Pharmacognostical and pharmaceutical evaluation of haridradi pratisarana
Journal name: World Journal of Pharmaceutical Research
Original article title: Pharmacognostical and pharmaceutical evaluation of haridradi pratisarana - a herbomineral formulation
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Tumpa Brahma Dr. D.B. Vaghela, Harisha C. R. and V. J. Shukla
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Pharmacognostical and pharmaceutical evaluation of haridradi pratisarana - a herbomineral formulation
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20175-8372
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
Tonsillitis is a prevalent condition among school-aged children, affecting nearly 30 million each year due to bacterial and viral infections, with the incidence of this disease accounting for approximately 7% of pediatric visits. In Ayurvedic literature, Tundikeri is classified under Mukharoga—conditions of the mouth—falling under the categories of Kanthagata or Talugata Roga. The symptoms associated with Tundikeri, such as inflammation, pain, sore throat, and suppurative inflammation, closely resemble those of Tonsillitis. This study focuses on the formulation Haridradi Pratisarana, which is utilized for treating Tundikeri, to standardize its identity, quality, and purity through pharmacognostical and pharmaceutical evaluations.
Pharmacognostical Study of Haridradi Pratisarana
Pharmacognostical analysis involves both organoleptic and microscopic assessments to establish the characteristics of Haridradi Pratisarana. Organoleptic evaluation includes parameters such as color, taste, odor, and texture, providing foundational insights into the formulation's authenticity. The microscopic examination further reveals diagnostic characteristics, showing the presence of elements such as oil globules, starch granules, and crystalline materials, which support its medicinal properties. This multifaceted approach helps confirm the formulation's quality by identifying its active constituents and ensuring that it meets the necessary standards for medicinal use.
Physico-Chemical Analysis
The study evaluated the physico-chemical properties of Haridradi Pratisarana to determine its quality and consistency. Specific analysis included measurements such as the loss on drying (10.54%), ash values (42.15%), and both water-soluble and acid-soluble extract percentages (46.06% and 32.41%, respectively). The pH of the formulation was found to be 9.0, with only 1.47% of acid-insoluble ash. These assessments provide critical data regarding the formulation's composition and stability, further illustrating its potential efficacy and safety as a treatment for Tonsillitis.
High-Performance Thin Layer Chromatography (HPTLC) Study
To establish a fingerprint profile of Haridradi Pratisarana, HPTLC was performed using methanolic extract of the drug. The chromatographic analysis at 254 nm revealed five distinct spots, while three spots were observed at 366 nm, with specific Rf values noted for each. This molecular profiling is vital as it assists in identifying the formulation's active components that contribute to its pharmacological and clinical effects. Such detailed chromatographic data enhances the understanding of the formulation's active compounds, which is crucial for validating its use and efficacy in clinical settings.
Conclusion
The research underscores the necessity of quality control in herbo-mineral formulations like Haridradi Pratisarana. Through pharmacognostical evaluations and physico-chemical analysis, the study confirmed the formulation's purity and genuineness. The findings provide a solid foundation for further research, potentially contributing to future studies in quality control and therapeutic efficacy of similar Ayurvedic formulations. The established standards may serve as important reference points for researchers aiming to explore the benefits and applications of Haridradi Pratisarana in treating Tonsillitis and related conditions.
FAQ section (important questions/answers):
What is Tonsillitis and how prevalent is it among children?
Tonsillitis is a common disease in school-going children, affecting about 30 million annually due to bacterial and viral infections. It accounts for approximately 7% of pediatrician visits.
What is the significance of Haridradi Pratisarana in Ayurveda?
Haridradi Pratisarana is an Ayurvedic formulation used for Pratisarana, effectively treating Tonsillitis. It contains Haridra and Tankana, both known for their anti-inflammatory and antimicrobial properties.
What were the key findings from the pharmacognostical study?
The pharmacognostical study revealed specific organoleptic and microscopic characteristics of Haridradi Pratisarana, indicating the presence of active constituents like starch granules and oil globules.
How was the pharmaceutical evaluation conducted for Haridradi Pratisarana?
Pharmaceutical evaluation included tests for loss on drying, ash values, water soluble/extracts, and pH. These tests confirmed the quality and purity of Haridradi Pratisarana.
What are the results of the HPTLC study for this formulation?
The HPTLC study revealed five spots at 254 nm and three at 366 nm, indicating distinct compounds that may contribute to the pharmacological effects of Haridradi Pratisarana.
What is the conclusion regarding standardization of Haridradi Pratisarana?
Standardization is crucial for ensuring safety, purity, and reproducibility of formulations like Haridradi Pratisarana. The study confirmed its quality through pharmacognostical and physicochemical analyses.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Pharmacognostical and pharmaceutical evaluation of haridradi pratisarana”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Pratisharana (Pratisarana):
Pratisarana refers to the localized application of medicinal substances, often through gentle rubbing, to treat conditions affecting the throat, particularly in Ayurveda. In the context of the study, it denotes a treatment approach for Tonsillitis, utilizing the herbomineral formulation Haridradi Pratisarana to alleviate symptoms.
2) Haridradi (Haridra-adi):
Haridradi is an Ayurvedic term that describes a specific herbal formulation, which includes Haridra and Tankana. It's aimed at addressing throat ailments such as Tonsillitis. The study evaluates its therapeutic properties and effectiveness, establishing a foundation for its use in Ayurvedic practice.
3) Haridra:
Haridra, also known as turmeric (Curcuma longa), is a key ingredient in the formulation under study. It's well-regarded in Ayurveda for its anti-inflammatory and antimicrobial properties. This research highlights its role in potentially relieving symptoms associated with Tonsillitis by acting on inflammation.
4) Study (Studying):
The term 'study' denotes systematic research designed to investigate the properties and effects of the Haridradi Pratisarana formulation. It involves various scientific evaluations, including pharmacognostical and physico-chemical analyses, aimed at standardizing the drug for efficacy and safety in treating throat inflammation.
5) Drug:
In this context, 'drug' refers to the natural substance composed of herbal and mineral components, specifically Haridradi Pratisarana. The research focuses on evaluating this drug's quality, safety, and therapeutic effects, highlighting the importance of rigorous analysis in herbal medicine.
6) Tumpa:
Tumpa Brahma is the lead author of this research article. As a PG scholar in the Department of Shalakyatantra, her contributions indicate the involvement of emerging researchers in traditional medicine studies, emphasizing the integration of academic scrutiny in the field of Ayurveda.
7) Table:
Tables are used within the study to present organized data regarding the organoleptic properties, physicochemical evaluations, and HPTLC results of the Haridradi Pratisarana. They facilitate clarity and easy interpretation of research findings for readers and future researchers alike.
8) Pharmacognostical:
Pharmacognostical relates to the study of drugs derived from natural sources, particularly focusing on their botanical and chemical aspects. This analysis is crucial for confirming the identity, quality, and efficacy of Ayurvedic formulations like Haridradi Pratisarana, ensuring they meet safety standards.
9) Tankana (Tamkana):
Tankana refers to borax, a key ingredient in the Haridradi formulation. It is recognized for its therapeutic properties in Ayurveda. The study contextualizes its role in the formulation's efficacy against Tonsillitis, contributing to the overall chemical profile of the medicinal preparation.
10) Inflammation:
Inflammation describes the body's response to injury or infection, which is central to conditions like Tonsillitis. The study investigates Haridradi Pratisarana's effectiveness in reducing inflammation in the throat, aiming to provide a natural remedy that minimizes the need for conventional medications.
11) Gujarat:
Gujarat is the Indian state where the research was conducted at the Gujarat Ayurved University in Jamnagar. This geographical context is significant as it highlights the traditional practices of Ayurveda rooted in Indian culture and the region's ongoing contribution to herbal medicine research.
12) Quality:
Quality encompasses the safety, purity, and effectiveness of the Haridradi Pratisarana formulation. This study emphasizes the importance of quality control through rigorous testing and standardization to ensure that the herbal product can be safely administered to patients suffering from Tonsillitis.
13) Disease:
Disease in this context specifically refers to Tonsillitis, which is a common ailment diagnosed in children. The research aims to provide a potential Ayurvedic treatment option to manage this condition, highlighting the relevance of traditional remedies in modern healthcare.
14) Water:
Water is a critical component in the preparation and extraction processes of herbal formulations. The study includes analyses of water-soluble extracts from the Haridradi formulation, which helps in determining the efficacy and availability of active ingredients within the mixture.
15) Shalakyatantra (Salakyatantra, Shalakya-tantra, Shalakyatamtra):
Shalakyatantra is a branch of Ayurveda focusing on the treatment of conditions related to the head and neck. The expertise within this department is instrumental in the study of Haridradi Pratisarana, as it offers specialized knowledge required to address throat-related diseases.
16) Mukharoga (Mukha-roga):
Mukharoga refers to diseases associated with the mouth and throat in Ayurvedic terminology. It establishes the context for this study, as Haridradi Pratisarana is intended to treat Tundikeri, a muharoga condition reflecting its alignment with Ayurvedic principles.
17) Purity:
Purity in the context of pharmacological evaluation addresses the presence of contaminants or adulterants in the Haridradi Pratisarana formulation. This study emphasizes assessing botanical and mineral components to ensure the formulation maintains high standards for therapeutic use.
18) Yoga:
Yoga, in this context, refers not to the physical practice, but to a specific formulation or recipe in Ayurveda. Haridradi Pratisarana represents an 'Anubhuta Yoga,' showing the combination of ingredients intended for specific therapeutic effects within Ayurvedic healing practices.
19) Observation:
Observation refers to the systematic examination of data and outcomes during the study. This involves monitoring the effects of Haridradi Pratisarana on Tonsillitis, which informs future research and contributes to the evidence base for Ayurvedic formulations.
20) Ayurveda (Ayus-veda):
Ayurveda is a traditional system of medicine originating from India, emphasizing natural healing through herbal formulations and lifestyle practices. This study exemplifies Ayurvedic principles through the evaluation of a specific treatment for Tonsillitis using ancient knowledge combined with modern scientific methods.
21) Prapaka:
Prapaka, relating to suppurative inflammation in Ayurvedic texts, describes symptoms associated with Tonsillitis. It underlines the clinical focus of the study, as Haridradi Pratisarana targets these symptoms, aiming to provide relief through its anti-inflammatory properties.
22) Brahma:
Brahma refers to Tumpa Brahma, the main author of the research, signifying the contributions of scholars in advancing the understanding of Ayurvedic formulations. Their work bridges traditional knowledge with contemporary scientific rigor in herbal medicine.
23) Visit:
Visit pertains to the consultations children have with pediatricians for ailments like Tonsillitis. The research emphasizes the prevalence of this condition, indicating the need for effective, non-invasive treatment options based in traditional practices.
24) Roga:
Roga, an Ayurvedic term for disease or disorder, helps contextualize the study within traditional healing frameworks. It highlights the classification of Tonsillitis as a throat-related ailment requiring specialized treatment as indicated by Haridradi Pratisarana.
25) Daha:
Daha refers to the symptom of sore throat associated with Tonsillitis. The study investigates how the application of Haridradi Pratisarana can alleviate this discomfort, showcasing the formulation's potential benefits in managing throat inflammation.
26) Pain:
Pain is a prominent symptom of Tonsillitis, often manifested as throat discomfort. This study aims to evaluate the effectiveness of Haridradi Pratisarana in reducing pain and inflammation, contributing to the management strategies for this common condition.
27) Curcuma longa:
Curcuma longa, or turmeric, is a crucial ingredient in Haridradi Pratisarana known for its medicinal properties. It has anti-inflammatory and antimicrobial effects, making it essential in the formulation's efficacy against Tonsillitis, representing a key component of traditional Ayurvedic medicine.
28) Pharmacological:
Pharmacological pertains to the study of how drugs work in the body. This study includes a pharmacological analysis of the Haridradi formulation, aiming to substantiate its therapeutic claims and demonstrate its effects on ameliorating symptoms associated with Tonsillitis.
29) Performance:
Performance in this study refers to the effectiveness and functional attributes of Haridradi Pratisarana in managing Tonsillitis. The analytical methods employed aim to quantify the formulation's ability to produce the desired therapeutic outcomes, ensuring reliability in treatment.
30) Measurement:
Measurement relates to the quantifiable aspects of the study, including the analysis of active components and physicochemical properties of Haridradi Pratisarana. Accurate measurement is crucial for standardizing the formulation to ensure consistent therapeutic effects.
31) Discussion:
Discussion in the context of this study involves analyzing the findings, comparing them with existing literature, and considering the implications of the results on the understanding of Ayurvedic therapies. It's critical for contextualizing the research within broader medicinal frameworks.
32) Antibiotic (Antibacterial):
Antibiotics refer to conventional medications used to treat bacterial infections, commonly prescribed for Tonsillitis. The study contrasts the use of these drugs with the benefits of using Haridradi Pratisarana, advocating for natural alternatives that minimize side effects.
33) Medicine:
Medicine encompasses the field of health and healing, including all forms of therapy, both conventional and traditional like Ayurveda. This study showcases how traditional Ayurvedic preparations can be integrated into modern healthcare practices for treating prevalent ailments.
34) Activity:
Activity refers to the pharmacological action of herbs within the Haridradi formulation. Understanding the biological activity of its components, such as Haridra, is essential for validating the formulation's effectiveness in treating throat conditions.
35) Teaching:
Teaching indicates the educational aspect involving the dissemination of Ayurvedic knowledge and practices. The study signifies the importance of academia within Ayurveda, aiming to educate future practitioners about the efficacy and application of herbal formulations in clinical settings.
36) Harisha (Harisa):
Harisha C. R. is one of the co-authors, indicating the collaborative research effort. Contributions from multiple authors signify the value of interdisciplinary approaches in Ayurvedic research, merging insights from various fields for comprehensive evaluations.
37) Vaghela:
Dr. D.B. Vaghela serves as an associate professor and one of the authors, showcasing the role of academic professionals in guiding research. Their expertise is vital for ensuring rigorous scientific methodology and interpretation in studies of traditional medicine.
38) Mineral:
Mineral refers to the inorganic components within Haridradi Pratisarana, specifically Suddha Tankana (Borax). Its presence in the formulation expands the therapeutic profile, illustrating the complementary roles of herbs and minerals in Ayurvedic formulations to treat diseases effectively.
39) Science (Scientific):
Science signifies the systematic study and application of knowledge to understand phenomena. This research combines traditional Ayurvedic practices with modern scientific methodologies, representing a holistic approach to validating and advancing the efficacy of herbal treatments.
40) Surface:
Surface often pertains to the examination of physical properties of materials. In this study, it may relate to the microscopic evaluation of the formulation to understand its texture and composition, contributing essential data to pharmacognostical assessments.
41) Shukla (Sukla):
V. J. Shukla, as another co-author from the research team, indicates the team-based approach to exploring Ayurvedic formulations. Involving multiple experts helps to enrich the study with diverse perspectives on traditional medicine practices and their scientific validation.
42) Shuddha (Suddha):
Suddha refers to the purified form of Tankana (Borax) used in the formulation. Its purity is vital for ensuring the safety and efficacy of the Haridradi Pratisarana in treating Tonsillitis, aligning with Ayurvedic principles that prioritize quality and cleanliness in medicinal preparations.
43) India:
India is the origin of Ayurveda, the traditional medicine system being researched. This context establishes the cultural and historical significance of the study in relation to herbal medicine, showcasing India's ongoing contributions to health and wellness.
44) Borax:
Borax, scientifically known as Tankana, is used in Haridradi Pratisarana. It is recognized for its therapeutic properties and roles in treating throat ailments, embodying the synergistic potential of combining herbal and mineral ingredients in traditional formulations.
45) Sign:
Sign refers to the observable effects or changes that indicate a therapeutic response from the Haridradi formulation. Recognizing these signs is crucial to assessing the success of the treatment in alleviating symptoms associated with Tonsillitis.
46) Post:
Post signifies the phase following the completion of a study. It often involves disseminating findings and implications for further research, emphasizing the continuing journey of validating Ayurvedic practices through scientific inquiry.
47) Life:
Life often represents the overall health and wellness, central to Ayurvedic philosophy. This study on Haridradi Pratisarana aligns with the broader goal of improving life quality through natural, effective treatments for common ailments like Tonsillitis.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Pharmacognostical and pharmaceutical evaluation of haridradi pratisarana’. Further sources in the context of Science might help you critically compare this page with similair documents:
Tundikeri, Curcuma longa, Loss on drying, Standardization, Physico-chemical analysis, Anti-inflammatory property, HPTLC study, Ayurvedic Pharmacopoeia of India, Acid insoluble ash, Pharmacognosy, Pharmacognostical study, Organoleptic study, Pharmaceutical analysis, Talugata roga, Kanthagata Roga, Tonsillitis, Mukhroga.