and pharmacology.
8) Pharmacological:
Pharmacological pertains to the study of drug action and interactions in biological systems. It encompasses the assessment of herbal extracts' effects on physiological functions, critical for determining therapeutic benefits and safety, especially concerning species like Clerodendrum philippinum that show promise in treating various conditions.
9) Anxiety:
Anxiety refers to a mental health condition characterized by excessive worry or fear. The investigation of Clerodendrum philippinum's potential anti-anxiety effects reflects the growing interest in herbal remedies for treating psychological disorders, aligning with holistic approaches to health and the search for alternative therapies.
10) Disease:
Disease signifies a pathological condition characterized by various physiological and psychological symptoms that can affect individual well-being. Understanding the therapeutic potential of Clerodendrum philippinum in addressing diseases reaffirms the need for research into plant-based treatments and their efficacy in modern medicine.
11) Aureus:
Aureus refers specifically to the bacterium Staphylococcus aureus, a significant pathogen responsible for various infections. The review highlights the antibacterial efficacy of Clerodendrum philippinum against this bacterium, which underscores the relevance of exploring plant extracts as potential sources for new antimicrobial agents.
12) Drug:
Drug denotes a chemical substance used to diagnose, treat, or prevent disease. The exploration of pharmacological properties of plant extracts, including Clerodendrum philippinum, emphasizes the importance of discovering new drugs derived from natural sources to address health concerns and improve therapeutic strategies.
13) India:
India is a country with a rich tradition of using herbal medicine and a diverse flora. The relevance of Clerodendrum philippinum in Indian traditional medicine showcases the cultural and historical significance of plant-based therapies and their integration into contemporary health practices.
14) Study (Studying):
Study refers to the systematic investigation of a particular subject to acquire knowledge. The studies on Clerodendrum philippinum explore its phytochemical and pharmacological properties, showcasing the importance of research in identifying therapeutic applications and substantiating traditional claims of efficacy.
15) Family:
Family refers to a higher taxonomic rank grouping related plants under a shared lineage. The relevance of the Lamiaceae family in the context of Clerodendrum philippinum emphasizes the botanical relationships and characteristics important for understanding the ecological and pharmacological potential of the species within.
16) Pharmacology:
Pharmacology is the branch of medicine concerned with the study of drugs and their effects on biological systems. The pharmacological research on extracts of Clerodendrum philippinum reveals how traditional remedies are being validated through scientific examination, thus bridging traditional and modern medical insights.
17) Science (Scientific):
Scientific refers to knowledge or methods based on empirical evidence and systematic studies. The review illustrates how the scientific approach applied to research on Clerodendrum philippinum leads to a more profound understanding of its medicinal properties, supporting its credibility and potential in healthcare.
18) Flavonoid:
Flavonoid is a class of phytonutrients found in various plants, renowned for their antioxidant properties and potential health benefits. The presence of flavonoids in Clerodendrum philippinum suggests its nutritional value and highlights its role in traditional medicine as a source of natural therapeutic compounds.
19) Toxicity:
Toxicity refers to the degree to which a substance can cause harm to an organism. The assessment of toxicity in studies of Clerodendrum philippinum is crucial for establishing safe dosages and understanding the adverse effects of herbal medicines, ensuring their responsible use in pharmacological applications.
20) Anjali (Amjali):
Anjali is likely a representation of one of the authors, Sheelam Anjali, emphasizing the collaborative nature of scientific research and showcasing individual contributions to the collective pursuit of knowledge within the field of pharmacology and plant-based medicine.
21) Malli:
Malli is a name used in India to refer to Clerodendrum philippinum, indicating its local significance and cultural relevance. Understanding vernacular names contributes to the recognition and preservation of traditional medicinal practices and the ethnobotanical knowledge associated with such plants.
22) Water:
Water is a universal solvent often used in extraction processes to yield phytochemicals from plant materials. The mention of water in the context implies its important role in the preparation of medicinal extracts from Clerodendrum philippinum, indicating its relevance in traditional herbal practices.
23) Blood:
Blood signifies the vital fluid in the body responsible for transporting nutrients and oxygen. The focus on blood glucose levels in diabetic studies involving Clerodendrum philippinum reflects the significance of understanding the plant's potential effects on metabolic health and disease management.
24) Pain:
Pain refers to a physical sensation indicating harm or discomfort. The study of Clerodendrum philippinum's application in alleviating pain, particularly in conditions such as rheumatism, underscores the importance of exploring herbal remedies as effective and safer alternatives in pain management.
25) Leucoderma:
Leucoderma, also known as vitiligo, is a skin condition characterized by loss of pigment. The historical use of Clerodendrum philippinum in treating conditions like leucoderma highlights the integration of traditional and medicinal approaches, indicating the plant's therapeutic potential in dermatological applications.
26) Developing:
Developing denotes nations or regions that are typically characterized by lower levels of industrialization and income. In the context, it emphasizes the significance of traditional medicine, where populations in developing countries often rely on plants like Clerodendrum philippinum for health care and primary treatment.
27) Leprosy:
Leprosy is a chronic infective disease that affects skin and nerves. The historical and cultural importance of plant extracts, such as those from Clerodendrum philippinum in treating such diseases demonstrates the rich heritage of herbal medicine and the continuous need for research in ethnopharmacology.
28) Challa:
Challa likely refers to Dr. Challa Pradeep Kumar, a co-author of the review. His contributions showcase the collaborative nature of research in understanding the pharmacological potential of herbal medicines like Clerodendrum philippinum, underscoring the teamwork inherent in scientific studies.
29) Medium:
Medium may refer to the growth environment for bacteria in studies. This term is important in microbiological research where the efficacy of plant extracts against specific pathogens is assessed, contributing to the understanding of antibacterial properties of substances like Clerodendrum philippinum.
30) Madra:
Madra may indicate a vernacular variation related to geographic or cultural aspects. It highlights the significance of local names and terms used in traditional medicine, facilitating a broader understanding of the relevance of plants like Clerodendrum philippinum in different cultural contexts.
31) Kumar:
Kumar refers to Dr. Challa Pradeep Kumar, the co-author of the article, emphasizing collaboration in research endeavors. His contribution illustrates the interdisciplinary efforts that are often necessary to conduct comprehensive investigations into the medicinal properties of plants like Clerodendrum philippinum.
32) Tamil:
Tamil is a Dravidian language spoken predominantly in the Indian state of Tamil Nadu and parts of Sri Lanka. Its mention highlights the regional significance of Clerodendrum philippinum and its traditional applications, underscoring the importance of ethnic and linguistic diversity in herbal medicine.
33) Cina:
China is a country with a long-standing tradition in herbal medicine. Including references to China reinforces the global use and study of plants like Clerodendrum philippinum, showcasing the diverse practices across different cultures in utilizing herbal remedies for health and wellness.
34) Ting:
Ting may refer to the descriptive term used for the flower's appearance within certain vernacular contexts. This emphasizes the botanical features and local lore surrounding plants, which contribute to their medicinal applications in various cultures and communities.
35) Tree:
Tree refers to the perennial woody plant, which could suggest the morphological features of Clerodendrum philippinum. Acknowledging the plant's characteristics can help in understanding its ecological role and its traditional uses, particularly in various cultures employing tree species for medicinal purposes.
36) Life:
Life signifies the biological existence of organisms and their interconnectivity within ecosystems. Understanding the importance of plants like Clerodendrum philippinum within the fabric of life itself reinforces the significance of preserving biodiversity for medical, nutritional, and ecological benefits essential for human health.
Other Science Concepts:
Discover the significance of concepts within the article: ‘A review of clerodendrum philippinum’. Further sources in the context of Science might help you critically compare this page with similair documents:
Traditional medicine, Phytochemical screening, Acute Toxicity Studies, Anti-inflammatory activities, Indigenous system of medicine, Ethanolic extract, Biological properties, Pharmacological studies, Anti-diabetic activity, Central nervous system depressant, Anti bacterial activity, Chemical constituent, Ornamental plant.