Evaluation of Sarsvata Choorna for generalized anxiety disorder.

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Journal name: World Journal of Pharmaceutical Research
Original article title: Pharmacognostical and pharmaceutical evaluation of sarsvata choorna in the management of chittodvega w.s.r. to generalised anxiety disorder
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Author:

Divya Zala, Anup B. Thakar, Nilesh N. Bhatt, Harisha C. R. and Shukla V. J.


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Pharmacognostical and pharmaceutical evaluation of sarsvata choorna in the management of chittodvega w.s.r. to generalised anxiety disorder

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20171-7627

Copyright (license): WJPR: All rights reserved


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Summary of article contents:

Introduction

Generalized Anxiety Disorder (GAD) is a prevalent psychiatric condition characterized by excessive worry that is difficult to control, leading to symptoms such as fatigue and insomnia. In Ayurvedic medicine, this disorder is equated with "Chittodvega," which is understood through classical texts. The formulation "Sarsvata Choorna," derived from Ayurvedic principles, contains various Medhya Rasayana herbs that are believed to help in managing cognitive functions and anxiety disorders. The primary objective of this study involves pharmacognostical and pharmacological evaluations of Sarsvata Choorna, particularly its efficacy in treating GAD.

Pharmacognostical Analysis of Sarsvata Choorna

The pharmacognostical study of Sarsvata Choorna revealed unique microscopic characteristics of its ingredients, including various types of plant cells and structures. For example, the presence of stone cells from Patha, Pippali, and Maricha, border pitted cells from Ashwagandha, and epidermal cells from Brahmi were identified. Organoleptic examinations showed that Sarsvata Choorna has a brownish color, bitter taste, and fine texture. Such studies confirm the identity and quality of the formulation, alongside the visible characteristics of its ingredients, thereby facilitating its effective utilization in therapeutic practices.

Physicochemical Properties

The physicochemical analysis of Sarsvata Choorna assessed several key parameters, including loss on drying, water-soluble extract, alcohol-soluble extract, and pH. Results indicated a loss on drying of 9.4% w/w, with water and methanol soluble extracts being 25% and 18.08% w/w, respectively, and a pH value of 6.5. These parameters are pivotal for gauging the quality and stability of herbal formulations, ensuring they meet established standards for therapeutic efficacy.

HPTLC Profile Analysis

High-Performance Thin Layer Chromatography (HPTLC) of Sarsvata Choorna revealed a chromatogram with seven distinct spots at 254 nm and ten spots at 366 nm. This analysis highlights the presence of various active compounds within the formulation, suggesting multiple therapeutic constituents. Such profiling is essential for identifying bioactive elements in Ayurvedic formulations and can play a significant role in understanding the complex interactions that contribute to the formulation’s efficacy against GAD.

Conclusion

In summary, the research meticulously confirms the pharmacognostical identity and physicochemical integrity of Sarsvata Choorna, establishing it as a potentially effective treatment for GAD within Ayurveda. The extensive analysis provided through microscopy, physicochemical testing, and HPTLC reinforces the quality and therapeutic potential of this formulation. These findings can serve as important reference points for further research and clinical applications in managing anxiety disorders, marking Sarsvata Choorna as a valuable component in holistic mental health care.

FAQ section (important questions/answers):

What is the focus of the study on Sarsvata Choorna?

The study evaluates the pharmacognostical and pharmaceutical properties of Sarsvata Choorna in managing Generalized Anxiety Disorder (GAD), highlighting its ingredients and their potential benefits.

What ingredients are included in Sarsvata Choorna?

Sarsvata Choorna comprises various Ayurvedic herbs, including Shankhpushpi, Brahmi, Ashwagandha, and others, which are traditionally used for their cognitive and anti-anxiety effects.

How was the pharmacognostical study of Sarsvata Choorna conducted?

The study involved organoleptic evaluation, powdered microscopy, and analysis of physical and chemical properties to authenticate and examine the ingredient's characteristics.

What were the findings regarding the HPTLC analysis?

HPTLC analysis revealed seven spots at 254 nm and ten spots at 366 nm, indicating the presence of multiple active ingredients in the Sarsvata Choorna.

What are the medicinal benefits of Sarsvata Choorna?

Sarsvata Choorna is believed to provide anti-stress, anxiolytic, tranquilizing, and cognitive enhancement effects, making it potentially useful for managing anxiety disorders.

What are the physicochemical characteristics observed in Sarsvata Choorna?

The physicochemical analysis demonstrated 9.4% loss on drying, 25% water-soluble extract, 18.08% methanol soluble extract, and a pH value of 6.5.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Evaluation of Sarsvata Choorna for generalized anxiety disorder.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Gujarat:
Gujarat is a state in India where the Gujarat Ayurved University is located. This institution plays a significant role in the study and research of Ayurvedic medicine, contributing to the validation and development of traditional remedies like Sarsvata Choorna for treating conditions such as generalized anxiety disorder.

2) Drug:
In the context of the text, 'drug' refers to various medicinal substances derived from natural ingredients, including Sarsvata Choorna, which is formulated for certain psychiatric illnesses. The term encompasses the raw materials used and the concoctions created to target specific health issues in Ayurvedic medicine.

3) Divya:
Divya Zala is the primary author of the study, contributing as a PG scholar at Gujarat Ayurved University. Her involvement signifies academic research in the field of Ayurveda, specifically focusing on the efficacy and pharmacognostical properties of the traditional formulation Sarsvata Choorna.

4) Study (Studying):
The study investigates the pharmacognostical and pharmaceutical evaluation of Sarsvata Choorna for managing generalized anxiety disorder. It involves comprehensive research methodologies including characterization of the drug's components, exploring its effectiveness, and establishing a scientific basis for its traditional uses as recorded in Ayurvedic texts.

5) Anxiety:
Anxiety is the condition that the study aims to address, specifically generalized anxiety disorder (GAD). The research highlights the potential of Sarsvata Choorna in alleviating symptoms of anxiety, which can range from mild nervousness to severe distress, significantly impacting a person's quality of life.

6) Jiraka:
Jiraka refers to caraway seeds, significant for their therapeutic properties in traditional Ayurvedic formulations. In this study, Krishna Jiraka and Shweta Jiraka are mentioned as ingredients in Sarsvata Choorna, contributing to its pharmacological attributes aimed at addressing anxiety and enhancing cognitive function.

7) Pharmacognostical:
Pharmacognostical refers to the branch of pharmacology that deals with the study of medicinal drugs derived from plants and other natural sources. The study emphasizes pharmacognostical evaluations to authenticate the quality and therapeutic potential of Sarsvata Choorna's components in treating anxiety disorders.

8) Ashvagandha (Asvagandha, Ashwagandha, Ashvagamdha, Ashva-gandha):
Withania somnifera, commonly known as Ashwagandha, is an important herb in Ayurvedic medicine recognized for its adaptogenic properties. Its presence in Sarsvata Choorna supports its use in managing anxiety and stress-related disorders, enhancing mental clarity and resilience against psychological distress.

9) Sarasvata:
Sarasvata refers to a specific Ayurvedic formulation, Sarsvata Choorna, created for neurological and psychological benefits. This compound is presented in the study as a key focus for treating generalized anxiety disorder, emphasizing the value of traditional knowledge in modern health care.

10) Krishna (Krsna):
Krishna Jiraka is one of the herbs included in the formulation, known for its anti-inflammatory and digestive properties. Its incorporation in Sarsvata Choorna illustrates the use of diverse botanical ingredients to combine their effects in alleviating anxiety and improving overall cognitive function.

11) Medhya:
Medhya signifies a category of herbal formulations in Ayurveda that are aimed at enhancing cognitive functions like memory and intellectual abilities. The classification of Sarsvata Choorna as a Medhya Rasayana highlights its role in promoting mental health and addressing the symptoms of anxiety disorders.

12) Powder:
In the context of this text, 'powder' refers to the granular form of the herbs and ingredients used in Sarsvata Choorna. The preparation and morphological studies conducted on the powdered formulation are crucial for understanding its pharmacological efficacy and quality assessments.

13) Table:
Tables in the document provide organized data, particularly regarding the ingredients of Sarsvata Choorna and their organoleptic properties. This structured presentation of information aids in the clarity of data interpretation and supports the research findings in a scientific format.

14) Vaca:
Acorus calamus, known as Vacha, is included in Sarsvata Choorna for its potential nootropic and anxiolytic effects. Its role in enhancing speech and cognition aligns with the Ayurvedic aim to manage anxiety while improving mental clarity and function.

15) Pippali (Pippalin):
Piper longum, referred to as Pippali, is recognized for its digestive and anti-inflammatory properties. Its presence in Sarsvata Choorna is critical for enhancing bioavailability of other ingredients and contributing to the overall therapeutic effect in managing anxiety.

16) Kushtha (Kustha):
Kustha indicates another important plant used in Ayurvedic formulations, noted for its psychoactive and mental health benefits. Its inclusion in Sarsvata Choorna reflects the traditional perspective of using diverse botanicals to contribute to mental wellness.

17) Brahmi:
Brahmi, or Bacopa monnieri, is an important ingredient in Ayurvedic preparations known for its cognitive-enhancing properties. Its inclusion in Sarsvata Choorna emphasizes the formulation's aim to support brain health and improve mental clarity.

18) Water:
Water is essential in the preparation of Ayurvedic formulations, influencing the extraction and solubility of active ingredients. Its role in the study relates to assessing the water-soluble extractive properties of Sarsvata Choorna, which are critical for determining its therapeutic efficacy.

19) Shunthi (Sunthi, Sumthi, Shumthi):
Shunthi, or ginger, is included in Sarsvata Choorna for its significant health benefits. Recognized in Ayurveda for enhancing digestion and possibly reducing anxiety, its presence demonstrates the careful selection of herbs to achieve well-rounded therapeutic effects in formulations.

20) Patha:
Cissampelos pareira, known as Patha, is traditionally used in Ayurvedic formulations for its therapeutic benefits. Its incorporation in Sarsvata Choorna signifies the use of a holistic approach to treat anxiety through a blend of various herbs with synergistic effects.

21) Rasayana (Rasa-ayana):
Rasayana refers to the rejuvenative aspect of Ayurveda that promotes vitality and longevity. The classification of Sarsvata Choorna as a Rasayana underscores its intended use for overall health promotion, particularly enhancing mental clarity and alleviating anxiety symptoms.

22) Bitter:
The term 'bitter' refers to one of the taste characteristics of several ingredients in Sarsvata Choorna. In Ayurveda, bitter tastes are believed to have detoxifying effects and promote various health benefits, including digestion and mental health enhancement.

23) Manas (Mano, Manash):
Manas, in Ayurveda, refers to the mind or mental faculties. The connection between Manas and treatments like Sarsvata Choorna highlights the holistic perspective of Ayurveda, treating both physical and psychological dimensions of health, particularly in managing anxiety.

24) Dosha (Dosa):
Dosha in Ayurvedic philosophy refers to the three energies (Vata, Pitta, and Kapha) that define an individual's constitution. The study involves understanding how formulations like Sarsvata Choorna can balance doshas and affect mental health, particularly in the case of anxiety disorders.

25) Satva (Shatva):
Satva embodies the qualities of clarity and purity in the context of mental health. The concept of Satva is crucial in Ayurvedic practices focusing on enhancing positive mental states and combating conditions such as anxiety, showcasing the interplay between herbal remedies and mental well-being.

26) Alpa:
Alpa suggests a lesser degree or deficiency, particularly relating to mental strength (Alpa Satva) in this context. Identifying individuals with Alpa Satva leads to targeted Ayurvedic interventions, such as Sarsvata Choorna, aimed at enhancing mental resilience against anxiety disorders.

27) Mana:
Mana emphasizes the importance of focusing on mental processes in Ayurvedic medicine. Understanding Mana promotes the application of treatments like Sarsvata Choorna for anxiety management, acknowledging the value of healing the mind alongside physical health improvements.

28) Zingiber officinale:
Zingiber officinale, commonly known as ginger or Sunthi, is a potent herb used in various Ayurvedic formulations. Its integration into Sarsvata Choorna provides both digestive benefits and potential psychological relief, supporting holistic treatment approaches for anxiety.

29) Withania somnifera:
Withania somnifera, also known as Ashwagandha, is a significant Ayurvedic herb included in Sarsvata Choorna. Recognized for its adaptogenic properties, it aids in stress management and offers considerable advantages in treating symptoms associated with anxiety and mental fatigue.

30) Saussurea lappa:
Saussurea lappa, known as Kushtha, is highlighted in the study as part of Sarsvata Choorna. Its psychoactive properties are valued in Ayurveda, aligning with the objective of using this formulation for promoting mental clarity and reducing anxiety symptoms.

31) Cuminum cyminum:
Cuminum cyminum, or cumin seed, is noted for its antiseptic and digestive properties in Sarsvata Choorna. Its inclusion in the formulation reflects Ayurveda's comprehensive approach to healing, emphasizing the integration of multiple herbal benefits in addressing mental health.

32) Piper longum:
Piper longum, known as Pippali, is significant for enhancing bioavailability in herbal formulations. Its addition to Sarsvata Choorna is essential, as it contributes to the overall efficacy of the formulation against anxiety, showcasing the importance of synergistic herbal combinations.

33) Acorus calamus:
Acorus calamus, also known as Vacha, is recognized for promoting clear speech and cognitive functions. Its use in Sarsvata Choorna reinforces the formulation's intent to improve mental clarity and reduce anxiety-related symptoms effectively.

34) Prajnaparadha (Prajna-paradha):
Prajnaparadha refers to the error of judgment or misuse of intellect. It is relevant in Ayurvedic philosophy, especially regarding mental health as conditions like anxiety may arise from such imbalances, justifying the need for formulations like Sarsvata Choorna.

35) Performance:
Performance in this study pertains to the effectiveness of Sarsvata Choorna in alleviating symptoms of generalized anxiety disorder. Evaluating the performance of various herbal components highlights their individual and collective impact in promoting mental health and cognitive function.

36) Discussion:
The discussion section of the study provides an analysis of the findings related to Sarsvata Choorna's pharmacognostical attributes and efficacy in managing anxiety. It offers insights into the significance of traditional herbal formulations in modern health paradigms and their potential for therapeutic interventions.

37) Goghrita (Goghrta, Go-ghrita):
Go-ghrita, or cow ghee, is used as a carrier or anupan in Ayurvedic formulations. Its presence in Sarsvata Choorna emphasizes the importance of traditional vehicles for enhancing the properties of medicinal herbs and ensuring effective delivery systems for treatment.

38) Ayurveda (Ayus-veda):
Ayurveda is a traditional system of medicine from India that emphasizes holistic health. The study focuses on the application of Ayurvedic principles through formulations like Sarsvata Choorna to address mental health issues such as anxiety in contemporary society.

39) Activity:
Activity refers to the therapeutic effects of Sarsvata Choorna in managing generalized anxiety disorder. The study evaluates the pharmacological activities of various components within the formulation that contribute to their combined efficacy in alleviating anxiety symptoms.

40) Vitiation (Vitiated):
Vitiated describes the disruption of balance in doshas or bodily functions as understood in Ayurveda. The text discusses how imbalances can lead to conditions such as anxiety, supporting the therapeutic role of formulations like Sarsvata Choorna in restoring harmony.

41) Samhita:
Samhita refers to a classical text of Ayurveda that documents ancient knowledge on herbal formulations and treatments. The reference to Samhita emphasizes the study's reliance on traditional wisdom when validating the efficacy of ingredients in Sarsvata Choorna.

42) Ajamoda (Aja-moda):
Ajamoda, the seeds from the celery plant, is valued for its digestive and anti-anxiety properties. Including Ajamoda in Sarsvata Choorna reflects Ayurveda's holistic approach, aiming to address both physical and mental health through comprehensive herbal treatments.

43) Harisha (Harisa):
Harisha refers to one of the authors associated with the study. As a contributor from Gujarat Ayurved University, their insights and expertise in Ayurvedic practices help validate the findings related to Sarsvata Choorna, enhancing the research's credibility.

44) Quality:
Quality pertains to the standards and characteristics evaluated in the pharmacognostical study of Sarsvata Choorna. Ensuring high quality of ingredients and the final formulation is critical in determining its efficacy and safety in treating anxiety disorders.

45) Disease:
Disease refers to the pathological conditions addressed by Sarsvata Choorna, focusing particularly on generalized anxiety disorder. The study emphasizes the importance of herbal formulations like Sarsvata Choorna in alleviating mental health concerns through traditional Ayurvedic methods.

46) Buddhi:
Buddhi signifies intellect or wisdom in the Ayurvedic context, closely tied to the formulation Sarsvata Choorna. The intent to enhance Buddhi aligns with the overall goal of the formulation to improve cognitive abilities and provide relief from anxiety symptoms.

47) Smriti (Smrti):
Smriti represents memory in Ayurveda. The inclusion of herbs in Sarsvata Choorna aiming to enhance Smriti illustrates the formulation's broader objective of improving cognitive function, which is especially beneficial in addressing mental disturbances associated with anxiety.

48) Vikara:
Vikara denotes disturbance or alteration in health, particularly related to mental and emotional balance in Ayurveda. The study recognizes anxiety disorders as Vikara, supporting the development of formulations like Sarsvata Choorna designed to restore mental equilibrium.

49) Ghrita (Ghrta):
Ghrita, or ghee, is often employed as a base in Ayurvedic formulations. Its usage in Sarsvata Choorna highlights the traditional method of enhancing the transport and effectiveness of herbal remedies aimed at improving mental health and cognitive function.

50) Shukla (Sukla):
Shukla may refer to one of the authors involved in the study from Gujarat Ayurved University. This individual's contribution underscores the collaborative nature of research aimed at validating the efficacy of Sarsvata Choorna in the context of traditional Ayurvedic medicine.

51) Madhu:
Madhu, referring to honey, is often used as an anupan in Ayurvedic formulations. Its inclusion in Sarsvata Choorna emphasizes the role of sweet vehicles in enhancing the bioavailability and therapeutic actions of the active ingredients within the formulation.

52) Medha (Medhas):
Medha implies intelligence or mental strength in Ayurveda. The study focuses on how formulations like Sarsvata Choorna aim to enhance Medha, thereby providing support for individuals suffering from anxiety and related cognitive impairments.

53) India:
India, the origin of Ayurveda, is where the study conducted at Gujarat Ayurved University is based. The rich heritage of Ayurvedic practice, especially concerning mental health therapies such as Sarsvata Choorna, reflects the ongoing integration of traditional knowledge into modern health solutions.

54) Worry (Worried, Worrying):
Worry is associated with the emotional distress experienced in anxiety disorders. The focus on alleviating worry through herbal formulations like Sarsvata Choorna demonstrates the relevance of Ayurveda in addressing psychological challenges and enhancing overall mental wellness.

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Discover the significance of concepts within the article: ‘Evaluation of Sarsvata Choorna for generalized anxiety disorder.’. Further sources in the context of Science might help you critically compare this page with similair documents:

Clinical study, Ayurvedic formulation, Generalized Anxiety Disorder, Physico-chemical analysis, Microscopic characters, HPTLC study, Organoleptic evaluation, Medhya Rasayana, Anti-stress activities, Pharmacognostical study.

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