Efficacy of Myristica fragrans seed extracts on glucose tolerance
Journal name: World Journal of Pharmaceutical Research
Original article title: Evaluation of oral glucose tolerance efficacy of various solvent extracts of myristica fragrans seeds
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Muhammad Shaiful Alam Bhuiyan, Md. Saiful Islam, Amlan Ganguly, Md. Zobaer Al-Mahmud, Md. Mamunur Rashid, Md. Salehuddin Ayubee, Farhana Akhter, Mohammed Rahmatullah
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World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Evaluation of oral glucose tolerance efficacy of various solvent extracts of myristica fragrans seeds
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr201818-13577
Copyright (license): WJPR: All rights reserved
Summary of article contents:
Introduction
Diabetes is a prevalent disorder characterized by elevated blood glucose levels, affecting millions worldwide. Its considerable global increase points to a pressing need for effective treatments, particularly in developing countries like Bangladesh where access to allopathic medications may be limited. Previous research has explored natural remedies, focusing on the potential of various plants to assist in glucose management. This study evaluates the oral glucose tolerance efficacy of different solvent extracts from the seeds of Myristica fragrans, commonly known as nutmeg, which is used as a spice across many cuisines.
Effectiveness of Myristica fragrans Extracts
The research conducted used oral glucose tolerance tests (OGTT) to assess the blood glucose-lowering effects of solvent extracts from Myristica fragrans seeds in glucose-loaded mice. Results showed that the methanol extract lowered blood glucose levels by 58.8% and 61.4% at doses of 200 mg/kg and 400 mg/kg, respectively. The petroleum ether fraction was even more effective, reducing glucose levels by 62.0% and 63.6%. The chloroform fraction exhibited the highest efficacy, with reductions of 64.0% and 65.1% at the same doses. In comparison, the standard antihyperglycemic drug, glibenclamide, decreased blood glucose levels by 63.3% at a dose of 10 mg/kg.
Analysis of Bioactive Components
It is essential to identify the bioactive compounds contributing to the hypoglycemic effects observed in the study. The seeds of Myristica fragrans are known to contain epicatechin, a compound linked with blood glucose reduction in diabetic patients. The potential mechanism behind the glucose-lowering action of the various extracts from the seeds could be attributed to this bioactive constituent and warrants further investigation to confirm its role and efficacy.
Significance of Natural Remedies
This study underscores the potential of natural extracts as viable alternatives to conventional diabetes treatments. With diabetes treatment often relying on medications that are unaffordable for many patients in developing countries, incorporating affordable natural products like Myristica fragrans into diets could help manage blood glucose levels effectively. This approach aligns with a broader trend of exploring plant-based solutions for health issues, integrating traditional knowledge and modern research.
Conclusion
In summary, extracts from the seeds of Myristica fragrans exhibit significant potential as blood glucose-lowering agents, demonstrated through their effectiveness in oral glucose tolerance tests in mice. Given the increasing prevalence of diabetes worldwide and the challenge of accessing medications, these findings highlight an important area for further research and applicability in managing diabetes, particularly in populations with limited access to traditional medical treatments. The study suggests that exploring natural remedies could lead to the discovery of novel therapeutic agents for diabetes management.
FAQ section (important questions/answers):
What is the main focus of the study on Myristica fragrans?
The study evaluates the oral glucose tolerance efficacy of various solvent extracts from Myristica fragrans seeds in glucose-loaded mice to assess their potential as blood glucose lowering agents.
How were the extracts of Myristica fragrans prepared for the study?
The seeds were ground into powder, extracted with methanol, and then subjected to solvent-solvent partitioning to obtain various fractions, including petroleum ether, n-hexane, and chloroform extracts.
What animal model was used for testing the extracts' efficacy?
Swiss albino mice weighing between 30-35g were used in the study to evaluate the antihyperglycemic activity of the extracts through oral glucose tolerance tests.
What was the impact of the chloroform extract on blood glucose levels?
The chloroform fraction of Myristica fragrans seeds reduced blood glucose levels by 64.0% and 65.1% at doses of 200 mg and 400 mg per kg body weight, respectively.
How do the extracts compare to the standard drug glibenclamide?
The extracts showed comparable or better blood glucose lowering effects compared to glibenclamide, which reduced glucose levels by 63.3% at a dose of 10 mg/kg.
What potential bioactive compound is mentioned in the study?
Epicatechin is identified as a potential bioactive compound in Myristica fragrans that could contribute to lowering blood glucose levels in diabetic patients.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Efficacy of Myristica fragrans seed extracts on glucose tolerance”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Blood:
Blood refers to the bodily fluid that carries oxygen and nutrients throughout the body. In the context of this study, blood glucose levels are crucial for understanding diabetes and glucose tolerance, as the primary aim is to evaluate how various extracts of Myristica fragrans seeds can influence these levels in treated mice.
2) Animal:
Animal refers to the use of living organisms in research. In this study, Swiss albino mice are utilized to assess the efficacy of various extracts of Myristica fragrans seeds. The research highlights the importance of animal models in understanding processes connected to diabetes and testing potential treatments.
3) Drug:
Drug typically means a chemical substance used for medical treatment. In this article, glibenclamide is mentioned as a standard antihyperglycemic drug used for comparison purposes in oral glucose tolerance tests, demonstrating the importance of evaluating new therapeutic options against established medications.
4) Activity:
Activity pertains to the effects or actions of a substance, in particular its biological effects. In this research, the 'activity' refers to the glucose-lowering effects of Myristica fragrans extracts, which is evaluated through specific tests to determine their potential as treatments for diabetes.
5) Disease:
Disease refers to an impairment of health or a condition of abnormal functioning. Diabetes is the primary disease addressed in this study, characterized by elevated blood glucose levels. The research aims to find natural remedies to help manage or mitigate the effects of this widespread disease.
6) Study (Studying):
Study indicates a structured inquiry to investigate a specific hypothesis or question. This research focuses on the evaluation of Myristica fragrans seed extracts for their potential antihyperglycemic effects, thereby contributing valuable data to the field of diabetes treatment and management.
7) Powder:
Powder in this context refers to the ground form of Myristica fragrans seeds utilized to prepare various extracts. The process of grinding the seeds into powder is essential for the extraction of bioactive compounds necessary for testing their efficacy in lowering blood glucose levels.
8) Table:
Table represents a method of organizing data in a structured manner, providing clear comparisons between results. In this article, a table is included to effectively present the blood glucose levels before and after treatment with various extracts, making it easier to analyze the results.
9) Death:
Death is the cessation of life and is mentioned in reference to the significant mortality rates associated with diabetes and its complications. Understanding the severe consequences of uncontrolled diabetes underscores the importance of finding effective treatments, such as those derived from natural plant sources.
10) Tree:
Tree describes the botanical classification of Myristica fragrans, which is a tropical evergreen tree. The significance lies in its seeds, which are the subject of this research, highlighting the potential of plant-derived substances in the development of diabetes therapies.
11) Pharmacology:
Pharmacology is the branch of medicine focused on drugs and their effects. This research aligns with pharmacological principles by investigating the glucose-lowering effects of Myristica fragrans extracts, offering insights into potential natural treatments for diabetes.
12) Discussion:
Discussion refers to the section of the research where findings are interpreted, compared with existing literature, and implications are drawn. This part of the paper elaborates on how the results contribute to understanding glucose metabolism and the potential of Myristica fragrans in diabetes management.
13) Substance:
Substance refers to a specific material or compound being studied. In this research, various solvent extracts from Myristica fragrans seeds are the primary subjects of investigation. Their effects on blood glucose levels exemplify the search for effective antihyperglycemic agents derived from natural sources.
14) Medicine:
Medicine pertains to the science of diagnosing, treating, and preventing diseases. The article discusses potential natural medicinal uses of Myristica fragrans seed extracts for managing diabetes, contributing to the broader field of herbal medicine and alternative therapies.
15) Mahmud:
Mahmud refers to a co-author, Md. Zobaer Al-Mahmud, contributing to the research. Authors collaborate to enhance the study's credibility and share expertise, illustrating the collaborative nature of scientific research in understanding the antihyperglycemic effects of natural substances.
16) Indian:
Indian pertains to the geographical and cultural context, particularly in relation to traditional medicine practices that recognize diabetes. The study connects historical perspective with modern research by exploring natural remedies familiar to Indian medicinal systems, such as the use of Myristica fragrans seeds.
17) Madhu:
Madhu is a term from the Indian traditional medical system referring to sweet urine, an early indication of diabetes. Its inclusion highlights the historical recognition of diabetes in India and the ongoing search for effective treatments, linking cultural practices to contemporary scientific inquiry.
18) Water:
Water serves as a universal solvent and medium for biological processes. In this study, it is primarily referenced concerning the preparation of extracts from Myristica fragrans seeds. The importance of water in biological and experimental contexts emphasizes the need for hydration and solvent applications in scientific studies.
19) Meha:
Meha is another term associated with diabetes in traditional Indian medicine. It underscores the long-standing awareness of diabetic conditions in cultural practices, providing context for the current research on Myristica fragrans and its potential nutritional benefits in managing diabetes.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Efficacy of Myristica fragrans seed extracts on glucose tolerance’. Further sources in the context of Science might help you critically compare this page with similair documents:
Oxidative stress, Glucose metabolism, Oral glucose tolerance test, Glibenclamide, Methanol extract, Blood glucose level, Pharmaceutical Research, Antihyperglycemic drug, Diabetic patient, Petroleum ether fraction, Chloroform fraction, Clinical pharmacy, N-hexane fraction, MYRISTICA FRAGRANS SEED, Spice, Diabetes-induced complications.