Evaluation of antioxidant properties in "Thoothuvelai Karpam"

| Posted in: Science

Journal name: World Journal of Pharmaceutical Research
Original article title: Evaluation of anti-oxidant property of siddha herbal formulation "thoothuvelai karpam''
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:

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Author:

Rahini Nivedhidha C., Ranjitham K., Sivakkumar S., Visweswaran S., Maariappan A. and Banumathi V.


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Evaluation of anti-oxidant property of siddha herbal formulation "thoothuvelai karpam''

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr201817-13241


Summary of article contents:

1) Introduction

The Siddha system of medicine is one of the ancient medical practices in India, rooted in holistic principles that focus on both preventive and therapeutic health measures. Among its various branches, Kaya Karpam is particularly significant, as it addresses rejuvenation, longevity, and spiritual well-being. This study evaluates the antioxidant properties of "Thoothuvelai Karpam," a traditional Siddha herbal formulation, by examining its potential to inhibit oxidative stress-induced conditions that contribute to diseases such as diabetes, cancer, and aging. The study employs various assays, including the DPPH free radical scavenging assay, Nitric Oxide scavenging, ABTS assays, and Hydrogen Peroxide scavenging, to quantify the antioxidant efficacy of the formulation.

2) The Importance of Antioxidants in Health

Oxidative stress, caused by the imbalance between free radical production and the body’s antioxidant defenses, is implicated in numerous chronic diseases and aging processes. Free radicals can damage vital macromolecules—proteins, lipids, and DNA—leading to severe health issues such as cancer and cardiovascular diseases. The antioxidant properties of natural compounds are crucial as they provide safe alternatives to synthetic antioxidants, offering protective effects against oxidative stress-related disorders. This study highlights that various plant-based antioxidants, particularly those from the Siddha medicinal formulation, are essential in counteracting these harmful effects.

3) Antioxidant Activity of Thoothuvelai Karpam

The study presents promising results regarding the antioxidant capabilities of "Thoothuvelai Karpam." The DPPH radical scavenging assay results showed a percentage inhibition of 50.73% at a concentration of 100 μg/ml, indicating that the formulation possesses significant radical scavenging activity. It also demonstrated effective inhibition in other assays, including Nitric Oxide, ABTS, and Hydrogen Peroxide, with varying percentages of inhibition. The calculated IC50 values for these assays further suggest that while Thoothuvelai Karpam holds antioxidant properties, its efficacy relative to standard compounds such as ascorbic acid and gallic acid varies markedly, necessitating further exploration into its potential health benefits.

4) Relevance to Kaya Karpam Concepts

The findings underscore the relevance of Thoothuvelai Karpam to the Siddha concept of Kaya Karpam, which aims to prevent aging and diseases through herbal remedies. By providing substantial evidence of its antioxidant activity, the study affirms the potential of Thoothuvelai Karpam not only to alleviate age-related conditions like whitening hair, skin aging, and diseases but also to enhance overall vitality and longevity. This connection to traditional beliefs enhances the formulation’s significance in contemporary health practices, suggesting a renewed interest in ancient medical systems in addressing modern health challenges.

5) Conclusion

The investigation into the antioxidant properties of "Thoothuvelai Karpam" reveals its potential as a natural source of antioxidants, aligning with the Siddha philosophy of promoting health and longevity. The results suggest that regular intake of this herbal formulation could be beneficial in preventing oxidative stress-related disorders, thus supporting both individual health and the traditional practices of the Siddha system. Future research is warranted to explore its active components and further elucidate its role in modern medicine. This study ultimately reinforces the need to integrate traditional herbal formulations into contemporary therapeutic strategies to enhance public health outcomes.

FAQ section (important questions/answers):

What is the significance of Siddha medicine in health?

Siddha medicine is an ancient Indian healthcare system focused on holistic well-being, emphasizing rejuvenation, longevity, and disease prevention through natural remedies.

What is 'Thoothuvelai Karpam' and its uses?

'Thoothuvelai Karpam' is a Siddha herbal formulation used for various ailments, including anemia, obesity, skin diseases, and is believed to enhance overall immune health.

How does oxidative stress affect human health?

Oxidative stress leads to free radical production, which can damage vital biomolecules, resulting in diseases like cancer, heart disease, and premature aging.

What methods were used to assess antioxidant activity?

Antioxidant activity was assessed using DPPH, Nitric Oxide, ABTS, and Hydrogen Peroxide radical scavenging assays, comparing the results to known standards like ascorbic acid.

What were the findings regarding 'Thoothuvelai Karpam' antioxidant properties?

The study found significant antioxidant activity in 'Thoothuvelai Karpam', indicating potential as a natural source of antioxidants for promoting overall health and longevity.

What are the implications of the study's findings?

The findings suggest 'Thoothuvelai Karpam' can contribute to preventing aging and diseases, aligning with the Siddha concept of 'Kaaya Karpam' for promoting longevity and health.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Evaluation of antioxidant properties in "Thoothuvelai Karpam"”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Drug:
A drug is a substance used in the treatment, prevention, or diagnosis of disease. In the context of Siddha medicine, 'Thoothuvelai Karpam' is identified as a natural drug, exhibiting antioxidant properties that help combat oxidative stress and promote health, reflecting modern and traditional medicinal practices.

2) Siddha:
Siddha is one of the ancient systems of medicine originating in India, emphasizing holistic health through natural remedies. It incorporates unique practices and herbal formulations aimed at rejuvenation and disease prevention, highlighting its role in promoting a balance between body, mind, and spirit, integral to Indian health traditions.

3) Activity:
Activity in the context of this study refers to the functional capacity of the herbal formulation 'Thoothuvelai Karpam' to exhibit antioxidant effects. This encompasses its ability to scavenge free radicals, thus protecting the body from oxidative stress which contributes to various diseases, including aging and chronic conditions.

4) Disease:
Disease refers to any condition that adversely affects an organism's structure or function. The study emphasizes non-communicable diseases linked to oxidative stress, indicating that addressing these through herbal formulations like 'Thoothuvelai Karpam' could improve health outcomes and prevent deterioration associated with aging and environmental factors.

5) Medicine:
Medicine is the science and practice of diagnosing, treating, and preventing illness, focusing on health restoration. In this text, the Siddha system is highlighted, combining therapeutic approaches and herbal preparations that integrate traditional knowledge and practices aimed at holistic health and long life.

6) Study (Studying):
Study refers to the systematic investigation aimed at discovering or demonstrating facts. Here, the study examines the antioxidant properties of 'Thoothuvelai Karpam' through various assays. The findings aim to validate the traditional claims of Siddha medicine regarding its efficacy in promoting health and well-being.

7) Kaya:
Kaya denotes the physical body in the context of Siddha medicine. It emphasizes the importance of maintaining bodily health through rejuvenation practices like 'Kaya Karpam.' The concept signifies the correlation of physical health with longevity and the prevention of diseases, fundamental to Siddha therapeutics.

8) Species:
Species refers to distinct groups of plants or organisms utilized in medicines. In this context, various plant species used in the formulation of 'Thoothuvelai Karpam' are examined for their antioxidant capabilities. This reveals traditional knowledge of biodiversity and its therapeutic potential in disease management.

9) Cancer:
Cancer is a class of diseases characterized by uncontrolled cell growth. The study notes that antioxidants from herbal preparations like 'Thoothuvelai Karpam' may play a role in preventing oxidative stress-related conditions, including certain cancers, supporting the need for natural alternatives in cancer prevention.

10) Tirai:
Thirai signifies skin in the Siddha medical terminology. Addressing skin health is a part of the rejuvenation concept ('Kaya Karpam'). The formulation 'Thoothuvelai Karpam' aims to prevent skin aging and other related diseases, ensuring overall vitality and physical appearance.

11) Kalpa:
Kalpa in the Siddha context refers to the rejuvenation or longevity aspect of treatment. The study links 'Kalpa' with the concept of maintaining health and vitality through herbal formulations like 'Thoothuvelai Karpam,' supporting the philosophy of achieving balance and longevity through natural means.

12) Death:
Death is the cessation of biological functions that sustain life. The Siddha perspective on health emphasizes the prevention of conditions that lead to premature death. 'Thoothuvelai Karpam' is regarded as a formulation to promote longevity and reduce risks associated with aging and disease.

13) Hair:
Hair symbolizes youth and beauty in many cultures, including Indian tradition. The term 'Narai,' or hair whitening, is mentioned in this study as a sign of aging. 'Thoothuvelai Karpam' aims to delay such aging signs, showcasing its role in enhancing appearance and promoting youthful vitality.

14) Phytochemical:
Phytochemicals are bioactive compounds found in plants, contributing to their medicinal properties. This study emphasizes the antioxidant abilities of phytochemicals in 'Thoothuvelai Karpam,' reinforcing the reliance on natural sources to derive health benefits and manage oxidative stress-related diseases effectively.

15) Deliberating:
Deliberating reflects a process of careful consideration or discussion. The study deliberates on the efficacy of 'Thoothuvelai Karpam' in combating oxidative stress, contributing to broader discussions on the significance of traditional medicine in modern healthcare, underscoring its value in disease prevention and longevity.

16) Accumulation (Accumulating, Accumulate):
Accumulation refers to the gradual build-up of substances, which, in the context of free radicals, can lead to oxidative stress. This study identifies that chronic accumulation of free radicals may result in various health disorders, advocating for the use of antioxidants from natural sources to mitigate these effects.

17) Tirumular (Thiru-mular, Thirumular):
Thirumoolar is a revered figure in Siddha medicine known for his contributions to its philosophy and practices. His teachings on 'Kaya Karpam' provide a foundational understanding to this study, linking spiritual wellness with physical health and longevity through traditional herbal practices.

18) Discussion:
Discussion refers to the exploration of findings and implications. In this context, the discussion of antioxidant activities in 'Thoothuvelai Karpam' emphasizes its validity as a potential therapeutic agent, integrating scientific evidence with traditional knowledge for applications in health and disease prevention.

19) Developing:
Developing indicates the process of creating or evolving something. In the study, developing understanding of medicinal herbs like 'Thoothuvelai Karpam' fosters integration of traditional practices into modern medicine, suggesting a collaborative approach to health that respects both historical and contemporary healthcare methods.

20) Science (Scientific):
Science is a systematic enterprise that builds and organizes knowledge in the form of testable explanations and predictions. The study exemplifies the fusion of traditional Siddha knowledge with scientific inquiry to explore the health benefits of herbal formulations in managing oxidative stress and promoting longevity.

21) Knowledge:
Knowledge represents information, awareness, or familiarity gained through experience or education. This study showcases the importance of traditional knowledge in Siddha medicine, highlighting its potential to expand contemporary health practices by integrating age-old wisdom with scientific exploration of natural remedies.

22) Pesticide:
Pesticides are chemical substances used to eliminate pests, but their use contributes to oxidative stress and potential health risks. Discussing pesticides in this context emphasizes the need for natural solutions, like herbal antioxidants from 'Thoothuvelai Karpam,' to mitigate health hazards from chemical exposure.

23) Nature:
Nature encompasses the physical world and its phenomena, emphasizing the innate healing properties found in plants. The study of 'Thoothuvelai Karpam' parallels the natural approach of Siddha medicine, highlighting the significance of utilizing nature to promote health, wellness, and disease prevention.

24) Indian:
Indian refers to anything related to India, especially its rich cultural and medicinal heritage. The Siddha system, emergent from this tradition, showcases the interplay of cultural practices and natural remedies, emphasizing the role of holistic approaches to health within the Indian context.

25) India:
India is a country known for its diverse culture and traditional medicine systems, including Siddha. The emphasis on herbal treatments like 'Thoothuvelai Karpam' reflects India’s long-standing history in utilizing natural resources for health and wellness, combining spiritual and physical health practices.

26) Water:
Water is essential for all forms of life and plays a critical role in health. In the context of herbal medicine, water is often used as a solvent in extracting bioactive compounds from plants, thereby enhancing the efficacy of formulations like 'Thoothuvelai Karpam' in delivering health benefits.

27) Ulcer:
An ulcer is a painful sore that can occur in various parts of the body. In the study, herbal formulations like 'Thoothuvelai Karpam' are cited for their potential effects on conditions like ulcers, demonstrating the holistic approach of Siddha medicine in addressing multiple health concerns.

28) Food:
Food relates to substances consumed for nutritional support. The study highlights the significance of incorporating plant-based foods in diets for their antioxidant properties, advocating for a lifestyle that emphasizes natural sources of nutrition to alleviate oxidative stress and maintain overall health.

29) Rich (Rch):
Rich refers to an abundance of resources or qualities. In this context, it highlights plant species rich in phytochemicals used in 'Thoothuvelai Karpam.' It emphasizes the wealth of natural compounds that can be harnessed for health benefits, particularly in traditional medicinal practices.

30) Life:
Life denotes the existence of living organisms. In this context, it reflects the overarching goal of Siddha medicine to promote health and well-being through products like 'Thoothuvelai Karpam,' aiming to enhance life quality by preventing disease and encouraging longevity through natural means.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Evaluation of antioxidant properties in "Thoothuvelai Karpam"’. Further sources in the context of Science might help you critically compare this page with similair documents:

Siddha medicine, Oxidative stress, DPPH free radical scavenging assay, IC50 value, Nitric oxide radical scavenging assay, Bioactive compound, Free Radical, Natural antioxidant, Phenolic compound.

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