Qualitative analysis and α-amylase inhibition of Lantana camara extract
Journal name: World Journal of Pharmaceutical Research
Original article title: Qualitative analysis and α-amylase inhibition assay of aqueous foliar extract of lantana camara (linn)
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Debapriyo Bhowmick, Dr. Garima Bartariya and Abhishek Kumar
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Qualitative analysis and α-amylase inhibition assay of aqueous foliar extract of lantana camara (linn)
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr201814-12934
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Summary of article contents:
Introduction
Lantana camara (Linn), a plant belonging to the verbena family, is native to the American tropics and is commonly referred to by various names across the globe. This plant has long been recognized for its extensive medicinal properties, including antimicrobial, fungicidal, and insecticidal effects. Traditionally, it has been employed in herbal medicine to treat ailments such as cancer, skin issues, leprosy, and diabetes, among others. The present study focuses on examining the phytochemical constituents of L. camara, particularly its potential in diabetic therapy through the inhibition of α-amylase, an enzyme crucial for carbohydrate digestion.
Phytochemical Analysis of Lantana Camara
The qualitative analysis of the foliar extract from Lantana camara revealed the presence of specific phytochemicals like flavonoids and phenolic compounds, while amino acids, alkaloids, and saponins were absent. The study utilized various tests to confirm these results, including Mayer’s test for alkaloids and the froth formation test for saponins, among others. Flavonoids, known for their health-promoting properties, were confirmed present through the alkaline reagent test. This phytochemical composition indicates the potential value of L. camara extracts in the development of natural remedies, particularly in the management of health conditions linked to oxidative stress.
α-Amylase Inhibition Activity
The α-amylase inhibition assay conducted in the study aimed to evaluate the effectiveness of Lantana camara extracts in regulating carbohydrate digestion. This enzyme plays a significant role in breaking down carbohydrates into simple sugars, thereby influencing blood glucose levels. The study demonstrated that the aqueous foliar extract of L. camara inhibited α-amylase activity in a dose-dependent manner. Maximum inhibition was noted at a concentration of 5 mg/ml, with recorded inhibition percentages of 71.7%. This finding underlines the potential of L. camara as a functional food ingredient or supplement for diabetes management.
Conclusion
The study underscores the significance of Lantana camara as a source of bioactive compounds that may aid in glycemic control through α-amylase inhibition. With notable phytochemical constituents present in its foliar extracts, L. camara exhibits promising therapeutic potential in the management of diabetes, warranting further investigations. As diabetes continues to rise globally, exploring natural remedies and their underlying mechanisms could pave the way for developing effective treatment strategies. The research lays the foundation for future studies focused on developing L. camara as a valuable component in antidiabetic therapies.
FAQ section (important questions/answers):
What is Lantana camara and its medicinal uses?
Lantana camara is a plant from the verbena family known for its antimicrobial, fungicidal, and insecticidal properties. It has been used in traditional herbal medicine to treat various ailments, including cancer, skin itches, and respiratory infections.
What is the significance of α-amylase in diabetes treatment?
α-Amylase is a carbohydrate-hydrolyzing enzyme that breaks down starches into sugars. Inhibiting this enzyme can decrease glucose absorption in the blood, making it a therapeutic target for managing diabetes.
Which phytochemicals were found in Lantana camara leaves?
The qualitative analysis revealed the presence of flavonoids and phenols in Lantana camara leaves. However, alkaloids, amino acids, and saponins were absent in the tested extracts.
How was α-amylase inhibition tested in the study?
The study performed an α-amylase inhibition assay using varying concentrations of aqueous foliar extract. The inhibition of enzyme activity was measured by assessing absorbance at 540 nm after the reaction.
What were the key results of the α-amylase inhibition assay?
The aqueous foliar extract exhibited significant α-amylase inhibition in a dose-dependent manner, with maximum inhibition of 71.7% at a concentration of 5 mg/ml.
What further research is suggested based on these findings?
The study suggests that further research is required to explore Lantana camara as a potential antidiabetic therapy through α-amylase inhibition and to investigate its underlying mechanisms for health benefits.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Qualitative analysis and α-amylase inhibition of Lantana camara extract”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Camara (Camará):
Camara refers to 'Lantana camara,' a plant belonging to the verbena family. This particular species is known for its wide array of bioactive compounds and various medicinal properties. It has been used traditionally to treat ailments, making it relevant in studies focused on natural therapies and pharmacognosy.
2) Water:
Water is a vital component in the extraction process of phytochemicals from various plant materials, including 'Lantana camara.' It acts as a solvent that facilitates the dissolution of active compounds. In this study, distilled water was specifically used for extracting the leaves to analyze their bioactivity.
3) Phytochemical:
Phytochemicals are naturally occurring compounds found in plants, significant for their health-promoting effects. They play a crucial role in the study of herbal medicine as they exhibit various biological activities, including antioxidant, anti-inflammatory, and antidiabetic effects. Understanding these chemical properties contributes to developing alternative therapies.
4) Flavonoid:
Flavonoids are a class of phytochemicals characterized by their polyphenolic structure. These compounds contribute to various health benefits, including anti-inflammatory and antioxidant effects. Their presence in 'Lantana camara' indicates potential therapeutic applications, specifically in managing conditions like diabetes and promoting overall health.
5) Blood:
Blood plays a critical role in the context of diabetes, which is characterized by elevated glucose levels. The study explores the α-amylase inhibition activity of 'Lantana camara' to manage blood sugar levels. Effective management of blood glucose is vital for preventing complications associated with diabetes.
6) Study (Studying):
The study involves a systematic investigation focused on analyzing the phytochemical properties and α-amylase inhibition potential of 'Lantana camara.' It aims to understand the plant's potential in treating conditions like diabetes, thereby contributing to scientific knowledge and practical applications in herbal medicine.
7) Gwalior:
Gwalior is a city in Madhya Pradesh, India, where the research was conducted. The geographical context enriches the study by showcasing local biodiversity and traditional knowledge related to medicinal plants, making it easier to evaluate local flora for potential therapeutic benefits.
8) Disease:
Disease refers to conditions disrupting normal bodily functions, including diabetes, which was the focus of this research. The study aims to investigate natural therapeutic options for managing such chronic conditions, emphasizing the need for alternative medicine and the role of phytochemicals in disease management.
9) Madhya:
Madhya Pradesh is a state in central India known for its rich biodiversity. This region provides a unique opportunity to study indigenous plants like 'Lantana camara,' exploring their medicinal properties rooted in local traditions and enhancing understanding of plant-based therapies.
10) India:
India is the country where the research originated, providing a diverse range of medicinal plants used in traditional medicine systems like Ayurveda. The country’s rich biodiversity enhances the relevance of exploring plants such as 'Lantana camara' for potential health benefits.
11) Kumar:
Kumar refers to Abhishek Kumar, the corresponding author of the study. His name represents the contribution of researchers in examining the medicinal properties of 'Lantana camara,' highlighting the importance of academic efforts in promoting scientific research related to phytochemistry and herbal medicine.
12) Sage:
Sage refers to common names associated with 'Lantana camara,' which includes wild-sage, indicating its traditional uses. The term reflects the plant's medicinal heritage and the potential significance of its active compounds in treating various ailments, illustrating cultural perceptions of this species.
13) Ulcer:
Ulcer is one of the ailments that 'Lantana camara' has been traditionally used to treat. Studying the qualities of the plant in this research aligns with herbal remedies that target conditions like ulcers, reinforcing the relevance of phytochemicals in healing processes.
14) Medicine:
Medicine encompasses the study and application of treatments for various health conditions. In this context, the study of 'Lantana camara' contributes to the broader field of herbal medicine, merging traditional knowledge with scientific inquiry to assess its therapeutic efficacy.
15) Activity:
Activity refers to the biological effects or the capability of 'Lantana camara' to inhibit key enzymes such as α-amylase, which impacts carbohydrate digestion. Understanding these activities is crucial for evaluating the plant's potential as a natural remedy for managing conditions like diabetes.
16) Leprosy:
Leprosy is one of the historical diseases for which 'Lantana camara' has been used in traditional treatments. Studying plants with such medicinal backgrounds enables research on their efficacy in treating various disorders, thus documenting their medicinal value in modern science.
17) Family:
Family refers to the taxonomic category that classifies 'Lantana camara' under the verbena family. Recognizing the plant's classification aids in understanding its biological characteristics and potential medicinal properties, as related species may share similar phytochemical benefits.
18) Cancer:
Cancer is another serious health condition that 'Lantana camara' has been traditionally used against. Exploring its phytochemicals through this study broadens the understanding of plant-based therapies in oncology, emphasizing the importance of research in discovering new treatment avenues.
19) Table:
Table refers to the organized representation of data within the study, summarizing findings from qualitative analyses and α-amylase inhibition assays. Such tables enable easier understanding of research outcomes and contribute to data transparency and effective scientific communication.
20) Discussion:
Discussion entails the section of the research where findings are interpreted and contextualized within the broader scientific landscape. This allows researchers to explore the implications of their results, rationale for observed outcomes, and suggestions for future studies.
21) Developing:
Developing refers to the process of advancing knowledge and applications in the field of herbal medicine. This study contributes to the development of potential antidiabetic therapies derived from 'Lantana camara' by exploring its inhibitory effects on α-amylase.
22) Science (Scientific):
Science refers broadly to the systematic enterprise that builds and organizes knowledge about the universe through observation, experimentation, and evidence. The study on 'Lantana camara' represents the scientific pursuit of uncovering the therapeutic potential of plants in health care.
23) Container:
Container refers to the storage vessel used for keeping phytochemical extracts during the study. Proper use of containers is essential for preserving the integrity of the extracts, ensuring that the phytochemicals remain stable for accurate testing and analysis.
24) Surface:
Surface relates to the interaction of the aqueous extracts with other substances during assays. Understanding surface interactions can be critical in conducting accurate enzymatic activity tests, which contributes to the reliability of results derived from the conducted experiments.
25) Sugar:
Sugar, specifically glucose, is a critical aspect of the research focused on diabetes. High sugar levels in the blood are a primary concern in diabetic management, and the study seeks to evaluate ways to reduce these levels through phytochemical inhibition of carbohydrate-digesting enzymes.
26) Life:
Life signifies the biological context of the research, embodying the study of living organisms and their interactions with plants like 'Lantana camara.' The research ultimately aims to improve human health and quality of life through the exploration of natural therapeutic agents.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Qualitative analysis and α-amylase inhibition of Lantana camara extract’. Further sources in the context of Science might help you critically compare this page with similair documents:
Lantana camara, Diabetes, High concentration, Qualitative analysis, Phytochemical analysis, Metabolic disorder, Non-insulin dependent diabetes mellitus, Botanical garden, Secondary metabolite, Insulin Dependent Diabetes Mellitus, Traditional herbal medicine.