Evaluation of anti-diarrhoeal and appetizer effects of nigella sativa seeds

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Journal name: World Journal of Pharmaceutical Research
Original article title: Evaluation of anti-diarrhoeal and appetizer effects of nigella sativa seeds
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:

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Author:

Nousseiba Abed, Asma Bennini, Hadjer Merdaci, Abdelkader Rouabah, Leila Rouabah


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Evaluation of anti-diarrhoeal and appetizer effects of nigella sativa seeds

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20174-7987

Copyright (license): WJPR: All rights reserved


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Summary of article contents:

Introduction

This research study evaluates the anti-diarrheal and appetizer effects of Nigella sativa seeds. The study was conducted using male albino Wistar rats to assess the seeds' potential as an alternative treatment for diarrhea and as a natural appetite stimulant. The research highlights the traditional medicinal uses of Nigella sativa and aims to provide scientific evidence supporting these claims through experimental methodologies.

Anti-Diarrheal Effects of Nigella sativa

The anti-diarrheal effect was tested using a castor oil-induced diarrhea model in Wistar rats. The crude extract of Nigella sativa seeds was administered via oral gavage at doses of 100, 250, and 500 mg/kg. The extract at a dosage of 500 mg/kg demonstrated a significant decrease in both the frequency and weight of wet stools compared to the control group. Notably, the anti-diarrheal activity of the crude extract at this higher dosage was found to be superior to that of the standard drug loperamide (3 mg/kg). These results suggest that active constituents within the seeds may exert a strong antisecretory effect, thus reducing diarrhea.

Appetizer Effects of Nigella sativa

In a separate part of the study, the appetizer effect of Nigella sativa was evaluated in 36 healthy adult volunteers divided into four groups. The participants received varying doses of Nigella sativa seed powder (1g, 2g, and 3g) or a control group received fenugreek. After 20 minutes, visual analog scale assessments indicated a significant increase in subjective appetite scores for those treated with Nigella sativa compared to the control. The results demonstrated a dose-dependent increase in appetite, particularly at doses of 2g and 3g, supporting the traditional use of this seed as an appetite stimulant.

Mechanisms and Active Constituents

Several mechanisms were posited regarding the actions of Nigella sativa seeds. The presence of various bioactive compounds such as flavonoids, tannins, and saponins, which are known for their medicinal properties, may contribute to both the anti-diarrheal and appetite-enhancing effects. The research suggests that the seeds' bitterness may stimulate digestive secretions and enhance appetite, while their chemical constituents may assist in reducing intestinal motility and increasing fluid absorption. These findings align with traditional medicinal practices that employ Nigella sativa for digestive health.

Conclusion

In summary, this study provides compelling evidence for the anti-diarrheal and appetizer effects of Nigella sativa seeds. The research demonstrates that the seeds not only significantly reduce diarrhea in rats but also effectively enhance appetite in healthy human subjects. These findings support the use of Nigella sativa as a potential natural remedy for gastrointestinal issues, emphasizing its relevance in traditional medicine. Further studies are recommended to isolate and identify the specific active compounds responsible for these beneficial effects and to further investigate the underlying mechanisms.

FAQ section (important questions/answers):

What are the primary effects studied in Nigella sativa seeds?

This study investigates the anti-diarrheal and appetizer effects of Nigella sativa seeds, showing significant potential in reducing diarrhea and enhancing appetite among participants.

How was the anti-diarrheal effect tested in the study?

The anti-diarrheal effect was tested using castor oil-induced diarrhea in albino Wistar rats, where various doses of crude extract were administered and their effects on stool frequency were measured.

What doses of Nigella sativa extract were used in the experiment?

The study used doses of 100, 250, and 500 mg/kg of crude extract of Nigella sativa seeds to assess its anti-diarrheal activity in rats.

How was the appetite effect measured among human volunteers?

Appetite was assessed using a visual analog scale after administering different doses of Nigella sativa seeds powder, comparing the results with participants who received fenugreek.

What were the significant results regarding appetite enhancement?

Oral administration of Nigella sativa seeds significantly increased subjective appetite scores in human participants, with the highest enhancement observed at doses of 2g and 3g.

What conclusions can be drawn from the study regarding Nigella sativa?

The study concludes that Nigella sativa seeds have notable anti-diarrheal and appetite-stimulating effects, supporting their traditional medicinal uses and potential as a natural treatment.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Evaluation of anti-diarrhoeal and appetizer effects of nigella sativa seeds”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Study (Studying):
The term 'study' refers to the systematic investigation aimed at discovering or verifying facts and principles. In this context, the study evaluates the anti-diarrheal and appetizer effects of Nigella sativa seeds. Understanding study design and results is crucial for validating the efficacy of natural remedies used in traditional medicine.

2) Castor:
Castor, in this context, refers to castor oil, a substance derived from the seeds of the Ricinus communis plant, known to induce diarrhea in experimental models. The study employs castor oil to investigate the anti-diarrheal effects of Nigella sativa, making it relevant in the evaluation of medicinal properties.

3) Fenugreek:
Fenugreek, scientifically known as Trigonella foenum-graecum, is an herb known for its appetite-stimulating properties. In the study, it serves as a control treatment against which the effects of Nigella sativa seeds powder are compared, elucidating the effectiveness and potential of natural appetite enhancers.

4) Activity:
The term 'activity' refers to the effectiveness of a substance in producing a desired effect. The study assesses both anti-diarrheal and appetizer activities of Nigella sativa seeds. Understanding these biological activities is fundamental in pharmacology and for the validation of traditional medicinal uses.

5) Drug:
A drug is any substance that causes a physiological change in the body. In this context, the study explores the potential of Nigella sativa extract as a natural drug for treating diarrhea and stimulating appetite, highlighting the importance of finding safer alternatives to synthetic medications.

6) Disease:
Disease refers to a pathological condition caused by an infection or malfunctioning of an organism. Diarrheal diseases are significant public health concerns, especially in developing countries. This study aims to address these issues by evaluating the anti-diarrheal effects of traditional medicinal plants.

7) Powder:
'Powder' refers to the form in which Nigella sativa seeds were administered in the study. The seeds were ground and then prepared as an aqueous extract. This preparation method is crucial for determining the bioavailability and efficacy of the active compounds within the botanical.

8) Water:
Water acts as a solvent in pharmaceutical and biological studies. In the context of this research, distilled water was used to extract active compounds from Nigella sativa seeds. It is a critical component for formulating medicinal extracts and for maintaining the health of animal models.

9) Food:
Food is any substance consumed to provide nutritional support for the body. The article discusses the appetizer effects of Nigella sativa, indicating its potential role in stimulating appetite and food intake, which is crucial for maintaining health and preventing conditions like anorexia.

10) Medicine:
Medicine refers to substances or practices used for the treatment of diseases and health conditions. The study discusses the use of Nigella sativa as a traditional medicine, emphasizing the overall relevance of natural compounds in modern medicine and their role in providing alternative treatments.

11) Animal:
In this context, 'animal' pertains to the use of Wistar rats as a model for studying the anti-diarrheal effects of Nigella sativa. The use of animal models is vital in biomedical research, allowing researchers to understand physiological responses and the efficacy of treatments before clinical trials.

12) Table:
The term 'table' refers to tabulated data summarizing the findings of the study, specifically the results of the anti-diarrheal effect of Nigella sativa. Tables help organize complex datasets, making it easier to compare results and draw conclusions about the efficacy of different treatments.

13) Life:
Life in this context broadly refers to biological systems, including humans and animals. The study's findings on appetite stimulation and anti-diarrheal properties directly relate to improving the quality of life by addressing health issues commonly associated with poor digestion and appetite.

14) Science (Scientific):
Scientific methods and approaches validate traditional medicine claims. The research applies rigorous experimental design to assess the medicinal properties of Nigella sativa seeds, contributing to the overall scientific understanding and credibility of herbal therapies.

15) Nature:
Nature refers to the inherent qualities and characteristics of living organisms and the environment. The study highlights how natural products like Nigella sativa can provide therapeutic effects, reinforcing the importance of preserving biodiversity for potential medicinal benefits.

16) Trigonella foenum-graecum:
Trigonella foenum-graecum, known as fenugreek, is an herb with documented appetite-enhancing properties. In the research, it serves as a comparative agent to assess the appetite-stimulating effects of Nigella sativa, showcasing the relevance of traditional herbs in promoting health.

17) Flavonoid:
Flavonoids are a class of bioactive compounds in plants known for their antioxidant and anti-inflammatory effects. Their presence in Nigella sativa may contribute to its medicinal properties, making them significant in the study's evaluation of anti-diarrheal and appetite-enhancing activities.

18) Family:
In the biological context, 'family' refers to a group of related plants. Nigella sativa belongs to the Ranunculaceae family. Understanding plant taxonomy is important for identifying beneficial compounds and studying their uses in traditional and modern medicine.

19) Bitter:
Bitter substances can stimulate digestive secretions and enhance appetite. In this study, the bitter taste of Nigella sativa seeds is believed to play a role in its appetite-stimulating effect, demonstrating how sensory properties of food can influence physiological responses.

20) Death:
Death refers to the cessation of biological functions that sustain an organism. Diarrheal diseases contribute to significant mortality rates in developing countries, emphasizing the need for effective treatments like Nigella sativa to prevent such outcomes and improve public health.

21) Measurement:
Measurement refers to the quantification of variables, essential for assessing the effects of treatments in the study. Accurate measurement of appetite and anti-diarrheal outcomes enhances the reliability of the conclusions regarding the efficacy of Nigella sativa extracts.

22) Observation:
Observation is a method of gathering data through careful monitoring. In the study, observations of appetite changes and stool characteristics in rats were crucial for evaluating the effectiveness of Nigella sativa in treating diarrhea and stimulating appetite.

23) Discussion:
Discussion is a section of research where results are interpreted and contextualized. In this study, the discussion on findings related to Nigella sativa's anti-diarrheal and appetite enhancement effects provides insights into traditional uses and encourages further research.

24) Developing:
Developing countries often face high rates of diarrheal diseases, leading to significant morbidity and mortality. This research emphasizes the need for accessible and effective treatments like Nigella sativa to address health disparities present in these regions.

25) Substance:
A substance in this context refers to a compound with distinct properties. The study focuses on the active components within Nigella sativa seeds, exploring how these substances contribute to its anti-diarrheal and appetite-enhancing effects in both animals and humans.

26) Vomiting:
Vomiting is a common adverse effect associated with certain anti-diarrheal medications. The study highlights the benefits of using Nigella sativa as a safer alternative in managing diarrhea without inducing nausea or other adverse effects typically seen with synthetic drugs.

27) Relative:
Relative refers to the comparative nature of data or findings. In the study, references to relative measures, such as appetite scores and the efficacy of treatments like Nigella sativa compared to fenugreek, are essential for understanding their effectiveness.

28) Channel:
In a biological context, 'channel' often refers to pathways through which substances traverse membranes, notably ion channels involved in physiological processes. The understanding of such mechanisms aids in explaining the effects of Nigella sativa on digestive motility and secretory functions.

29) Quality:
Quality pertains to the standard or degree of excellence of a substance or treatment. The study investigates how the quality of Nigella sativa extracts influences their anti-diarrheal and appetite-enhancing effects, emphasizing the importance of preparation methods in therapeutic applications.

30) Cancer:
Cancer is a disease characterized by uncontrolled cell growth. While not the primary focus of this study, anorexia and weight loss associated with cancer can severely impact patients. The appetite-enhancing effects of Nigella sativa may therefore be beneficial in providing supportive care.

31) Sugar:
Sugar in this context possibly refers to nutritional components related to appetite regulation and energy provision. The pharmacological action of Nigella sativa may include the modulation of nutrient absorption, impacting dietary intake and potentially aiding in conditions of anorexia.

32) Tanki (Tamki):
Dangi is mentioned as a reference to a previous study methodology. This citation fosters continuity in scientific discourse, allowing researchers to build upon established knowledge frameworks when investigating the anti-diarrheal properties of substances like Nigella sativa.

33) Asma (Ashma):
Asma is one of the authors of the study, contributing to the research on Nigella sativa. Collaborative efforts in research exemplify the importance of interdisciplinary approaches in understanding complex health issues and developing evidence-based treatments.

34) Cage:
Cage refers to the controlled environment in which the Wistar rats were observed during the study. Using specially designed cages ensures accurate data collection on defecation patterns and physiological responses, essential for drawing valid conclusions from the experimental results.

35) Pain:
Pain is a symptom commonly associated with various physiological conditions, including those related to digestive health. Understanding the role of substances like Nigella sativa in managing gastrointestinal pain can strengthen its case as a valuable therapeutic agent.

36) Hand:
The term 'hand' may symbolize human intervention in the study, highlighting the roles of researchers in conducting experiments, administering treatments, and analyzing data. This emphasizes the role of skilled human involvement in scientific inquiry and experimentation.

37) Sour:
Sour, as a taste, can also stimulate digestive secretions. In traditional medicine, taste profiles of herbal substances, including the sourness associated with some plants, can influence their appetite-enhancing properties, further supporting their therapeutic claims.

38) Pur:
'Poor' often describes inadequate health conditions. The research emphasizes that many individuals suffer from poor appetite due to various diseases. Addressing these conditions with natural remedies like Nigella sativa is critical for improving overall health and well-being.

39) Dish (Dis):
Dish refers to the container used to measure the weight of stool in the study's experiments. Properly using dishes ensures accurate data collection regarding the anti-diarrheal effects of treatments tested in the animal model, contributing to the validity of the results.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Evaluation of anti-diarrhoeal and appetizer effects of nigella sativa seeds’. Further sources in the context of Science might help you critically compare this page with similair documents:

Castor oil, Healing power, Adverse effect, Traditional medicine, Oral administration, Visual analog scale, Dose-dependent, Weight loss, Alcoholic extract, Saponin, Albino Wistar rats, Crude extract.

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