Efficacy of Mesua ferrea seed extracts against pathogenic strains
Journal name: World Journal of Pharmaceutical Research
Original article title: Antimicrobial efficacy of mesua ferrea l. seed extracts and some isolated compounds in different solvents against infection causing pathogenic strains
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:
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Faizan Danish Khaleel, B. K. Mehta and Darshana Mehta
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Antimicrobial efficacy of mesua ferrea l. seed extracts and some isolated compounds in different solvents against infection causing pathogenic strains
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20171-6742
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Summary of article contents:
Introduction
The study focuses on the antimicrobial efficacy of Mesua ferrea L. seed extracts and some isolated compounds against various pathogenic microorganisms. With the growing problem of antibiotic resistance, there is an increasing need to discover new and effective antimicrobial agents from natural sources. The research employed multiple solvents to extract compounds from the seeds of M. ferrea and evaluated their antimicrobial properties using the agar disc diffusion method. The results demonstrated promising potential for these extracts, particularly against certain Gram-positive bacteria.
Antimicrobial Activity of Seed Extracts
The antimicrobial activity of M. ferrea seed extracts was assessed using different solvents, such as hexane, methanol, and aqueous extracts. Results indicated that hexane and methanol extracts exhibited significant antibacterial activity against Gram-positive bacteria, particularly Bacillus subtilis and Proteus vulgaris. The hexane extract was notably potent, with measurable inhibition zones being greater than those of other extracts. Conversely, the aqueous extract showed the least efficacy, even demonstrating resistance against Escherichia coli. The findings underscore the variable efficacy of plant extracts, dependent on the solvent used for extraction.
Impact of Isolated Compounds
The study also investigated isolated compounds from M. ferrea, specifically compounds A9, A13, SD4, SD5, and SD6. Among these, compound A9 demonstrated maximum activity against B. subtilis and P. vulgaris, while other compounds showed moderate activity against several tested strains. Compounds SD4, SD5, and SD6 displayed similar patterns of moderate effectiveness against specific pathogens. This part of the research highlights the potential for specific phytochemicals derived from M. ferrea to serve as effective antimicrobial agents, thus augmenting traditional treatment options.
Challenges with Antibiotic Resistance
The research draws attention to the urgent need for alternative antimicrobial sources due to the rise of antibiotic-resistant microorganisms. The inconvenient consequences of the overuse of antibiotics have necessitated the exploration of natural products with antimicrobial properties. Extracts from plants rich in secondary metabolites, like tannins, terpenoids, and flavonoids, present promising opportunities for developing new antimicrobial drugs. This aspect of the study points out a crucial area of investigation, especially in light of growing public awareness regarding the limitations of traditional antibiotics.
Conclusion
The study concludes that Mesua ferrea L. seed extracts and some isolated compounds exhibit noteworthy antimicrobial properties against pathogenic microorganisms. The various solvent extractions highlight the potential for optimizing these plant extracts for better efficacy. The findings encourage further exploration into the antimicrobial activities of natural products, which may play a vital role in overcoming the challenges of antibiotic resistance and contribute to the development of new therapeutic agents. The study reinforces the importance of continuing research in this field to promote the use of herbal solutions in modern medicine.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Efficacy of Mesua ferrea seed extracts against pathogenic strains”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
The term 'activity' refers to the effectiveness of a substance, particularly in an antimicrobial context. In this study, it pertains to how well Mesua ferrea extracts inhibit the growth of bacteria and fungi. Measuring antimicrobial activity involves quantifying zones of inhibition, which help evaluate the therapeutic potential of the extracts.
2) Drug:
'Drug' signifies a substance used for medical treatment, influencing physiological functions in living organisms. In the context of the study, it refers to either the extracts from Mesua ferrea or synthesized compounds demonstrating antimicrobial properties. The pursuit of new drugs is vital, particularly in combatting antibiotic-resistant pathogens.
3) Antibiotic (Antibacterial):
'Antibiotic' pertains to substances that combat bacterial infections, either by killing bacteria or inhibiting their growth. The research compares the antimicrobial efficacy of Mesua ferrea extracts to commercial antibiotics, emphasizing the necessity for new antibiotics due to rising drug resistance in pathogenic microbes.
4) Aureus:
'Aureus' is a species within the Staphylococcus genus, specifically Staphylococcus aureus, known for causing a range of infections in humans, from mild skin infections to severe illnesses. Its relevance in the study is to assess the susceptibility of this bacterium to the inhibitory effects of Mesua ferrea extracts.
5) Mesua ferrea:
'Mesua ferrea' is a medicinal plant known for its potential therapeutic properties. The study investigates its seed extracts for antimicrobial activity. This term's relevance lies in shedding light on the plant’s bioactive components and their potential in developing new antimicrobial agents against resistant pathogens.
6) Water:
In the context of this study, 'water' is a solvent used for extracting phytochemicals from Mesua ferrea seeds. Its significance lies in providing a medium that may solubilize bioactive compounds, playing a crucial role in the extraction process for evaluating the antimicrobial properties of the extracts obtained.
7) Medium:
'Medium' refers to the nutrient-rich environment where microorganisms grow during the study. Various media, including Muller-Hinton agar and yeast malt agar, were employed to test the antimicrobial activity of extract samples. The choice of medium is vital for accurately assessing the growth conditions of the target organisms.
8) Substance:
'Substance' denotes a specific material or compound being studied, which, in this research, refers to the extracts from Mesua ferrea and isolated compounds. Understanding various substances is essential for evaluating their biological activities, enabling researchers to identify potential therapeutic agents in the context of antimicrobial research.
9) Disease:
'Disease' refers to a pathological condition affecting the body, often caused by infections from bacteria, fungi, or viruses. The study aims to discover natural antimicrobial agents, like those from Mesua ferrea, that can address and potentially alleviate diseases caused by antibiotic-resistant microorganisms, thus highlighting its medical relevance.
10) Study (Studying):
'Study' signifies a systematic investigation aimed at acquiring knowledge regarding the antimicrobial potential of Mesua ferrea extracts. The research's methodical approach in testing various extracts against different pathogens underscores an essential framework for scientific inquiry, contributing valuable insights to the field of pharmacognosy and phytochemistry.
11) Phytochemical:
'Phytochemical' refers to biologically active compounds obtained from plants. The research focuses on identifying these compounds within Mesua ferrea that demonstrate antimicrobial properties, emphasizing their potential as alternatives to synthetic drugs, particularly given the increasing resistance observed in traditional antimicrobial agents.
12) Ujjain:
'Ujjain' is a city in Madhya Pradesh, India, where the research team is based. The geographical context is essential for understanding the local flora and traditional medicinal practices, which often utilize plants like Mesua ferrea. The region may also influence the phytochemical constituents present in the studied extracts.
13) Accumulation (Accumulating, Accumulate):
'Accumulated' describes the gathering of evidence over time. In this context, it refers to the body of research supporting the antimicrobial properties of various medicinal plants, underscoring the systematic compilation of findings that validate the ongoing search for new, effective antimicrobial agents from natural sources.
14) Discussion:
'Discussion' refers to the section in a scientific study where results are interpreted and contextualized. It allows researchers to relate their findings to existing literature, explore the implications of their results, and propose further research directions, making it an essential part of scientific communication and knowledge advancement.
15) Darshana (Darsana):
'Darshana' likely signifies a contributor to the research team. Identifying collaborators in scientific studies is vital for acknowledging their roles and expertise, which often complement each other in a multidisciplinary approach, enhancing the study's quality and range of insights gained from the research conducted.
16) Medicine:
'Medicine' encompasses the science of diagnosing, treating, and preventing illness, often involving pharmaceuticals. The research connects with this broader field by investigating plant extracts as potential sources for new medicinal agents, especially in response to the challenges posed by antibiotic resistance faced by modern medicine.
17) Enjoying:
'Enjoying' in this context likely refers to the growing popularity of alternative medicinal treatments among the public, particularly plants and natural remedies. This trend indicates an increasing preference for self-medication with phytochemicals among individuals seeking therapeutic options outside conventional medical practices.
18) Species:
'Species' identifies a distinct group of organisms that share common attributes. In this study, it refers to both the specific plant, Mesua ferrea, under investigation and the various microbial strains tested against its extracts. Understanding species-level distinctions is crucial for ecological and medicinal studies.
19) Reason:
'Reason' refers to the rationale behind conducting research. Here, it relates to the need for finding effective natural alternatives to combat increasing antibiotic resistance. By examining Mesua ferrea’s extracts, the study addresses a critical challenge in modern healthcare and emphasizes the significance of herbal remedies.
20) Misuse:
'Misuse' indicates the improper or excessive use of medications, particularly antibiotics. In the study's context, it highlights the concern over antibiotic over-prescription leading to resistance, thereby justifying the search for new antimicrobial agents from natural sources like Mesua ferrea to provide safer alternatives.
21) Powder:
'Powder' refers to a finely ground form of a substance. In this research, it pertains to the powdered seed used for extracting various solvents. The powder's preparation is crucial for effectively isolating phytochemicals for subsequent antimicrobial activity testing, ensuring accurate results in assessing its efficacy.
22) Cotton:
'Cotton' likely refers to cotton swabs used in the experimental procedure for applying microbial cultures to growth media. Its role is practical, pertaining to laboratory techniques, although it reflects the broader practice of using standard materials in microbiological research to ensure hygienic and effective experimental conditions.
23) Earth:
'Earth' signifies the planet and its diverse ecosystems, representing the vast array of natural resources available for exploration. In the study's context, it reflects the global search for phytochemicals, emphasizing the importance of conserving biodiversity for potential discoveries in medicinal plant research and drug development.
24) Food:
'Food' refers to substances consumed for nutritional support and energy. The connection to this study lies in the potential for naturally sourced antimicrobial agents to enhance food safety by combating microbial contamination, thereby improving public health and promoting new applications for the medicinal properties of plants.
25) Rich (Rch):
'Rich' describes a high abundance or variety. In this context, it emphasizes the richness of phytochemicals present in Mesua ferrea and other plants used in traditional medicine. This statement accentuates the potential for exploring these diverse compounds as sources of new therapeutic agents against microbial infections.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Efficacy of Mesua ferrea seed extracts against pathogenic strains’. Further sources in the context of Science might help you critically compare this page with similair documents:
Medicinal plant, Essential oil, Traditional medicine, Drug resistance, Gram positive bacteria, Triplicate experiments, Zones of inhibition, Antimicrobial efficacy.