Evaluation of anti-histamine and anti-inflammatory effects of Shayathirku Ennai.
Journal name: World Journal of Pharmaceutical Research
Original article title: Evaluation of anti - histamine and anti – inflammatory activity using siddha polyherbal formulation – shayathirku ennai
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Dheebiga S. V., Gandhimathi S., Meenakumari R., Muralidaran P.
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Evaluation of anti - histamine and anti – inflammatory activity using siddha polyherbal formulation – shayathirku ennai
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr201818-13503
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Summary of article contents:
Introduction
The Siddha system of medicine, a traditional healing method originating from South India, is known for its robust approaches to treating various ailments, particularly in children. One common condition among children is Sura Peenisam, which resembles sinusitis and manifests through symptoms such as nasal discharge, mucous membrane inflammation, and headaches. This condition is increasingly prevalent, especially in developing countries where environmental factors like pollution play a significant role. The polyherbal formulation Shayathirku Ennai, as documented in Siddha texts, is utilized for treating Sura Peenisam and other respiratory infections in pediatrics. The study aims to scientifically validate the anti-histamine and anti-inflammatory properties of this formulation.
Anti-Histamine Activity Evaluation
The assessment of the anti-histamine activity of Shayathirku Ennai was conducted using a vascular permeability test on rats. In this experiment, a control group and groups treated with standard antihistamine Cetirizine and varying doses of Shayathirku Ennai were analyzed. The results indicated a significant degree of protection from exudation in the groups administered with the formulation, with results showing that higher doses of Shayathirku Ennai led to increased areas of protection compared to the control. The findings demonstrate that Shayathirku Ennai possesses a noteworthy anti-histamine effect, positioning it as a viable alternative for managing allergic responses.
Anti-Inflammatory Activity Evaluation
The anti-inflammatory properties of Shayathirku Ennai were evaluated through a formal experiment involving the administration of carrageenan to induce paw edema in rats. Various groups, including a control and those receiving standard Indomethacin, as well as low and high doses of the Siddha formulation, were closely monitored for changes in paw volume over time. Results indicated that groups receiving Shayathirku Ennai showed a reduction in paw edema, particularly following the higher dosage. This suggests a distinct anti-inflammatory action attributable to the formulation, reaffirming its potential utility in treating inflammatory conditions.
Significance of the Ingredients
The study details the specific herbal components of Shayathirku Ennai, which play integral roles in the formulation's therapeutic action. Six key ingredients were utilized, including Poovanthi Pattai and Eranda Ennai, among others. Each of these herbs has been selected based on traditional knowledge and their established applications in Siddha medicine. The formulation's careful balance of these natural constituents not only aids in treating Sura Peenisam but also in reinforcing the overall immune response against respiratory ailments in children. This underscores the importance of polyherbal medicine in holistic approaches to health.
Conclusion
The experimental results affirm the significant anti-histamine and anti-inflammatory activities of Shayathirku Ennai, advocating for its potential as a natural remedy in managing Sura Peenisam in children. This study not only contributes to the validation of a traditional Siddha formulation but also encourages further research in this area to expand understanding and application. Continued exploration of the therapeutic benefits of Siddha medicines could lead to enhanced treatment options for common pediatric respiratory conditions, marrying traditional wisdom with modern scientific validation.
FAQ section (important questions/answers):
What is the primary focus of the study conducted on Shayathirku Ennai?
The study focused on evaluating the Anti-Histamine and Anti-Inflammatory activity of Shayathirku Ennai, a polyherbal formulation, in treating Sura Peenisam, which is comparable to sinusitis in children.
What is Sura Peenisam and its clinical features in children?
Sura Peenisam is a condition resembling sinusitis in children, characterized by nasal discharge, inflammation of sinus membranes, nasal block, and heaviness of head, often caused by microbial infections or allergies.
How was the Anti-Histamine activity of Shayathirku Ennai evaluated?
The Anti-Histamine activity was assessed using a vascular permeability test in rats, comparing the effects of Shayathirku Ennai with a standard drug, Cetirizine.
What ingredients are included in the Shayathirku Ennai formulation?
Shayathirku Ennai contains six herbal ingredients, including Poovanthi Pattai, Eranda Ennai, Kadukkai, Kasthuri Manjal, Vanni Ver Root, and Karunjeeragam, each selected for their therapeutic properties.
What results were observed for the Anti-Inflammatory activity of the formulation?
Shayathirku Ennai demonstrated significant Anti-Inflammatory activity when administered to rats, as evidenced by reduced paw edema compared to control groups.
What conclusion was drawn from the evaluation of Shayathirku Ennai?
The study concluded that Shayathirku Ennai exhibits significant Anti-Histamine and Anti-Inflammatory activity, supporting its use in treating Sura Peenisam in children.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Evaluation of anti-histamine and anti-inflammatory effects of Shayathirku Ennai.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Siddha:
Siddha is a traditional system of medicine originating from South India, emphasizing holistic health and wellness. It integrates ancient medical practices with natural elements, suggesting a deep connection between the human body and nature. Siddha also refers to practitioners who have attained proficiency in various life sciences, including medicine, philosophy, and spirituality.
2) Sura (Shura):
Sura refers to Sura Peenisam, a term used in Siddha medicine to describe a condition akin to sinusitis in children. This condition involves inflammation of the sinuses leading to symptoms such as nasal discharge and blockages. Understanding Sura is crucial in determining appropriate treatments within Siddha medicinal philosophy and practice.
3) Activity:
In this context, 'activity' pertains to the therapeutic actions of Shayathirku Ennai, particularly its anti-histamine and anti-inflammatory effects. The evaluation of these activities helps in understanding and validating the efficacy of traditional remedies in treating conditions like Sura Peenisam, thereby bridging traditional knowledge with modern scientific inquiry.
4) Animal:
Animal models are often employed in research to study the physiological and pharmacological effects of substances. In this study, Wistar rats were used to evaluate the effects of Shayathirku Ennai. Utilizing animal models allows researchers to observe biological responses and side effects that may mimic human disease conditions more closely than in vitro studies.
5) Medicine:
Siddha medicine is a holistic healing approach that blends natural elements, herbs, and traditional practices to treat various ailments. This study evaluates a polyherbal formulation, Shayathirku Ennai, aiming to enhance health outcomes, particularly in children suffering from respiratory diseases, highlighting the relevance of ancient practices in modern medicine.
6) Disease:
Disease refers to any condition that disrupts normal bodily functions, leading to illness or discomfort. In this research, Sura Peenisam exemplifies a common respiratory condition in children akin to sinusitis. Understanding disease mechanisms enables effective treatment strategies and highlights the need for effective remedies in pediatric healthcare.
7) India:
India is a country rich in cultural heritage and diverse medical practices, including Siddha medicine. This system has deep roots in Indian history and philosophy, providing access to traditional healing methods that are crucial in addressing the healthcare needs of its population, particularly for chronic conditions faced by children.
8) Tamilnadu (Tamil-nadu):
Tamilnadu is a state in southern India, renowned for its rich traditions, including Siddha medicine. The geographical and cultural context significantly influences the development and practice of Siddha healing techniques. This study originates from Tamilnadu, underscoring the state’s role in the preservation and advancement of traditional medical practices.
9) Chennai:
Chennai is the capital of Tamilnadu and a significant hub for healthcare and education. The research was conducted at the Government Siddha Medical College in Chennai, highlighting the city's importance as a center for traditional medical studies and its contribution to the field of Siddha medicine and research.
10) Study (Studying):
The study represents a scientific evaluation of Shayathirku Ennai's effects on anti-histamine and anti-inflammatory activities. It seeks to establish empirical evidence supporting traditional claims within Siddha medicine. Such studies are crucial for integrating traditional practices with modern medical science, fostering better healthcare solutions for contemporary health issues.
11) Drug:
In this research, 'drug' refers to Shayathirku Ennai, a polyherbal formulation tested for its medicinal properties. Studying the drug's efficacy in treating conditions like Sura Peenisam provides insights into its potential therapeutic uses, emphasizing the importance of validating traditional remedies through scientific investigation.
12) Edema (Oedema):
Oedema is often used interchangeably with edema, describing the accumulation of fluid in bodily tissues leading to swelling. In this study, the term is linked to assessing inflammation levels in experimental subjects. Evaluating oedema response after treatment provides critical insights into the effectiveness of Siddha formulations like Shayathirku Ennai.
13) Terminalia chebula:
Terminalia chebula, commonly known as Haritaki, is an important medicinal herb in Siddha and Ayurvedic practices. It is one of the ingredients in Shayathirku Ennai, believed to have various health benefits. Understanding its role enhances the analysis of the formulation’s therapeutic properties against respiratory diseases in children.
14) Ricinus communis:
Ricinus communis, or castor oil plant, is another key ingredient in Shayathirku Ennai. Known for its medicinal attributes, including anti-inflammatory properties, this plant exemplifies the application of natural resources in Siddha medicine. Its inclusion underscores the polyherbal formulation's potential benefits for respiratory health.
15) Inflammation:
Inflammation is a biological response to harmful stimuli, often leading to redness, swelling, and pain. In this study, inflammation is a central focus as researchers evaluate Shayathirku Ennai's anti-inflammatory activity. Understanding inflammation helps to grasp the underlying mechanisms of conditions like Sura Peenisam and supports treatment development.
16) Calculation:
Calculation refers to the quantitative analysis of data collected during experiments. It includes determining the area of skin affected by edema after treatment. Accurate calculations are essential for assessing the efficacy of Shayathirku Ennai, ensuring that results are statistically valid and can contribute to scientific knowledge.
17) Performance:
Performance in this study relates to the therapeutic efficacy of Shayathirku Ennai in mitigating symptoms of Sura Peenisam. The performance of the treatment is gauged through both behavioral observations and measurable biochemical markers, contributing to the overall evaluation of its effectiveness in improving children's health.
18) Developing:
Developing countries often face challenges in healthcare access and disease management. India, characterized as a developing nation, showcases the necessity for effective and accessible treatment options, particularly for common ailments in children. Research like this supports the utilization of traditional medicines to address contemporary health issues.
19) Science (Scientific):
Scientific validation involves the systematic investigation of traditional remedies through controlled studies and empirical data. This study seeks to contribute to the scientific understanding of Siddha medicine, bridging ancient practices with modern methodologies, thereby enhancing the credibility and acceptance of these healing traditions in contemporary healthcare.
20) Relative:
Relative refers to the comparison between different groups in the study. It is important for establishing effectiveness, as seen when comparing the effects of Shayathirku Ennai against control and standard drugs. Relative assessments help to determine the significance and relevance of the treatment outcomes observed.
21) Kasturi:
Kasthuri (Curcuma aromatica), known as fragrant turmeric, is another ingredient in Shayathirku Ennai. It is valued in traditional medicine for its potential anti-inflammatory and healing properties. The inclusion of Kasthuri emphasizes the rich biodiversity utilized in Siddha formulations, contributing to their therapeutic efficacy.
22) Siddhar:
A Siddhar refers to a practitioner of Siddha medicine, often regarded as a sage or enlightened being possessing profound knowledge of natural healing. The teachings and formulations developed by Siddhars are foundational to Siddha practices. Their profound wisdom and experiences shape the therapeutic landscape of traditional medicine in India.
23) Siddhi:
Siddhi denotes the attainment of perfection or mastery in various arts, including medicine, within the context of Siddha philosophy. The pursuit of Siddhi reflects a holistic approach to health that encompasses physical, mental, and spiritual components. Understanding Siddhi enriches the context in which Siddha medicine is practiced and taught.
24) Eranda (Eramda):
Eranda refers to Ricinus communis, commonly known as castor oil. It is used in Siddha formulations for its medicinal properties, including anti-inflammatory effects. Its relevance within Shayathirku Ennai highlights the use of familiar native plants to treat prevalent conditions like Sura Peenisam, representing the integration of nature in traditional healing.
25) Wisdom:
Wisdom in this context refers to the accumulated knowledge and understanding derived from traditional practices and experiences of Siddhars. It plays a crucial role in the development of remedies such as Shayathirku Ennai, underscoring the importance of integrating historical insights into modern medicinal practices for enhanced healthcare.
26) Nature:
Nature refers to the natural world and the resources it provides, which are extensively utilized in Siddha medicine. The principles of Siddha, grounded in the workings of nature, emphasize harmony, balance, and the therapeutic potential of natural substances. Understanding nature's role in health guides the formulation of traditional medicines.
27) Indian:
Indian medicine encompasses a range of traditional healing practices, with Siddha being one of the oldest. This identity is contextualized within the broader tapestry of India's rich cultural history. Recognizing the role of Indian medical systems is essential for enhancing healthcare practices and preserving ancient wisdom in modern contexts.
28) Yoga:
Yoga is a discipline that embodies a holistic approach to health, integrating physical, mental, and spiritual practices. It is historically associated with Siddha philosophy, emphasizing overall well-being. The relationship between yoga and Siddha medicine represents a comprehensive understanding of health that includes physical remedies alongside mental and spiritual balance.
29) Padi:
Padi refers to a measurement unit used in Siddha formulations. It signifies the importance of precise quantities in preparing herbal remedies, indicating a systematic approach to traditional medicine. Accurate dosing is critical for ensuring the efficacy and safety of treatments like Shayathirku Ennai within Siddha practice.
30) Hind:
Hind refers to the historical and cultural context concerning the Indian subcontinent, where Siddha medicine has developed. Acknowledging the 'Hind' perspective enriches the understanding of Siddha practices, connecting them with broader cultural narratives and traditional wisdom that influence health practices across generations in the region.
31) Pur:
Poor performance or health outcomes often refer to the negative impacts of untreated diseases, particularly in vulnerable populations like children. Addressing the conditions like Sura Peenisam in Siddha medicine underscores a commitment to improving health equity and enhancing overall life quality in communities facing healthcare challenges.
32) Life:
Life encompasses the holistic view of existence, interweaving the physical, mental, and spiritual dimensions in Siddha philosophy. The pursuit of wellness in Siddha medicine aims at enhancing the quality of life through treatments that harmonize mind and body. Understanding life from this perspective informs health practices that seek balance and well-being.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Evaluation of anti-histamine and anti-inflammatory effects of Shayathirku Ennai.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Siddha medicine, Experimental study, Animal model, Anti-inflammatory, School going children, Nasal Discharge, Indomethacin, Carrageenan induced paw oedema.