Antidiabetic properties of thirteen local medicinal plants in nigeria, a review
Journal name: World Journal of Pharmaceutical Research
Original article title: Antidiabetic properties of thirteen local medicinal plants in nigeria, a review
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Adamu J. Alhassan, Tajudeen A. Lawal and M. A. Dangambo
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Antidiabetic properties of thirteen local medicinal plants in nigeria, a review
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20178-9055
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Summary of article contents:
1) Introduction
Diabetes mellitus is a serious metabolic disorder characterized by chronic hyperglycemia, leading to various complications, including neuropathy, nephropathy, and cardiovascular diseases. The prevalence of diabetes has significantly increased over the decades, affecting millions globally, particularly in developing countries. Traditional remedies utilizing local medicinal plants for diabetes management have gained attention due to their efficacy, lower side effects, and relative cost-effectiveness compared to pharmaceutical alternatives. This review compiles the antidiabetic properties of thirteen local medicinal plants in Nigeria, aiming to provide a comprehensive resource for researchers and patients.
2) Efficacy of Traditional Medicinal Plants
Numerous studies on traditional medicinal plants have shown their potential in managing diabetes due to their antidiabetic properties. These plants often contain phytochemicals such as glycosides, alkaloids, flavonoids, and terpenoids, which have been linked to hypoglycemic effects. Among the thirteen plants reviewed, significant findings highlighted the ability of certain extracts to enhance insulin secretion, improve insulin receptor sensitivity, and inhibit intestinal glucose absorption. For instance, Persea americana (Avocado pear) has shown antioxidant and antidiabetic effects, while Sida acuta has been documented to reduce blood sugar levels in both normoglycemic and alloxan-induced diabetic rabbits, showcasing the plants' varying modes of action.
3) Mechanisms of Action of Phytochemicals
The antidiabetic effects of these local medicinal plants can be attributed to their unique phytochemical compositions. For example, Aframomum melegueta (Alligator Pepper) contains bioactive constituents that significantly lower blood glucose levels in diabetic subjects. Another notable example is Momordica charantia (Bitter melon), which has demonstrated mechanisms such as stimulating peripheral glucose utilization and inhibiting intestinal glucose uptake, indicating its multifaceted approach to managing diabetes. Understanding these mechanisms is crucial in developing effective natural treatments and emphasizing the importance of continued research into these plants' properties.
4) Comparison with Conventional Treatments
While pharmaceutical treatments for diabetes are widely used, they often come with adverse side effects such as gastrointestinal issues, weight gain, and potential organ damage. In contrast, the reviewed medicinal plants are perceived to be safer and more effective alternatives with minimal side effects. For example, Azadirachta indica (Neem) has shown promising antidiabetic effects in diabetic rats without significant toxicity. This highlights the need for integrating herbal medicine into existing treatment paradigms, especially in regions where access to pharmaceutical options is limited.
5) Conclusion
The rising global prevalence of diabetes calls for urgent solutions, and traditional medicinal plants represent a viable avenue for treatment. This review identifies thirteen medicinal plants native to Nigeria that exhibit potent antidiabetic properties through various mechanisms. As the demand for natural remedies grows, future research ought to further investigate these plants to substantiate their efficacy and safety. Ultimately, fostering a greater understanding of these natural products can lead to innovative therapies for diabetes management, potentially yielding safer alternatives that complement existing treatment options.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Antidiabetic properties of thirteen local medicinal plants in nigeria, a review”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Phytochemical:
Phytochemicals are natural compounds found in plants that contribute to their color, flavor, and disease resistance. They can provide beneficial health effects, including anti-diabetic properties. Their role in traditional medicine highlights their potential in treating various ailments, including diabetes, by affecting metabolic processes and promoting overall health.
2) Blood:
Blood is a vital fluid that circulates in the body, delivering essential nutrients, oxygen, and hormones to cells while removing waste products. In the context of diabetes, monitoring blood glucose levels is crucial for managing the disease and preventing complications such as neuropathy, nephropathy, and cardiovascular issues.
3) Family:
In biological taxonomy, a family is a rank in the classification hierarchy that groups related organisms. Many medicinal plants belong to specific families, such as Meliaceae or Asteraceae. Understanding plant families helps researchers identify phytochemicals and potential medicinal properties relevant to treating diseases, including diabetes.
4) Flavonoid:
Flavonoids are a class of phytochemicals with antioxidant properties, found abundantly in fruits, vegetables, and herbs. They play a role in plant defense mechanisms and dietary interventions, showing potential in managing diseases like diabetes by improving insulin sensitivity and reducing oxidative stress through their bioactive effects.
5) Disease:
A disease is a pathological condition characterized by specific signs and symptoms. Diabetes mellitus, for instance, is a major metabolic disorder that affects blood sugar regulation. Understanding the mechanisms and treatments of diseases is essential in medical research, leading to novel therapeutic approaches using traditional and phytochemical treatment options.
6) Bitter:
Bitter often describes a taste profile in plants associated with certain bioactive compounds. Bitter plants like Momordica charantia (bitter melon) possess pharmacological properties that can lower blood sugar levels and improve metabolic health. Their bitterness is linked with their medicinal efficacy, showcasing nature’s way of signaling health benefits.
7) Activity:
Activity refers to the functional attributes of a compound or organism, particularly concerning biological interactions. In pharmacology, the activity of phytochemicals can influence therapeutic outcomes, such as the hypoglycemic effects of various plant extracts, indicating potential for use in managing health conditions like diabetes.
8) Sugar:
Sugar, specifically glucose, is a primary energy source for the body. In diabetes, managing blood sugar levels is critical to prevent complications. Phytochemical interventions often aim to regulate blood sugar, highlighting the importance of understanding sugars' role in metabolism and their impact on overall health.
9) Momordica charantia:
Momordica charantia, commonly known as bitter melon, is a tropical plant with recognized antidiabetic properties. Its extracts have been shown to lower blood glucose levels, offering potential therapeutic benefits for diabetes management. Its use in traditional medicine emphasizes the relevance of studying local plants for modern pharmaceuticals.
10) Pain:
Pain is an unpleasant sensory and emotional experience often signaling injury or illness. In the context of diabetes, neuropathic pain is a severe complication that can arise. The discovery of natural pain relievers from traditional plants illustrates the synergy between traditional and modern medicine in addressing health issues.
11) Azadirachta indica:
Azadirachta indica, known as neem, is a versatile plant with extensive medicinal properties. It has demonstrated antidiabetic effects, and its use in traditional medicine underscores the importance of exploring indigenous flora for effective treatments. Neem’s compounds are studied for their potential benefits, including regulatory effects on blood glucose.
12) Tree:
A tree is a perennial plant with an elongated stem, supporting branches and leaves. Trees like Azadirachta indica provide not only medicinal benefits but also ecological advantages. Understanding the role of trees in the environment and their contributions to health can guide sustainable practices and herbal research.
13) Medicine:
Medicine encompasses the science and practice of diagnosing, treating, and preventing diseases. Exploring traditional remedies from plants adds depth to modern medicine, particularly in treating chronic conditions like diabetes. This interplay between traditional and contemporary practices emphasizes the potential for a more holistic health approach.
14) Science (Scientific):
Scientific pertains to systematic knowledge gained through observation and experimentation. Fostering a scientific approach in studying medicinal plants supports the discovery of therapeutic agents. This is particularly important in diabetes research, where understanding the mechanisms of action can enhance treatment options using natural remedies.
15) Sida (Shida):
Sida refers to the genus of flowering plants in the Malvaceae family. Sida acuta, for example, is noted for its medicinal properties, particularly in treating diabetes. The study of such plants highlights the importance of ethnobotany in discovering bioactive compounds that can aid in health management.
16) Neem:
Neem, or Azadirachta indica, is a significant plant in traditional and modern medicine, known for its antidiabetic and antimicrobial properties. Its ability to influence various health conditions makes it a focal point for research on natural medicines and their pharmacological applications in treating diseases.
17) Drug:
A drug is a substance used to diagnose, cure, treat, or prevent disease. The study of plant-derived drugs highlights the importance of ethnopharmacology in identifying effective treatments, particularly in diabetes management, where traditional remedies are increasingly recognized for their efficacy and reduced side effects.
18) Rich (Rch):
Rich describes a high presence or abundance of certain compounds or nutrients. In discussing medicinal plants, richness in bioactive phytochemicals correlates with potential health benefits, notably in plants used in diabetes treatment. Understanding a plant’s richness informs its therapeutic potential in managing various health conditions.
19) Genu:
Genu aligns with biological classifications, often referring to lineage or type within broader categories. In botany, understanding the genu of plants aids in identifying specific medicinal properties, such as the hypoglycemic effects found in certain plant species, thereby guiding therapeutic use and research into efficacy.
20) Soup:
Soup is a liquid dish traditionally made by combining ingredients like meat, vegetables, and spices. In nutritional contexts, soups may be fortified with medicinal plants, enhancing their health benefits, including anti-diabetic properties, showcasing how food can integrate therapeutic elements into everyday diets.
21) Antibiotic (Antibacterial):
Antibacterial refers to substances that inhibit bacterial growth or kill bacteria. This property is significant in medicinal plants, focusing on their roles in treating infections. Research into the antibacterial effects of plants can complement their use in traditional medicine, providing holistic approaches to health care.
22) Developing:
Developing refers to the ongoing process of growth and advancement, often associated with countries or regions. In the context of healthcare, exploring traditional medicine in developing areas can lead to discoveries of effective treatments using local plants, addressing issues like diabetes in underserved populations.
23) Language:
Language is a system of communication used by individuals. In the context of traditional medicine, language encompasses the terminology and local names of medicinal plants, which are critical for both cultural transmission of knowledge and scientific research, bridging gaps between traditional practices and modern advancements.
24) Quality:
Quality refers to the standard of something, often in terms of its effectiveness or suitability for a specific purpose. In phytochemistry, evaluating the quality of plant extracts can influence their therapeutic applications, particularly in addressing chronic conditions such as diabetes through traditional remedies and modern formulations.
25) Account:
Account can refer to a narrative or record of events. In scientific contexts, keeping accounts of medicinal uses of plants aids research into their effects and promotes understanding of their applications in diseases. Documenting traditional knowledge is crucial for preserving cultural practices and guiding future research.
26) Mineral:
Minerals are inorganic nutrients essential for various bodily functions, including bone health, nerve function, and metabolic processes. Some medicinal plants are rich in minerals that can support overall health and contribute to managing conditions like diabetes, emphasizing the need for a balanced diet in treatment protocols.
27) Forest:
A forest is a large area dominated by trees and underbrush, serving as a habitat for diverse flora and fauna. Forests are significant sources of medicinal plants, providing natural remedies used in traditional medicine. Their conservation is vital for sustainable healthcare and biodiversity.
28) Water:
Water is essential for all forms of life, serving as a solvent for biochemical reactions and maintaining physiological balance. Understanding the role of water in the extraction of bioactive compounds from plants, particularly in traditional medicine, highlights its importance in dietary and therapeutic contexts.
29) Field:
Field, in a botanical context, refers to an area where plants are cultivated or studied. Research fields focusing on phytochemistry and ethnobotany explore the relationships between plants and their medicinal uses, aiming to uncover new treatments, particularly for chronic conditions like diabetes.
30) Fever:
Fever is a common physiological response to infection or illness, characterized by elevated body temperature. Plants with antipyretic properties can aid in managing fevers. Understanding the traditional uses of herbal medicine for treating fever can guide modern therapeutic practices.
31) Food:
Food comprises substances consumed to provide nutritional support for the body. The intersection of food and medicine is crucial, as many medicinal plants are integrated into daily diets for nutritional benefits, highlighting the concept of functional foods in health management, including diabetes treatment.
32) Soil:
Soil is a natural resource that provides essential nutrients for plant growth. The quality of soil affects the phytochemical content of plants, impacting their medicinal efficacy. Understanding soil composition and health is vital for sustainable cultivation of medicinal herbs, especially those with therapeutic properties.
33) Life:
Life is the characteristic state of living organisms marked by growth, reproduction, and metabolism. In addressing health issues like diabetes, understanding the biological processes that govern life at cellular and systemic levels informs treatment strategies that can restore and maintain health.
34) Coconut water:
Coconut water is the clear liquid found inside young coconuts, rich in electrolytes and nutrients. Its hydrating properties make it beneficial in health management. Studies on its medicinal effects, such as lowering blood glucose levels, emphasize its potential role in holistic diabetes treatment.
35) Bitter gourd:
Bitter gourd, or Momordica charantia, is recognized for its high medicinal value, particularly in diabetes management. Its extracts can lower blood sugar levels, representing an important natural remedy. Understanding its role in traditional and modern treatments highlights the significance of dietary plants in health care.
36) Inflammation:
Inflammation is a protective response by the body to injury or infection, but chronic inflammation can lead to various diseases. Many medicinal plants possess anti-inflammatory properties, which are essential in managing conditions like diabetes. Understanding the link between inflammation and chronic diseases underlines the importance of therapeutic plants.
37) Arrangement:
Arrangement refers to the organization or order of components. In botany, it can imply the structural organization of plant parts. The arrangement of phytochemicals in plants impacts their efficacy and potential therapeutic roles, guiding research into optimizing benefits for conditions like diabetes.
38) Suffering:
Suffering is the experience of pain, distress, or hardship. Many individuals with chronic diseases like diabetes endure suffering due to complications or treatment side effects. Addressing suffering through effective herbal treatments provides an essential avenue for improving quality of life for those affected.
39) Composite:
Composite refers to a botanical family, particularly the Asteraceae, characterized by flower heads. Understanding composite species is essential for identifying potential medicinal uses. Researching members of this group aids the discovery of effective treatments, including plants that manage conditions like diabetes.
40) Epidemic:
An epidemic refers to the rapid spread of a disease within a population. Diabetes has reached epidemic proportions in many regions, necessitating effective management strategies and research into dietary interventions, including the utilization of traditional medicinal plants to curb its effects on health.
41) Relative:
Relative refers to the comparative relationship between organisms. In botany, understanding relatives helps in identifying similar species and their potential uses as medicinal plants. This knowledge guides research on the effectiveness of different plant species in treating conditions like diabetes.
42) Species:
Species is a fundamental unit of biological classification, grouping organisms with common characteristics. The study of various plant species enhances the understanding of their unique properties, particularly their medicinal potential, which is critical in developing effective treatments for diseases like diabetes.
43) Coconut (Cocoanut):
Coconuts are tropical fruits that provide water, milk, and oil, with numerous health benefits. Coconut water, in particular, is rich in electrolytes and is studied for its potential antidiabetic effects, exemplifying the relevance of traditional foods in modern healthcare practices.
44) Chilla:
Chilla refers to a specific traditional dish or preparation, often associated with local cuisine. Understanding local culinary practices, which might include medicinal plants, can highlight the important cultural context of food as medicine and its role in managing health conditions like diabetes.
45) Cancer:
Cancer encompasses a group of diseases characterized by uncontrolled cell growth. Some medicinal plants possess anticancer properties, showcasing their potential in holistic treatment strategies. Research into traditional remedies can uncover new pathways in managing cancer alongside other chronic conditions like diabetes.
46) Edema (Oedema):
Oedema refers to the accumulation of fluid in body tissues, often causing swelling. Understanding the role of medicinal plants in managing oedema is vital as some plants exhibit diuretic or anti-inflammatory effects, providing alternative or complementary treatment strategies for conditions with fluid retention.
47) Police:
Police refers to law enforcement organizations that maintain public order and security. In the context of medicinal plants, the police may be involved in regulating the trade of traditional medicines to ensure safety and efficacy. Their role is critical in protecting consumers from exploitation.
48) Animal:
Animal refers to multicellular organisms that exhibit various levels of mobility and response to stimuli. In research, animals are often used in studies to evaluate the efficacy and safety of medicinal plants, bridging traditional practices and contemporary drug development, particularly in diabetes management.
49) Powder:
Powder refers to a fine, dry substance created by grinding or crushing solid materials. Many traditional medicines are prepared in powdered form from various plants, facilitating effective administration of bioactive compounds in therapeutic treatments, especially in cases of diabetes and other chronic illnesses.
50) Thirst:
Thirst is the sensation of wanting to drink, often signaling a need for hydration. In diabetes, excessive thirst is a common symptom due to elevated blood glucose levels. Understanding the relationship between thirst and blood sugar management highlights the importance of both diet and hydration in treatment.
51) Manure:
Manure refers to organic matter, typically animal waste, used to fertilize land. In agricultural contexts, using manure promotes soil fertility and plant health, which can impact the growth of medicinal plants. Healthy plant cultivation supports the efficacy of natural remedies in addressing health issues, including diabetes.
52) Death:
Death denotes the cessation of biological functions that sustain life. Chronic diseases, including diabetes, can lead to premature death if not managed effectively. Research into medicinal plants aims to reduce mortality rates by identifying safe, effective treatments that improve quality of life for patients.
53) Study (Studying):
Study refers to the detailed examination and analysis of a subject. In the context of medicinal plants, rigorous studies are essential to validate traditional uses and uncover new therapeutic potentials, particularly concerning the management of diseases such as diabetes through natural means.
54) Road:
A road refers to a pathway allowing for travel. In a broader context, the road symbolizes progress and the journey towards understanding and utilizing medicinal plants effectively in health care. Accessibility to such plants can facilitate their use in traditional and modern medicine.
55) Male:
Male refers to the sex of organisms that produce small, mobile gametes. In research involving plants and animals, understanding gender differences can affect study outcomes, especially in the context of diabetes, where different physiological responses may be observed based on sex, impacting treatment strategies.
Other Science Concepts:
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