PRP therapy for acne scars as Tvaka Rasayanam management.
Journal name: World Journal of Pharmaceutical Research
Original article title: Management of acne scars with platelet-rich-plasma (prp) therapy as a tvaka rasayanam
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Dr. Anupama Thakur and Dr. Rajesh Sood
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Management of acne scars with platelet-rich-plasma (prp) therapy as a tvaka rasayanam
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr201816-13317
Download the PDF file of the original publication
Summary of article contents:
Introduction
Acne vulgaris is a common condition that can lead to significant scarring, which may be classified as atrophic or hypertrophic, depending on the degree of inflammation during the disease. The management of acne scars poses a significant challenge for dermatologists. Platelet-rich plasma (PRP) therapy, which utilizes concentrated platelets to promote tissue repair and healing, has emerged as a promising treatment modality for acne scars. This study aims to investigate the efficacy and safety of PRP therapy as a form of "tvaka rasayanam," or rejuvenation treatment, within an Ayurvedic framework.
Advantages of Platelet-Rich-Plasma Therapy
PRP therapy capitalizes on the regenerative properties of platelets, which are abundant in various growth factors critical for tissue healing and remodeling. The preparation involves extracting platelets from the patient's blood through a double spin centrifugation method, resulting in a plasma rich in growth factors. This therapy has been noted for its effectiveness in accelerating wound healing, as the activated PRP can restore skin texture and minimize the appearance of scars. The study revealed that after a series of PRP injections, a significant percentage of patients demonstrated marked and moderate improvement in their acne scars, further validating the procedure's efficacy.
Patient Participation and Outcomes
In a prospective study involving twenty patients aged 20 to 30 years, the subjects were treated with autologous PRP over a three-month period. The results indicated that 20% experienced substantial improvement in scar grading, while 50% had moderate improvements. Only a small fraction reported no significant changes, although many noted an enhancement in skin texture. This study confirmed the patient satisfaction rate, demonstrating that a substantial number were satisfied with the overall results, highlighting the positive impact of PRP therapy on self-esteem and quality of life.
Considerations for Integrative Approaches
The study not only focused on the clinical outcomes of PRP therapy but also aimed to explore its relevance in Ayurvedic practices. The authors suggest that the principles of Ayurveda could be integrated into modern dermatological treatments by emphasizing the body’s inherent regenerative mechanisms, likening PRP’s effects to those of traditional Ayurvedic "rasayana" therapies. This integrative approach encourages collaboration between modern medicine and traditional practices to enhance patient care and address cosmetic concerns.
Conclusion
The application of PRP therapy for managing acne scars presents a safe and effective treatment option in the field of dermatology. Given its minimally invasive nature and the absence of significant adverse effects, PRP can be confidently used to improve the quality of life of patients suffering from acne scarring. By merging contemporary medical techniques with time-honored Ayurvedic principles, there is potential for the development of more comprehensive treatment protocols, thereby advancing patient care in both dermatology and holistic health practices.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “PRP therapy for acne scars as Tvaka Rasayanam management.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Rich (Rch):
The term 'rich' in the context of platelet-rich plasma (PRP) therapy indicates a high concentration of platelets and growth factors in the plasma, enhancing its effectiveness in promoting tissue healing and regeneration, particularly beneficial in treatments for acne scars and related skin conditions.
2) Dhatu:
In Ayurveda, 'Dhatu' refers to the fundamental tissue elements of the body, which include seven primary tissues essential for maintaining health. Each Dhatu has unique functions and properties that contribute to overall vitality and well-being, making their understanding crucial in Ayurvedic treatment methodologies.
3) Blood:
Blood is a vital fluid in the body, responsible for transporting oxygen, nutrients, and growth factors. In the context of PRP, blood is the source from which platelets are derived, emphasizing its importance in regenerative therapies that aim to heal and rejuvenate skin tissue.
4) Study (Studying):
Studying involves the in-depth investigation of specific subjects to gain knowledge and insights. In this context, studying PRP therapy’s effects offers valuable information on acne scar management, facilitating the integration of traditional Ayurvedic practices with modern scientific methodologies for enhanced patient outcomes.
5) Ayurveda (Ayus-veda):
Ayurveda is an ancient Indian system of medicine that emphasizes holistic health through balance in body, mind, and spirit. It incorporates natural remedies, herbal treatments, and spiritual practices, providing a comprehensive framework for understanding health and disease management, particularly relevant in skin care treatments.
6) Ojas:
Ojas is a vital concept in Ayurveda, representing the essence of vitality and immunity derived from the proper digestion and metabolism of food. It is believed to protect against diseases and enhance overall health, playing a crucial role in the body's regenerative processes including skin healing.
7) Life:
The term 'life' in this study signifies the essence and vitality of living organisms, which Ayurveda aims to sustain through balanced health practices. PRP therapy seeks to enhance life quality and longevity by promoting healing and rejuvenation of tissues affected by conditions like acne scars.
8) Sutrasthana (Sutra-sthana):
Sutrasthana is a section in classical Ayurvedic texts where foundational principles and guidelines are discussed. Familiarity with Sutrasthana aids practitioners in applying Ayurvedic philosophy systematically in clinical practices, emphasizing the structured approach to diagnosis and treatment methodologies in patient care.
9) Quality:
In the context of this study, 'quality' refers to the standard of results achieved through PRP therapy. The quality of skin texture restoration and scar improvement affects patient satisfaction and determines the effectiveness of treatment protocols, making it a focal point in clinical outcomes assessment.
10) Repair:
The term 'repair' refers to the biological process of healing damaged tissues. In PRP therapy, repair is facilitated by the growth factors present in plasma, which stimulate cell regeneration, collagen synthesis, and tissue remodeling, thereby enhancing recovery from acne scars.
11) Rakta:
Rakta translates to blood in Ayurveda and symbolizes vitality and life force. It plays a crucial role in nourishing the body's tissues and maintaining overall health. In the context of PRP therapy, Rakta is the source of platelets, essential for healing processes.
12) Table:
In the study, 'table' refers to a structured representation of data summarizing patient outcomes, satisfaction, and improvement metrics. Tables help organize complex information, making it easier to understand trends, compare results, and analyze the effectiveness of PRP therapy quantitatively.
13) Rasa (Rasha):
Rasa, meaning essence or fluid, signifies the vital bodily fluid responsible for nourishment and vitality in Ayurveda. It encompasses the properties of plasma, indicating its role in tissue health, similar to the functions of PRP in stimulating healing and rejuvenation.
14) Hair:
Hair is often a focus in dermatological treatments, and PRP has shown efficacy in hair regrowth applications. The principles of tissue repair and regeneration observed in acne scar management through PRP highlight its potential use in improving hair health as well.
15) Post:
The term 'post' refers to the period following a procedure, in this case, after PRP therapy. Post-treatment assessments measure outcomes and side effects, gauging the treatment effectiveness and patients’ recovery experiences, crucial for evaluating the overall success of the therapy.
16) Inflammation:
Inflammation is a biological response that plays a central role in skin conditions, including acne. Understanding inflammation is critical in treating acne scars, as it influences scar formation and healing processes, making anti-inflammatory strategies significant in PRP therapy applications.
17) Raktadhatu (Rakta-dhatu):
Rakta-dhatu refers specifically to the blood tissue in Ayurveda. It is believed to be crucial for delivering nutrients and oxygen to other body tissues. In this study, Rakta-dhatu's role emphasizes the importance of blood components in enhancing skin healing through PRP.
18) Shrikantha (Srikantha, Shri-kantha, Shrikamtha):
Shrikantha is a reference to the editor of classical Ayurvedic texts, signifying the importance of established scholarly work in understanding traditional medicine principles. His contributions provide insights into the Ayurvedic perspective on blood physiology and treatment methodologies, informing contemporary practices.
19) Varanasi (Varanashi):
Varanasi is a city known for its historical and cultural significance in India. In the context of Ayurveda, it symbolizes the rich heritage and traditional knowledge systems that shaped Indian medical practices over centuries, influencing modern approaches to health and wellness.
20) Medicine:
Medicine encompasses the science and practice of diagnosing and treating diseases. The study of PRP therapy within the framework of Ayurveda bridges traditional and modern medical paradigms, promoting an integrative approach to enhancing health outcomes in skin care treatments.
21) Disease:
Disease refers to any abnormal condition affecting the body's functions, requiring diagnosis and treatment. Acne vulgaris, as a chronic skin condition, exemplifies the necessity for effective management strategies like PRP therapy to address its complications such as scarring and compromised skin health.
22) Rasadhatu (Rasa-dhatu):
Rasa-dhatu, or the essence of fluid in all body processes, is essential for ensuring nutritional and metabolic balance. Its understanding in Ayurveda aids in recognizing the pivotal role fluids play in skin health and recovery, particularly in treatments revolving around PRP.
23) Science (Scientific):
The term 'scientific' refers to methods and approaches based on systematic observation and experimentation. The study’s scientific basis strives to apply modern research methodologies to demonstrate the efficacy of PRP therapy while aligning with Ayurvedic traditional knowledge for optimized patient care.
24) Siddhanta (Siddha-anta, Siddhamta):
Siddhanta refers to the principles or theories underlying a particular discipline. In Ayurveda, Siddhanta helps frame the knowledge of health, disease, and treatment protocols, guiding practitioners in forming holistic and effective health strategies like those employed in PRP therapy.
25) Ashtanga (Astanga, Ashtan-anga):
Ashtanga refers to an eightfold path in traditional Ayurvedic literature, representing a systematic approach to health and wellness. It highlights different aspects of treatment and patient care, framing the integrative methods applied in PRP therapy and skin rejuvenation.
26) Kangra:
Kangra is a region in India where traditional Ayurvedic practices are prevalent. It serves as a backdrop for the study, symbolizing the geographical context where integrative health approaches, like PRP therapy, are explored and applied in contemporary healing practices.
27) Filling (Filled):
The term 'filled' implies the action of completing or incorporating a component within a process. In the study, it may relate to filling out assessments or data entries regarding patient outcomes, contributing to the overall evaluation of treatment efficacy and patient satisfaction.
28) Field:
Field refers to the specific area of study or practice. In this context, it denotes dermatology and regenerative medicine, where PRP therapy is applied. Knowledge from both realms enhances treatment methodologies, optimizing approaches to acne scar management and skin rejuvenation.
29) Raktamokshana (Raktamoksana, Rakta-mokshana):
Raktamokshana is an Ayurvedic therapeutic procedure involving bloodletting to detoxify the body. Its concepts relate to PRP therapy, highlighting traditional practices applied for skin healing, showing the potential for integrating ancient Ayurvedic treatments with modern scientific understanding.
30) Grahanidosha (Grahanidosa, Grahani-dosha):
Grahani-dosha refers to an Ayurvedic concept related to digestive disorders and malabsorption issues. Understanding Grahani-dosha is essential in holistic treatment approaches, ensuring the body’s nutritional status is optimized for the efficacy of therapies, including those aimed at skin health.
31) Observation:
Observation involves closely monitoring and recording changes in patient conditions or treatment outcomes. In the study, observations are essential for evaluating the effectiveness of PRP therapy, supporting clinical assessments, and guiding future treatment strategies in managing acne scars.
32) Discussion:
Discussion represents the analytical evaluation of findings, insights, and implications from the research. In the study, discussions help contextualize PRP therapy outcomes, compare with existing literature, and explore integrative approaches within Ayurvedic and modern medicinal frameworks.
33) Agnivesha (Agnivesa, Agni-vesha):
Agnivesha is recognized as a classical Ayurvedic physician and author of foundational texts that inform modern Ayurvedic practice. His contributions establish critical theoretical frameworks and treatment guidelines still influencing contemporary perspectives on health care and wellness strategies.
34) Substance:
Substance refers to a material with specific properties and functions in health care. In the context of PRP therapy, substances like growth factors and cytokines derived from blood are instrumental in facilitating healing, making understanding their roles essential for effective treatment implementation.
35) Vagbhata:
Vagbhata is another esteemed figure in Ayurvedic medicine, known for his comprehensive classifications and treatments of various conditions. His works enhance the understanding of Ayurvedic principles and practices, guiding contemporary practitioners in integrating traditional knowledge with modern health care approaches.
36) Tridosha (Tridosa, Tri-dosha):
Tridosha is a foundational concept in Ayurveda, describing the three biological energies—Vata, Pitta, and Kapha—that govern bodily functions. Understanding Tridosha aids practitioners in diagnosing and treating ailments holistically, emphasizing balance as central to health restoration and maintenance.
37) Sandhana (Samdhana):
Sandhana, or unification, represents the process of harmonizing various bodily elements in Ayurvedic treatment. This integrative approach applies to methods like PRP therapy, where multiple principles are utilized to enhance skin healing and rejuvenation, promoting holistic patient outcomes.
38) Rasayana (Rasa-ayana):
Rasayana refers to rejuvenation therapies in Ayurveda aimed at improving health, longevity, and vitality. PRP therapy aligns with Rasayana principles by using the body's own growth factors to stimulate healing and revitalization, emphasizing the regenerative potential inherent in natural substances.
39) Prakriya (Prakriye):
Prakriya translates to method or procedure in Ayurveda. It encapsulates the systematic approaches practitioners use to implement treatments. In the study, Prakriya outlines the protocols followed for PRP therapy, emphasizing standardized methods for patient safety and treatment efficacy.
40) Dressing:
Dressing refers to protective coverings applied to wounds or treated areas. In the context of PRP therapy, the absence of a dressing post-treatment highlights the minimally invasive nature of the procedure, allowing for ease of recovery while maintaining proper skin care practices after therapy.
41) Bleeding:
Bleeding is a physiological process where blood escapes from the vascular system, often indicating injury. In PRP therapy, managing bleeding is crucial during blood collection and preparation, illustrating the importance of proper techniques to minimize complications and optimize patient care.
42) Grafting:
Grafting is a surgical technique often used in dermatology to transplant skin from one area to another. In the context of PRP, while not a grafting technique per se, it complements skin regeneration strategies by enhancing healing and skin quality, often used alongside other procedures.
43) Grahani:
Grahani refers to the concept of digestion and nutrient absorption in Ayurveda. Understanding Grahani is essential to ensure that treatments, including those for skin issues, consider the holistic interaction of bodily systems and the influence of digestion on overall health.
44) Shonita (Sonita):
Shonita refers to blood and its various qualities in Ayurveda. It plays a critical role in nourishing body tissues and maintaining health. Recognizing Shonita's importance underlines the biological significance of blood in therapies like PRP for enhancing skin health and tissue repair.
45) Srotas (Shrotas):
Shrotas represents the channels for nutrient and fluid transportation in the body within Ayurvedic physiology. Understanding Shrotas is essential for effective treatment in Ayurveda, as it emphasizes the interconnectedness of systems responsible for health and the distribution of substances like PRP.
46) Hemadri (Heman-adri):
Hemadri refers to a commentator on Ayurvedic texts who elaborated on various theories and practices. His insights enrich the understanding of Ayurvedic principles and their application in modern contexts, guiding practitioners in integrating time-honored wisdom with contemporary medical practices.
47) Channel:
Channel denotes physical or conceptual pathways through which life forces, nutrients, and fluids navigate in the body. The understanding of channels, as represented by Shrotas in Ayurveda, is pivotal for effective treatment approaches, including PRP therapy as it supports healing processes.
48) Surface:
Surface pertains to the outermost layer of the skin, which is directly affected during PRP therapy. The surface's condition plays a critical role in treatment efficacy, influencing outcomes such as texture improvement and overall skin appearance post-therapy.
49) Anjali (Amjali):
Anjali, often translated as a handful, is used in Ayurvedic contexts for dosages and measurements. It signifies the quantity of blood drawn during processes like Raktamokshana within traditional healing methodologies, showcasing the blend of practical application in Ayurvedic practices.
50) Reason:
Reason pertains to the rationale behind observed phenomena or practices. Understanding the reasons for therapy outcomes, especially in treatments like PRP for acne scars, provides insights into mechanisms of action and aids in refining treatment methodologies for better patient care.
51) Dosha (Dosa):
Dosha refers to the three fundamental energies in Ayurveda—Vata, Pitta, and Kapha—that govern physiological functions. Identifying imbalances in Dosha is critical for diagnosing health issues and formulating individualized treatment plans, particularly relevant in the context of skin health and treatments.
52) Edema (Oedema):
Edema is the medical term for swelling caused by excess fluid trapped in the body's tissues. Recognizing edema's causes and implications is essential in skin treatments, including PRP therapy, as it informs post-treatment care and management strategies to support recovery.
53) Shuci (Suci, Sucin, Shucin):
Suchi refers to purity and cleanliness in Ayurvedic philosophies. Ensuring Suchi in therapeutic settings, especially in procedures involving blood, is paramount for preventing infections and promoting effective healing, thereby fostering a safe environment for PRP therapy.
54) Agni:
Agni, the digestive fire in Ayurveda, represents the metabolic processes vital for maintaining health. A balanced Agni enhances nutrient absorption and waste elimination, underlying the importance of digestive health in effective treatment outcomes, particularly in rejuvenating therapies like PRP.
55) Tvak:
Tvak refers to the skin in Ayurvedic terminology, underscoring its significance in health and beauty practices. The condition of Tvak is essential for assessing skin health, making it a focal point in therapies aimed at rejuvenating and repairing skin damage.
56) Mala:
Mala indicates waste products in the body that can accumulate and cause imbalances. Understanding Mala is critical for Ayurvedic treatments as it influences systemic health, highlighting the need for detoxification and cleansing processes to promote overall well-being and effective therapies.
57) Sood:
Sood is likely a reference to Dr. Rajesh Sood, a co-author of the study, indicating his contributions to the research on PRP therapy. The inclusion of experienced practitioners enriches the credibility of the findings, ensuring a comprehensive exploration of treatment methods.
58) Seat (Seated):
The term 'seat' denotes the location where vital processes occur. In Ayurveda, the seat of life is often attributed to blood or specific tissues. Recognizing the seat of various physiological processes informs treatment approaches aimed at restoring balance and promoting healing.
59) Burning (Burn, Burned, Burnt):
Burn refers to physical damage caused to tissues, often requiring medical intervention for healing. In the study’s context, understanding burns as types of skin injuries emphasizes the role of reparative therapies like PRP in enhancing recovery processes for optimal skin restoration.
60) Drug:
Drug refers to any substance used for treatment, prevention, or diagnosis of health conditions. In the context of PRP therapy, understanding drug interactions and patient safety is crucial for ensuring effective treatment outcomes and avoiding adverse effects during therapeutic procedures.
61) Male:
Male denotes one of the gender classifications in the study population. Recognizing gender differences in treatment responses and outcomes is vital for creating tailored therapeutic approaches, ensuring that health care practices address specific needs and conditions associated with male patients.
Other Science Concepts:
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