Study of preliminary phytochemical anti-diabetic property of cleome gynandra
Journal name: World Journal of Pharmaceutical Research
Original article title: Study of preliminary phytochemical anti-diabetic property of cleome gynandra
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
This page presents a generated summary with additional references; See source (below) for actual content.
Original source:
This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.
Sangameswaran B., Venkataraman S., ShriShastikaa S., Sudhakaran S., Suganya E., Sureshkumarand S. and Vasavi P.
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Study of preliminary phytochemical anti-diabetic property of cleome gynandra
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr201712-9549
Copyright (license): WJPR: All rights reserved
Download the PDF file of the original publication
Summary of article contents:
Introduction
The study focuses on the phytochemical and anti-diabetic properties of Cleome gynandra, a plant widely used in traditional medicine systems like Ayurveda and Siddha. Due to the rising interest in herbal medicines as alternatives to conventional therapies, this research aims to validate traditional claims about the plant. Cleome gynandra is noted for its abundance across India, where it is often found in fields and along roadsides. The aim of the study is to evaluate the phytochemical constituents of the plant and its potential inhibitory effect on key digestive enzymes associated with diabetes management.
Antidiabetic Potential of Cleome gynandra
The research highlights the in vitro efficacy of Cleome gynandra in inhibiting digestive enzymes such as α-amylase and α-glucosidase, which are critical for the metabolism of carbohydrates. The ethanol extract of the plant (EECG) demonstrated a significant concentration-dependent inhibition of these enzymes, suggesting that the plant may provide a natural alternative for managing postprandial blood sugar levels. The study found that the IC50 values for EECG and the aqueous extract (AECG) were 77.53 μg/ml and 123.5 μg/ml, respectively, indicating a promising anti-diabetic effect compared to the standard drug, acarbose.
Phytochemical Analysis
A comprehensive phytochemical analysis revealed the presence of various bioactive compounds in Cleome gynandra, such as alkaloids, flavonoids, saponins, and phenolic compounds. The study utilized both qualitative and quantitative methods to extract and identify these constituents, which are believed to contribute to the therapeutic effects of the plant. This analysis underscores the rich source of medicinally valuable compounds that could play a role in herbal medicine and provide health benefits, especially in the context of diabetes.
Pharmacognostical Evaluation
The research also included pharmacognostical evaluations, which focused on determining physicochemical parameters such as ash values, extractive values, and loss on drying. Results indicated a total ash value of 10.4% and a water-soluble extractive value of 3.6%. These evaluations are crucial for establishing the quality and purity of herbal drugs derived from Cleome gynandra, which, alongside the presence of phytochemicals, supports its potential as a reliable medicinal source.
Conclusion
In conclusion, the study substantiates the traditional use of Cleome gynandra by demonstrating its significant anti-diabetic properties and rich phytochemistry. The findings suggest that this plant could be a valuable resource for developing novel therapies for diabetes management, emphasizing the importance of further research into its phytochemical profiles and mechanisms of action. The authors encourage broader exploration of Cleome gynandra as a complementary treatment for diabetes and highlight the need for quality control measures in the commercialization of herbal products.
FAQ section (important questions/answers):
What is the main purpose of the study on Cleome gynandra?
The study aims to investigate the phytochemical constituents and anti-diabetic properties of Cleome gynandra. It evaluates its inhibitory effects on key intestinal enzymes involved in blood sugar regulation.
What phytochemicals were identified in Cleome gynandra extracts?
The extracts of Cleome gynandra were found to contain alkaloids, flavonoids, saponins, carbohydrates, glycosides, steroids, and phenolic compounds, highlighting its potential health benefits.
What were the extraction methods used in the study?
Two extraction methods were utilized: Soxhlet extraction with ethanol (EECG) and aqueous extraction (AECG) to isolate the active phytochemicals from the whole plant.
How does Cleome gynandra affect diabetes management?
Cleome gynandra exhibits α-amylase and α-glucosidase inhibitory activity, which can improve glucose metabolism and lower blood sugar levels in type 2 diabetes patients.
What were the significant findings related to enzyme inhibition?
The ethanol extract showed a higher inhibitory effect on α-amylase (65.34%) compared to the aqueous extract (48.59%), indicating its potential as a natural anti-diabetic agent.
What conclusion can be drawn from the study findings?
The study concludes that Cleome gynandra can serve as an alternative and medicinal source for treating diabetes mellitus due to its significant phytochemical content and enzyme inhibitory effects.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Study of preliminary phytochemical anti-diabetic property of cleome gynandra”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
The term 'Drug' relates to substances that are utilized for therapeutic purposes. In the presented study, Cleome gynandra is investigated for its potential medicinal properties, particularly its anti-diabetic effects. The research aims to establish scientific evidence for using this plant as a natural remedy for diabetes-related ailments.
2) Activity:
'Activity' refers to the biological effects or actions of a substance. In this study, the focus is on the anti-diabetic activity of Cleome gynandra, which can inhibit enzymes like α-amylase and α-glucosidase. The activity of these enzymes is crucial in carbohydrate metabolism, affecting blood sugar levels.
3) Water:
Water is a solvent used in extracting phytochemicals from plants. In this study, aqueous extraction of Cleome gynandra is performed to obtain its constituents. Water's role is essential for solubilizing water-soluble compounds, thereby facilitating the analysis of ingredients that may contribute to the plant's medicinal properties.
4) Phytochemical:
'Phytochemical' refers to the chemical compounds produced by plants. These substances play various roles, including potential health benefits when consumed. The study investigates the phytochemical constituents of Cleome gynandra, which includes flavonoids, saponins, and alkaloids, to determine their efficacy in anti-diabetic treatment.
5) Venkataraman:
Dr. Venkataraman is the professor and corresponding author of the study on Cleome gynandra. His role signifies leadership in conducting the research, guiding methodologies, and ensuring scientific rigor in evaluating the plant's potential medicinal benefits. This attribution of work to Venkataraman adds credibility to the findings.
6) India:
'India' is the geographic context of the study, where Cleome gynandra is abundantly found and traditionally used in herbal medicine. The diversity of plant species in India supports the exploration of various natural remedies, aligning with growing interests in alternative medicine and the therapeutic properties of local flora.
7) Study (Studying):
The term 'Study' encapsulates the systematic investigation of Cleome gynandra for its anti-diabetic properties. The research seeks to quantify phytochemical efficacy and explore potential therapeutic applications. A well-structured study format also helps validate traditional claims regarding the plant's medicinal uses.
8) Flavonoid:
'Flavonoid' is a type of phytochemical present in Cleome gynandra that may contribute to its antioxidant and anti-diabetic effects. The research focuses on the identification of flavonoids among other compounds to elucidate how these substances aid in managing blood sugar levels, hence their relevance in diabetes treatment.
9) Powder:
'Powder' refers to the form of the dried plant material used in the study. Powdering the whole plant allows for effective extraction of phytochemicals, facilitating the analysis of the plant's bioactive components. This preparation method ensures that the maximum amount of active constituents is available for experimentation.
10) Medicine:
'Medicine' denotes the application of healing substances for treating ailments. This study investigates Cleome gynandra as a potential herbal medicine for diabetic conditions, affirming the plant's relevance in traditional and modern healing practices. The research aims to connect empirical evidence with the therapeutic claims made by herbalists.
11) Table:
In the context of the research, 'Table' refers to data presentation that summarizes findings, such as the extraction values or inhibitory activities against enzymes. Tables serve to present results in a clear and organized manner, enhancing understanding and highlighting the significance of the data analyzed during the study.
12) Tamilnadu (Tamil-nadu):
'Tamilnadu' is the state in southern India from where the Cleome gynandra samples were collected. This regional focus underlines the significance of local flora in traditional medicine practices, providing insight into the cultural and geographical relevance of the plant in local healing traditions.
13) Bhavani:
Bhavani is a town in Tamil Nadu, India, identified as the collection site for Cleome gynandra in the study. This location emphasizes the importance of local biodiversity and contributes to the understanding of how traditional medicine practices incorporate local plants into healthcare systems specific to the region.
14) Disease:
'Disease' refers to health conditions requiring treatment, particularly diabetes in this study. The research aims to explore the benefits of Cleome gynandra in managing diabetes, aligning with the growing need for effective medicinal alternatives to conventional therapies for chronic diseases.
15) Nature:
'Nature' encompasses the intrinsic properties of plants and ecosystems. In this research, the study of Cleome gynandra underscores the natural therapeutic potential that can be harnessed from plant species, promoting a shift toward utilizing nature's resources in developing medicinal treatments.
16) Pharmacognostical:
'Pharmacognostical' relates to the study of medicinal drugs derived from plants. This research incorporates pharmacognostical evaluations to identify and categorize the phytochemical constituents of Cleome gynandra, enhancing understanding of its constituents' therapeutic properties concerning traditional uses in medicinal practices.
17) Substance:
'Substance' refers to the phytonutrients present in Cleome gynandra that can exhibit health benefits. The study assesses the various substances extracted from the plant to determine their biological activities, particularly their potential in lowering blood sugar levels through enzyme inhibition.
18) Species:
'Species' classifies Cleome gynandra as a distinct plant type within the Cleomaceae family. Understanding the species allows for targeted research into its specific properties and potential medical applications, thus contributing to botanical and pharmacological knowledge concerning herbal remedies.
19) Family:
'Family' in a botanical context refers to taxonomic grouping of related plants. Cleome gynandra belongs to the Cleomaceae family, which signifies its biological relationships and potential shared characteristics among plants in this family, aiding in understanding its medicinal significance in traditional medicine.
20) Sugar:
'Sugar' refers to simple carbohydrates absorbed into the bloodstream affecting blood glucose levels. Understanding sugar's role is crucial in diabetes management, and the study evaluates Cleome gynandra's effectiveness in inhibiting enzymes responsible for digesting sugars, providing insights into dietary management for diabetic patients.
21) Dish (Dis):
'Dish' may refer to laboratory apparatus such as Petri dishes used in the research for culturing or testing extracts. It highlights the practical aspects of experimentation in a laboratory setting, emphasizing the importance of proper techniques in conducting phytochemical analyses and biological assays.
22) Pharmacological:
'Pharmacological' pertains to the study of how substances interact with biological systems. This study integrates pharmacological evaluation to determine the impact of Cleome gynandra's extracts on diabetes, contributing to a broader understanding of how herbal remedies function at a molecular level.
23) Antibiotic (Antibacterial):
'Antibacterial' refers to the properties of substances that inhibit bacterial growth. Cleome gynandra may exhibit antibacterial effects, adding to its profile as a valuable medicinal plant. Addressing such properties enhances its potential applications beyond treating diabetes, indicating its versatile uses in natural medicine.
24) Discussion:
'Discussion' encompasses the analysis and interpretation of the research findings. It serves to contextualize results within the broader scientific discourse, elaborating on the implications of findings regarding Cleome gynandra's properties and how they relate to established medicinal knowledge and practices.
25) Ayurveda (Ayus-veda):
'Ayurveda' is a traditional Indian system of medicine that utilizes natural herbs for healing. Cleome gynandra's inclusion in Ayurvedic practices supports the study's rationale for exploring its medicinal properties, showing how traditional knowledge continues to inform modern scientific inquiries into plant-based treatments.
26) Quality:
'Quality' pertains to the composition and efficacy of the plant extracts. Assessing quality ensures that the bioactive compounds being studied have the potential for therapeutic impact, allowing for accurate claims about the medicinal benefits of Cleome gynandra within a scientific framework.
27) Heating:
'Heating' refers to the method used in the extraction process for obtaining phytochemicals from Cleome gynandra. Controlled heating plays a role in solubilizing compounds, ensuring thorough extraction during the study, thereby influencing the yield and efficacy of the resulting plant extracts.
28) Siddha:
'Siddha' is another traditional Indian system of medicine emphasizing holistic health through herbal formulations. The relevance of Cleome gynandra in both Siddha and Ayurveda illustrates its cultural significance and the importance of integrating such traditional practices into contemporary pharmaceutical research.
29) Purity:
'Purity' measures the absence of contaminants in the plant extracts. The study assesses the purity of Cleome gynandra to verify that the extracted constituents are not influenced by adulterants, ensuring that the medicinal properties attributed to the plant can be consistently evaluated.
30) Field:
'Field' refers to the natural habitat where Cleome gynandra grows. Understanding its growth environment is essential for studying the plant's natural adaptations, influences on phytochemical composition, and the practical aspects of harvesting it for medicinal purposes, particularly in the context of rural health.
31) Blood:
'Blood' relates to its crucial role in the human body in transporting nutrients, including glucose. By focusing on Cleome gynandra's effects on blood sugar regulation, the study addresses significant concerns related to diabetes, a disease that affects blood glucose management, hence its relevance.
32) Human body:
'Human body' refers to the biological system in which diabetes and other diseases manifest. Understanding how Cleome gynandra interacts within this system is essential for evaluating its therapeutic potential, emphasizing the plant's relevance in traditional and modern medical practices designed to promote health.
33) Purification:
'Purification' denotes processes to remove impurities from plant extracts. This study emphasizes the importance of purification techniques in ensuring the extracts of Cleome gynandra contain active, beneficial compounds free from contaminants which could impact their therapeutic efficacy.
34) Observation:
'Observation' reflects the empirical evidence collected during the research process. Systematic observation during the testing and extraction phases aids in drawing comprehensive conclusions about the efficacy of Cleome gynandra, ensuring that results are reliably documented and scientifically valid.
35) Science (Scientific):
'Scientific' pertains to the rigor and methodical approach taken in studying Cleome gynandra. The methodology employed in the research reflects established scientific principles, thereby affirming the reliability of findings and the importance of evidence-based conclusions regarding the plant's medicinal use.
36) Toxicity:
'Toxicity' indicates the potential harmful effects of substances. This study highlights the importance of evaluating the toxicity of Cleome gynandra extracts to ensure safety for therapeutic use, reflecting a growing concern in herbal medicine regarding adverse effects and patient safety.
37) Colouring (Coloring):
'Coloring' may refer to the visual attributes of the extracts resulting from chemical reactions during testing. These color changes can provide preliminary insights into the presence of specific phytochemicals, serving as a diagnostic tool in qualitative analysis of the plant's constituents.
38) Crushing:
'Crushing' involves grinding the plant material to facilitate extraction and analysis of phytochemicals. This method enhances surface area contact with solvents, promoting effective extraction of bioactive compounds from Cleome gynandra, thereby increasing yield and ensuring thorough evaluation of its potential benefits.
39) Gelatin:
'Gelatin' refers to a substance that can be used in tests for tannins and phenolic compounds. Reactions with gelatin can indicate the presence of certain plant metabolites, highlighting methods employed in analyzing the phytochemical composition of Cleome gynandra and establishing its medicinal applications.
40) Surface:
'Surface' refers to the area exposed during the analysis of plant materials and their extracts. The surface characteristics can influence extraction efficiency and, understanding these aspects is vital for optimizing methods used to analyze Cleome gynandra’s phytochemical constituents.
41) Cancer:
'Cancer' relates to one of the chronic diseases towards which Cleome gynandra's medicinal properties may extend. Given the reported antibacterial and potential anti-cancer activities, the study may contribute to broader discussions on the plant's role in addressing serious health concerns beyond diabetes.
42) Animal:
'Animal' often refers to testing subjects in pharmacological studies. Understanding the effects of Cleome gynandra in animal models is crucial for extrapolating results to human health, illustrating the link between traditional herbal applications and modern scientific evaluations of their effectiveness.
43) Indian:
'Indian' signifies the cultural and geographic context for the study. The emphasis on Indian traditional medicine heritage, including Ayurveda and Siddha, supports the significance of local plant species like Cleome gynandra, whose uses are deeply rooted in the historical practices of healthcare.
44) Birth:
'Birth' can refer to the traditional use of Cleome gynandra in aiding childbirth. Acknowledging this application illustrates the plant's diverse medicinal roles within local cultural practices and its potential contributions to maternal health and traditional birthing methods.
45) Paddy:
'Paddy' refers to rice cultivation where Cleome gynandra is often found growing as a weed. Recognizing the agricultural context highlights the plant's availability and accessibility in rural settings, reinforcing its role in local herbal medicine practices historically adopted by community members.
46) Food:
'Food' represents the dietary components influencing health, particularly in diabetes management. Studies like this one on Cleome gynandra align with food science, exploring how dietary choices and natural products can combine to offer holistic treatment options for managing blood sugar levels effectively.
47) Crop:
'Crop' refers to cultivated plants and highlights the agricultural aspect of Cleome gynandra, which can grow in crop fields. This relation emphasizes the significance of incorporating local flora into agricultural practices while also recognizing the plant's dual role as both a crop and a herbal remedy.
48) Rich (Rch):
'Rich' can refer to the diverse bioactive compounds present in Cleome gynandra. The richness of these phytochemicals enhances the potential of the plant in providing health benefits when used as a natural remedy for various ailments, particularly diabetes-related conditions.
49) Road:
'Road' indicates the geographical locations where Cleome gynandra might grow, illustrating the accessibility of this plant in its natural habitat. This aspect is important as it underscores the significance of local biodiversity in providing medicinal resources for rural communities.
50) Wall:
'Wall' might refer metaphorically to the structural context of cells in the plant, where secondary metabolites are synthesized. Understanding the cellular architecture contributes to the overall knowledge of how biological systems produce and regulate phytochemicals within plants like Cleome gynandra.
51) Pain:
'Pain' indicates the symptomatic experiences often associated with diseases. The potential therapeutic effects of Cleome gynandra may extend to pain management, particularly in conditions where inflammation and discomfort are prevalent, thus enhancing the plant's relevance in holistic treatment approaches.
52) Worm:
'Worm' might relate to the traditional use of Cleome gynandra in treating parasitic infections. As the plant exhibits various biological activities, exploring its efficacy against parasites adds another dimension to understanding its medicinal applications beyond commonly researched areas like diabetes.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Study of preliminary phytochemical anti-diabetic property of cleome gynandra’. Further sources in the context of Science might help you critically compare this page with similair documents:
Flavonoid, Diabetes mellitus, Phytochemical screening, Pharmacognostical evaluation, Scientific validation, Soxhlet extraction, Alkaloid, Alpha amylase, Analytical parameter, Glycoside, Phytochemical constituent.