Mammea suriga extract's antioxidant and hepatoprotective effects.

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Journal name: World Journal of Pharmaceutical Research
Original article title: Antioxidant and hepatoprotective potential of mammea suriga aqueous extract against ccl4 induced hepatotoxicity in rat models
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Original source:

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Author:

Sudhesh L. Shastri, V. Krishna, Ravishnakar B., Vinay Kumar N. M. and Chethan Kumara G. P.


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Antioxidant and hepatoprotective potential of mammea suriga aqueous extract against ccl4 induced hepatotoxicity in rat models

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20176-8696

Copyright (license): WJPR: All rights reserved


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Summary of article contents:

Introduction

The study conducted by Shastri et al. (2017) investigates the antioxidant and hepatoprotective potential of the aqueous extract of Mammea suriga against carbon tetrachloride (CCl4)-induced hepatotoxicity in rat models. This plant, belonging to the Calophyllaceae family, has a history of traditional medicinal use, yet it has not been extensively studied for its chemical or pharmacological properties, apart from its antimicrobial activity. The research aims to provide systematic evidence supporting the medicinal claims regarding this plant by exploring its antioxidant properties and effects on liver damage.

Antioxidant Activity of Mammea Suriga

The antioxidant activity of the aqueous extract of M. suriga was analyzed through various in vitro assays, including assessments of total antioxidant capacity, total reductive capacity, and free radical scavenging. The extract demonstrated significant scavenging activities against DPPH, nitric oxide, and metal ions in a dose-dependent manner. Notably, the study reported high levels of total phenolic (79.97 µg/mg) and flavonoid (113 µg/mg) content, which are believed to contribute to its antioxidant efficacy. These findings underscore the potential of M. suriga as a natural source of antioxidants, highlighting its relevance in combating oxidative stress-related disorders.

Hepatoprotective Effects

In vivo studies assessed the hepatoprotective effects of M. suriga extract against CCl4-induced liver damage. The experimental rats were treated with varying doses of the extract, revealing significant protective effects on liver function. Parameters such as serum levels of SGOT, SGPT, total protein, and others improved in the treated groups compared to control groups, indicating reduced hepatotoxicity. Additionally, lipid peroxidation levels, as assessed through malondialdehyde (MDA) assay, decreased significantly in rats treated with the extract, suggesting that its antioxidant properties may play a critical role in protecting liver cells from oxidative damage.

Histopathological Observations

Histopathological evaluations further support the hepatoprotective findings. The examination of liver tissues from M. suriga-treated rats revealed normal architecture, with well-preserved hepatocytes and minimal necrosis compared to the significant damage observed in CCl4-only treated rats. The treatment appeared to mitigate the toxic effects of CCl4, as evidenced by the reduction in fatty degeneration and the restoration of tissue arrangement. This emphasizes the extract's potential application in protecting against liver injury and its role as a therapeutic agent in managing hepatotoxic conditions.

Conclusion

The results from this study affirm that the aqueous extract of Mammea suriga possesses considerable antioxidant and hepatoprotective properties, suggesting its utility as a natural remedy for oxidative stress-related liver damage. Given its significant efficacy demonstrated through both biochemical assays and histopathological evaluations, M. suriga may serve as a promising source of natural antioxidants and could play a beneficial role in therapeutic applications for liver health. This research encourages further investigations into the use of M. suriga in traditional medicine and its potential development into a standardized herbal therapeutic agent.

FAQ section (important questions/answers):

What is the focus of the study on Mammea suriga?

The study investigates the antioxidant and hepatoprotective potential of Mammea suriga aqueous extract, particularly its protective effects against carbon tetrachloride (CCl4) induced hepatotoxicity in rat models.

What are the key phytochemical constituents found in Mammea suriga?

The preliminary phytochemical screening of Mammea suriga revealed the presence of flavonoids, phenolic compounds, and terpenoids, suggesting its potential use in medicinal applications.

How was the antioxidant activity of Mammea suriga assessed?

Antioxidant activity was measured through several assays: total antioxidant capacity, reducing power, DPPH radical scavenging activity, nitric oxide scavenging activity, and metal chelating activity.

What were the results of the in vivo hepatoprotective study?

Results showed that the administration of Mammea suriga extract significantly reduced serum levels of liver enzymes, indicating its protective role against CCl4 induced liver damage.

What was the dosage and method used in the hepatoprotective study?

Two different concentrations of aqueous extract (200 mg/kg and 400 mg/kg) were administered orally for seven days in CCl4 induced hepatotoxicity models.

What implications do the study results have for natural antioxidants?

The study suggests that Mammea suriga could serve as a natural source of antioxidants, potentially offering a safer alternative to synthetic antioxidants for health benefits.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Mammea suriga extract's antioxidant and hepatoprotective effects.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Activity:
In research, 'activity' refers to the effectiveness of a substance, like the antioxidant or hepatoprotective effects tested in plant extracts. It is crucial for determining the potential medicinal benefits of compounds derived from natural sources, assessing their role in combating oxidative stress or cellular damage.

2) Krishna (Krsna):
Krishna is a common surname in India and is referenced in the study as one of the authors involved in researching the medicinal properties of Mammea suriga. His contributions underscore the collaborative effort in scientific research, highlighting the importance of scholarly collaboration in exploring health benefits.

3) Study (Studying):
The study mentioned is a comprehensive analysis aimed at evaluating the antioxidant and hepatoprotective properties of Mammea suriga extracts. Research studies like this are pivotal for validating traditional medicinal claims and provide scientific backing to the use of herbal remedies in modern medicine.

4) Flavonoid:
Flavonoids are a class of bioactive compounds known for their antioxidant properties. Their presence in Mammea suriga is significant, as they contribute to the plant's ability to scavenge free radicals and protect against oxidative damage, thus offering potential health benefits.

5) Table:
In scientific literature, tables are used to systematically present data and results, enabling easier comparison and analysis. The tables in the study showcase the quantitative phytochemical analysis, demonstrating concentrations of flavonoids and phenolic compounds in Mammea suriga extracts.

6) Animal:
In the context of this research, animals, specifically albino Wistar rats, are used as models for understanding the effects of Mammea suriga extracts. Animal studies are essential for preclinical testing of treatments to ascertain efficacy and safety before human trials.

7) Water:
Water serves as a solvent in the extraction process of Mammea suriga's flower buds. Its role is critical in phytochemistry, allowing the solubility of various phytochemicals, aiding in the study of their properties, and ensuring effective extraction during biochemical assays.

8) Phytochemical:
Phytochemicals are biologically active compounds in plants that often contribute to health benefits. The presence of phytochemicals such as flavonoids and terpenoids in Mammea suriga's aqueous extract substantiates its traditional use in medicine, particularly for antioxidant and hepatoprotective properties.

9) Kumar:
Kumar is another common Indian surname associated with the research team studying Mammea suriga. Collaborative efforts from multiple researchers, including those with the surname Kumar, highlight interdisciplinary approaches in pharmacological research and the significance of diverse expertise in scientific inquiries.

10) Blood:
Blood analysis in the study is crucial for assessing biochemical markers that indicate liver function and toxicity. Monitoring blood parameters helps evaluate the extent of hepatoprotection provided by Mammea suriga extracts, thereby indicating their therapeutic potential against chemically induced liver damage.

11) Arrangement:
Arrangement refers to the organization of liver cells (hepatocytes) observed in histopathological examinations. The study assesses how Mammea suriga extracts impact the structural integrity and arrangement of liver tissue, which is vital for determining the efficacy of potential hepatoprotective treatments.

12) Toxicity:
Toxicity is a critical factor in evaluating the safety of Mammea suriga extracts. The study addresses the hepatotoxic effects of carbon tetrachloride (CCl4), and the ability of the extract to mitigate these effects is crucial for establishing its therapeutic viability.

13) Disease:
The study references diseases related to oxidative stress and liver damage. Understanding the relationship between antioxidant properties and disease prevention is essential for developing treatments using natural compounds from plants like Mammea suriga, which may provide insights into managing chronic diseases.

14) Species:
In biological research, species refers to the specific organism being studied. Mammea suriga as a species in this study represents an important target for studying natural antioxidants, emphasizing the role of native flora in potential medical applications.

15) Sharman (Sarma, Sarman, Sharma):
Sharma is another surname represented within the research team. The inclusion of various researchers, including those with the surname Sharma, illustrates the collaborative nature of scientific research, optimizing the findings related to Mammea suriga and its health benefits.

16) India:
The research was conducted in India, where Mammea suriga is endemic. The cultural and biological richness of India makes it a focal point for exploring traditional medicinal plants and their pharmacological properties, highlighting the intersection of folk medicine and scientific validation.

17) Tree:
Mammea suriga is identified as an endemic tree belonging to the family Calophyllaceae. It plays a significant role in natural medicine and ecology, emphasizing the importance of conserving plant species that offer potential health benefits and contribute to biodiversity.

18) Antibiotic (Antibacterial):
Antibacterial properties, highlighted in previous studies on Mammea suriga, indicate its potential in fighting infections. This aspect complements its antioxidant capabilities, showcasing the multifaceted therapeutic applications of the plant in traditional and modern medicine.

19) Pharmacology:
Pharmacology is the study of drug interactions and their effects on biological systems. The research delves into the pharmacological aspects of Mammea suriga extracts, providing insight into their potential as therapeutic agents in treating liver damage and other associated disorders.

20) Toxicology:
Toxicology focuses on the adverse effects of substances, particularly in this study concerning carbon tetrachloride-induced liver damage. The research evaluates how Mammea suriga can mitigate toxicity, thereby contributing to the field of toxicology with respect to herbal medicine alternatives.

21) Bharathi:
Bharathi is a surname associated with contributors to the research studies on Mammea suriga. As part of a collaborative research team, individuals like Bharathi emphasize the diverse expertise that aids in thorough investigations of the plant’s medicinal properties.

22) Bleeding:
Bleeding disorders mentioned in the context of traditional usage suggest a therapeutic benefit of Mammea suriga in managing such conditions. This highlights the relevance of exploring plants known for their folkloric uses in modern science to validate and enhance treatments.

23) Family:
The term 'family' refers to the taxonomic grouping to which Mammea suriga belongs (Calophyllaceae). Understanding plant family relationships is essential in botany and pharmacology, as it aids in predicting chemical composition and potential health benefits of related species.

24) Cancer:
The study discusses the cellular damage caused by oxidative stress, which is linked to cancer progression. Investigating natural antioxidants such as Mammea suriga can contribute to strategies for cancer prevention and treatment through dietary or supplementary interventions.

25) Indian:
Indian references in the study denote the rich cultural heritage of herbal medicine. The exploration of Mammea suriga, an indigenous plant, reflects the significance of traditional knowledge in the pursuit of modern scientific validation for medicinal applications.

26) Rich (Rch):
The 'rich' context in the study often pertains to the abundant presence of phytochemicals in Mammea suriga. Rich sources of antioxidants are vital for developing natural remedies and underscore the plant’s potential as a health-promoting agent in preventive medicine.

27) Drug:
The study highlights the potential of Mammea suriga as a natural drug alternative due to its antioxidant and hepatoprotective properties. This reinforces the ongoing search for effective herbal treatments in modern pharmacotherapy, emphasizing the relevance of traditional medicine.

28) Male:
The study utilized male albino rats for assessing the hepatoprotective effects of Mammea suriga. Male subjects in preclinical studies are important for standardizing experimental conditions and understanding gender-related differences in responses to treatments in later human studies.

29) Solanum xanthocarpum:
Solanum xanthocarpum is referenced as another plant known for its hepatoprotective effects. Comparative studies among various plants, including Mammea suriga and Solanum xanthocarpum, enrich the understanding of plant-based treatments for liver ailments and their potential synergistic effects.

30) Burning sensation:
Burning sensation relates to a symptom mitigated by the use of Mammea suriga in traditional medicine. This underlines the importance of studying ethnobotanical uses of plants for developing treatments for symptom relief in various clinical conditions.

31) Mesua ferrea:
Mesua ferrea is cited as a plant with protective properties against liver damage. Its mention alongside Mammea suriga underscores the ongoing research into various plants, enhancing the knowledge base regarding natural alternatives for hepatoprotection and other therapeutic applications.

32) New Delhi:
New Delhi is noted as the location for DBT, which funded the research. The involvement of government support highlights the institutional backing for scientific research in herbal medicine, facilitating advancements in understanding and harnessing traditional knowledge for contemporary health solutions.

33) Pharmacological:
Pharmacological studies are essential for elucidating the active compounds and mechanisms of action of Mammea suriga. These studies help provide a comprehensive understanding of how herbal extracts can be integrated into modern medical practices for treating various conditions.

34) Inflammation:
Inflammation is a significant pathological response that Mammea suriga extracts may combat due to their antioxidant properties. Understanding how plants can modulate inflammatory responses is crucial in developing holistic therapies that address both symptoms and underlying causes.

35) Measurement:
Measurement refers to the quantification of biochemical markers in the study. Accurate measurement is vital for determining the efficacy of Mammea suriga extracts in reducing liver enzymes and lipid peroxidation, supporting the conclusions drawn from the study's findings.

36) Observation:
Observation is a crucial aspect of the experimental process. Careful observation of the effects of Mammea suriga on liver health, toxic reactions, and overall behavior of test subjects enhances the reliability and validity of the research outcomes.

37) Manjunatha:
Manjunatha is mentioned as a contributor to the study, representing the collaborative effort behind the research. Including various researchers named Manjunatha highlights the coordination of expertise necessary to conduct thorough scientific inquiries into the medicinal properties of plants.

38) Discussion:
The discussion section is where the authors interpret and contextualize the findings from the study. Insights into how Mammea suriga can serve as a natural hepatoprotective agent are framed within existing literature, providing a comprehensive overview of the research significance.

39) Science (Scientific):
Science encompasses systematic investigation to establish knowledge through evidence-based practice. The study on Mammea suriga exemplifies scientific inquiry, focused on unraveling the biochemical properties and medicinal potential of plant extracts through rigorous testing and analysis.

40) Karnataka:
Karnataka is noted as the geographical location where the medicinal plant Mammea suriga is found. This highlights the regional biodiversity and the significance of exploring indigenous plants for their inherent health benefits, contributing to local and global pharmacology.

41) Attacking:
In the context of the study, 'attacking' can relate to how oxidative stress factors, such as free radicals, are damaging to cells. Understanding the mechanisms behind cellular attacks informs research on how Mammea suriga extracts can vitalize cellular defenses.

42) Fragrance:
The fragrance of Mammea suriga flowers, known to be used in the perfumery industry, signifies the plant's economic and cultural relevance. This aspect builds on the holistic understanding of the plant, blending its aromatic qualities with its medicinal potential.

43) Medicine:
The term 'medicine' encompasses the therapeutic use of substances for healing. Mammea suriga's documented ethnobotanical applications signify its role as a traditional medicine, urging further examination of its properties for modern therapeutic usage.

44) Punnaga (Pumnaga):
Punnaga refers to the essential oil extracted from Mammea suriga flowers. Its use in perfume and traditional medicine showcases the multifaceted applications of the plant, reinforcing its cultural significance and the interplay between traditional practices and contemporary science.

45) Kannada:
Kannada references the regional language of Karnataka, India, where Mammea suriga is native. This highlights the cultural significance of the plant within local communities and its role in traditional medicine practices within its linguistic context.

46) Amartya:
Amartya is mentioned in association with the research team, indicating collaborative efforts in the investigation. Each researcher, including those named Amartya, contributes diverse perspectives and expertise in evaluating the pharmacological properties of Mammea suriga.

47) Burning (Burn, Burned, Burnt):
The term 'burning' often describes the symptoms that Mammea suriga may be used to alleviate, particularly those related to digestive issues or inflammation. Understanding symptom management from a herbal perspective enhances the therapeutic applications of the plant.

48) Zoology:
Zoology refers to the study of animal biology, relevant in the context of the study involving rats as test subjects. Knowledge in zoology is invaluable for ensuring ethical standards and scientific accuracy when conducting research on live animal models.

49) Samtosha (Samtosa, Santosa, Santosha, Santosh):
Santosh is also a contributor to the research team, signifying the collaborative nature of the study. The contributions of individuals like Santosh highlight the diverse expertise gathered to investigate potential health benefits associated with Mammea suriga.

50) Partha:
Partha is another researcher involved in the study of Mammea suriga. Collaborative authorship emphasizes the pooling of knowledge and skills from different individuals, enhancing the depth and breadth of research conducted on the plant’s therapeutic properties.

51) Thomas:
Thomas, mentioned as part of the research, showcases how collective author contributions can deepen the understanding of plant-based medicinal properties. This collaborative approach is essential for comprehensive analysis and validation of traditional uses in modern contexts.

52) Uttara:
Uttara refers to the region in Karnataka, India, where Mammea suriga is found. Understanding the geographical distribution of medicinal plants offers insights into biodiversity and ecological aspects that are crucial for conservation and research efforts.

53) Forest:
Forests provide the natural habitat where Mammea suriga grows. The study of forest ecosystems is critical for understanding the environmental contexts of medicinal plants, linking biodiversity conservation with sustainable practices in herbal medicine.

54) Botany:
Botany is the scientific study of plants, essential for understanding the classification, properties, and potential uses of species like Mammea suriga. Knowledge in botany informs research methodologies and conservation strategies for medicinal herbs.

55) Kumara:
Kumara is mentioned as part of the research team, adding to the list of contributors. The collaboration reflects the multi-disciplinary nature of scientific research which often involves experts from various fields working towards a common goal.

56) Pitta:
Pitta refers to a concept in traditional Indian medicine related to an imbalance that Mammea suriga may help address. Understanding such traditional health theories is important for integrating herbal remedies into modern healthcare frameworks.

57) Gupta:
Gupta is referenced as a contributing author in the study, which emphasizes collective scientific inquiry. Each member of the research team, including those with the surname Gupta, plays a significant role in advancing knowledge regarding natural health products.

58) Kashi (Kasi):
Kashi refers to a contributor to the research. Collaborators such as Kashi represent the collective effort necessary to validate and explore the rich potential of herbal remedies like Mammea suriga in modern therapeutic contexts.

59) Delhi:
Delhi, specifically New Delhi, is representative of the administrative and funding bodies supporting the research, showcasing the collaboration between local governments and scientific inquiries aimed at leveraging traditional medicine in contemporary health strategies.

60) Shutha (Sutha):
Sutha is mentioned within the research team, signifying the various contributors involved in the investigation. Each team member, including Sutha, collaborates to enrich the research quality and depth regarding Mammea suriga and its potential benefits.

61) Glass:
Glass refers to laboratory equipment, often used in various experiments during the study. Proper use of glassware ensures accurate measurements and contamination-free samples, which are crucial for the validity of biochemical analyses conducted in the research.

62) Death:
The study indirectly addresses death concerning liver toxicity and the implications of uncontrolled oxidative stress. Understanding how Mammea suriga can prevent cell death provides important insights into potential preventative health strategies in drug development.

63) Ravi (Ravin):
Ravi is another author’s name associated with the research. The collective contributions of researchers like Ravi enhance the credibility and comprehensive nature of the study on Mammea suriga, indicating deep engagement in scientific exploration.

64) Asha (Asa):
Asha is mentioned as part of the research team, highlighting the collaborative environment necessary for conducting thorough scientific studies. The involvement of diverse authors, including Asha, signifies the importance of team dynamics in achieving effective research outcomes.

65) Alam (Alaṁ):
Alam is referenced among the contributors of the study, illustrating the shared effort in scientific research on Mammea suriga. The inclusion of researchers across various fields enriches the methodologies employed in assessing the plant's medicinal properties.

66) Ghat (Gham):
Ghat refers to geographical features in India, where specific plants like Mammea suriga may thrive. Understanding the environmental conditions and regions like forests and ghats helps in studying biodiversity and the conservation of medicinal plant species.

67) Diet:
Diet relates to the nutritional aspects and health impacts of consuming natural antioxidants such as Mammea suriga. Understanding the dietary supplementation of such plants can lead to better health management practices focusing on preventive care.

68) Crop:
Crop references the cultivation of plants, including medicinal varieties like Mammea suriga. Fostering an understanding of sustainable agricultural practices can enhance the availability and accessibility of herbal remedies in communities reliant on them.

69) Post:
Post references areas of research following initial findings. Continued investigations post-study are vital for establishing long-term implications and applications of compounds derived from Mammea suriga in various areas of health and medicine.

70) Chan:
Chan is mentioned as part of the research network, indicating collaborative work among various contributors. The diverse backgrounds of researchers like Chan add depth to studies, enhancing the understanding of Mammea suriga’s medicinal potential within the research community.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Mammea suriga extract's antioxidant and hepatoprotective effects.’. Further sources in the context of Science might help you critically compare this page with similair documents:

Oral administration, Treatment group, Antioxidant activity, Preliminary phytochemical screening, Phytochemical analysis, Lipid peroxidation, DPPH assay, In vivo hepatoprotective activity, Total phenolic content, Histopathological studies, LD50, Total flavonoid content, Metal chelating activity, Soxhlet Apparatus, Phosphomolybdenum method, Nitric Oxide Radical Scavenging Activity, Biochemical marker, Natural antioxidant, Carbon tetrachloride induced hepatotoxicity, Acetylation.

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