Study of Madhukadivati for asrugdara (excessive uterine bleeding)
Journal name: World Journal of Pharmaceutical Research
Original article title: A clinical study of madhukadivati on asrugdara (excessive and irregular uterine bleeding)
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Dr. Neha Pandya, Dr. Hetal P. Baraiya and Dr. M. A. Pandya
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: A clinical study of madhukadivati on asrugdara (excessive and irregular uterine bleeding)
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr201714-10000
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
Asrugdara, characterized by excessive and irregular uterine bleeding, is a prevalent gynecological condition affecting women's health significantly. It can disrupt not only reproductive health but also the overall well-being of women. Although contemporary medicine offers options like medical therapy and surgical interventions, such as hysterectomy, Ayurveda approaches Asrugdara through the use of haemostatic drugs. The study conducted by Baraiya et al. investigates the effectiveness of Madhukadi Vati, an Ayurvedic formulation, in managing Asrugdara, analyzing clinical outcomes and patient responses to treatment.
Effectiveness of Madhukadi Vati
The clinical trial involved 36 patients diagnosed with Asrugdara, out of which 30 completed the treatment with Madhukadi Vati. The assessment criteria focused on improvements in the cardinal symptoms of the condition. Results demonstrated a statistically significant reduction in the duration and amount of bleeding, indicating that Madhukadi Vati effectively alleviates the symptoms associated with Asrugdara. Notably, the formulation showed remarkable efficacy in managing blood loss and bleeding durations, suggesting its potential as a viable therapeutic option in excessive uterine bleeding cases.
Understanding the Etiopathogenesis
According to Ayurvedic principles, the underlying causes of Asrugdara often relate to imbalances in the body’s doshas, particularly a combination of Pitta and Kapha. Contributing factors include dietary choices and lifestyle habits that vitiate these doshas, leading to the emergence of symptoms. The study highlighted poor dietary practices, such as consuming excessive sour, salty, and fatty foods, and psychological stressors like anxiety and anger, as significant contributors to the condition. Additionally, distinguishing between different body constitutions indicated that certain predominant prakritis, namely Pitta-Kapha, might be more susceptible to developing Asrugdara.
Associated Symptoms and Overall Improvements
The trial also noted a range of associated symptoms experienced by patients, including general weakness, paleness, and fatigue, among others. The use of Madhukadi Vati led to substantial relief in these accompanying symptoms, reinforcing the comprehensive benefits derived from the treatment. Patients reported improvements in general health as the medication not only addressed the primary issue of bleeding but also positively impacted related health issues, underscoring the holistic nature of Ayurvedic therapies in managing women's health conditions.
Conclusion
The findings from this clinical study underscore the potential of Madhukadi Vati as an effective treatment for Asrugdara, offering significant improvements in the severity of symptoms experienced by patients. The study elucidates the multifaceted nature of Asrugdara, influenced by dietary and psychological factors, and points towards Ayurvedic treatment's holistic efficacy in addressing both primary and associated symptoms. Overall, the research advocates for a more integrated approach to treat Asrugdara through Ayurveda, thereby enhancing the quality of life for affected women.
FAQ section (important questions/answers):
What is Asrugdara and its significance in women's health?
Asrugdara refers to excessive and irregular uterine bleeding, a common issue that affects women's reproductive and overall health. It can lead to various complications if not addressed properly.
What are the conventional treatments for Asrugdara?
Conventional treatments include medical therapies; if ineffective, surgical interventions like hysterectomy or uterine thermal balloon are often recommended for management.
How is Madhukadi Vati used in treating Asrugdara?
Madhukadi Vati is given orally at a dosage of 3 grams three times a day with milk for a duration of two months to manage Asrugdara effectively.
What symptoms were measured in assessing treatment efficacy?
Symptoms assessed included the duration of bleeding, the interval of menstrual cycles, amount of blood loss, and improvement in associated symptoms.
What were the results of Madhukadi Vati in the study?
The study showed significant improvements with Madhukadi Vati, highlighting its effectiveness in reducing blood loss duration and alleviating associated symptoms in patients.
Who were the most affected demographic groups in the study?
The most affected demographic consisted of women aged 26 to 35, predominantly housewives with diets rich in Pitta and Kapha aggravating foods.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Study of Madhukadivati for asrugdara (excessive uterine bleeding)”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Bleeding:
Bleeding refers to the excessive and irregular uterine bleeding known as Asrugdara, which is a common gynecological issue among women. This condition affects not only menstrual regularity but also overall health, leading to complications if not properly addressed. In Ayurveda, it is treated with specific medicinal approaches like Madhukadi Vati.
2) Madhukadi:
Madhukadi is a herbal formulation used in Ayurvedic medicine, indicated for treating Asrugdara. It comprises various beneficial herbs that act synergistically to control excessive bleeding and also help in restoring balance to the bodily doshas. Its therapeutic properties make it relevant for managing gynecological conditions effectively.
3) Vati:
Vati refers to a type of Ayurvedic tablet or pill, often made from powdered herbs. In this study, Madhukadi Vati is used to alleviate the symptoms of Asrugdara. Its preparation in a vati form ensures precise dosage and makes it easier for patients to consume, enhancing compliance in treatment.
4) Table:
Tables in the context of medical research provide a structured summary of findings, including statistical data such as symptom relief percentages. They serve as a visual representation of results, making it easier for practitioners and researchers to analyze and interpret treatment outcomes from the study.
5) Pitta:
Pitta is one of the three fundamental doshas in Ayurveda, associated with heat and metabolism. When vitiated, particularly in conditions like Asrugdara, it can lead to excess heat and imbalances in bodily functions, causing symptoms such as excessive uterine bleeding. Proper management of Pitta is essential in treatment.
6) Study (Studying):
The study referenced here evaluates the effectiveness of Madhukadi Vati in treating Asrugdara. By systematically gathering data from patients and analyzing outcomes, the study provides evidence supporting the use of traditional Ayurvedic medicine in managing excessive and irregular uterine bleeding, contributing to both medical knowledge and practice.
7) Baraiya:
Dr. Hetal P. Baraiya is one of the contributors to the research study on Madhukadi Vati's effectiveness in treating Asrugdara. His involvement underscores the collaborative nature of medical research, wherein multiple experts contribute their knowledge and skills to enhance the understanding of treatment efficacy.
8) Kapha:
Kapha is another of the three doshas in Ayurveda, often associated with stability and structure in the body. An imbalance or vitiated Kapha may contribute to conditions such as excessive uterine bleeding, exacerbating symptoms. Ayurvedic treatments aim to balance Kapha along with Pitta and Vata for comprehensive care.
9) Blood:
Blood is a vital fluid in the body, and its abnormal loss during menstruation is a key symptom of Asrugdara. The study monitors blood loss to evaluate the effectiveness of Madhukadi Vati treatment. Understanding blood dynamics is crucial for managing health conditions that affect women’s reproductive systems.
10) Drug:
In the context of this study, 'drug' refers to Madhukadi Vati, which is the Ayurvedic formulation tested. By analyzing its effects on Asrugdara, researchers aim to determine its efficacy compared to conventional treatments, contributing to the larger discourse on integrating traditional medicine into modern healthcare.
11) Prakriti (Prakrti):
Prakriti denotes an individual’s unique constitution in Ayurveda, determined by a combination of the three doshas: Vata, Pitta, and Kapha. Understanding a patient's Prakriti helps tailor treatments like Madhukadi Vati to address specific imbalances that could lead to conditions such as Asrugdara and related health issues.
12) Vata:
Vata is one of the primary doshas in Ayurveda, associated with air and movement in the body. Imbalances in Vata can lead to various health issues, including Asrugdara. Consequently, managing Vata through herbal treatments helps restore balance, thereby alleviating excessive uterine bleeding.
13) Amalaki:
Amalaki, known scientifically as Emblica officinalis, is a key ingredient in Madhukadi Vati. Its high vitamin C content promotes health by supporting blood management and enhancing immune function. Its role in Ayurvedic formulations is significant for its efficacy in treating various conditions, including Asrugdara.
14) Snigdha:
Snigdha refers to a quality associated with oily and moist substances. In Ayurveda, understanding dietary and lifestyle factors characterized by Snigdha is important for diagnosing imbalances in conditions like Asrugdara. Certain foods classified as Snigdha may aggravate or help alleviate symptoms of excessive bleeding.
15) Lavana:
Lavana means salt or salty substances, which in Ayurveda can impact the body's dosha balance. Excessive intake of Lavana can lead to Pitta and Kapha disturbances, potentially contributing to conditions like Asrugdara. Recognizing its effects assists in forming comprehensive dietary recommendations for patients.
16) Rakta:
Rakta refers to the blood and is one of the seven dhatus (tissues) in the body as per Ayurvedic medicine. The study addresses the role of Rakta in Asrugdara focusing on its management through drugs like Madhukadi Vati to alleviate excessive uterine bleeding and restore health.
17) Guru:
Guru refers to heavy or dense substances in Ayurveda. Dietary choices that are Guru can exacerbate Pitta and Kapha imbalances, contributing to conditions like Asrugdara. Understanding the role of Guru in a patient’s diet helps in personalized treatment plans that aim for balance and health.
18) Amla:
Amla, also known as Emblica officinalis, is noted for its high vitamin C content and antioxidant properties. In this study, its inclusion in Madhukadi Vati contributes to its overall therapeutic effects, particularly benefiting patients suffering from Asrugdara by promoting blood health and immunity.
19) Yashtimadhu (Yastimadhu, Yashti-madhu):
Yastimadhu, or Glycyrrhiza glabra, is another significant component of Madhukadi Vati. It is known for its anti-inflammatory and soothing properties, valuable in treating Asrugdara by addressing symptoms of excess bleeding and promoting overall uterine health through its medicinal qualities.
20) Vatapitta (Vata-pitta):
Vata-Pitta describes the constitution where both the Vata and Pitta doshas are prominent. Patients with a Vata-Pitta constitution may be prone to imbalances leading to conditions like Asrugdara. This understanding helps tailor treatments, notably the effectiveness of Madhukadi Vati for this demographic.
21) Vitiation (Vitiated):
Vitiation refers to the disruption or imbalance of the doshas and physiological processes in the body. In the context of Ayurvedic diagnosis and treatment, recognizing vitiated states helps practitioners identify underlying issues leading to conditions like Asrugdara, allowing for targeted therapeutic strategies.
22) Krodha:
Krodha translates to anger and is recognized as a psychological factor influencing physical health in Ayurveda. Stress and emotional disturbances like Krodha can exacerbate conditions such as Asrugdara by disrupting the hypothalamic-pituitary-ovarian axis, making emotional management vital in treatment plans.
23) Bhrama:
Bhrama signifies dizziness or confusion, often an associated symptom in conditions like Asrugdara. It highlights the interconnectedness of physical symptoms and emotional or psychological well-being. Addressing both aspects through herbal treatments in Ayurveda can enhance overall health and recovery.
24) Chinta:
Chinta denotes worry, a psychological condition that can impact physical health. In relation to Asrugdara, managing Chinta is essential to prevent exacerbating the condition. This interplay between mental and physical health exemplifies the holistic approach of Ayurveda in treating medical conditions.
25) Katu:
Katu refers to bitter or pungent tastes in Ayurveda, often linked to dietary habits that can disturb dosha balance. Understanding the role of Katu foods helps practitioners guide patients, particularly those with Asrugdara, in making dietary adjustments to alleviate symptoms and promote wellness.
26) Rasa (Rasha):
Rasa refers to taste, an important concept in Ayurveda that influences dietary choices and health outcomes. The study emphasizes the need for a balanced diet that aligns with individual dosha characteristics, shaping treatment strategies for conditions like Asrugdara by considering various tastes, including Rasa.
27) Shri (Sri, Sr):
Shri denotes respect or auspiciousness in traditional settings. In a medical research context, it reflects the reverence for cultural practices and the acknowledgment of Ayurveda's historical significance, honoring its long-standing contributions to holistic health management, including the treatment of conditions such as Asrugdara.
28) Terminalia chebula:
Terminalia chebula, known as Haritaki, is one of the components of Madhukadi Vati. Recognized for promoting digestion and overall well-being, it also supports treatment perspectives in Ayurveda concerning excessive bleeding, aligning with the formulation's objective to manage Asrugdara effectively through natural remedies.
29) Terminalia bellirica:
Terminalia bellirica, or Bibhitaki, is another essential herb in Madhukadi Vati. Its properties contribute to detoxification and rejuvenation processes in Ayurveda, significantly aiding in the treatment of conditions involving excessive bleeding by promoting gentle cleansing and restoring balance within the body.
30) Pandutva (Pandu-tva):
Pandutva refers to pallor or paleness, often associated with conditions like anemia due to excessive blood loss. In the context of Asrugdara, monitoring symptoms like Pandutva is crucial for comprehensive assessment and management, highlighting the interrelationship between blood loss and overall health.
31) Avarana:
Avarana refers to obstruction in bodily systems, often leading to imbalances. In treating Asrugdara, recognizing Vata's vitiation due to Avarana is significant, as it identifies the need for therapies focusing on relieving physical and energetic blockages to restore normal function and alleviate symptoms.
32) Lodhra:
Lodhra, or Symplocos recemosa, is an ingredient known for its haemostatic properties, making it pivotal in managing excessive uterine bleeding. Its inclusion in Madhukadi Vati emphasizes Ayurveda's reliance on natural remedies to address conditions like Asrugdara, supporting the aim of achieving balance and health.
33) Pandya (Pamdya, Pandyan):
Dr. Neha Pandya, mentioned in this study, represents the collective effort of practitioners in Ayurveda to contribute toward empirical research. Her involvement exemplifies the integration of traditional knowledge and scientific validation, crucial for advancing the understanding and application of Ayurvedic medicine.
34) Dosha (Dosa):
Dosha signifies the three fundamental energies within Ayurveda, namely Vata, Pitta, and Kapha. Each individual’s health is influenced by their unique dosha composition. Understanding dosha imbalances, especially in conditions such as Asrugdara, is essential for forming effective treatment strategies and achieving comprehensive wellness.
35) Mamsa (Mamsha):
Mamsa refers to muscle tissue and is one of the seven dhatus in Ayurveda. Its health and nourishment are crucial for overall well-being. In treating conditions like Asrugdara, assessments may include how Mamsa is impacted due to excessive bleeding, guiding interventions toward restoration.
36) Musta (Mushta):
Musta, or Cyperus rotundus, is a significant herb used for various ailments in Ayurveda. It is included in formulations like Madhukadi Vati for its properties that help balance doshas and manage conditions such as excessive bleeding. Its medicinal value underlines the holistic approach in Ayurvedic treatments.
37) Dhatu:
Dhatu signifies bodily tissues in Ayurveda. There are seven dhatus that encompass physical structure and function. Assessing dhatu status, particularly Rakta and Mamsa in the context of excessive bleeding or Asrugdara, helps practitioners tailor treatments and interventions more effectively to restore health.
38) Curd:
Curd is recognized in Ayurveda for its cooling properties and beneficial effects on digestion. When discussing dietary factors that might aggravate or alleviate conditions such as Asrugdara, the consumption of curd is significant as it impacts digestive health and promotes overall body balance.
39) Milk:
Milk is considered a nourishing substance in Ayurveda, often used in traditional remedies to enhance treatment efficacy. In the context of Madhukadi Vati, it serves as an Anupana (vehicle) to facilitate the absorption of herbal properties, thereby enhancing the therapeutic effects for managing issues like Asrugdara.
40) Glycyrrhiza glabra:
Glycyrrhiza glabra, known as Yastimadhu, is a crucial component of Madhukadi Vati, valued for its antiviral and anti-inflammatory properties. Its role in treating Asrugdara emphasizes the importance of traditional herbs in Ayurvedic formulations and their ability to address multifaceted health issues effectively.
41) Kaphadosha (Kaphadosa, Kapha-dosha):
Kapha-dosha denotes the element associated with structure and stability in Ayurveda. An imbalance in Kapha can contribute to disturbances that manifest in conditions like Asrugdara. Understanding it helps guide dietary and lifestyle recommendations aimed at achieving balance and alleviating excessive uterine bleeding.
42) Mamsadhatu (Mamsha-dhatu):
Mamsa-dhatu refers to the muscular tissue in the body as per Ayurveda's seven dhatus. Its role is significant in assessing overall health and recovery, particularly in conditions like Asrugdara, where muscle status can indicate the body's nutritional and recovery capabilities.
43) Observation:
Observation forms a foundational aspect of clinical research. It entails closely monitoring symptoms and treatment outcomes in patients undergoing therapy. In this study, careful observation helped quantify the effectiveness of Madhukadi Vati in treating Asrugdara, contributing to sound evidence-based practice in Ayurveda.
44) Sandhaniya:
Sandhaniya denotes substances that aid in the healing and repair processes within the body. In the context of Asrugdara treatment, herbs like Yastimadhu exhibit Sandhaniya properties, emphasizing the need to include restorative elements in therapeutic formulations for enhancing recovery and tissue regeneration.
45) Jatharagni (Jathara-agni):
Jatharagni refers to digestive fire in Ayurveda, essential for proper digestion and metabolism. Understanding the status of Jatharagni is critical when treating Asrugdara, as optimal digestive function supports nutrient absorption and overall health, contributing to the management of symptoms like excessive bleeding.
46) Shothahara (Sothahara, Shotha-hara):
Shothahara refers to substances that help reduce swelling or inflammation in Ayurvedic terms. Incorporating Shothahara properties in treatments for conditions like Asrugdara aids in alleviating additional symptoms associated with excessive bleeding, underscoring the holistic approach of Ayurveda in managing health issues.
47) Discussion:
The discussion section in a research study provides insight into interpreting findings, drawing connections between traditional knowledge and empirical evidence. This context illuminates the relevance of Madhukadi Vati in treating Asrugdara, ensuring that the potential benefits of Ayurvedic practices are highlighted and examined critically.
48) Daurbalya:
Daurbalya signifies weakness or debilitation, often observed in patients with nutritional deficiencies or blood loss, like those with excessive menstruation. Understanding this symptom is crucial in managing conditions such as Asrugdara, guiding dietary and therapeutic interventions to restore strength and vitality in affected individuals.
49) Dhatvagni (Dhatu-agni):
Dhatvagni refers to the metabolic activity associated with the seven dhatus in Ayurveda. A balanced Dhatvagni is vital for nourishing and rejuvenating tissues. In managing conditions like Asrugdara, assessing and supporting Dhatvagni can play a crucial role in restoring health and managing symptoms effectively.
50) Ayurveda (Ayus-veda):
Ayurveda is a holistic system of medicine that emphasizes balance in bodily energies (doshas) and natural remedies for health and well-being. The integration of Ayurvedic principles in addressing conditions like Asrugdara illustrates the efficacy and relevance of traditional wisdom in modern health care practices.
51) Haritaki:
Haritaki, known as Terminalia chebula, is an important herbal component in Ayurvedic formulations. Its benefits in digestion and blood purification are significant, especially in managing conditions like Asrugdara. Its holistic properties help restore balance within the body, underscoring its therapeutic roles.
52) Shodhana (Sodhana):
Shodhana refers to the process of detoxification or purification in Ayurveda. Implementing Shodhana techniques can support overall health and assist in alleviating conditions like Asrugdara by promoting the elimination of toxins and restoring the natural physiological balance within the body.
53) Sphatika:
Sphatika, also known as alum, possesses haemostatic properties, making it vital in treating excessive bleeding conditions in Ayurveda. Its role in Madhukadi Vati emphasizes the application of natural remedies that effectively address specific health issues such as Asrugdara through traditional knowledge.
54) Medicine:
Medicine broadly refers to the science and practice of diagnosing, treating, and preventing illnesses. The relevance of traditional Ayurvedic medicine, as demonstrated in the study on Madhukadi Vati for Asrugdara, underscores the importance of complementary approaches in modern health care paradigms.
55) Samhita:
Samhita refers to a collection of texts in Ayurveda that cover various medical principles and practices. Historical texts such as the Charaka Samhita are essential references for understanding the formulations and therapeutic approaches used, including the treatment of conditions like Asrugdara with Madhukadi Vati.
56) Gujarat:
Gujarat is the region where this study was conducted, home to Gujarat Ayurved University, where traditional healing practices are researched and validated. The work in this context emphasizes the contribution of specific geographical knowledge and application to global perspectives on health and wellness.
57) Anupana:
Anupana refers to the vehicle or medium through which Ayurvedic medicines are administered to enhance absorption and efficacy. In this study, milk is used as the Anupana for Madhukadi Vati, optimizing the therapeutic benefits of the formulation in addressing conditions like Asrugdara.
58) Samaka (Shamaka):
Shamaka signifies balancing or pacifying properties in Ayurvedic terms. The formulation provided in the study, particularly Madhukadi Vati, serves to balance vitiated doshas, thus addressing the symptoms of Asrugdara effectively. Understanding Shamaka properties is crucial for formulating effective treatments.
59) Kashaya (Kasaya):
Kashaya refers to astringent qualities in herbal medicines that help tighten tissues and reduce excessive fluid loss. In the context of Asrugdara, utilizing Kashaya properties in treatments like Madhukadi Vati can aid in controlling bleeding and promoting healing of the affected tissues.
60) Medhya:
Medhya denotes substances that enhance cognitive function and mental clarity. Understanding the role of Medhya herbs in Ayurveda can influence treatment strategies for women with Asrugdara, particularly where psychological factors impact the physiological symptoms, thus emphasizing holistic approaches in treatment.
61) Vyadhin (Vyadhi):
Vyadhi translates to disease or disorder in Ayurveda. Identifying specific Vyadhi, such as Asrugdara, allows practitioners to deploy targeted interventions using traditional herbal remedies. Understanding different Vyadhis enhances the discourse on effectively integrating Ayurvedic practices into modern healthcare systems.
62) Cancer:
Cancer signifies a significant health condition marked by uncontrolled cell growth. While not directly addressed in this study, understanding the pathway of various gynecological disorders and the role of Ayurveda can enrich discourse on preventive measures and holistic approaches toward serious health concerns.
63) Tikta:
Tikta represents a bitter taste in Ayurveda, which influences dietary choices and can impact dosha balance. Understanding Tikta's effects helps practitioners manage conditions like Asrugdara more effectively by fostering dietary modifications that contribute to improving overall health and eliminating excess symptoms.
64) Ulcer:
Ulcer refers to a sore that forms on the lining of the stomach or intestine. While this study focuses on Asrugdara, understanding conditions like ulcers highlights the need for a comprehensive approach in Ayurveda that accounts for interconnected health issues, potentially impacting reproductive health and overall wellness.
65) Agni:
Agni translates to digestion or metabolic fire, a central concept in Ayurveda. It governs the digestive processes and overall health. Assessing Agni is crucial in treating conditions like Asrugdara, as optimal digestion supports nutrient absorption and contributes to balanced bodily function and recovery.
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