Quantum analysis of the interaction of vortioxetine vs. neurotransmitters.
Journal name: World Journal of Pharmaceutical Research
Original article title: Quantum analysis of the interaction of vortioxetine vs. neurotransmitters.
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Bernardo Ojeda-Lara, Jesús Francisco Mondragón-Jiménez, Carlos Arturo Brito-Pérez, Adrián Alvarez-Aguilar, Francisco José Rosales-Hernández and Manuel González Pérez
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Quantum analysis of the interaction of vortioxetine vs. neurotransmitters.
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20178-9020
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Summary of article contents:
Introduction
Vortioxetine (Vx) is a novel medication approved by the Food and Drug Administration (FDA) for treating major depressive disorder (MDD), which significantly impacts an individual’s emotional state, resulting in persistent feelings of sadness and loss of interest in usual activities. The drug not only shows antidepressant properties but also exhibits anxiolytic effects, making it potentially effective in treating both depression and anxiety. This study aims to examine the interaction between Vx and various neurotransmitters (NT) utilizing the semi-empirical quantum method known as Parametrical Method 3 (SE-PM3), alongside Hyperchem for analysis.
Electron Transfer Coefficient (ETC) in Neurotransmitter Interaction
One of the key findings of the study involves the Electron Transfer Coefficient (ETC) between Vx and different neurotransmitters. The results indicate that the interaction between Vx and adrenalin (AD) yielded the lowest ETC, suggesting a high specificity and significant electron transfer from Vx to AD. Conversely, the interaction with noradrenaline (NE) resulted in the highest ETC, indicating a low specificity and minimal electron transfer. This suggests that Vx acts more as an antioxidant for AD than for NE, providing insights into the molecular dynamics at play in the therapeutic action of Vx.
Quantum Analysis of Vortioxetine
The quantum analysis conducted in this study utilized Hyperchem to visualize molecular interactions and assess the electrostatic potential between Vx and NTs. It was observed that Vx exhibited a greater affinity for dopamine, another NT in the catecholamine group, indicating a robust interaction that aids in cognitive function and emotional regulation. The analysis not only quantified electron transfer dynamics but also provided a visual representation of the interaction strengths, further emphasizing the significance of Vx in modulating neurotransmitter activity.
Importance in Clinical Application
The clinical implications of this research highlight Vx's role as a potential therapeutic agent, with particular effectiveness in enhancing interactions with certain neurotransmitters while demonstrating less efficacy with others, such as NE. By discerning the varying levels of interaction, this study aids in understanding how Vx could be optimized for patient care in MDD, allowing for more tailored treatment options that consider individual biochemical responses. The associations documented suggest that Vx might be especially beneficial in managing cognitive dysfunctions associated with depressive disorders due to its favorable interaction with key neurotransmitters.
Conclusion
In conclusion, this study provides valuable insights into the interactions between vortioxetine and various neurotransmitters, underpinned by quantum analysis through the SE-PM3 method. The pronounced electron transfer from Vx to adrenalin and dopamine, alongside the low interaction with noradrenaline, reinforces the drug's potential as an antioxidant and therapeutic agent for MDD. Further research is warranted to fully harness these interactions in clinical practice, ensuring a deeper understanding of how Vx can be effectively integrated into treatment regimens for those suffering from depression and related disorders.
FAQ section (important questions/answers):
What is Vortioxetine and what condition does it treat?
Vortioxetine (Vx) is a drug approved by the FDA for treating major depressive disorder (MDD), which significantly affects people's emotional states, causing persistent sadness and loss of interest in activities.
How does Vortioxetine interact with neurotransmitters?
The study used a semi-empirical quantum method to analyze the interaction of Vx with neurotransmitters, revealing varying interactions, with the lowest electron transfer for adrenalin (AD) and the highest for noradrenaline (NE).
What were the results of the electron transfer coefficient analysis?
Vortioxetine showed the highest specificity for adrenalin and dopamine, while it had the lowest affinity for noradrenaline, indicating that Vx acts more effectively as an antioxidant for adrenalin.
What methodology was used for the research conducted in the study?
The study utilized the Hyperchem molecular modeling program and the semi-empirical quantum method Parametrical Method 3 (SE-PM3) to analyze interactions between Vortioxetine and various neurotransmitters.
What implications do the findings have for treating MDD?
The findings suggest that Vortioxetine can effectively interact with neurotransmitters, particularly adrenalin and dopamine, which may enhance its therapeutic effects in patients with major depressive disorder.
What are the unique properties of Vortioxetine's mechanism of action?
Vortioxetine exhibits antidepressant and anxiolytic effects targeting serotonin receptors, enhancing neurotransmission across several systems, including serotonergic, noradrenergic, and dopaminergic pathways, which are essential for mood regulation.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Quantum analysis of the interaction of vortioxetine vs. neurotransmitters.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Table:
Table refers to a systematic arrangement of data organized in rows and columns. In scientific research, tables are essential for presenting results, comparisons, and relationships between variables. They summarize quantitative information for quick reference and analysis, helping to clearly convey findings and support conclusions drawn from the study.
2) Substance:
Substance denotes a particular kind of matter with uniform properties. In the context of pharmaceuticals and biochemistry, substances include raw materials, drugs, neurotransmitters, and other compounds analyzed for their interactions and effects. Understanding substances is crucial for evaluating their roles in therapeutic mechanisms and potential side effects.
3) Drug:
A drug is a chemical agent used to diagnose, cure, mitigate, treat, or prevent disease. In the context of vortioxetine, it highlights the therapeutic application to manage major depressive disorder. The study emphasizes understanding drug interactions at a molecular level to enhance efficacy and safety in treatments.
4) Disease:
Disease refers to any condition that impairs normal functioning and is typically characterized by identifiable signs and symptoms. The study focuses on major depressive disorder (MDD), which affects mental health significantly. Understanding diseases is vital for developing effective treatments and discovering how specific compounds can influence neural pathways.
5) Amol:
Amol is a unit of measurement in chemistry that signifies a specific quantity of substances. It often relates to the amount of a substance involved in chemical reactions. Accurate measurements are critical in pharmaceutical research to ensure consistent results and reliable interactions between drugs and target molecules.
6) Line:
Line can refer to graphical representation in charts or plots illustrating data trends and relationships. In scientific discussion, it may also relate to lines of reasoning or argumentation based on experimental evidence. Clear lines of thought facilitate understanding of complex interactions between compounds like vortioxetine and neurotransmitters.
7) Calculation:
Calculation is the process of determining results through mathematical operations. In scientific contexts, it is crucial for analyzing data, understanding interactions, and obtaining quantitative measures like electron transfer coefficients. Precise calculations allow researchers to draw valid conclusions and substantiate claims regarding the efficacy of substances and their mechanisms.
8) Discussion:
Discussion in scientific research involves interpreting results, contextualizing findings, and exploring implications. It is where researchers analyze relationships, address limitations, and propose future research directions. This section is essential for articulating the significance of results, like those related to vortioxetine's electron interactions with neurotransmitters.
9) Science (Scientific):
Scientific refers to a systematic approach grounded in empirical evidence and research methodologies. It emphasizes the importance of experimentation, observation, and analysis in understanding natural phenomena. In pharmaceutical research, a scientific mindset is paramount for validating hypotheses and ensuring that findings contribute to medical knowledge and practice.
10) Anxiety:
Anxiety is a common mental health condition characterized by excessive worry and fear, often co-occurring with depression. The study's focus on vortioxetine includes its potential benefits for treating not just depressive disorders but associated anxiety as well, highlighting the importance of targeting multiple symptoms in therapeutic interventions.
11) Summer:
Summer in this context refers to a period, specifically related to the 'Summer of Scientific Research' program at UJAT-DACS, where this research was conducted. Such programs facilitate student engagement in hands-on research projects, fostering skills, collaboration, and innovation in scientific inquiry, particularly in fields like pharmacology.
12) Medium:
Medium can refer to a means or mode of expression or communication, such as scientific articles or conferences. In the context of the study, it relates to the methods and tools used to explore interactions among compounds. A clear medium is essential for sharing knowledge and discussing findings effectively between scientists.
13) Beta:
Beta refers to a type of receptor or molecule involved in neurotransmission. In pharmacology, beta receptors are important targets for various drugs that influence cardiovascular and central nervous systems. Awareness of these receptors is crucial for understanding how drugs like vortioxetine interact with the body's biological pathways.
14) Food:
Food generally relates to substances consumed for nourishment but in the context of pharmaceuticals, it might also refer to the dietary interactions with drug absorption and metabolism. Understanding these interactions is critical in clinical research to ensure drugs are administered effectively and their therapeutic value is maximized.
15) Hand:
Hand often represents the manual aspect of conducting experiments and research in scientific studies. It emphasizes the importance of human involvement in collection, analysis, and interpretation of data. This element is crucial for ensuring accuracy and reliability in experimental procedures and the application of findings in real-world settings.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Quantum analysis of the interaction of vortioxetine vs. neurotransmitters.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Cognitive dysfunction, Food and Drug Administration, Major depressive disorder, Serotonin receptor.