Buoyant controlled release formulations of sumatriptan.
Journal name: World Journal of Pharmaceutical Research
Original article title: Design and evaluation of controlled release buoyant formulations of sumatriptan based on super porous hydrogel composites
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:
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D. Manasa, D. Srinivas Rao, D. Varun and T.M. Pramod Kumar
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World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Design and evaluation of controlled release buoyant formulations of sumatriptan based on super porous hydrogel composites
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20173-7936
Copyright (license): WJPR: All rights reserved
Summary of article contents:
Introduction
The research conducted by Manasa et al. focuses on the development of controlled release buoyant formulations of Sumatriptan utilizing super porous hydrogel composites. The primary goal is to enhance drug bioavailability and optimize pharmacokinetics parameters such as absorption and duration of action. Conventional dosage forms often require multiple daily administrations, leading to patient non-compliance. Therefore, controlled release systems aim to maintain a consistent plasma drug concentration over extended periods, facilitating better therapeutic outcomes.
Super Porous Hydrogels and Their Properties
Super porous hydrogels (SPHs) are highlighted for their rapid swelling capabilities, reaching full expansion in less than 30 seconds. Their unique three-dimensional network structure consists of hydrophilic polymer chains, which allow these materials to absorb significant amounts of water while maintaining their original shape. The synthesis of SPHs involves various components, including crosslinking agents and foaming agents like sodium bicarbonate, which contribute to their advantageous swelling properties and superabsorbent qualities.
Drug Solubility and Interaction
An essential aspect of the study was the examination of Sumatriptan's solubility across different media, revealing that it exhibits the highest solubility in 0.1N hydrochloric acid. The solubility levels in other solutions, including water and acetate buffers, remained relatively high as well. The solubility characteristics are crucial because they underline the drug's potential for effective gastrointestinal absorption. Understanding the compatibility of the drug with various excipients further supports the formulation of effective delivery systems.
Mechanical Strength and Swelling Behavior
The formulation with Ac-Di-Sol as a composite agent demonstrated superior mechanical strength and improved swelling properties. As the concentration of Ac-Di-Sol increased from 50 mg to 175 mg in various formulations, the swelling time decreased significantly, indicating faster drug release capabilities. The research underscores the relationship between the concentration of crosslinking agents and the mechanical characteristics of the super porous hydrogel composites, emphasizing the importance of optimizing these parameters for enhanced drug delivery performance.
Conclusion
The development of oral controlled release systems like Sumatriptan-based super porous hydrogels represents a significant advancement in drug delivery technologies. By addressing the challenges of dosage frequency and bioavailability through innovative formulations, the research points towards improved therapeutic efficacy and patient compliance. The findings suggest that further exploration of the mechanical and swelling properties of these hydrogels will be essential in refining their applications in the pharmaceutical industry.
FAQ section (important questions/answers):
What is the aim of the study on Sumatriptan formulations?
The study aims to design and evaluate hydro dynamically balanced buoyant formulations of Sumatriptan using super porous hydrogels, focusing on drug-excipient compatibility and in vitro drug release.
What are the properties of hydrogels discussed in the article?
Hydrogels are crosslinked hydrophilic polymers that can absorb large amounts of water. Their swelling properties depend on network elasticity, crosslinking extent, and the presence of hydrophilic functional groups.
What are super porous hydrogels and their advantages?
Super porous hydrogels (SPHs) are a three-dimensional network of hydrophilic polymers that swell completely in less than 30 seconds, providing fast swelling and potential for drug delivery applications.
How was the solubility of Sumatriptan determined?
Solubility was studied in four different media at 37°C. A known quantity of Sumatriptan was added until saturation, after which filtered samples were analyzed using UV spectrophotometry.
What effect does increasing Ac-Di-Sol concentration have on SPH?
Increasing Ac-Di-Sol concentration improves mechanical strength due to higher crosslinking density and significantly reduces swelling time from 38 minutes to 12 minutes, enhancing the hydrogel's performance.
What release mechanism was observed for the Sumatriptan-SPHCP formulation?
The Sumatriptan-SPHCP formulation successfully provided a controlled drug release, retarding the release of Sumatriptan for up to 8 hours, indicating its potential for sustained therapeutic effect.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Buoyant controlled release formulations of sumatriptan.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Swelling:
Swelling refers to the ability of hydrogels to absorb water and expand in volume. This property is crucial for controlled drug delivery, as it allows the hydrogel to release the encapsulated drug in a regulated manner. In the context of super porous hydrogels, fast swelling is essential for achieving desired drug release profiles.
2) Drug:
A drug is a substance used for medical treatment, and in this research, Sumatriptan is the specific drug being formulated for controlled release. Effective drug delivery systems aim to improve the bioavailability and therapeutic effects of drugs. The study focuses on enhancing the release kinetics of Sumatriptan using hydrogels.
3) Composite:
Composite in this context refers to materials made from two or more components, such as the super porous hydrogels that incorporate additives like chitosan and Ac-Di-Sol. These composites enhance the properties of the hydrogels, improving features like swelling behavior and mechanical strength, which are vital for effective drug delivery.
4) Manasa (Manasha):
Manasa is the lead author of the study, signifying her contribution to the research on controlled release formulations of Sumatriptan. In academic research, the lead author's involvement is critical as it reflects the guidance and effort put into the design and evaluation of the pharmaceutical formulations under investigation.
5) Water:
Water is the solvent used in various stages of hydrogel preparation and drug solubility studies. It plays a vital role in hydration processes that influence the swelling and release profiles of hydrogels, making it crucial for evaluating how these materials interact with the drug and function in vivo.
6) Karnataka:
Karnataka is the Indian state where the JSS College of Pharmacy is located. This geographical context is relevant as it indicates the institution's academic environment and contributes to the overall body of pharmaceutical research being conducted in India, highlighting local advancements in drug delivery technologies.
7) Mysore:
Mysore is a city in Karnataka, India, associated with JSS College of Pharmacy. The mention of Mysore underscores the regional academic infrastructure supporting pharmaceutical research. It places the research within a specific cultural and historical context that may influence the ethos of the academic community involved.
8) Nagara (Naga-ra):
Nagara refers to the locality of Sri Shivarathreeshwara University, indicating the specific area where the research is conducted. It reflects the institutional identity and local resources that support the investigation into pharmaceutical formulations, emphasizing the localized nature of research efforts in this field.
9) India:
India is the country where the research is conducted, providing insights into the local pharmaceutical industry and research landscape. The inclusion of India highlights the broader context of drug formulation research, showcasing efforts towards addressing healthcare challenges in a rapidly growing economy with diverse medical needs.
10) Container:
Container signifies the vessel used in the formulation and preparation of hydrogels and drug solutions. The choice of container influences factors such as reaction conditions and containment of the reagents, which are essential during the synthesis and evaluation processes for the controlled release drug delivery systems being studied.
11) Medicine:
Medicine encompasses the fields surrounding healthcare and pharmacotherapy, which are relevant as the research focuses on developing advanced drug delivery systems for pharmaceuticals. The goal of optimizing medication delivery through controlled release technologies directly contributes to improving patient outcomes and medical therapies for various conditions.
12) Surface:
Surface refers to the outer layer of the super porous hydrogel composites where drug release occurs. Understanding and characterizing the surface properties of these materials is essential for determining how they interact with fluids and drugs, impacting their effectiveness as delivery systems in medical applications.
13) Reason:
Reason in this context refers to the motivations behind the formulation of controlled release systems. A driving force for the research is the need to enhance drug absorption and efficacy, addressing challenges in patient compliance due to frequent dosing and aiming to deliver therapeutic agents in a predictable manner.
14) Kumar:
Kumar is another co-author of the study, indicating collaboration in the research efforts related to Sumatriptan formulations. The contributions of Kumar, alongside other authors, are crucial to the credibility and rigor of the research findings, reflecting the collaborative nature of scientific inquiry in pharmaceutical sciences.
15) Field:
Field refers to the broader area of pharmaceutical sciences and drug delivery systems. The ongoing research in this field aims to innovate drug formulations that improve patient experiences and therapeutic benefits. It encompasses the systematic studies required to develop effective medical treatments utilizing advanced technologies.
16) Study (Studying):
Study denotes the scientific investigation focused on designing and evaluating controlled release buoyant formulations. It represents the structured approach taken to explore the interactions between drugs and hydrogels, providing systematic data essential for future advancements in drug delivery technologies tailored to specific medical needs.
17) Hema (Heman):
Hema may refer to contributors or relevant entities in the broader context of the research, emphasizing the collaborative nature of scientific research. While not directly related to the presented text, it could reflect similar themes of partnership and joint efforts within pharmaceutical research communities.
18) Pur:
Poor refers particularly to the drug's characteristics that may limit its bioavailability or absorption. The term highlights the challenges faced in drug formulation, especially for medications requiring innovative delivery methods to enhance their therapeutic potential, which drives research in controlled release systems.
19) Life:
Life signifies the biological aspect of drug delivery as it pertains to patient health and therapeutic efficacy. The ultimate goal of developing controlled release formulations is to enhance the quality of life for patients by improving medication effectiveness and ensuring adherence to treatment regimens over extended periods.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Buoyant controlled release formulations of sumatriptan.’. Further sources in the context of Science might help you critically compare this page with similair documents:
In vitro studies, Mechanical strength, Drug-excipient compatibility studies, Sodium bicarbonate, Conventional dosage form, Pharmacokinetics parameters, Swelling properties, Controlled Release Drug Delivery System, Oral controlled release system, Gastro retentive dosage form, Slower drug release, Swelling time, Super porous hydrogel, Crosslinking agent.