Effect of āragvadhādi lepa in eczema (vicarcikā) – a pilot study

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Journal name: World Journal of Pharmaceutical Research
Original article title: Effect of āragvadhādi lepa in eczema (vicarcikā) – a pilot study
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Author:

Dr. Talekar Manisha, Dr. Deshmukh Prashant Nareshrao, Dr. Mandal Sisir Kumar, Dr. B. K. Sevatkar and Dr. R. Govind Reddy


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Effect of āragvadhādi lepa in eczema (vicarcikā) – a pilot study

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20178-9117


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Summary of article contents:

Introduction

Eczema, reflecting an inflammatory condition of the skin, is characterized by vesicular lesions that may exude and scale, closely resembling the Ayurvedic concept of Vicarcika Kushtha. The classical texts of Ayurveda elaborate on numerous formulations to address skin diseases, emphasizing the efficacy of herbal remedies. To evaluate the therapeutic potential of Aragvadhadi Lepa in managing eczema, a pilot study was conducted involving ten patients from the National Institute of Ayurveda, Jaipur, assessing both subjective symptoms and objective laboratory parameters over a treatment course of 30 days.

The Therapeutic Role of Aragvadhadi Lepa

Aragvadhadi Lepa is an Ayurvedic topical formulation composed mainly of Cassia fistula (Aragvadha), Nerium indicum (Karavira), and Solanum indicum (Kakamaci). This formulation was specifically selected for its potential benefits in treating skin diseases. The preparation involved creating a paste from fresh leaves mixed with buttermilk for application on affected skin areas. The application aims to provide soothing effects and promote healing while addressing inflammation, itching, and infection, aligning with the Ayurvedic directive of utilizing topical agents for managing external ailments.

Assessment of Efficacy

The efficacy of Aragvadhadi Lepa was assessed with an emphasis on both subjective symptoms, such as itching (Kandu), discharge (Srava), and skin thickening (Raji), and objective laboratory measures like Erythrocyte Sedimentation Rate (ESR) and Neutrophil counts. Results indicated statistically significant improvements in most subjective parameters, with Kandu and Srava showing remarkable reductions (both P=0.002). Additionally, laboratory results demonstrated significant enhancements in neutrophil levels (P=0.0442) and ESR (P=0.0481), supporting the formulation's effectiveness in managing eczema.

Safety and Side Effects

One notable aspect of the study was the absence of adverse reactions among the participating patients throughout the treatment duration. This lack of reported side effects highlights Aragvadhadi Lepa as a safe alternative to conventional treatments, which often come with significant side effects, including skin thinning and susceptibility to infections. The natural composition of the formulation appears to mitigate the risks associated with synthetic medications, affirming the importance of exploring traditional remedies within the context of modern healthcare.

Conclusion

The findings from this pilot study suggest that Aragvadhadi Lepa holds considerable promise as a therapeutic modality for managing Vicarcika (eczema). Not only does the formulation exhibit antibiotic, anti-inflammatory, and analgesic effects, but it also promotes healing without complications. Given its efficacy and safety profile, Aragvadhadi Lepa presents an appealing, cost-effective alternative to conventional treatments for eczema, advocating for the incorporation of Ayurvedic practices in the management of skin diseases. Further research with larger populations is recommended to consolidate these findings and investigate long-term effects.

FAQ section (important questions/answers):

What is the primary objective of the study on Aragvadhadi Lepa?

The primary objective of the study is to assess the effect of Aragvadhadi Lepa in managing eczema, specifically Vicarcika Kushtha, through a pilot study involving ten patients.

What characteristics define eczema according to the study?

Eczema is defined as an inflammatory skin condition characterized by erythema, oozing, crusting, and lichenification, resembling Vicarcika Kushtha in Ayurvedic medicine.

How was Aragvadhadi Lepa administered to the patients in the study?

Aragvadhadi Lepa was administered as a local application once daily for 30 days to the patients suffering from Vicarcika Kushtha.

What were the significant results of using Aragvadhadi Lepa?

The study found very significant improvements in symptoms like itching, oozing, burning sensation, eruptions, and skin thickening, along with laboratory parameters like ESR and neutrophil count.

What ingredients are used to prepare Aragvadhadi Lepa?

Aragvadhadi Lepa is prepared using fresh leaves of Aragvadha (Cassia fistula), Karavira (Nerium indicum), and Kakamaci (Solanum indicum), mixed into a paste.

What conclusion did the study draw regarding Aragvadhadi Lepa's effectiveness?

The study concluded that Aragvadhadi Lepa is safe, cost-effective, and effective in managing various types of Vicarcika Kushtha (eczema), showing significant therapeutic potential.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Effect of āragvadhādi lepa in eczema (vicarcikā) – a pilot study”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Lepa:
Lepa refers to a paste or ointment used in Ayurvedic medicine for topical application on skin diseases such as eczema. It plays a crucial role in treatment by providing direct relief from symptoms, enhancing healing, and addressing localized skin issues, thus emphasizing the efficacy of herbal formulations.

2) Aragvadhadi (Aragvadha-adi):
Aragvadhadi is a specific Ayurvedic formulation composed of the leaves of Aragvadha, among other ingredients. This formulation is recognized for its therapeutic properties, particularly in treating skin ailments like eczema by addressing inflammation, itching, and infection, underlining the holistic approach of Ayurveda in managing health.

3) Drug:
In the context of this study, 'drug' refers to the medicinal substance or formulation being tested, specifically Aragvadhadi Lepa. It highlights the importance of traditional Ayurvedic substances as potential therapeutic agents, exploring their effects on diseases and enhancing the understanding of alternative treatments in pharmacology.

4) Vicarcika:
Vicarcika is a term used in Ayurveda to denote a skin condition that closely resembles eczema. Understanding Vicarcika is essential for accurate diagnosis and treatment within Ayurvedic practices, as it allows practitioners to use appropriate formulations like Aragvadhadi Lepa to alleviate symptoms and promote healing.

5) Ayurveda (Ayus-veda):
Ayurveda is an ancient system of medicine originating from India that emphasizes balance in the body, mind, and spirit. It advocates for natural remedies and treatments derived from herbs, dietary regulations, and lifestyle changes, making it relevant in the modern quest for holistic and less invasive therapeutic options.

6) Kushtha (Kustha):
Kushtha is a Sanskrit term used in Ayurveda to describe skin diseases. This category includes various dermatological conditions, helping practitioners classify and treat these ailments. Understanding Kushtha aids in targeting appropriate herbal remedies, thereby aligning treatment strategies with ancient Ayurvedic teachings.

7) Jaipur:
Jaipur is a city in India where the National Institute of Ayurveda is located. The research highlighted in this study took place here, reflecting the institution's commitment to integrating traditional medicine with modern research, enhancing the understanding and application of Ayurveda in clinical settings.

8) Aragvadha:
Aragvadha, or Cassia fistula, is a medicinal plant used in Ayurveda known for its purgative and skin-healing properties. Its leaves are a primary ingredient in Aragvadhadi Lepa, which is studied for its application in treating skin diseases like eczema, demonstrating the plant's therapeutic relevance.

9) Kakamaci (Kaka-maci):
Kakamaci, also known as Solanum indicum, is another herb used in traditional medicine. It is included in the Aragvadhadi formulation for its healing and anti-inflammatory properties, highlighting its significance in Ayurvedic approaches to treat skin ailments and support overall health restoration.

10) Activity:
Activity in this context refers to the biological effects and therapeutic properties exhibited by the substances used in the study. Understanding these activities is crucial for evaluating the efficacy of the formulations like Aragvadhadi Lepa in treating skin conditions, providing insight into their mechanisms of action.

11) Vikriti (Vikrti):
Vikriti refers to the concept of one's individual constitution or imbalance according to Ayurveda. It entails understanding how various factors can affect health, and it is essential for diagnosing ailments accurately, ensuring that treatments are tailored to restore balance effectively in patients.

12) Kandu (Kamdu):
Kandu translates to itching in English and is one of the primary symptoms of eczema or Vicarcika. Addressing Kandu is crucial for alleviating the discomfort associated with skin conditions, and treatments like Aragvadhadi Lepa are specifically aimed at providing relief from such symptoms.

13) Shrava (Srava):
Srava indicates the secretion or discharge associated with skin lesions. It is an important clinical parameter in evaluating skin diseases like eczema, and the effectiveness of treatments such as Aragvadhadi Lepa can be assessed by observing changes in Srava over the course of treatment.

14) Raji:
Raji refers to the thickening or roughening of the skin that often occurs in chronic skin conditions. Monitoring Raji helps in understanding the progression of skin diseases like eczema, allowing practitioners to evaluate the effectiveness of treatments aimed at restoring skin health.

15) Daha:
Daha denotes the burning sensation experienced by patients with conditions like eczema. It is a significant symptom that contributes to discomfort, making it vital to target with therapeutic agents like Aragvadhadi Lepa, which aims to reduce inflammation and improve the quality of life for sufferers.

16) Nerium indicum:
Nerium indicum, commonly known as the oleander plant, possesses medicinal properties that are beneficial in treating skin conditions. Its inclusion in formulations like Aragvadhadi Lepa highlights its role in Ayurveda as a therapeutic agent with antimicrobial and anti-inflammatory effects against skin ailments.

17) Kandughna (Kandu-ghna):
Kandughna signifies an anti-itching property of certain Ayurvedic drugs. It is relevant in the context of treating eczema since patients often suffer from severe itching. Formulations with Kandughna properties help in alleviating this discomfort, thus improving patient satisfaction and recovery times.

18) Vaivarṇya (Vaivarnya, Vaivanrya):
Vaivarnya refers to discoloration of the skin often associated with eczema. It is an important parameter to assess in treatments as it can indicate healing progress. Effective formulations like Aragvadhadi Lepa aim to restore natural skin coloration and improve the aesthetic aspect of skin health.

19) Karavira (Kara-vira):
Karavira, or Nerium indicum, plays an essential role in Ayurvedic treatments for skin diseases. Its therapeutic properties contribute to the effectiveness of formulations like Aragvadhadi Lepa, showcasing the importance of combining various plants with specific benefits to address complex health issues like eczema.

20) Itching:
Itching is a common symptom in various skin conditions including eczema. It is often debilitating and can affect a person's quality of life. Treatments that reduce itching, such as Aragvadhadi Lepa, are essential in alleviating discomfort and allowing individuals to resume daily activities without impairment.

21) Table:
Table refers to the organized presentation of research data and results in scientific documentation. It allows for quick reference and comparison of results related to the efficacy of treatments like Aragvadhadi Lepa on various symptoms and parameters crucial for evaluating therapeutic outcomes.

22) Study (Studying):
Study refers to the systematic investigation conducted to assess the effects of Aragvadhadi Lepa on eczema patients. It plays a critical role in validating the efficacy and safety of Ayurvedic treatments through rigorous research methodologies, which enhances credibility and acceptance within the broader medical community.

23) Ruja:
Ruja signifies pain in the context of skin diseases. As a symptom, it is crucial to monitor along with other parameters. Treatment formulations aim to address Ruja to improve overall patient comfort and are vital in assessing the therapeutic effectiveness of interventions like Aragvadhadi Lepa.

24) Disease:
Disease refers to the pathological condition affecting health, such as eczema in this study. Understanding the nature of the disease is crucial for determining appropriate treatment strategies, emphasizing the role of Ayurvedic methodologies in offering holistic remedies for skin disorders.

25) Pidika:
Pidika denotes eruptions or vesicular lesions formed on the skin in conditions like eczema. Monitoring Pidika helps assess disease progression and treatment effectiveness. Using formulations like Aragvadhadi Lepa can lead to significant improvement in these skin manifestations, aiding in overall recovery.

26) Pain:
Pain is a critical symptom noted in various conditions, including eczema. The presence of pain can significantly impact a patient's quality of life, making it essential for treatments to address this symptom effectively. Formulations like Aragvadhadi Lepa aim to alleviate pain while improving skin health.

27) Solanum indicum:
Solanum indicum, known as Kakamaci, is a plant with valuable medicinal properties in treating skin ailments. Its incorporation in formulations like Aragvadhadi Lepa highlights Ayurvedic practices which utilize a diverse range of herbs to create synergistic effects for improved health outcomes.

28) Antibiotic (Antibacterial):
Antibiotic refers to substances that kill or inhibit bacterial growth, essential in treating infections associated with skin diseases. Recognizing the antibacterial properties of ingredients in treatments like Aragvadhadi Lepa highlights the importance of traditional remedies in managing both the symptoms and underlying causes of diseases.

29) Suffering:
Suffering is the subjective experience of pain or distress experienced by individuals with skin conditions like eczema. Addressing the physical and psychological aspects of suffering is crucial in treatment, where therapeutic modalities aim not only to heal but also to enhance the overall quality of life.

30) Burning (Burn, Burned, Burnt):
Burning is a significant discomfort experienced by patients with skin diseases, indicating inflammation or irritation. Treatments effective at reducing burning symptoms are critical for improving patient experiences, making formulations like Aragvadhadi Lepa particularly relevant in managing such conditions.

31) Surface:
Surface refers to the outer layer of the skin where eczema lesions can appear. The condition of the skin surface is vital when assessing treatment efficacy, as it reflects the progress of healing and the effectiveness of applications like Aragvadhadi Lepa.

32) Caraka:
Caraka, a prominent figure in ancient Ayurvedic texts, provided insights into medicinal formulations and treatments. His teachings form the foundational knowledge guiding contemporary practices, emphasizing the use of herbal remedies, which remain relevant in the development of treatments for conditions like eczema.

33) Acarya:
Acarya denotes a teacher or expert in the context of Ayurveda. Acknowledging the contributions of Acarya in the development of therapeutic practices highlights the importance of traditional knowledge in treating diseases, thereby underscoring the relevance of expert guidance in pharmaceutical research.

34) Burning sensation:
Burning sensation is a common complaint among eczema patients, indicative of pain and irritation. Treatments focusing on alleviating this sensation are vital for patient relief. Formulations like Aragvadhadi Lepa target burning sensations, thereby enhancing comfort and improving the overall treatment experience.

35) Tuberculosis:
Tuberculosis represents a serious health concern that could exclude individuals from clinical studies due to its chronic nature. Understanding the intersection of various diseases, including skin conditions like eczema, is essential for comprehensive patient assessment and ensuring suitable treatment plans are developed.

36) Inflammation:
Inflammation is a biological response often observed in skin conditions, indicating the body's defense mechanism. Aiming to reduce inflammation is key in treating diseases like eczema, which is the focus of formulations like Aragvadhadi Lepa, showcasing the treatment's anti-inflammatory properties in practice.

37) Kushthahara (Kusthahara, Kushtha-hara):
Kushthahara refers to agents or formulations specifically targeted at treating skin diseases in Ayurveda. This term emphasizes the focus on addressing skin health within Ayurvedic practices, guiding therapy towards addressing issues contextualized by traditional understanding and herbal remedy usage.

38) Calculation:
Calculation pertains to the statistical analysis of research data gathered during clinical studies. Through proper calculation, researchers can determine the effectiveness of treatments like Aragvadhadi Lepa for eczema, ensuring valid conclusions are drawn and contributing to the credibility of the findings.

39) Shothaghna (Sothaghna, Shotha-ghna):
Shothaghna signifies the property of a substance that reduces swelling. This attribute is significant in treating inflammatory conditions like eczema, where formulations like Aragvadhadi Lepa aim to mitigate swelling and thereby promote healing, improving patients' overall experience.

40) Discussion:
Discussion is a critical component of research reporting, where findings are interpreted in context. It allows researchers to compare their results with existing literature, explore implications, and suggest future research directions regarding treatments like Aragvadhadi Lepa for skin conditions.

41) Knowledge:
Knowledge encompasses the understanding and wisdom gained through research and experience. In the context of Ayurvedic practices and their efficacy, expanding knowledge on formulations like Aragvadhadi Lepa contributes to better treatment protocols and supports a broader acceptance within healthcare.

42) Cleansing:
Cleansing refers to the process of removing impurities from the skin. This practice is vital in treating eczema as it reduces the risk of secondary infections and promotes healing. Formulations like Aragvadhadi Lepa aim to support cleansing alongside therapeutic effects for effective skin health management.

43) Medicine:
Medicine encompasses the science and practice of diagnosing, treating, and preventing diseases. This study integrates traditional Ayurvedic medicine with modern clinical research, aiming to highlight the therapeutic potential of formulations like Aragvadhadi Lepa for skin conditions, showcasing the relevance of both fields.

44) Swelling:
Swelling is a common symptom in inflammatory skin conditions, including eczema. Effective treatments must address swelling to relieve discomfort and improve skin condition. The anti-inflammatory properties of Aragvadhadi Lepa play a crucial role in reducing swelling, vital for patient care.

45) Kashaya (Kasaya):
Kashaya refers to the astringent property of certain medicinal substances. In Ayurvedic treatments, Kashaya can help in controlling secretion and inflammation, making it relevant in the management of skin diseases like eczema, where formulations aim to balance these aspects for effective healing.

46) Samana (Shamana):
Shamana refers to palliative treatments that provide relief from symptoms without necessarily curing the underlying disease. Understanding Shamana is essential in practicing Ayurveda, as it informs the choice of therapeutics aimed at symptom management in skin conditions like eczema.

47) Dravya:
Dravya translates to substance or material in Ayurveda. This term is significant as it encompasses all medicinal ingredients used in formulations like Aragvadhadi Lepa, emphasizing the critical role of plant-based substances in achieving therapeutic outcomes for various health conditions.

48) Vaidya:
Vaidya refers to an Ayurvedic physician or practitioner who possesses knowledge of traditional medicine. Their role is crucial in diagnosing and treating conditions through herbal remedies, as seen in the study of Aragvadhadi Lepa, highlighting the importance of expertise in applying Ayurvedic principles effectively.

49) Pidaka:
Pidaka stands for eruptions or papules formed on the skin, representing visible manifestations of skin diseases. Monitoring Pidaka is essential in evaluating treatment outcomes, showcasing how Aragvadhadi Lepa aims to reduce these manifestations while promoting overall skin health.

50) Mandal:
Mandal represents an individual's realm or circle in the context of medical practice. In the study, it may refer to the affiliations of practitioners or researchers involved. Recognizing Mandal emphasizes collaboration and the interdisciplinary approach in exploring treatments for skin ailments.

51) Cancer:
Cancer is a serious disease that may exclude patients from certain clinical studies due to its complexity. Understanding its multifactorial nature and the need for specialized care highlights the necessity of integrating various traditional and modern therapies when considering overall patient health.

52) Bitter:
Bitter refers to one of the seven basic tastes identified in Ayurveda, attributed to herbs like Aragvadha. The bitter taste is linked to various health benefits, including detoxification and anti-inflammatory effects. In formulations like Aragvadhadi Lepa, bitterness can enhance therapeutic effectiveness.

53) Edema (Oedema):
Oedema denotes the swelling caused by excess fluid trapped in body tissues, often linked to inflammation. It is relevant in treating skin conditions where reducing oedema can alleviate symptoms. Formulations that target oedema contribute to overall recovery in patients with skin ailments.

54) Sharman (Sarma, Sarman, Sharma):
Sharma is a common surname in India that may indicate the authorship or affiliation of researchers in the study. Recognizing authors by their surnames emphasizes the collaborative nature of scientific inquiry, combining efforts to advance understanding and treatment methodologies in Ayurveda.

55) Patra:
Patra refers to the leaves of plants used in Ayurvedic formulations. In this study, leaves of plants like Aragvadha form essential components of the therapeutic paste, highlighting the significance of plant parts in ensuring the effectiveness of herbal treatments for various ailments.

56) Tikta:
Tikta signifies the bitter taste in Ayurvedic herbal medicine, known for its potential health benefits, including detoxification and antimicrobial properties. Understanding Tikta's role enhances awareness of how different tastes contribute to the overall healing properties of Ayurvedic formulations like Aragvadhadi Lepa.

57) Takra:
Takra refers to buttermilk in Ayurveda, often used as a medium for making pastes or lepas. In the preparation of formulations like Aragvadhadi Lepa, Takra serves to enhance absorption and efficacy of herbs, showcasing the significance of combining various substances for improved health outcomes.

58) Kumar:
Kumar is a common Indian name and may refer to one of the researchers involved in the study. Recognizing individual contributions highlights the importance of collaboration and interdisciplinary approaches in investigating traditional medicine and its relevance in contemporary therapeutic practices.

59) Water:
Water serves as a universal solvent and plays a vital role in the preparation of herbal formulations. In creating pastes like Aragvadhadi Lepa, the appropriate use of water enhances the consistency and effectiveness of the treatment, emphasizing the importance of its role in Ayurvedic medicine.

60) Roga:
Roga translates to disease or ailment in Sanskrit and is central to Ayurvedic practice where diagnosing and treating specific Rogas guides therapy. Understanding Rogas leads to tailored treatment strategies for conditions like eczema, underpinning the personalized nature of Ayurvedic medicine.

61) Rasa (Rasha):
Rasa refers to the taste or essence of substances in Ayurvedic medicine. It plays a crucial role in determining the therapeutic properties of herbs. The categorization of Rasa helps practitioners understand which formulations like Aragvadhadi Lepa are best suited for treating specific health conditions.

62) Food:
Food is vital for health, serving as nourishment and influencing overall well-being. In Ayurveda, dietary recommendations are integral to treatment plans for diseases like eczema, emphasizing the significance of food choices in recovery and the synergistic effect of diet with herbal remedies.

63) Diet:
Diet refers to the specific dietary choices and regimen recommended to patients in Ayurvedic practices. A well-planned diet is essential in conjunction with treatments like Aragvadhadi Lepa for conditions like eczema, highlighting the importance of holistic approaches that include nutrition in healthcare.

64) Line:
Line may refer to the boundary or conditions defining certain aspects of research or methodology in clinical studies. Clarity in delineating lines between various factors is crucial for accurate assessment, ensuring that findings from studies concerning treatments like Aragvadhadi Lepa are robust and reliable.

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Adverse effect, Topical application, Informed consent, Assessment criteria, Pilot study, Statistical evaluation, Clinical presentation, National Institute of Ayurveda, E.S.R, Dermatitis, Roganidana evam vikriti vijanana department.

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